Progress in the emerging role of selenoproteins in cardiovascular disease: focus on endoplasmic reticulum-resident selenoproteins

Utilization of selenocysteine in early-branching fungal phyla

(2019) Marco Mariotti et al.   Nature Microbiology

Selenoprotein P in Myocardial Infarction with Cardiogenic Shock

(2019) Petra Büttner et al.   SHOCK

A selenoprotein T-derived peptide protects the heart against ischaemia/reperfusion injury through inhibition of apoptosis and oxidative stress

(2018) C. Rocca et al.   Acta Physiologica

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Endoplasmic reticulum-resident selenoproteins as regulators of calcium signaling and homeostasis

(2018) Matthew W. Pitts et al.   CELL CALCIUM

Hypothalamic redox balance and leptin signaling - Emerging role of selenoproteins

(2018) Ting Gong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Consequences of mutations and inborn errors of selenoprotein biosynthesis and functions

(2018) Noelia Fradejas-Villar   FREE RADICAL BIOLOGY AND MEDICINE

Selenoprotein T is a key player in ER proteostasis, endocrine homeostasis and neuroprotection

(2018) Youssef Anouar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Associations and interactions between variants in selenoprotein genes, selenoprotein levels and the development of abdominal aortic aneurysm, peripheral arterial disease, and heart failure

(2018) Ewa Strauss et al.   PLoS One

Association of expression of selenoprotein P in mRNA and protein levels with metabolic syndrome in subjects with cardiovascular disease: Results of the Selenegene study

(2017) Mojgan Gharipour et al.   JOURNAL OF GENE MEDICINE

Gene expression of selenoproteins can be regulated by thioredoxin(Txn) silence in chicken cardiomyocytes

(2017) Jie Yang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Impact of Oxidative Stress on the Heart and Vasculature

(2017) Thomas Münzel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Selenoprotein T Exerts an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson's Disease

(2016) Loubna Boukhzar et al.   ANTIOXIDANTS & REDOX SIGNALING

Se Enhances MLCK Activation by Regulating Selenoprotein T (SelT) in the Gastric Smooth Muscle of Rats

(2016) Jia-ping Li et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Cardiovascular disease in Europe: epidemiological update 2016

(2016) Nick Townsend et al.   EUROPEAN HEART JOURNAL

Why 21? The significance of selenoproteins for human health revealed by inborn errors of metabolism

(2016) Ulrich Schweizer et al.   FASEB JOURNAL

Selenols are resistant to irreversible modification by HNO

(2016) Christopher L. Bianco et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selenoprotein Gene Nomenclature

(2016) Vadim N. Gladyshev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutation in human selenocysteine transfer RNA selectively disrupts selenoprotein synthesis

(2016) Erik Schoenmakers et al.   JOURNAL OF CLINICAL INVESTIGATION

Aging‐Related Decline of Glutathione Peroxidase 3 and Risk of Cardiovascular Events in Patients With Atrial Fibrillation

(2016) Daniele Pastori et al.   Journal of the American Heart Association

Selenoprotein W was Correlated with the Protective Effect of Selenium on Chicken Myocardial Cells from Oxidative Damage

(2015) Wei Liu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Selenium deficiency associated porcine and human cardiomyopathies

(2015) Marianne Oropeza-Moe et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Selenoprotein T Deficiency Leads to Neurodevelopmental Abnormalities and Hyperactive Behavior in Mice

(2015) Matthieu T. Castex et al.   MOLECULAR NEUROBIOLOGY

Selenoprotein biosynthesis defect causes progressive encephalopathy with elevated lactate

(2015) Anna-Kaisa Anttonen et al.   NEUROLOGY

Cyclosporine before PCI in Patients with Acute Myocardial Infarction

(2015) Thien-Tri Cung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Selenoproteins and cardiovascular stress

(2015) Aaron H. Rose et al.   THROMBOSIS AND HAEMOSTASIS

Selenium and Its Supplementation in Cardiovascular Disease—What do We Know?

(2015) Carina Benstoem et al.   Nutrients

Heart‐Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium

(2015) Claudia Kiermayer et al.   Journal of the American Heart Association

Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration

(2014) Raymond F. Burk et al.   FASEB JOURNAL

Selenoprotein K form an intermolecular diselenide bond with unusually high redox potential

(2014) Jun Liu et al.   FEBS LETTERS

SEPN1, an endoplasmic reticulum-localized selenoprotein linked to skeletal muscle pathology, counteracts hyperoxidation by means of redox-regulating SERCA2 pump activity

(2014) Marianna Marino et al.   HUMAN MOLECULAR GENETICS

Selective Up-regulation of Human Selenoproteins in Response to Oxidative Stress

(2014) Zahia Touat-Hamici et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioredoxin Reductase 2 (TXNRD2) Mutation Associated With Familial Glucocorticoid Deficiency (FGD)

(2014) Rathi Prasad et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mutations in the enzyme glutathione peroxidase 4 cause Sedaghatian-type spondylometaphyseal dysplasia

(2014) Amanda C Smith et al.   JOURNAL OF MEDICAL GENETICS

Selenoproteins: Molecular Pathways and Physiological Roles

(2014) Vyacheslav M. Labunskyy et al.   PHYSIOLOGICAL REVIEWS

Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex

(2014) Gregory J. Fredericks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different responses of selenoproteins to the altered expression of selenoprotein W in chicken myoblasts

(2014) Haidong Yao et al.   RSC Advances

Selenocysteine Confers Resistance to Inactivation by Oxidation in Thioredoxin Reductase: Comparison of Selenium and Sulfur Enzymes

(2013) Gregg W. Snider et al.   BIOCHEMISTRY

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

(2013) Derek J. Hausenloy et al.   JOURNAL OF CLINICAL INVESTIGATION

Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis

(2013) Svenja Meiler et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Selenium biochemistry and its role for human health

(2013) Marco Roman et al.   Metallomics

Polymorphisms in the Selenoprotein S gene and subclinical cardiovascular disease in the Diabetes Heart Study

(2012) Amanda. J. Cox et al.   ACTA DIABETOLOGICA

Simplified gyral pattern with cerebellar hypoplasia in Sedaghatian type spondylometaphyseal dysplasia: A clinical report and review of the literature

(2012) Canan Aygun et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Selenocysteine in Thiol/Disulfide-Like Exchange Reactions

(2012) Robert J. Hondal et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms of Cell Death in Heart Disease

(2012) Klitos Konstantinidis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Understanding selenoprotein function and regulation through the use of rodent models

(2012) Marina V. Kasaikina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Specific antioxidant selenoproteins are induced in the heart during hypertrophy

(2011) FuKun W. Hoffmann et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Glutathione Peroxidase-3 Deficiency Promotes Platelet-Dependent Thrombosis In Vivo

(2011) Richard C. Jin et al.   CIRCULATION

Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy

(2011) Dirk Sibbing et al.   EUROPEAN HEART JOURNAL

Type 2 deiodinase at the crossroads of thyroid hormone action

(2011) Rafael Arrojo e Drigo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Stimulation of Unprimed Macrophages with Immune Complexes Triggers a Low Output of Nitric Oxide by Calcium-dependent Neuronal Nitric-oxide Synthase

(2011) Zhi Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenoprotein K Binds Multiprotein Complexes and Is Involved in the Regulation of Endoplasmic Reticulum Homeostasis

(2011) Valentina A. Shchedrina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenoprotein K Knockout Mice Exhibit Deficient Calcium Flux in Immune Cells and Impaired Immune Responses

(2011) S. Verma et al.   JOURNAL OF IMMUNOLOGY

Endoplasmic Reticulum Stress Decreases Intracellular Thyroid Hormone Activation via an eIF2a-Mediated Decrease in Type 2 Deiodinase Synthesis

(2011) Rafael Arrojo e Drigo et al.   MOLECULAR ENDOCRINOLOGY

Establishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial

(2010) Rachel Hurst et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Mutations Disrupting Selenocysteine Formation Cause Progressive Cerebello-Cerebral Atrophy

(2010) Orly Agamy et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Why do proteins use selenocysteine instead of cysteine?

(2010) Thomas Nauser et al.   AMINO ACIDS

Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

(2010) Edith Lubos et al.   ANTIOXIDANTS & REDOX SIGNALING

SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis

(2010) Shaoqing Du et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia

(2010) Y. Kawatani et al.   BLOOD

Insights into Function, Catalytic Mechanism, and Fold Evolution of Selenoprotein Methionine Sulfoxide Reductase B1 through Structural Analysis

(2010) Finn L. Aachmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

(2010) Erik Schoenmakers et al.   JOURNAL OF CLINICAL INVESTIGATION

mRNA transcripts as molecular biomarkers in medicine and nutrition☆

(2010) Roger A. Sunde   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Unveiling the Molecular Mechanisms Behind Selenium-Related Diseases Through Knockout Mouse Studies

(2009) Marcus Conrad et al.   ANTIOXIDANTS & REDOX SIGNALING

The genetics of familial glucocorticoid deficiency

(2009) Adrian J.L. Clark et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Protection against reactive oxygen species by selenoproteins

(2009) Holger Steinbrenner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Selenoprotein expression and function—Selenoprotein W

(2009) P.D. Whanger   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4

(2009) Marcus Conrad   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The human selenoproteome: recent insights into functions and regulation

(2009) M. A. Reeves et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Heart Disease and Stroke Statistics—2009 Update

(2009) et al.   CIRCULATION

Depressed serum selenoprotein P: possible new predicator of increased risk for cerebrovascular events

(2009) Hiroshi Koyama et al.   NUTRITION RESEARCH

Genetic variant in glutathione peroxidase 1 gene is associated with an increased risk of coronary artery disease in a Chinese population

(2008) Na-Ping Tang et al.   CLINICA CHIMICA ACTA

Decreased Cardiac Glutathione Peroxidase Levels and Enhanced Mandibular Apoptosis in Malformed Embryos of Diabetic Rats

(2008) P. Wentzel et al.   DIABETES

Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion

(2008) Luca Grumolato et al.   FASEB JOURNAL

Thiol chemistry and specificity in redox signaling

(2008) Christine C. Winterbourn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of oxidative stress and nitric oxide in atherothrombosis

(2008) Edith Lubos   Frontiers in Bioscience-Landmark

Reduced Selenium Concentrations and Glutathione Peroxidase Activity in Preeclamptic Pregnancies

(2008) Hiten D. Mistry et al.   HYPERTENSION

MsrB1(Methionine-R-sulfoxide Reductase 1) Knock-out Mice

(2008) Dmitri E. Fomenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenoproteins

(2008) Jun Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury

(2008) Elizabeth Murphy et al.   PHYSIOLOGICAL REVIEWS