Very-low-calorie ketogenic diet (VLCKD) in the management of metabolic diseases: systematic review and consensus statement from the Italian Society of Endocrinology (SIE)

Cardiovascular disease risk factor responses to a type 2 diabetes care model including nutritional ketosis induced by sustained carbohydrate restriction at 1 year: an open label, non-randomized, controlled study

(2018) Nasir H. Bhanpuri et al.   Cardiovascular Diabetology

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet

(2018) Christine A. Olson et al.   CELL

The Global Epidemic of the Metabolic Syndrome

(2018) Mohammad G. Saklayen   CURRENT HYPERTENSION REPORTS

Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome

(2018) Helena J. Teede et al.   FERTILITY AND STERILITY

Interest in the Ketogenic Diet Grows for Weight Loss and Type 2 Diabetes

(2018) Jennifer Abbasi   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Efficacy of ketogenic diet on body composition during resistance training in trained men: a randomized controlled trial

(2018) Salvador Vargas et al.   Journal of the International Society of Sports Nutrition

Resting metabolic rate of obese patients under very low calorie ketogenic diet

(2018) Diego Gomez-Arbelaez et al.   Nutrition & Metabolism

A 4-Week Preoperative Ketogenic Micronutrient-Enriched Diet Is Effective in Reducing Body Weight, Left Hepatic Lobe Volume, and Micronutrient Deficiencies in Patients Undergoing Bariatric Surgery: a Prospective Pilot Study

(2018) Luigi Schiavo et al.   OBESITY SURGERY

Safety and tolerability of new-generation anti-obesity medications: a narrative review

(2018) Dhiren K Patel et al.   POSTGRADUATE MEDICINE

Metabolic effects, safety, and acceptability of very low-calorie ketogenic dietetic scheme on candidates for bariatric surgery

(2018) Vincenzo Pilone et al.   Surgery for Obesity and Related Diseases

Mediterranean diet and nonalcoholic fatty liver disease

(2018) Caterina Anania et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Association of Body Mass Index With Lifetime Risk of Cardiovascular Disease and Compression of Morbidity

(2018) Sadiya S. Khan et al.   JAMA Cardiology

Long-term effects of increased protein intake after weight loss on intrahepatic lipid content and implications for insulin sensitivity - a PREVIEW study

(2018) Mathijs Drummen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Increases in circulating levels of ketone bodies and cardiovascular protection with SGLT2 inhibitors: Is low-grade inflammation the neglected component?

(2018) Francesco Prattichizzo et al.   DIABETES OBESITY & METABOLISM

Lower Brain 18F-Fluorodeoxyglucose Uptake But Normal 11C-Acetoacetate Metabolism in Mild Alzheimer's Disease Dementia

(2018) Christian-Alexandre Castellano et al.   JOURNAL OF ALZHEIMERS DISEASE

Pre-operative Very Low Calorie Ketogenic Diet (VLCKD) vs. Very Low Calorie Diet (VLCD): Surgical Impact

(2018) Alice Albanese et al.   OBESITY SURGERY

The Efficacy of Energy-Restricted Diets in Achieving Preoperative Weight Loss for Bariatric Patients: a Systematic Review

(2018) Fathimath Naseer et al.   OBESITY SURGERY

Dietary Protein and Energy Balance in Relation to Obesity and Co-morbidities

(2018) Mathijs Drummen et al.   Frontiers in Endocrinology

Cardiovascular Implications of the Menopause Transition

(2018) Samar R. El Khoudary et al.   OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA

Molecular mechanisms underlying metabolic syndrome: the expanding role of the adipocyte

(2017) Andrea Armani et al.   FASEB JOURNAL

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Insulin resistance in a large cohort of women with polycystic ovary syndrome: a comparison between euglycaemic-hyperinsulinaemic clamp and surrogate indexes

(2017) Flavia Tosi et al.   HUMAN REPRODUCTION

Influence of diet on the gut microbiome and implications for human health

(2017) Rasnik K. Singh et al.   Journal of Translational Medicine

PURE study challenges the definition of a healthy diet: but key questions remain

(2017) Christopher E Ramsden et al.   LANCET

Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study

(2017) Mahshid Dehghan et al.   LANCET

Longitudinal analysis of changes in weight and waist circumference in relation to incident vasomotor symptoms

(2017) Ellen B. Gold et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Physiologically assessed hot flashes and endothelial function among midlife women

(2017) Rebecca C. Thurston et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Ageing: Improvement in age-related cognitive functions and life expectancy by ketogenic diets

(2017) Arne Astrup et al.   Nature Reviews Endocrinology

Global Health Effects of Overweight and Obesity

(2017) Edward W. Gregg et al.   NEW ENGLAND JOURNAL OF MEDICINE

American Society for Metabolic and Bariatric Surgery Integrated Health Nutritional Guidelines for the Surgical Weight Loss Patient 2016 Update: Micronutrients

(2017) Julie Parrott et al.   Surgery for Obesity and Related Diseases

Diet-Induced Low-Grade Metabolic Acidosis and Clinical Outcomes: A Review

(2017) Renata Carnauba et al.   Nutrients

Energy expenditure in the etiology of human obesity: spendthrift and thrifty metabolic phenotypes and energy-sensing mechanisms

(2017) P. Piaggi et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Drug-induced obesity and its metabolic consequences: a review with a focus on mechanisms and possible therapeutic options

(2017) A. A. Verhaegen et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

10 patients, 10 years – Long term follow-up of cardiovascular risk factors in Glut1 deficiency treated with ketogenic diet therapies: A prospective, multicenter case series

(2017) Nicole Heussinger et al.   CLINICAL NUTRITION

Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease

(2016) Stephen C. Cunnane et al.   Annals of the New York Academy of Sciences

Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial

(2016) Mark Ng Tang Fui et al.   BMC Medicine

The Failing Heart Relies on Ketone Bodies as a Fuel

(2016) Gregory Aubert et al.   CIRCULATION

Obesity and Cardiovascular Disease

(2016) Francisco B. Ortega et al.   CIRCULATION RESEARCH

Obesity, Diabetes, and Cardiovascular Diseases

(2016) Philipp E. Scherer et al.   CIRCULATION RESEARCH

Shift to Fatty Substrate Utilization in Response to Sodium–Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes

(2016) Ele Ferrannini et al.   DIABETES

Very Low-Calorie Diet and 6 Months of Weight Stability in Type 2 Diabetes: Pathophysiological Changes in Responders and Nonresponders

(2016) Sarah Steven et al.   DIABETES CARE

GUT MICROBIOTA, PREBIOTICS, PROBIOTICS, AND SYNBIOTICS IN MANAGEMENT OF OBESITY AND PREDIABETES: REVIEW OF RANDOMIZED CONTROLLED TRIALS

(2016) Elena Barengolts   Endocrine Practice

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY POSITION STATEMENT ON THE ASSOCIATION OF SGLT-2 INHIBITORS AND DIABETIC KETOACIDOSIS

(2016) Yehuda Handelsman et al.   Endocrine Practice

Guidelines for Obesity Management

(2016) Donna H. Ryan   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Ketogenic diet guidelines for infants with refractory epilepsy

(2016) Elles van der Louw et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Fat-Free Mass Changes during Ketogenic Diets and the Potential Role of Resistance Training

(2016) Grant M. Tinsley et al.   INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

(2016)   JOURNAL OF HEPATOLOGY

The effects of low carbohydrate diets on liver function tests in nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trials

(2016) Leila Azadbakht et al.   Journal of Research in Medical Sciences

Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants

(2016)   LANCET

Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants

(2016)   LANCET

Monitoring for compliance with a ketogenic diet: what is the best time of day to test for urinary ketosis?

(2016) Paul Urbain et al.   Nutrition & Metabolism

Beneficial Effects of a Dietary Weight Loss Intervention on Human Gut Microbiome Diversity and Metabolism Are Not Sustained during Weight Maintenance

(2016) Femke-Anouska Heinsen et al.   Obesity Facts

Clinical effectiveness of very-low-energy diets in the management of weight loss: a systematic review and meta-analysis of randomized controlled trials

(2016) H. M. Parretti et al.   Obesity Reviews

Commercial Very Low Energy Meal Replacements for Preoperative Weight Loss in Obese Patients: a Systematic Review

(2016) Lynda J. Ross et al.   OBESITY SURGERY

The Effectiveness of Different Diet Strategies to Reduce Type 2 Diabetes Risk in Youth

(2016) Megan Gow et al.   Nutrients

Position of the Academy of Nutrition and Dietetics: Interventions for the Treatment of Overweight and Obesity in Adults

(2016) Hollie A. Raynor et al.   Journal of the Academy of Nutrition and Dietetics

Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus

(2016) A Goday et al.   Nutrition & Diabetes

The Roles of Acidosis in Osteoclast Biology

(2016) Feng-Lai Yuan et al.   Frontiers in Physiology

Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis

(2015) Eduardo Vilar-Gomez et al.   GASTROENTEROLOGY

Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline

(2015) Cynthia A. Stuenkel et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease

(2015) Giuseppe Verdile et al.   MEDIATORS OF INFLAMMATION

Behavioral weight loss for the management of menopausal hot flashes

(2015) Rebecca C. Thurston et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Another Agent for Obesity — Will This Time Be Different?

(2015) Elias S. Siraj et al.   NEW ENGLAND JOURNAL OF MEDICINE

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

(2015) Bernard Zinman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical impact of Mediterranean-enriched-protein diet on liver size, visceral fat, fat mass, and fat-free mass in patients undergoing sleeve gastrectomy

(2015) Luigi Schiavo et al.   Surgery for Obesity and Related Diseases

The polycystic ovary syndrome: a position statement from the European Society of Endocrinology

(2014) Gerard Conway et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Very-low-energy diet for type 2 diabetes: An underutilized therapy?

(2014) Amy E. Rothberg et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

A Lower-Carbohydrate, Higher-Fat Diet Reduces Abdominal and Intermuscular Fat and Increases Insulin Sensitivity in Adults at Risk of Type 2 Diabetes

(2014) Barbara A Gower et al.   JOURNAL OF NUTRITION

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

Long-term effects of a ketogenic diet on body composition and bone mineralization in GLUT-1 deficiency syndrome: A case series

(2014) Simona Bertoli et al.   NUTRITION

Do ketogenic diets really suppress appetite? A systematic review and meta-analysis

(2014) A. A. Gibson et al.   Obesity Reviews

Very Low-Carbohydrate Ketogenic Diet Before Bariatric Surgery: Prospective Evaluation of a Sequential Diet

(2014) Frida Leonetti et al.   OBESITY SURGERY

The Epidemiology of Obesity: A Big Picture

(2014) Adela Hruby et al.   PHARMACOECONOMICS

Protein Quality and the Protein to Carbohydrate Ratio within a High Fat Diet Influences Energy Balance and the Gut Microbiota In C57BL/6J Mice

(2014) Liam McAllan et al.   PLoS One

Identification, assessment, and management of overweight and obesity: summary of updated NICE guidance

(2014) H. Stegenga et al.   BMJ-British Medical Journal

Ketogenic Diet for Obesity: Friend or Foe?

(2014) Antonio Paoli   International Journal of Environmental Research and Public Health

Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials

(2013) Nassib Bezerra Bueno et al.   BRITISH JOURNAL OF NUTRITION

Glucagon-Induced Acetylation of Foxa2 Regulates Hepatic Lipid Metabolism

(2013) Ferdinand von Meyenn et al.   Cell Metabolism

Very Low–Calorie Diet Mimics the Early Beneficial Effect of Roux-en-Y Gastric Bypass on Insulin Sensitivity and β-Cell Function in Type 2 Diabetic Patients

(2013) Clifton Jackness et al.   DIABETES

Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets

(2013) A Paoli et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Sustained cardiac remodeling after a short-term very low calorie diet in type 2 diabetes mellitus patients

(2013) Jacqueline T. Jonker et al.   INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING

2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults

(2013) Michael D. Jensen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Beneficial Effects of a High-Protein, Low-Glycemic-Load Hypocaloric Diet in Overweight and Obese Women with Polycystic Ovary Syndrome: A Randomized Controlled Intervention Study

(2013) Homeira Hamayeli Mehrabani et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Effects of dietary interventions on liver volume in humans

(2013) Hua Bian et al.   Obesity

Clinical Practice Guidelines for the Perioperative Nutritional, Metabolic, and Nonsurgical Support of the Bariatric Surgery Patient—2013 Update: Cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery

(2013) Jeffrey I. Mechanick et al.   Surgery for Obesity and Related Diseases

Ketone bodies as signaling metabolites

(2013) John C. Newman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Long Term Successful Weight Loss with a Combination Biphasic Ketogenic Mediterranean Diet and Mediterranean Diet Maintenance Protocol

(2013) Antonio Paoli et al.   Nutrients

Very low calorie ketogenic weight reduction diet in patients with cirrhosis: a case series

(2013) J C Temmerman et al.   Nutrition & Diabetes

Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans

(2012) Fanny Theytaz et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Very-low-calorie diet: a quick therapeutic tool to improve β cell function in morbidly obese patients with type 2 diabetes

(2012) Ilaria Malandrucco et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Dietary protein – its role in satiety, energetics, weight loss and health

(2012) Margriet S. Westerterp-Plantenga et al.   BRITISH JOURNAL OF NUTRITION

Role of Carbohydrate Modification in Weight Management among Obese Children: A Randomized Clinical Trial

(2012) Shelley Kirk et al.   JOURNAL OF PEDIATRICS

Effect of low-calorie versus low-carbohydrate ketogenic diet in type 2 diabetes

(2012) Talib A. Hussain et al.   NUTRITION

The effect of a very low calorie diet on insulin sensitivity, beta cell function, insulin clearance, incretin hormone secretion, androgen levels and body composition in obese young women

(2012) Pernille F. Svendsen et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction

(2011) Jeffrey D Browning et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effects of a whey protein supplementation on intrahepatocellular lipids in obese female patients

(2011) Murielle Bortolotti et al.   CLINICAL NUTRITION

Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

(2011) E. L. Lim et al.   DIABETOLOGIA

Negative Effect of Increased Body Weight on Sperm Conventional and Nonconventional Flow Cytometric Sperm Parameters

(2011) S. La Vignera et al.   JOURNAL OF ANDROLOGY

The biochemistry of ketogenesis and its role in weight management, neurological disease and oxidative stress

(2011) Peter Andrew C. McPherson et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Less fat reduction per unit weight loss in type 2 diabetic compared with nondiabetic obese individuals completing a very-low-calorie diet program

(2011) Scott T. Baker et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nutrition and physical activity in NAFLD: An overview of the epidemiological evidence

(2011) Shira Zelber-Sagi   WORLD JOURNAL OF GASTROENTEROLOGY

A Randomized Trial of a Low-Carbohydrate Diet vs Orlistat Plus a Low-Fat Diet for Weight Loss

(2010) William S. Yancy et al.   ARCHIVES OF INTERNAL MEDICINE

Heterogeneity in the responsiveness to long-term lifestyle intervention and predictability in obese women with polycystic ovary syndrome

(2010) Renato Pasquali et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Effects of a low-energy diet on sexual function and lower urinary tract symptoms in obese men

(2010) J Khoo et al.   INTERNATIONAL JOURNAL OF OBESITY

Efficacy and Safety of a High Protein, Low Carbohydrate Diet for Weight Loss in Severely Obese Adolescents

(2010) Nancy F. Krebs et al.   JOURNAL OF PEDIATRICS

The role of low-grade inflammation in the polycystic ovary syndrome

(2010) Andrea Repaci et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Meal Replacements in the Treatment of Adolescent Obesity: A Randomized Controlled Trial

(2010) Robert I. Berkowitz et al.   Obesity

Gluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet

(2009) Margriet AB Veldhorst et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

High protein intake reduces intrahepatocellular lipid deposition in humans

(2009) Murielle Bortolotti et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Low-carbohydrate (low & high-fat) versus high-carbohydrate low-fat diets in the treatment of obesity in adolescents

(2008) S Demol et al.   ACTA PAEDIATRICA

Progressive bone mineral content loss in children with intractable epilepsy treated with the ketogenic diet

(2008) AG Christina Bergqvist et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effects of weight loss on visceral and abdominal subcutaneous adipose tissue blood-flow and insulin-mediated glucose uptake in healthy obese subjects

(2008) Antti P. M. Viljanen et al.   ANNALS OF MEDICINE

A Case for Clarity, Consistency, and Helpfulness: State-of-the-Art Clinical Practice Guidelines in Endocrinology Using the Grading of Recommendations, Assessment, Development, and Evaluation System

(2008) Brian A. Swiglo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Bariatric Surgery: Risks and Rewards

(2008) Walter J. Pories   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Prolonged Caloric Restriction in Obese Patients With Type 2 Diabetes Mellitus Decreases Myocardial Triglyceride Content and Improves Myocardial Function

(2008) Sebastiaan Hammer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus

(2008) Eric C Westman et al.   Nutrition & Metabolism