Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies and Mitofusin-Stabilizing Peptides

Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies

(2018) Charles Miller et al.   BIOPHYSICAL JOURNAL

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A

(2018) Agostinho G. Rocha et al.   SCIENCE

Autophagy in Cardiovascular Aging

(2018) Mahmoud Abdellatif et al.   CIRCULATION RESEARCH

Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure

(2018) Phung N. Thai et al.   Scientific Reports

Myocardial Ischemia Suppresses Ketone Body Utilization

(2018) Yuichiro Arima et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Ketone bodies mimic the life span extending properties of caloric restriction

(2017) Richard L. Veech et al.   IUBMB LIFE

Reactive oxygen species trigger Parkin/PINK1 pathway–dependent mitophagy by inducing mitochondrial recruitment of Parkin

(2017) Bin Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association Between Circulating Ketone Bodies and Worse Outcomes in Hemodialysis Patients

(2017) Masaru Obokata et al.   Journal of the American Heart Association

Dissecting Redox Biology Using Fluorescent Protein Sensors

(2016) Markus Schwarzländer et al.   ANTIOXIDANTS & REDOX SIGNALING

Inositol 1,4,5-trisphosphate-mediated sarcoplasmic reticulum–mitochondrial crosstalk influences adenosine triphosphate production via mitochondrial Ca2+uptake through the mitochondrial ryanodine receptor in cardiac myocytes

(2016) Lea K. Seidlmayer et al.   CARDIOVASCULAR RESEARCH

Ketones Step to the Plate: A Game Changer for Metabolic Remodeling in Heart Failure?

(2016) Stephen C. Kolwicz et al.   CIRCULATION

Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload–Induced Mitochondrial Dysfunction and Heart FailureCLINICAL PERSPECTIVE

(2016) Akihiro Shirakabe et al.   CIRCULATION

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure

(2016) Kenneth C. Bedi et al.   CIRCULATION

The Failing Heart Relies on Ketone Bodies as a Fuel

(2016) Gregory Aubert et al.   CIRCULATION

Compartment-specific Control of Reactive Oxygen Species Scavenging by Antioxidant Pathway Enzymes

(2016) Swati Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lost in translation: miRNAs and mRNAs in ischemic preconditioning and ischemia/reperfusion injury

(2016) Roberta A. Gottlieb et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Parkin-dependent mitophagy in the heart

(2016) Gerald W. Dorn   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Correcting mitochondrial fusion by manipulating mitofusin conformations

(2016) Antonietta Franco et al.   NATURE

Negative risk markers for CVD

(2016) Karina Huynh   Nature Reviews Cardiology

Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum–mitochondria tether

(2016) Deborah Naon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mending a broken heart: the role of mitophagy in cardioprotection

(2015) Alexandra G. Moyzis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Autophagy machinery in the context of mammalian mitophagy

(2015) Saori R. Yoshii et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Distinct mPTP activation mechanisms in ischaemia–reperfusion: contributions of Ca2+, ROS, pH, and inorganic polyphosphate

(2015) Lea K. Seidlmayer et al.   CARDIOVASCULAR RESEARCH

How Mitochondrial Dynamism Orchestrates Mitophagy

(2015) O. S. Shirihai et al.   CIRCULATION RESEARCH

Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse HeartsNovelty and Significance

(2015) Moshi Song et al.   CIRCULATION RESEARCH

This old heart: Cardiac aging and autophagy

(2015) Phyllis-Jean Linton et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Ketone Body, β-Hydroxybutyrate Stimulates the Autophagic Flux and Prevents Neuronal Death Induced by Glucose Deprivation in Cortical Cultured Neurons

(2015) Lucy Camberos-Luna et al.   NEUROCHEMICAL RESEARCH

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells

(2014) C. Kishi-Itakura et al.   JOURNAL OF CELL SCIENCE

Mitochondrial quality control in the myocardium: Cooperation between protein degradation and mitophagy

(2014) Babette C. Hammerling et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Making connections: interorganelle contacts orchestrate mitochondrial behavior

(2014) Till Klecker et al.   TRENDS IN CELL BIOLOGY

Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health

(2013) Vassilios N. Kotiadis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mitochondria-mediated cardioprotection by trimetazidine in rabbit heart failure

(2013) Elena N. Dedkova et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial Infarction

(2012) Dieter A. Kubli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1- and Parkin-mediated mitophagy at a glance

(2012) Seok Min Jin et al.   JOURNAL OF CELL SCIENCE

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Measuring EGSH and H2O2 with roGFP2-based redox probes

(2011) Bruce Morgan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Measuring mitochondrial function in intact cardiac myocytes

(2011) Elena N. Dedkova et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Fluorescent Protein-Based Redox Probes

(2010) Andreas J. Meyer et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox-optimized ROS balance: A unifying hypothesis

(2010) M.A. Aon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Mitochondrial-targeted fluorescent probes for reactive oxygen species

(2009) Bryan C Dickinson et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Proximity-based Protein Thiol Oxidation by H2O2-scavenging Peroxidases

(2009) Marcus Gutscher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Real-time imaging of the intracellular glutathione redox potential

(2008) Marcus Gutscher et al.   NATURE METHODS