Article
Biochemistry & Molecular Biology
Qiaoyun Hou, Shuohua Chen, Qi An, Boya Li, Yan Fu, Yongzhang Luo
Summary: The study confirms plasma Hsp90 alpha as a biomarker for breast cancer, providing insights into its prognostic value across different clinical stages, and suggests that eHsp90 alpha plays a role in promoting lymphangiogenesis in breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Tingting Zhu, Zhangding Wang, Tianhui Zou, Lei Xu, Shu Zhang, Yali Chen, Chen Chen, Weijie Zhang, Shouyu Wang, Qingqing Ding, Guifang Xu
Summary: Metabolic reprogramming is a hallmark of malignancies such as gastric cancer, with the rate-limiting enzyme SOAT1 identified as highly expressed in cancerous tissues and associated with advanced tumor stage and lymph node metastasis. Inhibition of SOAT1 suppresses GC cell proliferation, cholesterol ester synthesis, and lymphangiogenesis, while overexpression promotes these processes by regulating cholesterol metabolism genes. Therefore, SOAT1 may serve as a promising prognostic biomarker for guiding clinical management and treatment decisions in gastric cancer.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Acoustics
Rui Zhao, Huan Jiang, Jingyan Cao, Bo Li, Lili Xu, Shaochun Dai
Summary: The aims of this study were to investigate the value of sound touch elastography (STE) in predicting axillary lymph node metastasis (ALNM) in patients with invasive breast cancer (IBC) and to explore whether lysyl oxidase (LOX) is correlated with increasing stiffness and promotion of metastasis in IBC. The study found that STE could serve as a non-invasive method for assessing lymph node status before surgery, and the maximum stiffness value and maximum shell stiffness value could be used to predict axillary lymph node metastasis of IBC. Furthermore, the overexpression of LOX and increased collagen fiber contributed to the increased stiffness in the lesions and metastases of IBC.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Thijs Koorman, Karin A. Jansen, Antoine Khalil, Peter D. Haughton, Daan Visser, Max A. K. Ratze, Wisse E. Haakma, Gabriele Sakalauskaite, Paul J. van Diest, Johan de Rooij, Patrick W. B. Derksen
Summary: The study reveals that increased collagen bundling promotes breast cancer invasion, while advanced glycation end product crosslinking prevents collective invasion. The collective invasion of ductal breast cancer cells depends on Lysyl oxidase-like 3 produced by tumor cells.
Article
Biochemistry & Molecular Biology
Mun Gyeong Bae, Jeon Hwang-Bo, Dae Young Lee, Youn-Hyung Lee, In Sik Chung
Summary: The research shows that 6,8-DG inhibits VEGF-A-induced lymphangiogenesis and lymph node metastasis by suppressing VEGF-A expression in cancer cells and the VEGF-A/VEGFR-2 signaling pathway in HLMEC. Therefore, 6,8-DG could be a novel and valuable therapeutic agent for metastasis prevention and treatment of oral cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Erika G. Kusajima, Yuhei Yamamoto, Kosuke Ishikawa, Takahiro Miura, Emi Funayama, Masayuki Osawa, Ryo Takagi, Taku Maeda
Summary: This study investigated the impact of vascularized lymph node transfer (VLNT) on dendritic cell (DC) dynamics against cancer in mouse models. It was found that mice with reconnected lymphatics after VLNT had reduced metastasis and an increased proportion of DCs, suggesting that VLNT may enhance the tumor immune response by promoting DC migration to lymph nodes.
Article
Multidisciplinary Sciences
Hyo Jin Kang, Soo Young Moon, Baek-Kyu Kim, Yujin Myung, Ju-Hee Lee, Jae Hoon Jeong
Summary: To overcome the limitations of lymphedema treatment, human adipose-derived stem cells (hADSCs) were injected into decellularized lymph nodes to produce a recellularized lymph node-scaffold, and the effect of lymphangiogenesis was investigated in lymphedema animal models.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Linlin Wang, Ling Li, Guiquan Zhu
Summary: Studies have shown that various cells in the tumor microenvironment release extracellular vesicles (EVs) encapsulating different molecules, which can be taken up by lymph endothelial cells (LECs) to regulate tumor lymphangiogenesis. EVs may serve as biomarkers for tumor lymph node metastasis and hold potential for anti-tumor lymphangiogenesis therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dante Alexander Patrick Louie, Darellynn Oo, Glory Leung, Yujia Lin, Matthew Stephens, Omar Alrashed, Marcus Tso, Shan Liao
Summary: Lymph node metastasis is closely related to tumor aggressiveness and poor prognosis. Research has shown that both anti-tumor and exhausted tumor-specific T cells can be induced in the tumor-draining lymph node (TDLN), but the activation and maturation of B cells in the TDLN have received less attention. In this study using mouse models, it was found that tumor growth promotes the entry of tumor-associated antigens into the B cell zone and facilitates access to follicular dendritic cells (FDCs) in the germinal centers (GCs), where antigen-specific B cell maturation occurs. Depletion of subcapsular sinus (SCS) macrophages in the TDLN increased GC formation and promoted tumor growth. These findings suggest that TDLN reconstruction creates a niche that favors B cell activation and maturation during tumor growth.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Xiangyu Zhao, Yuxing Chen, Xiaoqin Sun, Zaoke He, Tao Wu, Chenxu Wu, Jing Chen, Jinyu Wang, Kaixuan Diao, Xue-Song Liu
Summary: This study found that EFNA4, a member of the EPH family, is amplified and up-regulated in lung tumor patients, especially in those with lymph node metastases. Overexpression of EFNA4 promotes lung tumor cell proliferation and migration, while knockdown or knockout of EFNA4 inhibits cell proliferation and migration. These findings suggest that the amplification of the EFNA4 gene may play an oncogenic role in promoting lung cancer lymph node metastasis.
Article
Oncology
Qian Zhao, Fan Yang, Huai-liang Wu, Miao Mo, Yun-xiao Ling, Guang -yu Liu
Summary: This study aimed to investigate the clinical orientation and management of contralateral axillary lymph node metastasis (CAM). The results showed that patients with CAM had worse survival outcomes compared to those with oligometastasis or locoregional recurrence. Additionally, the study found that adding local treatment did not significantly improve overall survival.
Article
Medicine, Research & Experimental
Changhao Chen, Hanhao Zheng, Yuming Luo, Yao Kong, Mingjie An, Yuting Li, Wang He, Bowen Gao, Yue Zhao, Hao Huang, Jian Huang, Tianxin Lin
Summary: This study reveals that SUMOylation is a crucial mechanism promoting lymphatic metastasis in bladder cancer, by regulating the ELNAT1/UBC9/SOX18 axis to enhance lymphangiogenesis and LN metastasis. Blocking tumor cell SUMOylation could be a promising therapeutic strategy for LN metastatic BCa.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Biochemistry & Molecular Biology
Sandra Ferreira, Nuno Saraiva, Patricia Rijo, Ana S. Fernandes
Summary: LOX and LOXL2 are amine oxidases that catalyze cross-linking reactions of elastin and collagen in connective tissue, with LOXL2 showing high expression in certain tumors. Inhibition of LOX and LOXL2 is considered a promising strategy for preventing metastasis and invasion of breast cancer. Novel synthetic compounds acting as selective inhibitors for LOX/LOXL2 or dual LOX/LOXL inhibitors have been developed, showing potential for effective therapeutic approaches in breast cancer treatment.
Article
Chemistry, Multidisciplinary
Gokhan Bahcecioglu, Xiaoshan Yue, Erin Howe, Ian Guldner, M. Sharon Stack, Harikrishna Nakshatri, Siyuan Zhang, Pinar Zorlutuna
Summary: The study reveals that aging ECM can drive normal mammary epithelial cells to a more invasive and cancer-like phenotype, and enhance motility and invasiveness in breast cancer cells. Different responses of cells to young and aged ECMs may lead to the identification of new targets for cancer treatment and prevention.
Article
Biochemistry & Molecular Biology
Ryuhei Takemoto, Tetsuro Kamiya, Taku Atobe, Hirokazu Hara, Tetsuo Adachi
Summary: In M2-like macrophages, both HIF1α and STAT3 are essential for LOX induction, while the loss of FOXO1 facilitates HIF1α binding to the lox promoter region, promoting LOX induction.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Lin Jia, Xin-an Lu, Guanghua Liu, Shan Wang, Min Xu, Yang Tian, Shaosen Zhang, Yan Fu, Yongzhang Luo
JOURNAL OF PATHOLOGY
(2017)
Article
Agriculture, Dairy & Animal Science
Qiang Weng, Toshio Tsubota, Mingdao Dai, Jiaju Weng, Yang Tian, Meiyu Xu, Gen Watanabe, Kazuyoshi Taya
ANIMAL SCIENCE JOURNAL
(2012)
Article
Veterinary Sciences
Yong Shen, Yuning Liu, Jiajia Ma, Xiaoting Ma, Yang Tian, Haolin Zhang, Lin Li, Meiyu Xu, Qiang Weng, Gen Watanabe, Kazuyoshi Taya
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2012)
Article
Oncology
Jie Liu, Caihong Wang, Xuhui Ma, Yang Tian, Chunying Wang, Yan Fu, Yongzhang Luo
JOURNAL OF PATHOLOGY
(2019)
Article
Cell Biology
Yang Tian, Chunying Wang, Shuohua Chen, Jie Li, Yan Fu, Yongzhang Luo
JOURNAL OF CELL SCIENCE
(2019)
Article
Cell Biology
Caihong Wang, Shaosen Zhang, Jie Liu, Yang Tian, Boyuan Ma, Siran Xu, Yan Fu, Yongzhang Luo
Article
Cell Biology
Shaosen Zhang, Caihong Wang, Boyuan Ma, Min Xu, Siran Xu, Jie Liu, Yang Tian, Yan Fu, Yongzhang Luo