Review
Oncology
Yuhang Li, Yinghui Song, Yujing Zhang, Sulai Liu
Summary: This article discusses the lymph node pathways, metastatic directions, and treatment methods for gallbladder cancer, emphasizing the importance of developing individualized treatments for predicting the prognosis of patients with different lymph node conditions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qiaoyun Hou, Shuohua Chen, Qi An, Boya Li, Yan Fu, Yongzhang Luo
Summary: The study confirms plasma Hsp90 alpha as a biomarker for breast cancer, providing insights into its prognostic value across different clinical stages, and suggests that eHsp90 alpha plays a role in promoting lymphangiogenesis in breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Mohadeseh Nemati, Bipin Singh, Rakeeb Ahmad Mir, Mahdieh Nemati, Azadeh Babaei, Mahdi Ahmadi, Yousef Rasmi, Afsaneh Gholinejad Golezani, Jafar Rezaie
Summary: Plant-derived extracellular vesicles (P-EVs) have multiple functions in plant physiology and can be isolated from various plant species. P-EVs have potential applications in cell-free therapy and drug-delivery systems, but clinical translation faces challenges.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Oncology
Akira Yokoi, Takahiro Ochiya
Summary: This review summarizes recent studies on EVs from the perspective of EV heterogeneity and highlights their role in various steps from oncogenic to metastatic processes. Recognizing EV subtypes is crucial for identifying pathways affected by EVs and targeting specific subtypes in therapeutic approaches or liquid biopsies.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Urszula Szwedowicz, Zofia Lapinska, Agnieszka Gajewska-Naryniecka, Anna Choromanska
Summary: Until 30 years ago, extracellular vesicles (EVs) were believed to be used for removing unnecessary compounds from cells. However, their enormous potential for diagnosing and treating diseases has now been recognized. EVs play a crucial role in intercellular communication by transferring bioactive molecules between cells. Compared to lab-created drug nanocarriers, EVs are more stable in physiological conditions and have lower immunogenicity and cytotoxicity. EVs can deliver cargo to specific cells due to their membrane proteins and lipids. New strategies have been developed to create tailor-made therapeutic EVs. However, there are significant challenges in applying EVs as drug-delivery agents in clinical settings.
Article
Biology
Dmitry Ter-Ovanesyan, Tal Gilboa, Bogdan Budnik, Adele Nikitina, Sara Whiteman, Roey Lazarovits, Wendy Trieu, David Kalish, George M. Church, David R. Walt, Marcio L. Rodrigues
Summary: Extracellular vesicles (EVs) are challenging to separate from abundant free proteins and lipoproteins. We developed a digital ELISA assay to measure ApoB-100, a protein component of lipoproteins, and combined it with other assays to quantify the separation of EVs from lipoproteins and free proteins. We compared EV separation using different pore sizes in size exclusion chromatography and developed improved methods for EV isolation using multiple types of chromatography resins. Our approach allows quantitative measurement of impurities in EV isolation and enables novel methods for enriching EVs from human plasma.
Article
Pharmacology & Pharmacy
Tingting Zhu, Zhangding Wang, Tianhui Zou, Lei Xu, Shu Zhang, Yali Chen, Chen Chen, Weijie Zhang, Shouyu Wang, Qingqing Ding, Guifang Xu
Summary: Metabolic reprogramming is a hallmark of malignancies such as gastric cancer, with the rate-limiting enzyme SOAT1 identified as highly expressed in cancerous tissues and associated with advanced tumor stage and lymph node metastasis. Inhibition of SOAT1 suppresses GC cell proliferation, cholesterol ester synthesis, and lymphangiogenesis, while overexpression promotes these processes by regulating cholesterol metabolism genes. Therefore, SOAT1 may serve as a promising prognostic biomarker for guiding clinical management and treatment decisions in gastric cancer.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Eduardo Duran-Jara, Tamara Vera-Tobar, Lorena De Lourdes Lobos-Gonzalez
Summary: Lactadherin is associated with cancer development and progression, and can serve as a biomarker and therapeutic target for cancer. It plays important roles in cell adhesion, angiogenesis, and tissue regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Sedighe Khaksari, Khalil Abnous, Farzin Hadizadeh, Mohammad Ramezani, Seyed Mohammad Taghdisi, Seyed Ali Mousavi Shaegh
Summary: Extracellular vesicles (EVs) are membrane-enclosed vesicles secreted from mammalian cells, which act as multi-component delivery vehicles for intercellular communications. Probing circulating EVs has great potential for early diagnostics of diseases, and biosensors have attracted attention in the identification of EVs due to their simplicity and portability. Amplification strategies, including various detection modalities and microfluidic systems, are essential for detecting the extremely low concentrations of EVs in bodily fluids at early stages of a disease.
Review
Cell Biology
Lana Ginini, Salem Billan, Eran Fridman, Ziv Gil
Summary: Extracellular vesicles (EVs) are crucial heterogenous lipid structures secreted by cells for cell-to-cell communication. EVs primarily enter cells through endocytosis, a process that may depend on proteins and lipids on the surfaces of both vesicles and target cells.
Review
Endocrinology & Metabolism
Tingting Chen, Fang Wang, Jiayi Wei, Le Feng
Summary: Extracellular vesicles (EVs) are secreted by almost all cell types and present in almost all biological fluids. They have been found to have potential roles in the diagnosis and treatment of diabetic retinopathy (DR). Changes in EVs' quantity and content can function as biomarkers for the pathological status of DR, such as inflammation, neovascularization, and epithelial-mesenchymal transition. In addition, as natural, safe, and efficient drug carriers, EVs play crucial roles in intercellular communication by delivering essential cell-specific information to target cells. This review summarizes the roles of EVs secreted by various cell types and involved in various biological processes in the pathogenesis, diagnosis, and treatment of DR.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Forough Alemi, Fatemeh Sadeghsoltani, Khashayar Fattah, Parisa Hassanpour, Faezeh Malakoti, Sina Kardeh, Melika Izadpanah, Debora Aparecida Pires de Campos Zuccari, Bahman Yousefi, Maryam Majidinia
Summary: Noncoding RNAs play important roles in key cell biological and pathological events, and their altered expression is directly and indirectly linked to cancer progression. Numerous studies have highlighted the significant role of ncRNAs in cancer prevention and therapy, making them an interesting subject for cancer treatment. However, there are limitations in the application of ncRNAs in cancer treatment, such as delivery, uptake, and short half-life. Exosomes are introduced as promising options for delivering ncRNAs to target cells. This review briefly discusses the application and barriers of ncRNAs, with a focus on exosome-based ncRNA delivery, advantages, and the latest achievements in drugging ncRNAs with exosomes.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Medicine, Research & Experimental
Changhao Chen, Hanhao Zheng, Yuming Luo, Yao Kong, Mingjie An, Yuting Li, Wang He, Bowen Gao, Yue Zhao, Hao Huang, Jian Huang, Tianxin Lin
Summary: This study reveals that SUMOylation is a crucial mechanism promoting lymphatic metastasis in bladder cancer, by regulating the ELNAT1/UBC9/SOX18 axis to enhance lymphangiogenesis and LN metastasis. Blocking tumor cell SUMOylation could be a promising therapeutic strategy for LN metastatic BCa.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Oncology
Jinji Jin, Jianxin Tu, Jiahuan Ren, Yiqi Cai, Wenjing Chen, Lifang Zhang, Qiyu Zhang, Guanbao Zhu
Summary: The study evaluated the potential role of MAGEA3 in gastric cancer, revealing its upregulation is associated with poor prognosis and lymph node metastasis. Experimental verification indicated that MAGEA3 could be a novel biomarker correlated with lymph node metastasis and immune infiltrates in gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Shin-ei Kudo, Katsuro Ichimasa, Benjamin Villard, Yuichi Mori, Masashi Misawa, Shoichi Saito, Kinichi Hotta, Yutaka Saito, Takahisa Matsuda, Kazutaka Yamada, Toshifumi Mitani, Kazuo Ohtsuka, Akiko Chino, Daisuke Ide, Kenichiro Imai, Yoshihiro Kishida, Keiko Nakamura, Yasumitsu Saiki, Masafumi Tanaka, Shu Hoteya, Satoshi Yamashita, Yusuke Kinugasa, Masayoshi Fukuda, Toyoki Kudo, Hideyuki Miyachi, Fumio Ishida, Hayato Itoh, Masahiro Oda, Kensaku Mori
Summary: By using an artificial intelligence model, it is possible to more accurately identify the risk of lymph node metastasis in patients with T1 colorectal cancer, thus reducing unnecessary surgical resections.
Article
Biochemistry & Molecular Biology
Ling Li, Bangrong Cao, Xinhua Liang, Shun Lu, Huaichao Luo, Zhaohui Wang, Shaoxin Wang, Jian Jiang, Jinyi Lang, Guiquan Zhu
Article
Biochemistry & Molecular Biology
Hanyi Zhang, Siyao Deng, Jiayu Zhang, Guiquan Zhu, Jie Zhou, Wenjing Ye, Qingwei Wang, Yi Wang, Bingwen Zou, Peng Zhang, Shichuan Zhang, Jinyi Lang, Shun Lu
Summary: Genetic variants in genes involved in the LMP1 signaling pathway, particularly the NFKBIA promoter SNP rs2233409, may be moderately associated with the risk of nasopharyngeal carcinoma (NPC). Further studies with larger sample sizes and functional analysis are needed to confirm these findings.
Article
Oncology
Guiquan Zhu, Bangrong Cao, Xinhua Liang, Longjiang Li, Yaying Hao, Wanrong Meng, Chuanshi He, Linlin Wang, Ling Li
Summary: This study revealed the mechanisms by which hypoxic cancer cells induce CAF-like differentiation through secreting sEVs and TGF-beta, with miRNAs delivered by sEVs playing a crucial role in this process. Elevated levels of miR-192/215 in HNSCC tissue-derived sEVs indicated a hypoxic and aggressive cancer stroma, and miR-215 in tumor tissue-derived sEVs was associated with poor overall survival in HNSCC patients. The findings suggest that sEVs serve as a messenger to transfer miRNAs from cancer cells to fibroblasts, contributing to the remodeling of the hypoxic tumor microenvironment and indicating the potential of cancer tissue-derived sEVs as biomarkers.
Review
Oncology
Siyao Deng, Wenjing Ye, Shichuan Zhang, Guiquan Zhu, Peng Zhang, Yanqiong Song, Fanglei Duan, Jinyi Lang, Shun Lu
Summary: This case report describes a patient with Fanconi anemia who developed oral tongue cancer and experienced severe bone marrow failure after receiving cisplatin/radiation treatment. Genetic testing revealed novel mutations in the FANCA gene inherited from the patient's parents. Despite successful symptom relief with reduced-dose radiotherapy, the patient eventually died of disease progression.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Chuanshi He, Linlin Wang, Ling Li, Guiquan Zhu
Summary: Communication networks in the tumor microenvironment, particularly involving cancer-associated fibroblasts (CAFs), play a crucial role in tumor progression and treatment responsiveness. Extracellular vesicles (EVs) serve as important mediators of communication between tumors and CAFs, carrying proteins, miRNAs, and other biomolecules that regulate interactions between the two cell types.
TRANSLATIONAL ONCOLOGY
(2021)
Review
Oncology
Ruochong Wang, Guiquan Zhu
Summary: The Hippo-YAP pathway is becoming increasingly important in regulating cancers, with various binary oppositions and contradictory points emerging. While these complexities present challenges for current research, they also offer opportunities for fresh insights and future drug development.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Oncology
Yudong Ning, Hong Yang, Sheng Qin, Bangrong Cao, Zuxian Zhong, Chuanshi He, Guiquan Zhu
Summary: The study identified preoperative mean platelet volume (MPV) as a new prognostic factor for overall survival (OS) of patients with oral squamous cell carcinoma (OSCC), in addition to traditional prognostic factors. A nomogram was developed to predict the probability of 3-year and 5-year OS, and neoadjuvant chemotherapy was found to improve the OS of patients with OSCC.
CANCER MANAGEMENT AND RESEARCH
(2021)
Review
Dentistry, Oral Surgery & Medicine
En Long, Dongling You, Shubin Wang, Shun Lu, Peng Xu, Jie Zhou, Lu Li, Jian Wu, Biqin Zhang, Guiquan Zhu, Jinyi Lang
Summary: This study investigates the prognostic factors and treatment of primary intraosseous carcinoma (PIOC). The results suggest that surgery combined with adjuvant therapy is the superior treatment strategy for PIOC, and radiotherapy plays a positive role in the treatment of PIOC.
Article
Oncology
Su Chen, Khaled Alkebsi, Ming Xuan, Xiao-Yi Wang, Long-Jiang Li, Chun-Jie Li, Zhuang Zhang, Gui-Quan Zhu
Summary: Endoscopic parotidectomy is becoming a reliable procedure for benign and low-grade malignant parotid gland tumors, but it requires more precision and experience compared to traditional surgery. Clinicians have summarized a seven-step single incision-plus approach for gasless endoscopic parotidectomy through clinical exploration.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Oncology
Chang Sun, Shubin Wang, Wenjing Ye, RanLin Wang, Mingyu Tan, Hanyi Zhang, Jie Zhou, Minglun Li, Lichun Wei, Peng Xu, Guiquan Zhu, Jinyi Lang, Shun Lu
Summary: This study aimed to investigate the relationship between prognostic and tumor parameters of cervical cancer patients, and found that tumor size, tumor volume, and tumor volume reduction rate are associated with patients' survival rates.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ruiling Zu, Lin Wu, Rong Zhou, Xiaoxia Wen, Bangrong Cao, Shan Liu, Guishu Yang, Ping Leng, Yan Li, Li Zhang, Xiaoyu Song, Yao Deng, Kaijiong Zhang, Chang Liu, Yuping Li, Jian Huang, Dongsheng Wang, Guiquan Zhu, Huaichao Luo
Summary: This study developed a predictive model based on platelet features to assist in the diagnosis of early stage malignancy, ensuring accurate diagnosis and optimal management.
Review
Oncology
Chuanshi He, Ling Li, Linlin Wang, Wanrong Meng, Yaying Hao, Guiquan Zhu
Summary: The article reviews the role of exosome-mediated interactions between cells under radiotherapy conditions, highlighting the importance of exosomes in the tumor microenvironment and the rebuilding of regulatory processes under radiation stimulation.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Meng Wanrong, He Chuanshi, Hao Yaying, Wang Linlin, Li Ling, Zhu Guiquan
Article
Medicine, Research & Experimental
Guiquan Zhu, Linlin Wang, Wanrong Meng, Shun Lu, Bangrong Cao, Xinhua Liang, Chuanshi He, Yaying Hao, Xueyu Du, Xiaoyi Wang, Longjiang Li, Ling Li
Summary: Research shows that sEVs derived from the hypoxic tumor microenvironment of HNSCC can drive local invasion of non-hypoxic HNSCC cells and stimulate premetastatic niche formation by delivering LOXL2 to non-hypoxic HNSCC cells and fibroblasts to induce EMT and fibronectin production, respectively.
