Cross-Kingdom Small RNAs Among Animals, Plants and Microbes

Tobacco mosaic virus infection triggers an RNAi-based response in Phytophthora infestans

(2019) Tiziana Mascia et al.   Scientific Reports

DNA nanostructures coordinate gene silencing in mature plants

(2019) Huan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular vesicles as key mediators of plant–microbe interactions

(2018) Brian D Rutter et al.   CURRENT OPINION IN PLANT BIOLOGY

Trans-Kingdom RNA Silencing in Plant–Fungal Pathogen Interactions

(2018) Chenlei Hua et al.   Molecular Plant

Secondary amplification of siRNA machinery limits the application of spray-induced gene silencing

(2018) Xiu-Shi Song et al.   MOLECULAR PLANT PATHOLOGY

RNA interference technology in crop protection against arthropod pests, pathogens and nematodes

(2018) Moises Zotti et al.   PEST MANAGEMENT SCIENCE

Host-induced gene silencing of a regulator of G protein signalling gene (VdRGS1 ) confers resistance to Verticillium wilt in cotton

(2018) Jun Xu et al.   PLANT BIOTECHNOLOGY JOURNAL

Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes

(2018) Qiang Cai et al.   SCIENCE

Extracellular Vesicle RNA: A Universal Mediator of Microbial Communication?

(2018) James A. Tsatsaronis et al.   TRENDS IN MICROBIOLOGY

Identification and application of exogenous dsRNA confers plant protection against Sclerotinia sclerotiorum and Botrytis cinerea

(2018) Austein G. McLoughlin et al.   Scientific Reports

Patisiran: First Global Approval

(2018) Sheridan M. Hoy   DRUGS

Potential applications of engineered nanoparticles in medicine and biology: an update

(2018) Gudepalya Renukaiah Rudramurthy et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

MicroRNAs from the parasitic plant Cuscuta campestris target host messenger RNAs

(2018) Saima Shahid et al.   NATURE

The mysteries of insect RNAi: A focus on dsRNA uptake and transport

(2018) Ana M. Vélez et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Gating of miRNA movement at defined cell-cell interfaces governs their impact as positional signals

(2018) Damianos S. Skopelitis et al.   Nature Communications

Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota

(2018) Yun Teng et al.   Cell Host & Microbe

Bioavailability of transgenic microRNAs in genetically modified plants

(2017) Jian Yang et al.   Genes and Nutrition

The atypical genesis and bioavailability of the plant-based small RNA MIR2911: Bulking up while breaking down

(2017) Jian Yang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Puccinia striiformis f. sp. tritici microRNA-like RNA 1 (Pst -milR1), an important pathogenicity factor of Pst , impairs wheat resistance to Pst by suppressing the wheat pathogenesis-related 2 gene

(2017) Bing Wang et al.   NEW PHYTOLOGIST

Botrytis small RNA Bc-siR37 suppresses plant defense genes by cross-kingdom RNAi

(2017) Ming Wang et al.   RNA Biology

Spray-Induced Gene Silencing: a Powerful Innovative Strategy for Crop Protection

(2017) Ming Wang et al.   TRENDS IN MICROBIOLOGY

Plant microRNAs in larval food regulate honeybee caste development

(2017) Kegan Zhu et al.   PLoS Genetics

New Insight into Inter-kingdom Communication: Horizontal Transfer of Mobile Small RNAs

(2017) Geyu Zhou et al.   Frontiers in Microbiology

Bioavailability of transgenic microRNAs in genetically modified plants

(2017) Jian Yang et al.   Genes and Nutrition

Detection of dietetically absorbed maize-derived microRNAs in pigs

(2017) Yi Luo et al.   Scientific Reports

The Host Shapes the Gut Microbiota via Fecal MicroRNA

(2016) Shirong Liu et al.   Cell Host & Microbe

Cross-kingdom inhibition of breast cancer growth by plant miR159

(2016) Andrew R Chin et al.   CELL RESEARCH

Biological Activities of Extracellular Vesicles and Their Cargos from Bovine and Human Milk in Humans and Implications for Infants

(2016) Janos Zempleni et al.   JOURNAL OF NUTRITION

Commercial Dairy Cow Milk microRNAs Resist Digestion under Simulated Gastrointestinal Tract Conditions

(2016) Abderrahim Benmoussa et al.   JOURNAL OF NUTRITION

Host-Induced Gene Silencing of the Target Gene in Fungal Cells Confers Effective Resistance to the Cotton Wilt Disease Pathogen Verticillium dahliae

(2016) Tao Zhang et al.   Molecular Plant

Host-induced gene silencing compromises Verticillium wilt in tomato and Arabidopsis

(2016) Yin Song et al.   MOLECULAR PLANT PATHOLOGY

RNAi as a management tool for the western corn rootworm,Diabrotica virgifera virgifera

(2016) Elane Fishilevich et al.   PEST MANAGEMENT SCIENCE

Targeting insect mitochondrial complex I for plant protection

(2016) Xiu-Ming Wu et al.   PLANT BIOTECHNOLOGY JOURNAL

An RNAi-Based Control of Fusarium graminearum Infections Through Spraying of Long dsRNAs Involves a Plant Passage and Is Controlled by the Fungal Silencing Machinery

(2016) Aline Koch et al.   PLoS Pathogens

Gene regulation by dietary microRNAs

(2015) Janos Zempleni et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Conversations between kingdoms: small RNAs

(2015) Arne Weiberg et al.   CURRENT OPINION IN BIOTECHNOLOGY

Uptake and Function Studies of Maternal Milk-derived MicroRNAs

(2015) Alexandra C. Title et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determination of the potential bioavailability of plant microRNAs using a simulated human digestion process

(2015) Anna Philip et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Virus-induced gene silencing ofWithania somniferasqualene synthase negatively regulates sterol and defence-related genes resulting in reduced withanolides and biotic stress tolerance

(2015) Anup Kumar Singh et al.   PLANT BIOTECHNOLOGY JOURNAL

Nonfunctional ingestion of plant miRNAs in silkworm revealed by digital droplet PCR and transcriptome analysis

(2015) Ling Jia et al.   Scientific Reports

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses

(2014) Zhen Zhou et al.   CELL RESEARCH

MicroRNAs Are Absorbed in Biologically Meaningful Amounts from Nutritionally Relevant Doses of Cow Milk and Affect Gene Expression in Peripheral Blood Mononuclear Cells, HEK-293 Kidney Cell Cultures, and Mouse Livers

(2014) Scott R. Baier et al.   JOURNAL OF NUTRITION

Small RNAs break out: the molecular cell biology of mobile small RNAs

(2014) Peter Sarkies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New wind in the sails: improving the agronomic value of crop plants through RNAi-mediated gene silencing

(2014) Aline Koch et al.   PLANT BIOTECHNOLOGY JOURNAL

Mining of public sequencing databases supports a non-dietary origin for putative foreign miRNAs: underestimated effects of contamination in NGS

(2014) J. P. Tosar et al.   RNA

Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity

(2014) Amy H. Buck et al.   Nature Communications

Trans-kingdom Cross-Talk: Small RNAs on the Move

(2014) Marijn Knip et al.   PLoS Genetics

RNA interference in Colorado potato beetle: steps toward development of dsRNA as a commercial insecticide

(2014) Subba Reddy Palli   Current Opinion in Insect Science

Assessing the survival of exogenous plant microRNA in mice

(2014) GaoFeng Liang et al.   Food Science & Nutrition

Lack of detectable oral bioavailability of plant microRNAs after feeding in mice

(2013) Brent Dickinson et al.   NATURE BIOTECHNOLOGY

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond

(2013) Stephane E. Castel et al.   NATURE REVIEWS GENETICS

Deep sequencing-based identification of pathogen-specific microRNAs in the plasma of rabbits infected with Schistosoma japonicum

(2013) GUOFENG CHENG et al.   PARASITOLOGY

Host-induced gene silencing of cytochrome P450 lanosterol C14 -demethylase-encoding genes confers strong resistance to Fusarium species

(2013) A. Koch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Real-time quantitative PCR and droplet digital PCR for plant miRNAs in mammalian blood provide little evidence for general uptake of dietary miRNAs

(2013) Kenneth W. Witwer et al.   RNA Biology

Ineffective delivery of diet-derived microRNAs to recipient animal organisms

(2013) Jonathan W. Snow et al.   RNA Biology

Fungal Small RNAs Suppress Plant Immunity by Hijacking Host RNA Interference Pathways

(2013) Arne Weiberg et al.   SCIENCE

A mycoreovirus suppresses RNA silencing in the white root rot fungus, Rosellinia necatrix

(2013) Hajime Yaegashi et al.   VIROLOGY

Analysis of plant-derived miRNAs in animal small RNA datasets

(2012) Yuanji Zhang et al.   BMC GENOMICS

Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types

(2012) Jasenka Guduric-Fuchs et al.   BMC GENOMICS

Translocation of Sickle Cell Erythrocyte MicroRNAs into Plasmodium falciparum Inhibits Parasite Translation and Contributes to Malaria Resistance

(2012) Gregory LaMonte et al.   Cell Host & Microbe

Progress on RNAi-based molecular medicines

(2012) Jing Chen et al.   International Journal of Nanomedicine

Genome-wide identification of viral and host transcripts targeted by viral siRNAs inVitis vinifera

(2012) Laura Miozzi et al.   MOLECULAR PLANT PATHOLOGY

Intercellular communication: diverse structures for exchange of genetic information

(2012) Maria Mittelbrunn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

(2012) Esther N. M. Nolte-’t Hoen et al.   NUCLEIC ACIDS RESEARCH

Plant secondary siRNA production determined by microRNA-duplex structure

(2012) P. A. Manavella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted microRNAs: a new form of intercellular communication

(2012) Xi Chen et al.   TRENDS IN CELL BIOLOGY

Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA

(2011) Lin Zhang et al.   CELL RESEARCH

Cell-to-cell and long-distance siRNA movement in plants: mechanisms and biological implications

(2011) Christopher Andrew Brosnan et al.   CURRENT OPINION IN PLANT BIOLOGY

Characterization of extracellular circulating microRNA

(2011) Andrey Turchinovich et al.   NUCLEIC ACIDS RESEARCH

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral Small Interfering RNAs Target Host Genes to Mediate Disease Symptoms in Plants

(2011) Neil A. Smith et al.   PLoS Pathogens

A Viral Satellite RNA Induces Yellow Symptoms on Tobacco by Targeting a Gene Involved in Chlorophyll Biosynthesis using the RNA Silencing Machinery

(2011) Hanako Shimura et al.   PLoS Pathogens

HIGS: Host-Induced Gene Silencing in the Obligate Biotrophic Fungal PathogenBlumeria graminis

(2010) Daniela Nowara et al.   PLANT CELL

22-nucleotide RNAs trigger secondary siRNA biogenesis in plants

(2010) H.-M. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimization of enzymatic reaction conditions for generating representative pools of cDNA from small RNA

(2010) D. B. Munafo et al.   RNA

Small RNA Duplexes Function as Mobile Silencing Signals Between Plant Cells

(2010) P. Dunoyer et al.   SCIENCE

Beyond Drosophila: RNAi In Vivo and Functional Genomics in Insects

(2009) Xavier Bellés   Annual Review of Entomology

Roles of Plant Small RNAs in Biotic Stress Responses

(2009) Virginia Ruiz-Ferrer et al.   Annual Review of Plant Biology

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Small silencing RNAs: an expanding universe

(2009) Megha Ghildiyal et al.   NATURE REVIEWS GENETICS

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

(2008) Xi Chen et al.   CELL RESEARCH

Trans-specific gene silencing between host and parasitic plants

(2008) Alexey A. Tomilov et al.   PLANT JOURNAL