Review
Physics, Applied
Wen Zhou, Xiuqing Wang, Xiaojing Huang
Summary: Cold atmospheric pressure plasmas (CAP) have wide applications in dentistry, including surface modification of dental materials, biofilm removal, disinfection, endodontic therapy, periodontitis treatment, wound healing, and head and neck cancer control.
PLASMA PROCESSES AND POLYMERS
(2022)
Article
Food Science & Technology
Shanrui Li, Xi Yao, Xiaolong Wang, Shuqi Tian, Yuantao Zhang
Summary: This study used a Reactive Molecular Dynamics simulation to examine the interaction between reactive oxygen species (ROS) and aflatoxin B-1 (AFB(1)) in cold atmospheric plasma (CAP) decontamination. The simulation results showed that ROS can effectively reduce the toxicity of AFB(1) by reacting with its key structures. The findings provide valuable insights for the optimization of aflatoxin degradation in industrial applications.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2022)
Review
Multidisciplinary Sciences
Neha Kaushik, Sarmistha Mitra, Eun Jung Baek, Linh Nhat Nguyen, Pradeep Bhartiya, June Hyun Kim, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: This review critically examines methods for generating reactive oxygen species (ROS) and explores their potential as a solution for virus deactivation. The study highlights the ability of ROS to directly eradicate pathogens through oxidative stress and indirectly through non-oxidative mechanisms. Additionally, the novel and environmentally friendly cold plasma delivery system for virus destruction is discussed in detail.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jinsen Guo, Yuantao Zhang
Summary: The abuse of tetracycline antibiotics has caused environmental pollution and risks to public health. Cold atmospheric plasmas (CAPs) have been found to efficiently degrade tetracycline antibiotics. A reactive molecular dynamics simulation was conducted to investigate the interaction mechanisms between reactive oxygen species produced in CAPs and tetracycline antibiotics, revealing the main reaction sites and specific reactions for different antibiotic structures. The study provides theoretical support, explains degradation mechanisms, and suggests optimizations for improving the efficiency of CAPs in degrading tetracycline antibiotics.
Article
Physics, Applied
Hossam Saadawy, Esraa M. Fathi, Islam Elsayed, Janset S. Anzour, Ahmed Zaki, Mohamed El Shaer, Marwan Emara
Summary: Since the development of cold atmospheric plasma (CAP), significant progress has been made in the application of CAP in medicine. In this study, we developed two combined plasma sources to produce in situ plasma-activated air-driven water mist (PAAWM). The PAAWM showed effective antitumor efficacy against both chemosensitive and chemoresistant hepatocellular carcinoma cells, suggesting its potential use alone or in combination with other treatments.
PLASMA PROCESSES AND POLYMERS
(2023)
Article
Chemistry, Analytical
Zahra Nasri, Giuliana Bruno, Sander Bekeschus, Klaus-Dieter Weltmann, Thomas von Woedtke, Kristian Wende
Summary: The study presented the development of an electrochemical sensor for in-situ assessment of reactive species in redox-based therapies, enabling the detection of the production of reactive oxygen and nitrogen species like hydrogen peroxide through chronoamperometry at different potentials.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Environmental Sciences
Dongjie Cui, Yue Yin, Hao Sun, Xiaojie Wang, Jie Zhuang, Lin Wang, Ruonan Ma, Zhen Jiao
Summary: Atmospheric pressure cold plasma (APCP) has great potential in improving crop production. This study investigates the regulation mechanism of APCP-generated reactive oxygen and nitrogen species (RONS) on intracellular redox homeostasis and plant growth. The results demonstrate that APCP treatment has a dual effect on Arabidopsis seedling growth, depending on the treatment time. APCP treatment leads to an increase in RONS in the liquid, conductivity, and oxidation reduction potential, and a decrease in pH. APCP treatment also causes an enrichment of intracellular RONS and an increase in malondialdehyde generation. Low-dose APCP treatment enhances intracellular antioxidants while high doses decrease their levels. These results highlight the importance of improved antioxidant capacity induced by moderate APCP-generated RONS in promoting plant growth.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biotechnology & Applied Microbiology
Som V. Thomas, Krista Dienger-Stambaugh, Michael Jordan, Yuxin Wang, Jason Hammonds, Paul Spearman, Donglu Shi
Summary: A Cold Atmospheric Plasma (CAP) apparatus was developed and tested for its ability to kill SARS-CoV-2 using pseudotyped viral infectivity assays. The reactive species generated by the plasma system were fully characterized, revealing the presence of various reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the plasma plume. Virus killing experiments showed that CAP treatment significantly reduced SARS-CoV-2 infectivity after 8 seconds, with further enhancement of killing observed with longer exposures of 15-120 seconds. The efficacy of killing was correlated with the type, intensity, energy, and frequency of the reactive species. These results demonstrate the effective use of cold plasma for virus inactivation through ROS and RNS under ambient conditions.
BIOENGINEERING-BASEL
(2023)
Article
Oncology
Peiyu Wang, Renwu Zhou, Patrick Thomas, Liqian Zhao, Rusen Zhou, Susmita Mandal, Mohit Kumar Jolly, Derek J. Richard, Bernd H. A. Rehm, Kostya (Ken) Ostrikov, Xiaofeng Dai, Elizabeth D. Williams, Erik W. Thompson
Summary: The study found that plasma-activated medium (PAM) is more effective at inhibiting cancer cells with epithelial-mesenchymal transition (EMT), which are often resistant to other therapies. This suggests a potential novel treatment option for aggressive cancers exhibiting EMT, highlighting the promising role of cold atmospheric plasma (CAP) and PAM in onco-therapy.
Article
Spectroscopy
M. C. Garcia, C. Yubero, A. Rodero
Summary: In this study, a new method for determining both the gas temperature and the air fraction in non-thermal atmospheric helium plasmas is presented. This technique, based on UV-Atomic Emission Spectroscopy and the measurement of collisional broadening of specific emission lines, is particularly sensitive under low gas temperature conditions and suitable for diagnosing cold helium plasmas used in biomedical applications. Quantifying the air content is crucial for understanding the chemistry and clinical effects of these plasmas.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2022)
Review
Immunology
Si-yue Zhai, Michael G. Kong, Yu-min Xia
Summary: Skin diseases can be categorized into infectious diseases, non-infectious inflammatory diseases, cancers, and wounds. The underlying causes include microbial infections, autoimmune responses, abnormal cellular proliferation or differentiation, and excessive production of inflammatory factors. Cold atmospheric plasma (CAP), as an innovative and non-invasive therapeutic approach, has shown promising efficacy in dermatology by inhibiting infections, promoting wound healing, suppressing cancer growth, and improving psoriasis or vitiligo lesions. This review summarizes recent advances in CAP therapies for various skin diseases and proposes future strategies for increasing effectiveness and expanding clinical indications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Namkyung Kim, Seunghun Lee, Soyoung Lee, Jinjoo Kang, Young-Ae Choi, Jeongsu Park, Chul-Kyu Park, Dongwoo Khang, Sang-Hyun Kim
Summary: A cold atmospheric plasma (CAP) patch was developed for the treatment of skin diseases, especially psoriasis. The patch induces the opening of calcium channels in keratinocytes and generates ROS/RNS, improving psoriatic symptoms. It can be used as a combination therapy with existing drugs, reducing side effects.
Review
Physics, Applied
Cuntao Lan, Haiwei Zhu, Shenghua Wang, Lanlan Nie, Dawei Liu, Qi Shi, Xinpei Lu
Summary: Cold atmospheric-pressure plasma (CAP) is a promising virus disinfection technique that can effectively inactivate various viruses in a short period. The simultaneous action of physical and chemical means is the key mechanism of CAP in virus inactivation. Nevertheless, there are still opportunities and challenges faced by plasma virus inactivation technology.
PLASMA PROCESSES AND POLYMERS
(2023)
Article
Chemistry, Applied
Anna Dzimitrowicz, Piotr Jamroz, Piotr Cyganowski, Aleksandra Bielawska-Pohl, Aleksandra Klimczak, Pawel Pohl
Summary: By controlling cold atmospheric pressure plasma (CAPP) treatment, the element composition pattern and phenolic compound content of beetroot juice were altered, inhibiting the proliferation of colorectal adenocarcinoma cell lines while exhibiting non-cytotoxic effects on non-malignant endothelial cells, resulting in a safe-to-consume beetroot juice with improved nutritional quality.
Article
Engineering, Environmental
Jing Xiao, Subiao Liu, Peng-Fei Sui, Chenyu Xu, Lu Gong, Hongbo Zeng, Jing-Li Luo
Summary: This study introduces in-situ generated hydroxides by synthesizing rhombohedral CdCO3 crystals under electrochemical CO2RR conditions, effectively inhibiting the competitive hydrogen evolution reaction and improving the selectivity and activity of the CO2 reduction reaction.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Xuedong Huang, Binxiao Li, Yanwei Lu, Yixin Liu, Shurong Wang, Neso Sojic, Dechen Jiang, Baohong Liu
Summary: Nanoconfinement in mesoporous nanoarchitectures can significantly influence molecular transport and reaction kinetics in electrochemical processes. A comprehensive understanding of nanoconfinement and mass transport is crucial for practical applications, but a proper approach to study it is currently lacking. In this work, we present a single nanoreactor electrochemiluminescence (SNECL) microscopy technique that utilizes Ru(bpy)(3)(2+)-loaded mesoporous silica nanoparticles to directly visualize and investigate the nanoconfinement-enhanced electrochemical reactions at the single molecule level. Additionally, we monitor and simulate the mass transport capability of single nanoreactors with high spatial resolution through analysis of decay time and recovery ability. The nanoconfinement effects in our system also enable the imaging of single proteins on cellular membranes. This SNECL approach could serve as a promising tool for unraveling the nanoconfinement effects during electrochemical processes and bridging the gap between mesoporous nanoarchitectures and potential electrochemical applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Anne de Poulpiquet, Neso Sojic, Laurent Bouffier, Alexander Kuhn, Dodzi Zigah
Summary: Electrochemistry is an important topic taught in undergraduate chemistry programs, but students often find it difficult due to the combination of various physical concepts involved. Bipolar electrochemistry is of special interest for teaching purposes, as it has a simple setup and allows for the tuning of electrochemical reactions through manipulating the electric field. Basic experiments using a commercially available light emitting diode (LED) as a bipolar electrode are introduced here, illustrating the key parameters driving electrochemical reactions and providing an eye-catching introduction to general electrochemistry.
JOURNAL OF CHEMICAL EDUCATION
(2023)
Article
Chemistry, Physical
Ritu Toor, Lysandre Hourdin, Sharvina Shanmugathasan, Pauline Lefrancois, Stephane Arbault, Veronique Lapeyre, Laurent Bouffier, Jean-Paul Douliez, Valerie Ravaine, Adeline Perro
Summary: The design of enzymatic droplet-sized reactors is an important challenge with potential applications in medical diagnostics, water purification, bioengineering, and the food industry. This study demonstrates the construction of enzymatic reactors using coacervates formed by ampholyte polymer chains stabilized with agar. The coacervates can sequester and preserve the catalytic activity of enzymes such as glucose oxidase and catalase. The study investigates the enzymatic cascade reaction within the coacervates and provides new insights into the impact of proximity and confinement on enzymatic activity.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Emily Kerr, Sara Knezevic, Paul S. Francis, Conor F. Hogan, Giovanni Valenti, Francesco Paolucci, Frederic Kanoufi, Neso Sojic
Summary: In this study, a novel approach to enhancing conventional heterogeneous electrochemiluminescence (ECL) assays is proposed by incorporating a second metal coordination complex, [Ir(sppy)3]3-. ECL microscopy is used to map the spatial distribution of ECL emission from [Ru(bpy)3]2+ labels on the surface of a bead and solution-phase emission from [Ir(sppy)3]3-. The developed [Ir(sppy)3]3--mediated enhancement approach significantly improves the ECL signal from [Ru(bpy)3]2+ labels immobilized on a polystyrene bead, with a 70.9-fold increase at 0.9 V and a 2.9-fold increase at 1.2 V vs Ag/AgCl. This enhancement has important implications for improving existing ECL assays and ECL-based microscopy.
Article
Electrochemistry
Yiran Zhao, Julie Descamps, Yoan Leger, Lionel Santinacci, Sandrine Zanna, Neso Sojic, Gabriel Loget
Summary: n-Si/SiOx/Ni photoanodes were studied for upconversion photoinduced electrochemiluminescence (PECL) in a 3-aminophthalhydrazide (luminol)-hydrogen peroxide (H2O2) model electrochemiluminescent (ECL) system at pH 13. The photoanode exhibited PECL emission at 440 nm when excited at 850 nm, showing an anti-Stokes shift of -410 nm at biases above 0 V vs Ag/AgCl. The alkaline pH value of the electrolyte prevented Ni dissolution, resulting in a longer active period (several hours) compared to similar photoanodes operating at neutral pH.
ELECTROCHIMICA ACTA
(2023)
Review
Biochemical Research Methods
Mathavan Sornambigai, Laurent Bouffier, Neso Sojic, Shanmugam Senthil Kumar
Summary: In recent years, electrochemiluminescence (ECL) has become a highly successful tool in analytical science, with a focus on solid-state ECL for its enhanced electron transfer kinetics and rapid response time. The key element in ECL is the luminophore, with Ru(bpy)(3)(2+) being the gold-standard in ECL. This review provides insights into the principles of ECL and classical reaction mechanisms, as well as fabrication methods and the importance of solid-state ECL over solution-phase ECL. It also discusses emerging technologies and potential applications of solid-state ECL, along with recent advances in hyphenated techniques.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Electrochemistry
Tommaso Nicolini, Youness Boukarkour, Stephane Reculusa, Neso Sojic, Alexander Kuhn, Gerardo Salinas
Summary: Electrochemical water-splitting is essential for storing energy from sustainable sources. This study introduces a novel method based on bipolar electrochemistry, using a conducting polymer layer as a variable-resistance switch to evaluate the electrocatalytic activity of electrode materials for hydrogen and oxygen evolution. The method was validated for Au, Pt, and Ni surfaces, with the results in agreement with classical electrochemical methods. This work provides an easy and straightforward approach for assessing the electrocatalytic activity of electrode materials in water-splitting.
ELECTROCHIMICA ACTA
(2023)
Article
Electrochemistry
Gerardo Salinas, Laurent Bouffier, Neso Sojic, Alexander Kuhn
Summary: Thermodynamics is an intriguing aspect of physical chemistry that is involved in various natural phenomena. The spontaneity of a chemical reaction is directly related to fundamental thermodynamic parameters such as the Gibbs free energy change. The visualization of electromotive force allows students to understand the underlying concepts of spontaneity in coupled reactions. This study introduces the thermodynamic concept of spontaneity to undergraduate students using the concepts of endogenous and exogenous bipolar electrochemistry. By encoding the chemical information of two coupled reactions through the light emission of a light-emitting diode used as a bipolar electrode, the thermodynamic information of the involved redox reactions can be directly read out.
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yiran Zhao, Julie Descamps, Nour al Hoda Al Bast, Marcos Duque, Jaume Esteve, Borja Sepulveda, Gabriel Loget, Neso Sojic
Summary: A new all-optical strategy for electrochemiluminescence (ECL) is reported, which eliminates the need for an external power supply and electrical wires. The fully integrated all-optical wireless device utilizes a modified nanostructured Si photovoltaic junction to induce ECL emission under illumination. This breakthrough opens up new opportunities for developing portable sensing devices.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Physical
Milica Sentic, Ivana Trajkovic, Dragan Manojlovic, Dalibor Stankovic, Maria Vesna Nikolic, Neso Sojic, Jasmina Vidic
Summary: This review presents the application of metal-organic frameworks (MOFs) in electrochemiluminescent (ECL) sensing for water pollutant detection. MOF composites enable the sensitive monitoring of common emerging contaminants such as heavy metals, volatile organic compounds, pharmaceuticals, industrial chemicals, and cyanotoxins.
Article
Chemistry, Multidisciplinary
Yiran Zhao, Yoan Leger, Julie Descamps, Neso Sojic, Gabriel Loget
Summary: This study develops an all-optical electrochemiluminescence (AO-ECL) system that uses small and cheap photodiodes and ECL-active and catalytic materials to generate ECL by illuminating photoelectrochemical devices in the electrolyte. These low-cost off-grid AO-ECL devices offer opportunities for remote photodetection and portable bioanalytical tools.
Article
Chemistry, Multidisciplinary
Miaoxia Liu, Gerardo Salinas, Jing Yu, Antoine Cornet, Haidong Li, Alexander Kuhn, Neso Sojic
Summary: Multimodal imaging is a powerful approach that integrates multiple optical modalities in a single device, with potential applications in various fields. In this study, we developed wireless multimodal light-emitting chemical systems by coupling two light sources based on different physical principles. The results provide a novel alternative for designing autonomous hybrid systems with multimodal and multicolor optical readouts for complex bio-chemical systems.
Article
Chemistry, Multidisciplinary
Julie Descamps, Yiran Zhao, Julie Le-Pouliquen, Bertrand Goudeau, Patrick Garrigue, Karine Tavernier, Yoan Leger, Gabriel Loget, Neso Sojic
Summary: Localized photoinduced electrochemiluminescence (PECL) was studied on photoanodes composed of Ir microbands on n-Si/SiOx. The results demonstrated that PECL microscopy accurately imaged the hole-driven heterogeneous photoelectrochemical reactivity. This method shows promise in elucidating the local activity of photoelectrodes used in solar energy conversion.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Lea Waldmann, Do-Nhu-Trang Nguyen, Stephane Arbault, Taco Nicolai, Lazhar Benyahia, Valerie Ravaine
Summary: This study investigates the influence of the bis-hydrophilic balance on the stability of emulsions formed by mixing incompatible polymers. It is found that emulsions stabilized by bis-hydrophilic soft microgels containing 50%wt of Dex exhibit the highest stability. The thermo-responsiveness of the microgels also affects the stability of the emulsions.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)
Article
Biochemistry & Molecular Biology
Camille Colin, Pierre Levallois, Ugo Botsos-Margerit, Franck Clement, Dodzi Zigah, Stephane Arbault
Summary: It was found that using oxygen plasma exposure can replace traditional polishing procedures for GC electrodes, improving their cyclic voltammetry response and making it close to theoretical values. The plasma effects on the electrodes remained stable for about a week when stored in water, attributed to increased surface energy and hydrophilicity. Additionally, the plasma treatment can remove surface blockades on the electrodes.
BIOELECTROCHEMISTRY
(2023)
