Unveiling the Molecular Mechanisms Behind Selenium-Related Diseases Through Knockout Mouse Studies

Hierarchical regulation of selenoprotein expression and sex-specific effects of selenium

(2009) Lutz Schomburg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Selenoprotein expression and function—Selenoprotein W

(2009) P.D. Whanger   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4

(2009) Marcus Conrad   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Life without Thyroxine to 3,5,3′-Triiodothyronine Conversion: Studies in Mice Devoid of the 5′-Deiodinases

(2009) Valerie Anne Galton et al.   ENDOCRINOLOGY

Down-regulation of the hepatic selenoprotein biosynthesis machinery impairs selenium metabolism during the acute phase response in mice

(2009) Kostja Renko et al.   FASEB JOURNAL

Mitochondrial glutathione peroxidase 4 disruption causes male infertility

(2009) Manuela Schneider et al.   FASEB JOURNAL

A Medical Mystery in Middle China

(2009) R. Stone   SCIENCE

Osteo-Chondroprogenitor–Specific Deletion of the Selenocysteine tRNA Gene, Trsp, Leads to Chondronecrosis and Abnormal Skeletal Development: A Putative Model for Kashin-Beck Disease

(2009) Charlene M. Downey et al.   PLoS Genetics

Peroxides and Peroxide-Degrading Enzymes in the Thyroid

(2008) Ulrich Schweizer et al.   ANTIOXIDANTS & REDOX SIGNALING

Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination inSepp-knockout mice

(2008) Kostja Renko et al.   BIOCHEMICAL JOURNAL

The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice

(2008) Bradley A. Carlson et al.   BIOCHEMICAL JOURNAL

Glutathione peroxidase 1-deficient mice are more susceptible to doxorubicin-induced cardiotoxicity

(2008) Jinping Gao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

A Protective Role for Type 3 Deiodinase, a Thyroid Hormone-Inactivating Enzyme, in Cochlear Development and Auditory Function

(2008) Lily Ng et al.   ENDOCRINOLOGY

Sensitivity of mouse lung fibroblasts heterozygous for GPx4 to oxidative stress

(2008) Michael R. Garry et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers

(2008) Scott M. Lippman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

MsrB1(Methionine-R-sulfoxide Reductase 1) Knock-out Mice

(2008) Dmitri E. Fomenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Megalin Mediates Selenoprotein P Uptake by Kidney Proximal Tubule Epithelial Cells

(2008) Gary E. Olson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenoproteins Mediate T Cell Immunity through an Antioxidant Mechanism

(2008) Rajeev K. Shrimali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion

(2008) Connie H. Y. Wong et al.   JOURNAL OF NEUROCHEMISTRY

Think globally: Act locally

(2008) Ulrich Schweizer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Role of Thioredoxin Reductases in Brain Development

(2008) Jonna Soerensen et al.   PLoS One

Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle

(2008) M. J. Jurynec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Podocyte specific knock out of selenoproteins does not enhance nephropathy in streptozotocin diabetic C57BL/6 mice

(2008) Marsha N Blauwkamp et al.   BMC Nephrology

Loss of housekeeping selenoprotein expression in mouse liver modulates lipoprotein metabolism

(2007) Aniruddha Sengupta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS