Synthesis and Biological Evaluation of RGD–Cryptophycin Conjugates for Targeted Drug Delivery

Novel unit B cryptophycin analogues as payloads for targeted therapy

(2018) Eduard Figueras et al.   Beilstein Journal of Organic Chemistry

On the design principles of peptide–drug conjugates for targeted drug delivery to the malignant tumor site

(2018) Eirinaios I Vrettos et al.   Beilstein Journal of Organic Chemistry

Synthesis and biological evaluation of RGD and isoDGR peptidomimetic-α-amanitin conjugates for tumor-targeting

(2018) Lizeth Bodero et al.   Beilstein Journal of Organic Chemistry

Modulating Antibody–Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification

(2018) Dian Su et al.   BIOCONJUGATE CHEMISTRY

FRET Reagent Reveals the Intracellular Processing of Peptide-Linked Antibody–Drug Conjugates

(2018) Byoung-Chul Lee et al.   BIOCONJUGATE CHEMISTRY

Cancer-targeted delivery systems based on peptides

(2018) Theodora Chatzisideri et al.   Future Medicinal Chemistry

Peptide-based targeted therapeutics: Focus on cancer treatment

(2018) Fatemeh Araste et al.   JOURNAL OF CONTROLLED RELEASE

RGD-mediated delivery of small-molecule drugs

(2017) Sotirios Katsamakas et al.   Future Medicinal Chemistry

Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma

(2017) Samuele Cazzamalli et al.   JOURNAL OF CONTROLLED RELEASE

Cryptophycins: cytotoxic cyclodepsipeptides with potential for tumor targeting

(2017) Christine Weiss et al.   JOURNAL OF PEPTIDE SCIENCE

Strategies and challenges for the next generation of antibody–drug conjugates

(2017) Alain Beck et al.   NATURE REVIEWS DRUG DISCOVERY

Exploring the Role of RGD-Recognizing Integrins in Cancer

(2017) Markus Nieberler et al.   Cancers

A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins

(2017) Tobias G. Kapp et al.   Scientific Reports

Cathepsin B Cleavage of vcMMAE-Based Antibody–Drug Conjugate Is Not Drug Location or Monoclonal Antibody Carrier Specific

(2016) Benson Gikanga et al.   BIOCONJUGATE CHEMISTRY

Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design

(2016) M. Dorywalska et al.   MOLECULAR CANCER THERAPEUTICS

Clinical Application of Radiolabeled RGD Peptides for PET Imaging of Integrin αvβ3

(2016) Haojun Chen et al.   Theranostics

The cryptophycins as potent payloads for antibody drug conjugates

(2015) Vishal A. Verma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

?v?3 Integrin-Targeted Peptide/Peptidomimetic-Drug Conjugates: In-Depth Analysis of the Linker Technology

(2015) Alberto Dal Corso et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Antibody–Drug Conjugates and Small Molecule–Drug Conjugates: Opportunities and Challenges for the Development of Selective Anticancer Cytotoxic Agents

(2015) Giulio Casi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Principles in the design of ligand-targeted cancer therapeutics and imaging agents

(2015) Madduri Srinivasarao et al.   NATURE REVIEWS DRUG DISCOVERY

Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

(2014) Ravi V. J. Chari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

(2014) Roger Stupp et al.   LANCET ONCOLOGY

Small Targeted Cytotoxics: Current State and Promises from DNA-Encoded Chemical Libraries

(2013) Nikolaus Krall et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conjugates of Modified Cryptophycins and RGD-Peptides Enter Target Cells by Endocytosis

(2013) Markus Nahrwold et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent approaches for the synthesis of modified cryptophycins

(2013) Christine Weiss et al.   NATURAL PRODUCT REPORTS

Development of a diketopiperazine-forming dipeptidyl Gly-Pro spacer for preparation of an antibody–drug conjugate

(2013) Shino Manabe et al.   MedChemComm

RGD-Based Strategies To Target Alpha(v) Beta(3) Integrin in Cancer Therapy and Diagnosis

(2012) Fabienne Danhier et al.   MOLECULAR PHARMACEUTICS

Approaches for the Synthesis of Functionalized Cryptophycins

(2010) Benedikt Sammet et al.   JOURNAL OF ORGANIC CHEMISTRY

Cyclic RGD-Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds as New Potent Integrin Ligands

(2009) Ana Sofia M. da Ressurreição et al.   CHEMISTRY-A EUROPEAN JOURNAL

Clustering and Internalization of Integrin αvβ3 With a Tetrameric RGD-synthetic Peptide

(2009) Sancey Lucie et al.   MOLECULAR THERAPY