Review
Biochemistry & Molecular Biology
David Millrine, Robert H. Jenkins, Stuart T. O. Hughes, Simon A. Jones
Summary: Understanding the molecular mechanisms behind functional pleiotropy in cytokines presents a significant challenge for researchers. While cytokine-receptor cross-reactivity and shared signalling pathways are believed to be major contributors to pleiotropy, studies on Jak-STAT cytokine signalling have revealed interesting biochemical and epigenetic factors influencing transcription factor regulation and cytokine responses. The regulatory interplay between STAT transcription factors and their convergence to specific genomic enhancers plays a role in fine-tuning cytokine responses to control host immunity, functional characteristics, and tissue homeostasis and repair.
Article
Biochemistry & Molecular Biology
Lihua Zhang, Weibo Shi, Jingmin Liu, Ke Chen, Guowei Zhang, Shengnan Zhang, Bin Cong, Yingmin Li
Summary: The dorsomedial hypothalamus nucleus (DMH) is responsible for regulating sympathetic outputs of the heart. Stress alters DMH neuronal activity and affects heart rate variability, but the molecular mechanisms behind this are not fully understood. In this study, a stressed rat model was used to investigate the role of IL-6 in regulating GABAA receptors in the DMH through the JAK/STAT pathway and its impact on heart rate variability. The findings suggest that IL-6 inhibits GABAA receptors in DMH neurons by activating the JAK/STAT pathway, leading to abnormal DMH neuronal activity and heart rate variability in stressed rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Feixue Wang, Xiang Zhang, Weixin Liu, Yunfei Zhou, Wenchao Wei, Dabin Liu, Chi Chun Wong, Joseph J. Y. Sung, Jun Yu
Summary: Activated NK cells in the liver promote NASH development by releasing pro-inflammatory cytokines and enhancing NASH progression through the cytokine-JAK-STAT1/3 axis. Modulation of NK cells may serve as a potential therapeutic strategy for NASH.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Cell Biology
Mohamad Mahjoor, Golnaz Mahmoudvand, Simin Farokhi, Alireza Shadab, Mojtaba Kashfi, Hamed Afkhami
Summary: The JAK/STAT signaling cascade plays a crucial role in regulating cell growth and differentiation, as well as immune responses and viral pathogenesis.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Hyunjung Park, Sangjik Lee, Jaehun Lee, Hyuk Moon, Simon Weonsang Ro
Summary: This review highlights the importance of the JAK/STAT pathway in hepatocellular carcinoma (HCC) and its association with factors such as chronic inflammation and cirrhosis. It also summarizes recent advancements in targeting the JAK/STAT pathway for HCC treatment, emphasizing the potential of this pathway as a promising avenue for therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Xiao Wang, Huijuan Xu, Yujie Song, Wenping Cao
Summary: This study investigated the role of TRIM27 in laryngeal cancer cells and the effects of IL-6 coupled with JAK-STAT signaling pathway on the pathogenesis of laryngeal cancer.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Minlan Yang, Sa Wu, Weisong Cai, Xiaoping Ming, Yuhao Zhou, Xiong Chen
Summary: This study reveals the changes in lipid metabolism of laryngocarcinoma cells under hypoxic conditions and explores the related mechanisms. It demonstrates that hypoxia induces reprogramming of lipid metabolism through the MIF/IL-6/JAK-STAT pathway, allowing laryngocarcinoma cells to adapt to the hypoxic tumor microenvironment. Targeting the MIF/IL-6/JAK-STAT pathway may be a promising therapeutic option for the treatment of laryngocarcinoma.
LIPIDS IN HEALTH AND DISEASE
(2022)
Review
Pathology
Ahmed Hjazi, Rasha Fadhel Obaid, Sally Saad Ali, Bekhzod Abdullaev, Hashem O. Alsaab, Huldani Huldani, Rosario Mireya Romero-Parra, Yasser Fakri Mustafa, Beneen M. Hussien, Sarah Jaafar Saadoon
Summary: Long non-coding RNAs (lncRNAs) transcribed from the human genome have emerged as important regulators in cellular activities, particularly in controlling gene expression. They have been found to regulate various factors related to tumorigenesis through the JAK-STAT signaling pathway, either by directly targeting or indirectly modulating its components. Moreover, lncRNAs can also act as downstream effectors of the pathway. The relationship between JAK-STAT signaling and lncRNAs varies among different types of cancers, and lncRNAs play a dual role in tumorigenesis or tumor suppression. This review focuses on the reciprocal regulation and functions of lncRNAs and the JAK-STAT pathway, providing insights into potential targets for clinical therapeutics.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Chemistry, Physical
Khaled Mukaddam, Sabrina Ruggiero, Steffen M. Berger, Dietmar Cholewa, Sebastian Kuhl, Daniel Vegh, Michael Payer, Michael M. Bornstein, Farah Alhawasli, Elizaveta Fasler-Kan
Summary: Zirconia implants have become widely used in dentistry due to their superior biological compatibility compared to traditional titanium implants, as they reduce bacterial adhesion, inflammation, and cellular interaction. This study investigated the activation of the JAK-STAT signaling pathway in osteoblast-like cells (MG-63) on zirconia and titanium surfaces using different cytokines. The results showed that various cytokines activated different STAT proteins on both surfaces, indicating the activation of the JAK-STAT pathway. The upregulation of MHC class I and class II proteins was observed when MG-63 cells were incubated on zirconia and titanium discs.
Review
Pharmacology & Pharmacy
Hong-Tai Tzeng, I-Tsu Chyuan, Jenn-Haung Lai
Summary: The JAK/STAT signaling pathway plays a crucial role in immune regulation, affecting cell proliferation, survival, inflammation, and immune tolerance. Aberrant activation of this pathway can lead to autoimmune diseases and cancer progression, while targeting JAK/STAT has shown efficacy in suppressing inflammation. The success of small-molecule JAK inhibitors in treating rheumatologic diseases highlights their therapeutic potential in other conditions.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Oncology
Zhe Cai, Song Zhang, Ping Wu, Qi Ren, Ping Wei, Ming Hong, Yu Feng, Chun Kwok Wong, Hong Tang, Huasong Zeng
Summary: The study investigated the potential regulatory mechanisms of IL-35 in relieving lupus nephritis by regulating the JAK/STAT and MAPK signaling pathways. The results suggest that IL-35 may modulate an interactive network involving LAIR1-PTPN11-JAK-STAT-FN1 to alleviate inflammation in JSLE-LN.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Editorial Material
Biochemistry & Molecular Biology
Robert A. Saxton, Kenan Christopher Garcia
Summary: IL-10 is an immunomodulatory cytokine with important roles in terminating inflammatory responses and preventing tissue damage from autoimmunity. However, its pleiotropic nature and ability to elicit proinflammatory effects in vivo have hindered therapeutic efforts utilizing IL-10.
Review
Pharmacology & Pharmacy
Qianqian Yin, Longyun Wang, Haiyang Yu, Daquan Chen, Wenwei Zhu, Changgang Sun
Summary: The JAK-STAT signaling pathway is closely related to cell proliferation, apoptosis, differentiation, and inflammatory response, essential for inhibiting inflammation, initiating innate immunity, and coordinating adaptive immune mechanisms. Various plant polyphenol compounds play a role in suppressing abnormal activation in the JAK-STAT pathway, showing significant effects in anti-inflammatory, antitumor, and cardiovascular disease control.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Annah Lee, Gabriela Cardoso Dal Pont, Michele Battaglia, Ryan J. Arsenault, Michael H. Kogut
Summary: This study examines the effect of chestnut tannins (ChT) on broiler chicken immunity pathways, finding that ChT may influence host immunity through an IL-6 mediated response beneficial for early defense against pathogens. Additionally, the inclusion of ChT alters the role of the JAK-STAT pathway in the regulation of the immune system.
Review
Oncology
Nagendra Awasthi, Clifford Liongue, Alister C. Ward
Summary: STAT proteins, an important family of evolutionarily conserved transcription factors, play key roles in blood and immune cell development and function. In addition to their classical role in transcriptional activation, STAT proteins also have non-canonical functions such as transcriptional repression and roles outside the nucleus. This review presents a revised framework for understanding the diverse functional modalities of STAT proteins.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Physiology
Sergio Adamo, Eva Pigna, Rosamaria Lugara, Viviana Moresi, Dario Coletti, Marina Bouche
FRONTIERS IN PHYSIOLOGY
(2019)
Review
Nutrition & Dietetics
Luana Tomaipitinca, Sara Mandatori, Romina Mancinelli, Federico Giulitti, Simonetta Petrungaro, Viviana Moresi, Antonio Facchiano, Elio Ziparo, Eugenio Gaudio, Claudia Giampietri
Article
Physiology
Alexandra Baccam, Alexandra Benoni-Sviercovicho, Marco Rocchi, Viviana Moresi, Marilia Seelaender, Zhenlin Li, Sergio Adamo, Zhigang Xue, Dario Coletti
FRONTIERS IN PHYSIOLOGY
(2019)
Review
Chemistry, Physical
Alessandra Costa, Sergio Adamo, Francesco Gossetti, Linda D'Amore, Francesca Ceci, Paolo Negro, Paolo Bruzzone
Article
Biochemistry & Molecular Biology
Nissrine Daou, Medhi Hassani, Emidio Matos, Gabriela Salim De Castro, Raquel Galvao Figueredo Costa, Marilia Seelaender, Viviana Moresi, Marco Rocchi, Sergio Adamo, Zhenlin Li, Onnik Agbulut, Dario Coletti
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Alessandra Renzini, Carles Sanchez Riera, Isidora Minic, Chiara D'Ercole, Biliana Lozanoska-Ochser, Alessia Cedola, Giuseppe Gigli, Viviana Moresi, Luca Madaro
Summary: The skeletal muscle, as a highly responsive tissue, undergoes metabolic changes in response to external demand. Various atrophic conditions, such as aging, ALS, and cancer-induced cachexia, lead to muscle wasting through different molecular signaling pathways. Nutritional interventions and physical exercise have been shown to be effective tools for counteracting muscle wasting in atrophic conditions.
Article
Geriatrics & Gerontology
Alessandra Renzini, Nicoletta Marroncelli, Giorgia Cavioli, Silvia Di Francescantonio, Laura Forcina, Alessandro Lambridis, Eros Di Giorgio, Sergio Valente, Antonello Mai, Claudio Brancolini, Claudia Giampietri, Alessandra Magenta, Francesca De Santa, Sergio Adamo, Dario Coletti, Viviana Moresi
Summary: The study reveals the crucial role of HDAC4 in mediating muscle repair response, suggesting potential therapeutic approaches for muscular dystrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Biochemistry & Molecular Biology
Silvia Consalvi, Luca Tucciarone, Elisa Macri, Marco De Bardi, Mario Picozza, Illari Salvatori, Alessandra Renzini, Sergio Valente, Antonello Mai, Viviana Moresi, Pier Lorenzo Puri
Summary: Late-stage mdx FAPs exhibit abnormal HDAC activity and genome-wide alterations of histone acetylation that cannot be fully reversed by HDACi. HDACi show general resistance in inducing H3K9/14 hyperacetylation in late-stage mdx FAPs, but is effective in reducing promoter acetylation and blunting SASP gene activation.
Review
Biochemistry & Molecular Biology
Viviana Moresi, Alessandra Renzini, Giorgia Cavioli, Marilia Seelaender, Dario Coletti, Giuseppe Gigli, Alessia Cedola
Summary: Neurogenic muscle atrophy is a condition associated with diseases and aging, leading to reduced interaction between motoneurons and skeletal fibers. Current therapeutic approaches provide no concrete resolution. Nutritional support could play a relevant part in mitigating neurogenic muscle atrophy.
Review
Biochemistry & Molecular Biology
Martina Sandona, Giorgia Cavioli, Alessandra Renzini, Alessia Cedola, Giuseppe Gigli, Dario Coletti, Timothy A. McKinsey, Viviana Moresi, Valentina Saccone
Summary: Histone deacetylases (HDACs) regulate the deacetylation of proteins, affecting cellular processes. Abnormal HDAC expression or activity is associated with various pathologies, making them potential therapeutic targets. For example, HDAC inhibitors have shown positive effects in preclinical and clinical studies for Duchenne Muscular Dystrophy (DMD). Understanding the cellular functions of HDACs in dystrophic muscles provides new insights for the development of effective therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Chiara Della Peruta, Biliana Lozanoska-Ochser, Alessandra Renzini, Viviana Moresi, Carles Sanchez Riera, Marina Bouche, Dario Coletti
Summary: Thanks to precision medicine, personalized treatments based on sex have emerged in recent years. Male and female skeletal muscles have significant differences, which impacts diagnosis and therapy. Men have more muscle and exhibit different inflammation responses, leading to different treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Alexandra Benoni, Alessandra Renzini, Giorgia Cavioli, Sergio Adamo
EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY
(2020)