Why are so many MLL lysine methyltransferases required for normal mammalian development?

A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response

(2018) Takayuki Hoshii et al.   CELL

Histone H3 lysine 4 monomethylation modulates long-range chromatin interactions at enhancers

(2018) Jian Yan et al.   CELL RESEARCH

KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis

(2018) Enrique Lin-Shiao et al.   GENES & DEVELOPMENT

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Mediator and RNA polymerase II clusters associate in transcription-dependent condensates

(2018) Won-Ki Cho et al.   SCIENCE

Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals

(2018) Anne K. Voss et al.   BIOESSAYS

HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis

(2018) Yuqing Sun et al.   CANCER CELL

Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4

(2018) Yanli Liu et al.   Nature Communications

Orphan CpG islands define a novel class of highly active enhancers

(2017) Joshua S. K. Bell et al.   Epigenetics

Histone H3 lysine 4 methyltransferase KMT2D

(2017) Eugene Froimchuk et al.   GENE

Polycomb and Trithorax Group Genes inDrosophila

(2017) Judith A. Kassis et al.   GENETICS

The MLL recombinome of acute leukemias in 2017

(2017) C Meyer et al.   LEUKEMIA

Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation

(2017) Svetlana Petruk et al.   MOLECULAR CELL

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation

(2017) Kristel M. Dorighi et al.   MOLECULAR CELL

Local epigenetic reprogramming induced by G-quadruplex ligands

(2017) Guillaume Guilbaud et al.   Nature Chemistry

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability

(2017) Ryan Rickels et al.   NATURE GENETICS

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis

(2017) Binbin Lai et al.   NUCLEIC ACIDS RESEARCH

Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70

(2017) Taosui Li et al.   Epigenetics & Chromatin

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

(2017) Jon Kerry et al.   Cell Reports

The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin

(2017) David A. Brown et al.   Cell Reports

Polycomb and Trithorax Group Genes inDrosophila

(2017) Judith A. Kassis et al.   GENETICS

BioEssays 1∕2017

(2016)   BIOESSAYS

SET/MLL family proteins in hematopoiesis and leukemia

(2016) Weiwei Yang et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Enhancer priming by H3K4 methyltransferase MLL4 controls cell fate transition

(2016) Chaochen Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia

(2016) L. Zhu et al.   Cancer Discovery

H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Consistency

(2015) Bérénice A. Benayoun et al.   CELL

Setd1a regulates progenitor B-cell-to-precursor B-cell development through histone H3 lysine 4 trimethylation and Ig heavy-chain rearrangement

(2015) Betsabeh Khoramian Tusi et al.   FASEB JOURNAL

Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes

(2015) Kaifu Chen et al.   NATURE GENETICS

MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia

(2014) Chong Chen et al.   CANCER CELL

UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells

(2014) Jae-Hwan Kim et al.   CANCER RESEARCH

H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Consistency

(2014) Bérénice A. Benayoun et al.   CELL

Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant

(2014) S. Denissov et al.   DEVELOPMENT

The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation

(2014) A. S. Bledau et al.   DEVELOPMENT

Gene Silencing Triggers Polycomb Repressive Complex 2 Recruitment to CpG Islands Genome Wide

(2014) Eva Madi Riising et al.   MOLECULAR CELL

DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier

(2014) Margarida A. Santos et al.   NATURE

MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters

(2014) Hiroshi Okuda et al.   NUCLEIC ACIDS RESEARCH

The Histone Methyltransferase Activity of MLL1 Is Dispensable for Hematopoiesis and Leukemogenesis

(2014) Bibhu P. Mishra et al.   Cell Reports

Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

(2014) Ignacio Izeddin et al.   eLife

ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection

(2013) Hannah K. Long et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

SET1 and p300 Act Synergistically, through Coupled Histone Modifications, in Transcriptional Activation by p53

(2013) Zhanyun Tang et al.   CELL

H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation

(2013) Shannon M. Lauberth et al.   CELL

Quantitative Dissection and Stoichiometry Determination of the Human SET1/MLL Histone Methyltransferase Complexes

(2013) R. van Nuland et al.   MOLECULAR AND CELLULAR BIOLOGY

The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers

(2013) D. Hu et al.   MOLECULAR AND CELLULAR BIOLOGY

The Drosophila Ortholog of MLL3 and MLL4 , trithorax related , Functions as a Negative Regulator of Tissue Growth

(2013) Hiroshi Kanda et al.   MOLECULAR AND CELLULAR BIOLOGY

ASH2L Regulates Ubiquitylation Signaling to MLL: trans-Regulation of H3 K4 Methylation in Higher Eukaryotes

(2013) Lipeng Wu et al.   MOLECULAR CELL

The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells

(2013) Deqing Hu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of transcription by the MLL2 complex and MLL complex–associated AKAP95

(2013) Hao Jiang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

(2013) Jocelyn O. Eidahl et al.   NUCLEIC ACIDS RESEARCH

Tudor: a versatile family of histone methylation ‘readers’

(2013) Rui Lu et al.   TRENDS IN BIOCHEMICAL SCIENCES

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

(2013) Ji-Eun Lee et al.   eLife

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

(2012) Ali Shilatifard   Annual Review of Biochemistry

TrxG and PcG Proteins but Not Methylated Histones Remain Associated with DNA through Replication

(2012) Svetlana Petruk et al.   CELL

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

(2012) Panagis Filippakopoulos et al.   CELL

Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells

(2012) T. Clouaire et al.   GENES & DEVELOPMENT

Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4

(2012) S. S. Dhar et al.   GENES & DEVELOPMENT

Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4

(2012) H.-M. Herz et al.   GENES & DEVELOPMENT

The Histone Methyltransferase Wbp7 Controls Macrophage Function through GPI Glycolipid Anchor Synthesis

(2012) Liv Austenaa et al.   IMMUNITY

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

(2012) Jing Huang et al.   NATURE

Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways

(2012) C. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The lac Repressor Displays Facilitated Diffusion in Living Cells

(2012) P. Hammar et al.   SCIENCE

Two Distinct Repressive Mechanisms for Histone 3 Lysine 4 Methylation through Promoting 3′-End Antisense Transcription

(2012) Thanasis Margaritis et al.   PLoS Genetics

Psip1/Ledgf p52 Binds Methylated Histone H3K36 and Splicing Factors and Contributes to the Regulation of Alternative Splicing

(2012) Madapura M. Pradeepa et al.   PLoS Genetics

Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis

(2012) Erica Ballabio et al.   Cancers

The Pathogenesis of Mixed-Lineage Leukemia

(2011) Andrew G. Muntean et al.   Annual Review of Pathology-Mechanisms of Disease

ECSASB2 mediates MLL degradation during hematopoietic differentiation

(2011) J. Wang et al.   BLOOD

Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions

(2011) Alexander J. Ruthenburg et al.   CELL

DrosophilaSet1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription

(2011) M Behfar Ardehali et al.   EMBO JOURNAL

Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation

(2011) Chuanbing Bian et al.   EMBO JOURNAL

CpG islands and the regulation of transcription

(2011) A. M. Deaton et al.   GENES & DEVELOPMENT

dSet1 Is the Main H3K4 Di- and Tri-Methyltransferase ThroughoutDrosophilaDevelopment

(2011) Graham Hallson et al.   GENETICS

Crystal Structure of Menin Reveals Binding Site for Mixed Lineage Leukemia (MLL) Protein

(2011) Marcelo J. Murai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The COMPASS Family of H3K4 Methylases in Drosophila

(2011) M. Mohan et al.   MOLECULAR AND CELLULAR BIOLOGY

Handpicking epigenetic marks with PHD fingers

(2011) C. A. Musselman et al.   NUCLEIC ACIDS RESEARCH

Structural Basis of Substrate Methylation and Inhibition of SMYD2

(2011) Andrew D. Ferguson et al.   STRUCTURE

Regulation of p53 function by lysine methylation

(2011) Lisandra E West et al.   Epigenomics

The PHD3 Domain of MLL Acts as a CYP33-Regulated Switch between MLL-Mediated Activation and Repression,

(2010) Sangho Park et al.   BIOCHEMISTRY

The PAF Complex Synergizes with MLL Fusion Proteins at HOX Loci to Promote Leukemogenesis

(2010) Andrew G. Muntean et al.   CANCER CELL

Pro Isomerization in MLL1 PHD3-Bromo Cassette Connects H3K4me Readout to CyP33 and HDAC-Mediated Repression

(2010) Zhanxin Wang et al.   CELL

Binding of the MLL PHD3 Finger to Histone H3K4me3 Is Required for MLL-Dependent Gene Transcription

(2010) Pei-Yun Chang et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Mechanism of MLL PHD3 and RNA Recognition by the Cyp33 RRM Domain

(2010) Robert A. Hom et al.   JOURNAL OF MOLECULAR BIOLOGY

Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis

(2010) T Gan et al.   LEUKEMIA

Multiple Interactions Recruit MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis

(2010) Thomas A. Milne et al.   MOLECULAR CELL

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

(2010) Johanna C. Scheuermann et al.   NATURE

CpG islands influence chromatin structure via the CpG-binding protein Cfp1

(2010) John P. Thomson et al.   NATURE

A unique chromatin signature uncovers early developmental enhancers in humans

(2010) Alvaro Rada-Iglesias et al.   NATURE

Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells

(2010) J Paggetti et al.   ONCOGENE

The structure of the FYR domain of transforming growth factor beta regulator 1

(2010) María M. García-Alai et al.   PROTEIN SCIENCE

MLL2 Is Required in Oocytes for Bulk Histone 3 Lysine 4 Trimethylation and Transcriptional Silencing

(2010) Claudia V. Andreu-Vieyra et al.   PLOS BIOLOGY

Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice

(2009) C.L. Fisher et al.   DEVELOPMENTAL BIOLOGY

CXXC finger protein 1 restricts the Setd1A histone H3K4 methyltransferase complex to euchromatin

(2009) Courtney M. Tate et al.   FEBS Journal

Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle

(2009) Bibhu P. Mishra et al.   FEBS Journal

Global Analysis of H3K4 Methylation Defines MLL Family Member Targets and Points to a Role for MLL1-Mediated H3K4 Methylation in the Regulation of Transcriptional Initiation by RNA Polymerase II

(2009) P. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Crucial Roles for Interactions between MLL3/4 and INI1 in Nuclear Receptor Transactivation

(2009) Seunghee Lee et al.   MOLECULAR ENDOCRINOLOGY

Histone modifications at human enhancers reflect global cell-type-specific gene expression

(2009) Nathaniel D. Heintzman et al.   NATURE

The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis

(2009) Stefan Glaser et al.   Epigenetics & Chromatin

Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes

(2008) Akihiko Yokoyama et al.   CANCER CELL

Alternative Splicing and Caspase-Mediated Cleavage Generate Antagonistic Variants of the Stress Oncoprotein LEDGF/p75

(2008) T. A. Brown-Bryan et al.   MOLECULAR CANCER RESEARCH

Combinatorial patterns of histone acetylations and methylations in the human genome

(2008) Zhibin Wang et al.   NATURE GENETICS

Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2

(2008) C Bach et al.   ONCOGENE