The pan‐cancer mutational landscape of the PPAR pathway reveals universal patterns of dysregulated metabolism and interactions with tumor immunity and hypoxia

A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers

(2019) Wai Hoong Chang et al.   Journal of Translational Medicine

Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies

(2019) Wai Hoong Chang et al.   Journal of Translational Medicine

Transcriptional landscape of DNA repair genes underpins a pan-cancer prognostic signature associated with cell cycle dysregulation and tumor hypoxia

(2019) Wai Hoong Chang et al.   DNA REPAIR

Pan-cancer genomic amplifications underlie a WNT hyperactivation phenotype associated with stem cell-like features leading to poor prognosis

(2019) Wai Hoong Chang et al.   Translational Research

Dual prognostic role of 2-oxoglutarate-dependent oxygenases in ten cancer types: implications for cell cycle regulation and cell adhesion maintenance

(2019) Wai Hoong Chang et al.   Cancer Communications

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis

(2017) Ewelina Krzywinska et al.   Nature Communications

Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

(2017) Manav Korpal et al.   Nature Communications

Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis

(2016) Mathias Wenes et al.   Cell Metabolism

Constitutive expression of PPARγ inhibits proliferation and migration of gastric cancer cells and down-regulates Wnt/β-Catenin signaling pathway downstream target genes TERT and ENAH

(2016) Fang Guo et al.   GENE

Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26

(2016) David Kung-Chun Chiu et al.   HEPATOLOGY

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

(2016) Marco De Simone et al.   IMMUNITY

Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer

(2016) George Plitas et al.   IMMUNITY

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

PPAR-delta promotes survival of breast cancer cells in harsh metabolic conditions

(2016) X Wang et al.   Oncogenesis

InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams

(2015) Henry Heberle et al.   BMC BIOINFORMATICS

Hypoxia and hypoxia inducible factors in tumor metabolism

(2015) Wen Zeng et al.   CANCER LETTERS

Metabolic Reprogramming of Immune Cells in Cancer Progression

(2015) Subhra K. Biswas   IMMUNITY

M-CSF from Cancer Cells Induces Fatty Acid Synthase and PPARβ/δ Activation in Tumor Myeloid Cells, Leading to Tumor Progression

(2015) Jonghanne Park et al.   Cell Reports

LXR-dependent and -independent effects of oxysterols on immunity and tumor growth

(2014) Catia Traversari et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Hypoxia downregulates PPARγ via an ERK1/2–NF-κB–Nox4-dependent mechanism in human pulmonary artery smooth muscle cells

(2013) Xianghuai Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

PPARγ maintains ERBB2-positive breast cancer stem cells

(2013) X Wang et al.   ONCOGENE

Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity

(2012) Yoko Kidani et al.   IMMUNOLOGICAL REVIEWS

Activation of Peroxisome Proliferator-activated Receptor α (PPARα) Suppresses Hypoxia-inducible Factor-1α (HIF-1α) Signaling in Cancer Cells

(2012) Jundong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

GeneCodis3: a non-redundant and modular enrichment analysis tool for functional genomics

(2012) D. Tabas-Madrid et al.   NUCLEIC ACIDS RESEARCH

Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion

(2012) T Adhikary et al.   ONCOGENE

PPARs: Fatty acid sensors controlling metabolism

(2012) Lars la Cour Poulsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Alternative Macrophage Activation and Metabolism

(2011) Justin I. Odegaard et al.   Annual Review of Pathology-Mechanisms of Disease

Expression of angiopoietin-like 4 (ANGPTL4) in human colorectal cancer: ANGPTL4 promotes venous invasion and distant metastasis

(2011) Nakayama   ONCOLOGY REPORTS

Activation of PPARγ in Myeloid Cells Promotes Lung Cancer Progression and Metastasis

(2011) Howard Li et al.   PLoS One

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

(2011) Craig H Mermel et al.   GENOME BIOLOGY

Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene

(2010) F M Buffa et al.   BRITISH JOURNAL OF CANCER

Suppression of NF-κB and GSK-3β is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone

(2010) Jung Ok Ban et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Fatty acid synthase as a potential therapeutic target in cancer

(2010) Richard Flavin et al.   Future Oncology

Expression of angiopoietin-like 4 in human gastric cancer: ANGPTL4 promotes venous invasion

(2010) Nakayama   ONCOLOGY REPORTS

Thiazolidinediones inhibit REG Iα gene transcription in gastrointestinal cancer cells

(2008) Akiyo Yamauchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PPARγ agonists inhibit growth and expansion of CD133+ brain tumour stem cells

(2008) W Chearwae et al.   BRITISH JOURNAL OF CANCER

Loss of XIAP sensitizes colon cancer cells to PPARγ independent antitumor effects of troglitazone and 15-PGJ2

(2008) Liang Qiao et al.   CANCER LETTERS

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

PPARγ agonists attenuate proliferation and modulate Wnt/β-catenin signalling in melanoma cells

(2008) Aaron G. Smith et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY