Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis

Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

(2019) Grant M. Fischer et al.   Cancer Discovery

Anti–PD-1/anti–CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8+T cell trafficking

(2018) David Taggart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptotic effect of a phytosterol-ingredient and its main phytosterol (β-sitosterol) in human cancer cell lines

(2018) Andrea Alvarez-Sala et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Dabrafenib plus trametinib in patients with BRAF V600 -mutant melanoma brain metastases (COMBI-MB): a multicentre, multicohort, open-label, phase 2 trial

(2017) Michael A Davies et al.   LANCET ONCOLOGY

Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy

(2016) Michael P. Smith et al.   CANCER CELL

Survival of patients with metastatic melanoma and brain metastases in the era of MAP-kinase inhibitors and immunologic checkpoint blockade antibodies: A systematic review

(2016) Francesco Spagnolo et al.   CANCER TREATMENT REVIEWS

Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors

(2016) Gao Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Bevacizumab Prevents Brain Metastases Formation in Lung Adenocarcinoma

(2016) A. Ilhan-Mutlu et al.   MOLECULAR CANCER THERAPEUTICS

Accessory subunits are integral for assembly and function of human mitochondrial complex I

(2016) David A. Stroud et al.   NATURE

Updates in the management of brain metastases

(2016) Nils D. Arvold et al.   NEURO-ONCOLOGY

Melanoma central nervous system metastases: current approaches, challenges, and opportunities

(2016) Justine V. Cohen et al.   Pigment Cell & Melanoma Research

New Strategies in Melanoma: Entering the Era of Combinatorial Therapy

(2015) R. J. Sullivan et al.   CLINICAL CANCER RESEARCH

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Drug repurposing in oncology—patient and health systems opportunities

(2015) Francesco Bertolini et al.   Nature Reviews Clinical Oncology

Melanoma brain metastasis is independent of lactate dehydrogenase A expression

(2015) Terje Sundstrøm et al.   NEURO-ONCOLOGY

Extrinsic factors can mediate resistance to BRAF inhibition in central nervous system melanoma metastases

(2015) Heike Seifert et al.   Pigment Cell & Melanoma Research

Molecular drivers of cellular metabolic reprogramming in melanoma

(2015) Cecilie Abildgaard et al.   TRENDS IN MOLECULAR MEDICINE

Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain

(2014) J. Chen et al.   CANCER RESEARCH

A randomized trial of efficacy of beta-sitosterol and its glucoside as adjuvant to cryotherapy in the treatment of anogenital warts

(2014) Christina Stefanaki et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

The malignant melanoma landscape

(2014) Rachel M. Webster et al.   NATURE REVIEWS DRUG DISCOVERY

Synergistic Anti-Cancer Effect of Phenformin and Oxamate

(2014) W. Keith Miskimins et al.   PLoS One

Human breast cancer metastases to the brain display GABAergic properties in the neural niche

(2014) J. Neman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

β-sitosterol induces G1 arrest and causes depolarization of mitochondrial membrane potential in breast carcinoma MDA-MB-231 cells

(2013) Shanthi Sri Vundru et al.   BMC Complementary and Alternative Medicine

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

(2013) Alexander Roesch et al.   CANCER CELL

Automated Tracking of Nanoparticle-labeled Melanoma Cells Improves the Predictive Power of a Brain Metastasis Model

(2013) T. Sundstrom et al.   CANCER RESEARCH

Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases

(2013) Frits Thorsen et al.   JOURNAL OF CONTROLLED RELEASE

Roadblocks to translational advances on metastasis research

(2013) Thomas Brabletz et al.   NATURE MEDICINE

Reactive Oxygen Species-Mediated Activation of AMP-Activated Protein Kinase and c-Jun N-terminal Kinase Plays a Critical Role in Beta-Sitosterol-Induced Apoptosis in Multiple Myeloma U266 cells

(2013) Song Hyo Sook et al.   PHYTOTHERAPY RESEARCH

Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast Cancer

(2013) Bruce Grattan   Nutrients

Incorporation of β-sitosterol into mitochondrial membrane enhances mitochondrial function by promoting inner mitochondrial membrane fluidity

(2012) Chun Shi et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Dietary intake of plant sterols stably increases plant sterol levels in the murine brain

(2012) Tim Vanmierlo et al.   JOURNAL OF LIPID RESEARCH

Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial

(2012) Georgina V Long et al.   LANCET ONCOLOGY

Importance of glycolysis and oxidative phosphorylation in advanced melanoma

(2012) Jonhan Ho et al.   Molecular Cancer

Mitochondrial Respiration - An Important Therapeutic Target in Melanoma

(2012) Michelle Barbi de Moura et al.   PLoS One

Immunohistochemical testing of BRAF V600E status in 1,120 tumor tissue samples of patients with brain metastases

(2011) David Capper et al.   ACTA NEUROPATHOLOGICA

Strategies to optimize the brain availability of central nervous system drug candidates

(2011) Travis T Wager et al.   Expert Opinion on Drug Discovery

Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis

(2011) E. S. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemopreventive potential of β-Sitosterol in experimental colon cancer model - an In vitro and In vivo study

(2010) Albert A Baskar et al.   BMC Complementary and Alternative Medicine

Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer

(2010) P. R. Lockman et al.   CLINICAL CANCER RESEARCH

β-Sitosterol Inhibits Cell Growth and Induces Apoptosis in SGC-7901 Human Stomach Cancer Cells

(2009) Yonghuan Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Chemoprevention of Tumor Metastasis by Liposomal β-Sitosterol Intake

(2008) Hiromichi Imanaka et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A low-cost flow cytometric assay for the detection and quantification of apoptosis using an anionic halogenated fluorescein dye

(2008) Mervin Meyer et al.   BIOTECHNIQUES

Dietary consumption of phytochemicals and breast cancer risk in Mexican women

(2008) Luisa Torres-Sanchez et al.   PUBLIC HEALTH NUTRITION