Cryptophycins: cytotoxic cyclodepsipeptides with potential for tumor targeting

Synthesis, biological studies and molecular dynamics of new anticancer RGD-based peptide conjugates for targeted drug delivery

(2016) Y. Gilad et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dual-drug RGD conjugates provide enhanced cytotoxicity to melanoma and non-small lung cancer cells

(2016) Y. Gilad et al.   BIOPOLYMERS

Antibody drug conjugates

(2016) Ray Bakhtiar   BIOTECHNOLOGY LETTERS

Double Methotrexate-Modified Neuropeptide Y Analogues Express Increased Toxicity and Overcome Drug Resistance in Breast Cancer Cells

(2016) David Böhme et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecules for Active Targeting in Cancer

(2016) Chin S. Kue et al.   MEDICINAL RESEARCH REVIEWS

The cryptophycins as potent payloads for antibody drug conjugates

(2015) Vishal A. Verma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Biological Evaluation of RGD Peptidomimetic-Paclitaxel Conjugates Bearing Lysosomally Cleavable Linkers

(2015) Alberto Dal Corso et al.   CHEMISTRY-A EUROPEAN JOURNAL

Design and synthesis of a new class of cryptophycins based tubulin inhibitors

(2015) Arvind Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Drug delivery and release systems for targeted tumor therapy

(2015) David Böhme et al.   JOURNAL OF PEPTIDE SCIENCE

Stabilizing versus Destabilizing the Microtubules: A Double-Edge Sword for an Effective Cancer Treatment Option?

(2015) Daniele Fanale et al.   Analytical Cellular Pathology

Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

(2014) Ravi V. J. Chari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conjugates of Modified Cryptophycins and RGD-Peptides Enter Target Cells by Endocytosis

(2013) Markus Nahrwold et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent approaches for the synthesis of modified cryptophycins

(2013) Christine Weiss et al.   NATURAL PRODUCT REPORTS

Total synthesis and biological evaluation of fluorinated cryptophycins

(2012) Christine Weiß et al.   Beilstein Journal of Organic Chemistry

Biological Evaluation of a Novel Doxorubicin−Peptide Conjugate for Targeted Delivery to EGF Receptor-Overexpressing Tumor Cells

(2011) Shibin Ai et al.   MOLECULAR PHARMACEUTICS

Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation

(2010) Ornella Mesenzani et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Approaches for the Synthesis of Functionalized Cryptophycins

(2010) Benedikt Sammet et al.   JOURNAL OF ORGANIC CHEMISTRY

“Clicktophycin-52”: A Bioactive Cryptophycin-52 Triazole Analogue

(2010) Markus Nahrwold et al.   ORGANIC LETTERS

Conformationally Homogeneous Heterocyclic Pseudotetrapeptides as Three-Dimensional Scaffolds for Rational Drug Design: Receptor-Selective Somatostatin Analogues

(2009) John M. Beierle et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and Cytotoxicity Studies of New Cryptophycin Analogues

(2009) Wen Lu Liu et al.   ARCHIV DER PHARMAZIE

Efficient Synthesis of Cryptophycin-52 and Novelpara-Alkoxymethyl Unit A Analogues

(2009) Stefan Eißler et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Strategies to Overcome or Circumvent P-Glycoprotein Mediated Multidrug Resistance

(2008) Xun Li et al.   CURRENT MEDICINAL CHEMISTRY

Secondary Metabolites from Cyanobacteria: Complex Structures and Powerful Bioactivities

(2008) Karl Gademann et al.   CURRENT ORGANIC CHEMISTRY