The JAK/STAT Pathway in Skeletal Muscle Pathophysiology

Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis

(2018) Luca Madaro et al.   NATURE CELL BIOLOGY

FAPs are sensors for skeletal myofibre atrophy

(2018) Giovanna Marazzi et al.   NATURE CELL BIOLOGY

Methyltransferase Dot1l preferentially promotes innate IL-6 and IFN-β production by mediating H3K79me2/3 methylation in macrophages

(2018) Xiang Chen et al.   Cellular & Molecular Immunology

Genome-wide DNA methylation drives human embryonic stem cell erythropoiesis by remodeling gene expression dynamics

(2017) Zhijing Liu et al.   Epigenomics

Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations

(2017) Christoph Hoffmann et al.   Cold Spring Harbor Perspectives in Medicine

Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling

(2017) Kristine Pettersen et al.   Scientific Reports

Molecular Communication from Skeletal Muscle to Bone: A Review for Muscle-Derived Myokines Regulating Bone Metabolism

(2016) Baosheng Guo et al.   CALCIFIED TISSUE INTERNATIONAL

Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer

(2016) Michela Serresi et al.   CANCER CELL

Signal transducer and activator of transcription 3 signaling as a potential target to treat muscle wasting diseases

(2016) David Sala et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The ever-expanding myokinome: discovery challenges and therapeutic implications

(2016) Martin Whitham et al.   NATURE REVIEWS DRUG DISCOVERY

Blockade of the IL-6 trans-signalling/STAT3 axis suppresses cachexia in Kras-induced lung adenocarcinoma

(2016) A Miller et al.   ONCOGENE

STAT3 in the systemic inflammation of cancer cachexia

(2016) Teresa A. Zimmers et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration

(2016) Han Zhu et al.   Cell Reports

Skeletal muscle wasting and renewal: a pivotal role of myokine IL-6

(2016) José E. Belizário et al.   SpringerPlus

Aerobic Exercise and Pharmacological Treatments Counteract Cachexia by Modulating Autophagy in Colon Cancer

(2016) Eva Pigna et al.   Scientific Reports

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

Leptin–STAT3–G9a Signaling Promotes Obesity-Mediated Breast Cancer Progression

(2015) Chao-Ching Chang et al.   CANCER RESEARCH

Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice

(2015) Laura Pelosi et al.   HUMAN MOLECULAR GENETICS

Inhibition of Stat3 Activation Suppresses Caspase-3 and the Ubiquitin-Proteasome System, Leading to Preservation of Muscle Mass in Cancer Cachexia

(2015) Kleiton Augusto Santos Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT5A regulates DNMT3A in CD34+/CD38− AML cells

(2015) Asako Takeuchi et al.   LEUKEMIA RESEARCH

Adipose Tissue Insulin Action and IL-6 Signaling after Exercise in Obese Mice

(2015) REBECCA E. K. MACPHERSON et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

(2015) Qian Zhang et al.   NATURE

The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development

(2015) Ana Ortega-Molina et al.   NATURE MEDICINE

Neutrophil and monocyte responses to downhill running: Intracellular contents of MPO, IL-6, IL-10, pstat3, and SOCS3

(2015) M. van de Vyver et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle

(2015) Francesca Pretto et al.   Oncotarget

Pancreatic Cancer-Induced Cachexia Is Jak2-Dependent in Mice

(2014) Marine Gilabert et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

(2014) G. Lal et al.   JOURNAL OF IMMUNOLOGY

Inhibition of JAK-STAT signaling stimulates adult satellite cell function

(2014) Feodor D Price et al.   NATURE MEDICINE

STAT3 signaling controls satellite cell expansion and skeletal muscle repair

(2014) Matthew Timothy Tierney et al.   NATURE MEDICINE

Stat3 promotes IL-10 expression in lupus T cells throughtrans-activation and chromatin remodeling

(2014) Christian M. Hedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stat3 Activation Links a C/EBPδ to Myostatin Pathway to Stimulate Loss of Muscle Mass

(2013) Liping Zhang et al.   Cell Metabolism

Regulation of STAT signaling by acetylation

(2013) Shougang Zhuang   CELLULAR SIGNALLING

Suppression of cytokine signaling: The SOCS perspective

(2013) Edmond M. Linossi et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Cellular dynamics in the muscle satellite cell niche

(2013) C Florian Bentzinger et al.   EMBO REPORTS

Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?

(2013) Pura Muñoz-Cánoves et al.   FEBS Journal

NF-κB–mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia

(2013) Wei A. He et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenetic Regulation of the miR142-3p/Interleukin-6 Circuit in Glioblastoma

(2013) Guang-Yuh Chiou et al.   MOLECULAR CELL

Distinct transcriptional regulatory modules underlie STAT3’s cell type-independent and cell type-specific functions

(2013) Andrew Paul Hutchins et al.   NUCLEIC ACIDS RESEARCH

JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia

(2012) Andrea Bonetto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways

(2012) Kenneth C.H. Fearon et al.   Cell Metabolism

Bimodal impact of skeletal muscle on pancreatic β-cell function in health and disease

(2012) P. Plomgaard et al.   DIABETES OBESITY & METABOLISM

JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

(2012) John J. O'Shea et al.   IMMUNITY

IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6

(2012) Stefan Rose-John   International Journal of Biological Sciences

Jak/Stat3 Signaling Promotes Somatic Cell Reprogramming by Epigenetic Regulation

(2012) Yong Tang et al.   STEM CELLS

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bimodal Effect on Pancreatic  -Cells of Secretory Products From Normal or Insulin-Resistant Human Skeletal Muscle

(2011) K. Bouzakri et al.   DIABETES

Mechanisms inducing low bone density in duchenne muscular dystrophy in mice and humans

(2011) Anna Rufo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Context-Specific Regulation of NF-κB Target Gene Expression by EZH2 in Breast Cancers

(2011) Shuet Theng Lee et al.   MOLECULAR CELL

Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2

(2011) Malay Mandal et al.   NATURE IMMUNOLOGY

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

(2011) Helga Ellingsgaard et al.   NATURE MEDICINE

Activation of host tissue trophic factors through JAK-STAT3 signaling: a mechanism of mesenchymal stem cell-mediated cardiac repair

(2010) Arsalan Shabbir et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

(2010) Lydia Durant et al.   IMMUNITY

Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells

(2010) Jacqueline A. Gasche et al.   INTERNATIONAL JOURNAL OF CANCER

Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men

(2010) Marissa K. Trenerry et al.   MUSCLE & NERVE

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

(2010) Aaron W. B. Joe et al.   NATURE CELL BIOLOGY

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

(2010) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes

(2009) Chiara Braconi et al.   HEPATOLOGY

The major inflammatory mediator interleukin-6 and obesity

(2009) Katalin Eder et al.   INFLAMMATION RESEARCH

Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy

(2008) Antonio L. Serrano et al.   Cell Metabolism

JAK2/STAT2/STAT3 Are Required for Myogenic Differentiation

(2008) Kepeng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Muscle wasting and interleukin-6-induced atrogin-I expression in the cachectic Apc Min/+ mouse

(2008) Kristen A. Baltgalvis et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

(2008) Bente K. Pedersen et al.   PHYSIOLOGICAL REVIEWS

Interleukin-6 and cachexia in ApcMin/+ mice

(2007) Kristen A. Baltgalvis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY