Functional Characterization of Clinically-Relevant Rare Variants in ABCG2 Identified in a Gout and Hyperuricemia Cohort

Inhibitors of Human ABCG2: From Technical Background to Recent Updates With Clinical Implications

(2019) Yu Toyoda et al.   Frontiers in Pharmacology

An update on the genetics of hyperuricaemia and gout

(2018) Tanya J. Major et al.   Nature Reviews Rheumatology

Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression

(2018) Boglárka Zámbó et al.   Scientific Reports

Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression

(2018) T. Takada et al.   Scientific Reports

Polymorphisms of the multidrug pump ABCG2: a systematic review of their effect on protein expression, function and drug pharmacokinetics

(2018) Niall Heyes et al.   DRUG METABOLISM AND DISPOSITION

Clinical and Molecular Evidence of ABCC11 Protein Expression in Axillary Apocrine Glands of Patients with Axillary Osmidrosis

(2017) Yu Toyoda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure of the human multidrug transporter ABCG2

(2017) Nicholas M. I. Taylor et al.   NATURE

Functional non-synonymous variants of ABCG2 and gout risk

(2017) Blanka Stiburkova et al.   RHEUMATOLOGY

GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes

(2016) Akiyoshi Nakayama et al.   ANNALS OF THE RHEUMATIC DISEASES

Gout

(2016) Nicola Dalbeth et al.   LANCET

Identification of Febuxostat as a New Strong ABCG2 Inhibitor: Potential Applications and Risks in Clinical Situations

(2016) Hiroshi Miyata et al.   Frontiers in Pharmacology

Regulation of the Axillary Osmidrosis-Associated ABCC11 Protein Stability by N-Linked Glycosylation: Effect of Glucose Condition

(2016) Yu Toyoda et al.   PLoS One

Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis

(2016) Yu Toyoda et al.   Scientific Reports

Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes

(2015) Hirotaka Matsuo et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences

(2015) A. J. Haider et al.   BIOSCIENCE REPORTS

Novel dysfunctional variant inABCG2as a cause of severe tophaceous gout: biochemical, molecular genetics and functional analysis

(2015) Blanka Stiburkova et al.   RHEUMATOLOGY

Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese

(2015) Changgui Li et al.   Nature Communications

Ethnic Differences in ATP-binding Cassette Transporter, Sub-family G, Member 2 (ABCG2/BCRP): Genotype Combinations and Estimated Functions

(2014) Masayuki Sakiyama et al.   Drug Metabolism and Pharmacokinetics

Complex Analysis of Urate Transporters SLC2A9, SLC22A12 and Functional Characterization of Non-Synonymous Allelic Variants of GLUT9 in the Czech Population: No Evidence of Effect on Hyperuricemia and Gout

(2014) Olha Hurba et al.   PLoS One

ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload

(2014) Hirotaka Matsuo et al.   Scientific Reports

Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors

(2014) Akiyoshi Nakayama et al.   Scientific Reports

Common dysfunctional variants in ABCG2 are a major cause of early-onset gout

(2013) Hirotaka Matsuo et al.   Scientific Reports

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

(2012) Anna Köttgen et al.   NATURE GENETICS

Decreased extra-renal urate excretion is a common cause of hyperuricemia

(2012) Kimiyoshi Ichida et al.   Nature Communications

Ubiquitin-Mediated Proteasomal Degradation of ABC Transporters: a New Aspect of Genetic Polymorphisms and Clinical Impacts

(2011) Hiroshi Nakagawa et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?

(2009) Yu Toyoda et al.   FASEB JOURNAL

Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2

(2009) Hiroshi Nakagawa et al.   FEBS Journal

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

(2009) O. M. Woodward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population

(2009) H. Matsuo et al.   Science Translational Medicine

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

(2009) Melanie Kolz et al.   PLoS Genetics

ABCG2: A perspective

(2008) Robert W. Robey et al.   ADVANCED DRUG DELIVERY REVIEWS

Mutations in Glucose Transporter 9 Gene SLC2A9 Cause Renal Hypouricemia

(2008) Hirotaka Matsuo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

(2008) Abbas Dehghan et al.   LANCET

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

(2008) Veronique Vitart et al.   NATURE GENETICS

SLC2A9 Is a High-Capacity Urate Transporter in Humans

(2008) Mark J Caulfield et al.   PLOS MEDICINE