The histone methyltransferase EZH2 is required for normal uterine development and function in mice†

Widespread enhancer activation via ERα mediates estrogen response in vivo during uterine development

(2018) Wendy N Jefferson et al.   NUCLEIC ACIDS RESEARCH

Deletion of RhoA in Progesterone Receptor–Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice

(2017) Ahmed E. El Zowalaty et al.   ENDOCRINOLOGY

EZH2 deletion in early mesenchyme compromises postnatal bone microarchitecture and structural integrity and accelerates remodeling

(2017) Sarah Hemming et al.   FASEB JOURNAL

Forkhead box a2 (FOXA2) is essential for uterine function and fertility

(2017) Andrew M. Kelleher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic histone methyltransferase EZH2: A novel prognostic marker with therapeutic potential in endometrial cancer

(2017) Shinya Oki et al.   Oncotarget

The Polycomb Group Protein EZH2 Impairs DNA Damage Repair Gene Expression in Human Uterine Fibroids1

(2016) Qiwei Yang et al.   BIOLOGY OF REPRODUCTION

Polycomb Ezh2 controls the fate of GABAergic neurons in the embryonic cerebellum

(2016) Xuesong Feng et al.   DEVELOPMENT

Membrane-Localized Estrogen Receptor 1 Is Required for Normal Male Reproductive Development and Function in Mice

(2016) Manjunatha K. Nanjappa et al.   ENDOCRINOLOGY

Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells

(2016) Martijn A.J. Koppens et al.   GASTROENTEROLOGY

Identification of Polycomb Group Protein EZH2-Mediated DNA Mismatch Repair Gene MSH2 in Human Uterine Fibroids

(2016) Qiwei Yang et al.   Reproductive Sciences

Neonatal Uterine and Vaginal Cell Proliferation and Adenogenesis Are Independent of Estrogen Receptor 1 (ESR1) in the Mouse1

(2015) Manjunatha K. Nanjappa et al.   BIOLOGY OF REPRODUCTION

Loss of EZH2 results in precocious mammary gland development and activation of STAT5-dependent genes

(2015) Kyung Hyun Yoo et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of epigenetic “readers, writers and erasers”: Implications for developmental reprogramming and the epigenetic basis for health and disease

(2015) Lindsey S. Treviño et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

H3K27me3 is an Epigenetic Mark of Relevance in Endometriosis

(2015) Mariano Colón-Caraballo et al.   Reproductive Sciences

Membrane-Localized Estrogen Receptor α Is Required for Normal Organ Development and Function

(2014) Ali Pedram et al.   DEVELOPMENTAL CELL

Histone Methyltransferase EZH2 Is Transcriptionally Induced by Estradiol as Well as Estrogenic Endocrine Disruptors Bisphenol-A and Diethylstilbestrol

(2014) Arunoday Bhan et al.   JOURNAL OF MOLECULAR BIOLOGY

The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER-positive breast cancers

(2014) Woo Kyun Bae et al.   MOLECULAR CARCINOGENESIS

Uterine epithelial cell proliferation and endometrial hyperplasia: evidence from a mouse model

(2014) Y. Gao et al.   MOLECULAR HUMAN REPRODUCTION

Polycomb Group Protein Ezh2 Regulates Hepatic Progenitor Cell Proliferation and Differentiation in Murine Embryonic Liver

(2014) Hiroyuki Koike et al.   PLoS One

Enhancer of zeste homolog 2 is involved in the proliferation of endometrial carcinoma

(2014) NAN JIA et al.   Oncology Letters

Exploiting the therapeutic potential of the PI3K-AKT-mTOR pathway in enriched populations of gynecologic malignancies

(2014) Ramez N Eskander et al.   Expert Review of Clinical Pharmacology

Isolation and analysis of linker histones across cellular compartments

(2013) Sean W. Harshman et al.   Journal of Proteomics

Persistently Altered Epigenetic Marks in the Mouse Uterus After Neonatal Estrogen Exposure

(2013) Wendy N. Jefferson et al.   MOLECULAR ENDOCRINOLOGY

Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice

(2013) T. Daikoku et al.   MOLECULAR HUMAN REPRODUCTION

Loss of the repressor REST in uterine fibroids promotes aberrant G protein-coupled receptor 10 expression and activates mammalian target of rapamycin pathway

(2013) B. V. Varghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polycomb group geneEzh2regulates mammary gland morphogenesis and maintains the luminal progenitor pool

(2013) Ewa Malgorzata Michalak et al.   STEM CELLS

Global Changes in the Mammary Epigenome Are Induced by Hormonal Cues and Coordinated by Ezh2

(2013) Bhupinder Pal et al.   Cell Reports

EZH2 Methyltransferase and H3K27 Methylation in Breast Cancer

(2012) Kyung Hyun Yoo et al.   International Journal of Biological Sciences

Environmental Estrogens Differentially Engage the Histone Methyltransferase EZH2 to Increase Risk of Uterine Tumorigenesis

(2012) K. L. Greathouse et al.   MOLECULAR CANCER RESEARCH

Conditional Ablation of Ezh2 in Murine Hearts Reveals Its Essential Roles in Endocardial Cushion Formation, Cardiomyocyte Proliferation and Survival

(2012) Li Chen et al.   PLoS One

Epigenomic reprogramming of the developing reproductive tract and disease susceptibility in adulthood

(2011) Cheryl Lyn Walker   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Down-Regulation of the Histone Methyltransferase EZH2 Contributes to the Epigenetic Programming of Decidualizing Human Endometrial Stromal Cells

(2011) Giulia Grimaldi et al.   MOLECULAR ENDOCRINOLOGY

Evaluation of Mammary Gland Development and Function in Mouse Models

(2011) Isabelle Plante et al.   Jove-Journal of Visualized Experiments

Xenoestrogen-Induced Regulation of EZH2 and Histone Methylation via Estrogen Receptor Signaling to PI3K/AKT

(2010) Tiffany G. Bredfeldt et al.   MOLECULAR ENDOCRINOLOGY

In Utero Exposure to Diethylstilbestrol (DES) or Bisphenol-A (BPA) Increases EZH2 Expression in the Mammary Gland: An Epigenetic Mechanism Linking Endocrine Disruptors to Breast Cancer

(2010) Leo F. Doherty et al.   Hormones & Cancer

EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency

(2008) Xiaohua Shen et al.   MOLECULAR CELL

In vivo analysis of progesterone receptor action in the uterus during embryo implantation

(2008) Heather L. Franco et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY