Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core
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Title
Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core
Authors
Keywords
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Journal
ACTA PHARMACOLOGICA SINICA
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-07-17
DOI
10.1038/s41401-019-0267-z
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Note: Only part of the references are listed.- Defining the Functional Role of NaV1.7 in Human Nociception
- (2019) Lucy A. McDermott et al. NEURON
- The Role of Voltage-Gated Sodium Channels in Pain Signaling
- (2019) David L. Bennett et al. PHYSIOLOGICAL REVIEWS
- Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain
- (2018) Thilo Focken et al. JOURNAL OF MEDICINAL CHEMISTRY
- Na V 1.7 as a Pharmacogenomic Target for Pain: Moving Toward Precision Medicine
- (2018) Yang Yang et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Identification of Selective Acyl Sulfonamide–Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity
- (2018) Shaoyi Sun et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain
- (2018) Guanglin Luo et al. JOURNAL OF MEDICINAL CHEMISTRY
- Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors
- (2018) Shannon D. Shields et al. JOURNAL OF NEUROSCIENCE
- Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity
- (2017) Russell F. Graceffa et al. JOURNAL OF MEDICINAL CHEMISTRY
- Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain
- (2017) Yong-Jin Wu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7
- (2017) Nigel. A. Swain et al. JOURNAL OF MEDICINAL CHEMISTRY
- Na V 1.7 as a pain target – From gene to pharmacology
- (2017) Irina Vetter et al. PHARMACOLOGY & THERAPEUTICS
- Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief
- (2016) Edward C Emery et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors
- (2016) Erin F. DiMauro et al. JOURNAL OF MEDICINAL CHEMISTRY
- Benzonatate inhibition of voltage-gated sodium currents
- (2016) M. Steven Evans et al. NEUROPHARMACOLOGY
- Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models
- (2016) Thilo Focken et al. ACS Medicinal Chemistry Letters
- Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release
- (2016) Aristos J. Alexandrou et al. PLoS One
- Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications
- (2015) Manuel de Lera Ruiz et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist
- (2015) S. Ahuja et al. SCIENCE
- Sodium channel genes in pain-related disorders: phenotype–genotype associations and recommendations for clinical use
- (2014) Stephen G Waxman et al. LANCET NEUROLOGY
- Painful and painless channelopathies
- (2014) David L H Bennett et al. LANCET NEUROLOGY
- Analgesic Effects of Huwentoxin-IV on Animal Models of Inflammatory and Neuropathic Pain
- (2014) Yu Liu et al. PROTEIN AND PEPTIDE LETTERS
- Synthesis and Analgesic Effects of μ-TRTX-Hhn1b on Models of Inflammatory and Neuropathic Pain
- (2014) Yu Liu et al. Toxins
- An Overview of Animal Models of Pain: Disease Models and Outcome Measures
- (2013) Nicholas S. Gregory et al. JOURNAL OF PAIN
- Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels
- (2013) K. McCormack et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models
- (2013) S. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Link Between Pain and Olfaction in an Inherited Sodium Channelopathy
- (2012) Frank Zufall et al. ARCHIVES OF NEUROLOGY
- The NaV1.7 sodium channel: from molecule to man
- (2012) Sulayman D. Dib-Hajj et al. NATURE REVIEWS NEUROSCIENCE
- Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons
- (2012) Michael S. Minett et al. Nature Communications
- Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation
- (2012) Gül Erdemli et al. Frontiers in Pharmacology
- Selective silencing of NaV1.7 decreases excitability and conduction in vagal sensory neurons
- (2011) Yukiko Muroi et al. JOURNAL OF PHYSIOLOGY-LONDON
- Loss-of-function mutations in sodium channel Nav1.7 cause anosmia
- (2011) Jan Weiss et al. NATURE
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