Review
Biochemistry & Molecular Biology
Camila Barbosa Oliveira, Camilla Albertina Dantas Lima, Gisele Vajgel, Paula Sandrin-Garcia
Summary: This review manuscript discusses the relationship between the NLRP3 inflammasome, SLE, and LN, emphasizing the impact of genetic susceptibility of NLRP3 polymorphisms on the disease and exploring NLRP3 inhibition mechanisms for the development of potential therapeutic drugs for LN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Zhi Lu, Yiqun Yao, Jinhong Wang, J-Y Peng
Summary: Dioscin exhibits protective effects on diabetes cognitive dysfunction by regulating the P2X7R/NLRP3 signal pathway, indicating its potential value in preventing type 2 diabetes cognitive dysfunction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Swayanka Biswas, Katja Bieber, Rudolf Armin Manz
Summary: IL-10 is a cytokine that has pleiotropic effects on immune cells, including both suppressive and activating functions. It plays a dual role in Systemic lupus Erythematosus (SLE), inhibiting pro-inflammatory effector functions while also promoting extrafollicular antibody response. IL-10 is produced by B cells, myeloid cells, and certain T cell subsets, and it drives B cell responses, proliferation, class switching, and plasma cell formation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yaling Liu, Xinyu Tao, Jinhui Tao
Summary: This paper reviews the role of inflammasomes in the pathogenesis of SLE and their therapeutic implications. It points out that inflammasomes not only regulate the abnormal differentiation of immune cells, but also modulate the production of pathogenic autoantibodies and participate in organ damage.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Fei-fei Chen, Xiao-tian Liu, Juan Tao, Zhao-min Mao, Hui Wang, Ying Tan, Zhen Qu, Feng Yu
Summary: The current study aimed to evaluate the activation of renal NLRP3 inflammasome pathway in Chinese lupus nephritis (LN) patients and its clinicopathological significances. It was found that expressions of NLRP3, ASC, caspase-1, IL-1 beta and IL-18 were significantly higher in the kidneys of LN patients, mainly in glomerular mesangial cells, podocytes, renal tubular epithelial cells, and macrophages. The expressions of NLRP3, ASC, caspase-1, and IL-1 beta were positively correlated with SLEDAI scores and renal pathological activity indices, while NLRP3 expression was negatively associated with chronicity scores. Furthermore, glomerular caspase-1 levels were positively correlated with foot process width, and podocyte injury markers were decreased significantly in LN patients with higher caspase-1 expression. The findings suggest that renal NLRP3 inflammasome is activated in LN patients and correlated with disease activity, which warrants further exploration.
CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Zi-Teng Zhang, Xiao-Lei Gu, Xin Zhao, Xian He, Hao-Wei Shi, Kun Zhang, Yi-Ming Zhang, Yi-Nan Su, Jiang-Bo Zhu, Zhi-Wei Li, Guo-Bao Li
Summary: Prior infection simulated by LPS/LTA injection resulted in latent inflammation with high cytokine levels, but did not affect animal survival or body temperature. Heat treatment induced heat stroke and death in animals without prior infection, showing no significant systemic or neuroinflammation. NLRP3 inflammasome-induced neuroinflammation was detected in animals with prior infection, and Nlrp3 knockout mice showed enhanced heat tolerance and reduced hypothalamus IL-1 beta production. IL-1 beta neutralizing antibody injection extended endotoxemic mice survival under heat stroke.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Chemistry, Multidisciplinary
Kai Chen, Qiuping Hu, Zhongcong Xie, Guang Yang
Summary: This study reveals that surgery leads to neuronal hypoactivity and impairs learning-dependent dendritic spine formation, resulting in deficits in multiple learning tasks. These neuronal and synaptic alterations are mediated by peripheral monocytes through NLRP3 inflammasome-dependent IL-1β production. Decreasing peripheral monocytes or inactivating NLRP3 inflammasomes can reduce IL-1β levels and improve neuronal and behavioral deficits.
Review
Rheumatology
Desh Nepal, David Gazeley
Summary: This narrative review examines the role of IL-6 in murine and human SLE, and its potential use as a targeted therapy in future studies. Currently, there are no registered clinical trials assessing IL-6 inhibition in SLE.
Article
Immunology
Chaoqing Zhong, Ruiqing Wang, Mingqiang Hua, Chen Zhang, Fengjiao Han, Miao Xu, Xinyu Yang, Guosheng Li, Xiang Hu, Tao Sun, Chunyan Ji, Daoxin Ma
Summary: NLRP3 inflammasome is over-expressed and highly activated in AML bone marrow leukemia cells, promoting leukemia cell proliferation, inhibiting apoptosis and increasing resistance to chemotherapy. IL-1 beta plays a crucial role in this process. Targeting NLRP3 inflammasome may offer a novel therapeutic option for AML.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
Katariina Mahonen, Annika Hau, Vincent Bondet, Darragh Duffy, Kari K. Eklund, Jaana Panelius, Annamari Ranki
Summary: This study investigated the expression of NLRP3 inflammasome components and levels of type I interferons in the skin of patients with cutaneous lupus erythematosus. The results showed that the expression of interleukin-1 beta was significantly upregulated in the lesional skin of patients. However, NLRP1/3, ASC and caspase-1 were not significantly upregulated. This suggests heterogeneity of pathological pathways in cutaneous lupus erythematosus.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Rheumatology
Naeim Ehtesham, Maryam Zare Rafie, Emran Esmaeilzadeh, Mohammad Dehani, Saeideh Davar, Meysam Mosallaei, Bahram Pakzad, Tahereh Ghorashi, Hossein Darvish, Mohsen Soosanabadi
Summary: The study reveals a significant association between NLRP3 polymorphisms and increased risk, clinical symptoms, and disease activity severity of SLE in the Iranian population. Specifically, rs10754558 GG genotype and G allele are significantly associated with higher SLE risk, while rs4612666 C allele and rs10754558 G allele are correlated with disease activity severity.
Article
Immunology
Jahirul Islam, Jung-Ah Cho, Ju-Yong Kim, Kyung-Sun Park, Young-Jae Koh, Chu Young Chung, Eun-Jae Lee, Soo Jeong Nam, Kyoungyul Lee, Seoung-Heon Kim, Sung-Hye Park, Dong Young Lee, Byeong C. Kim, Kyung-Hwa Lee, Seung-Yong Seong
Summary: This study demonstrates that inhibiting the activation of N3I by targeting P2X7R with taurodeoxycholate (TDCA), a GPCR19 ligand, can alleviate neuroinflammation in Alzheimer's disease (AD). TDCA reduces the number of A beta plaques, enhances A beta phagocytosis, and improves pathological and cognitive functions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Samuel G. Cook
Summary: Ascites is a rare initial symptom of systemic lupus erythematosus (SLE), and the diagnosis of SLE can be easily missed when the initial presentation is uncommon.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Immunology
N. Sippl, F. Faustini, J. Ronnelid, S. Turcinov, K. Chemin, I. Gunnarsson, V. Malmstrom
Summary: This study found elevated levels of IL-17A and IL-6 in the synovial fluids of patients with lupus arthritis, with a subset of CD4(+) T cells expressing markers associated with Th17 cells. Strong production of IFN-gamma was observed in both CD4(+) and CD8(+) cells, suggesting Th17 involvement in lupus arthritis.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Immunology
Zhenrui Shi, Yu-ping Zhang, Dan Hong, Xiaonan Qiu, Lin Zheng, Lijuan Bian, Fengqiu Hu, Liuyu Chen, Hui Xiong, Qiongqiong Yang, Shanping Jiang, Guozhen Tan, Liangchun Wang
Summary: Vascular inflammation can occur in various organs and tissues in patients with systematic lupus erythematosus (SLE), with the skin being the most common site. Anti-galectin-3 (Gal3) antibodies are identified as an important mediator of lupus cutaneous vasculopathy. The dys-regulation of vascular endothelial cells by anti-Gal3 antibodies leads to increased production of IL-10, which is dependent on NLRP3 inflammasome. Injection of anti-Gal3 antibodies in mice induces local inflammation with immune cell infiltration, which can be inhibited by blocking IL-10. Induction of anti-Gal3 antibodies in circulation not only causes skin histopathologic changes but also systemic autoimmune phenotypes and kidney damage. IL-10 overexpression is primarily associated with skin lesions in mice. The serum levels of IL-10 are comparable between SLE patients and healthy donors, but there is higher IL-10 expression in the local area of lupus skin lesions. These results suggest the important role of IL-10 in mediating anti-Gal3 antibody-induced skin vascular inflammation and the potential use of IL-10 blocking therapies in treating lupus cutaneous damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Rheumatology
Luca Quartuccio, Alessandra Bortoluzzi, Carlo Alberto Scire, Antonio Marangoni, Giulia Del Frate, Elena Treppo, Laura Castelnovo, Francesco Saccardo, Roberta Zani, Marco Candela, Paolo Fraticelli, Cesare Mazzaro, Piero Renoldi, Patrizia Scaini, Davide Antonio Filippini, Marcella Visentini, Salvatore Scarpato, Dilia Giuggioli, Maria Teresa Mascia, Marco Sebastiani, Anna Linda Zignego, Gianfranco Lauletta, Massimo Fiorilli, Milvia Casato, Clodoveo Ferri, Maurizio Pietrogrande, Pietro Enrico Pioltelli, Salvatore De Vita, Giuseppe Monti, Massimo Galli
Summary: Cryoglobulinemic vasculitis is a small-vessel vasculitis characterized by the proliferation of B-cell clones producing pathogenic immune complexes. It is often secondary to hepatitis C virus, autoimmune diseases, and hematological malignancies. The clinical course of cryoglobulinemic vasculitis is usually mild, but severe organ damage and life-threatening manifestations can occur.
CLINICAL RHEUMATOLOGY
(2023)
Correction
Rheumatology
Luca Quartuccio, Alessandra Bortoluzzi, Carlo Alberto Scire, Antonio Marangoni, Giulia Del Frate, Elena Treppo, Laura Castelnovo, Francesco Saccardo, Roberta Zani, Marco Candela, Paolo Fraticelli, Cesare Mazzaro, Piero Renoldi, Patrizia Scaini, Davide Antonio Filippini, Marcella Visentini, Salvatore Scarpato, Dilia Giuggioli, Maria Teresa Mascia, Marco Sebastiani, Anna Linda Zignego, Gianfranco Lauletta, Massimo Fiorilli, Milvia Casato, Clodoveo Ferri, Maurizio Pietrogrande, Pietro Enrico Pioltelli, Salvatore De Vita, Giuseppe Monti, Massimo Galli
CLINICAL RHEUMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sonia Missiroli, Mariasole Perrone, Roberta Gafa, Francesco Nicoli, Massimo Bonora, Giampaolo Morciano, Caterina Boncompagni, Saverio Marchi, Magdalena Lebiedzinska-Arciszewska, Bianca Vezzani, Giovanni Lanza, Franz Kricek, Alessandro Borghi, Francesco Fiorica, Keisuke Ito, Mariusz R. Wieckowski, Francesco Di Virgilio, Luigi Abelli, Paolo Pinton, Carlotta Giorgi
Summary: Uncontrolled inflammatory response from the tumor microenvironment significantly contributes to cancer progression. A trimeric complex at the mitochondria-associated membranes, involving P2X7 receptor-NLRP3 inflammasome interaction, is regulated by the tumor suppressor PML. Downregulation of PML leads to an exacerbated immune response and boosted tumor growth. Mislocalization of PML results in uncontrolled NLRP3 activation and cytokine production, fueling cancer development and worsening prognosis in various human cancers. Mechanistic insights into the PML-P2X7R-NLRP3 axis provide new opportunities for targeted therapeutic approaches in human carcinogenesis.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Neurosciences
Francesco Di Virgilio, Valentina Vultaggio-Poma, Simonetta Falzoni, Anna Lisa Giuliani
Summary: Nucleotides, especially extracellular ATP (eATP), play a crucial role in inter-species extracellular signaling. Different organisms have evolved sensors with varying affinity and selectivity for eATP, resulting in a highly flexible signaling system. In mammalian evolution, the control of intracellular ATP and eATP homeostasis is closely linked to that of Ca2+. Specific plasma membrane receptors, known as P2 receptors (P2Rs), sense eATP with various degrees of affinity and selectivity, adding to the plasticity of the system. The central nervous system (CNS) is a privileged site for purinergic signaling, with all brain cell types expressing P2Rs. Evidence suggests that eATP not only participates in synaptic transmission but also plays a crucial homeostatic role in brain cell responses. Modulating eATP concentration in the CNS may hold promise for the treatment of neuroinflammation.
Review
Biochemistry & Molecular Biology
Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A. Aaronson, John M. Abrams, Dieter Adam, Massimiliano Agostini, Patrizia Agostinis, Emad S. Alnemri, Lucia Altucci, Ivano Amelio, David W. Andrews, Rami Aqeilan, Eli Arama, Eric H. Baehrecke, Siddharth Balachandran, Daniele Bano, Nickolai A. Barlev, Jiri Bartek, Nicolas G. Bazan, Christoph Becker, Francesca Bernassola, Mathieu J. M. Bertrand, Marco E. Bianchi, Mikhail V. Blagosklonny, J. Magarian Blander, Giovanni Blandino, Klas Blomgren, Christoph Borner, Carl D. Bortner, Pierluigi Bove, Patricia Boya, Catherine Brenner, Petr Broz, Thomas Brunner, Rune Busk Damgaard, George A. Calin, Michelangelo Campanella, Eleonora Candi, Michele Carbone, Didac Carmona-Gutierrez, Francesco Cecconi, Francis K-M Chan, Guo-Qiang Chen, Quan Chen, Youhai H. Chen, Emily H. Cheng, Jerry E. Chipuk, John A. Cidlowski, Aaron Ciechanover, Gennaro Ciliberto, Marcus Conrad, Juan R. Cubillos-Ruiz, Peter E. Czabotar, Vincenzo D'Angiolella, Mads Daugaard, Ted M. Dawson, Valina L. Dawson, Ruggero De Maria, Bart De Strooper, Klaus-Michael Debatin, Ralph J. Deberardinis, Alexei Degterev, Giannino Del Sal, Mohanish Deshmukh, Francesco Di Virgilio, Marc Diederich, Scott J. Dixon, Brian D. Dynlacht, Wafik S. El-Deiry, John W. Elrod, Kurt Engeland, Gian Maria Fimia, Claudia Galassi, Carlo Ganini, Ana J. Garcia-Saez, Abhishek D. Garg, Carmen Garrido, Evripidis Gavathiotis, Motti Gerlic, Sourav Ghosh, Douglas R. Green, Lloyd A. Greene, Hinrich Gronemeyer, Georg Haecker, Gyorgy Hajnoczky, J. Marie Hardwick, Ygal Haupt, Sudan He, David M. Heery, Michael O. Hengartner, Claudio Hetz, David A. Hildeman, Hidenori Ichijo, Satoshi Inoue, Marja Jaeaettelae, Ana Janic, Bertrand Joseph, Philipp J. Jost, Thirumala-Devi Kanneganti, Michael Karin, Hamid Kashkar, Thomas Kaufmann, Gemma L. Kelly, Oliver Kepp, Adi Kimchi, Richard N. Kitsis, Daniel J. Klionsky, Ruth Kluck, Dmitri Krysko, Dagmar Kulms, Sharad Kumar, Sergio Lavandero, Inna N. Lavrik, John J. Lemasters, Gianmaria Liccardi, Andreas Linkermann, Stuart A. Lipton, Richard A. Lockshin, Carlos Lopez-Otin, Tom Luedde, Marion MacFarlane, Frank Madeo, Walter Malorni, Gwenola Manic, Roberto Mantovani, Saverio Marchi, Jean-Christophe Marine, Seamus J. Martin, Jean-Claude Martinou, Pier G. Mastroberardino, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Gerry Melino, Sonia Melino, Edward A. Miao, Ute M. Moll, Cristina Munoz-Pinedo, Daniel J. Murphy, Maria Victoria Niklison-Chirou, Flavia Novelli, Gabriel Nunez, Andrew Oberst, Dimitry Ofengeim, Joseph T. Opferman, Moshe Oren, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef M. Penninger, Francesca Pentimalli, David M. Pereira, Shazib Pervaiz, Marcus E. Peter, Paolo Pinton, Giovanni Porta, Jochen H. M. Prehn, Hamsa Puthalakath, Gabriel A. Rabinovich, Krishnaraj Rajalingam, Kodi S. Ravichandran, Markus Rehm, Jean-Ehrland Ricci, Rosario Rizzuto, Nirmal Robinson, Cecilia M. P. Rodrigues, Barak Rotblat, Carla Rothlin, David C. Rubinsztein, Thomas Rudel, Alessandro Rufini, Kevin M. Ryan, Kristopher A. Sarosiek, Akira Sawa, Emre Sayan, Kate Schroder, Luca Scorrano, Federico Sesti, Feng Shao, Yufang Shi, Giuseppe S. Sica, John Silke, Hans-Uwe Simon, Antonella Sistigu, Anastasis Stephanou, Brent R. Stockwell, Flavie Strapazzon, Andreas Strasser, Liming Sun, Erwei Sun, Qiang Sun, Gyorgy Szabadkai, Stephen W. G. Tait, Daolin Tang, Nektarios Tavernarakis, Carol M. Troy, Boris Turk, Nicoletta Urbano, Peter Vandenabeele, Tom Vanden Berghe, Matthew G. Vander Heiden, Jacqueline L. Vanderluit, Alexei Verkhratsky, Andreas Villunger, Silvia von Karstedt, Anne K. Voss, Karen H. Vousden, Domagoj Vucic, Daniela Vuri, Erwin F. Wagner, Henning Walczak, David Wallach, Ruoning Wang, Ying Wang, Achim Weber, Will Wood, Takahiro Yamazaki, Huang-Tian Yang, Zahra Zakeri, Joanna E. Zawacka-Pankau, Lin Zhang, Haibing Zhang, Boris Zhivotovsky, Wenzhao Zhou, Mauro Piacentini, Guido Kroemer, Lorenzo Galluzzi
Summary: Apoptosis is a regulated cell death process involving caspase family proteases. Inhibiting or delaying apoptosis experimentally through pharmacological and genetic strategies has demonstrated its importance in embryonic development, tissue homeostasis, and the pathogenesis of various human disorders. Defects in apoptotic cell death machinery impair development and promote oncogenesis, while inappropriate activation of apoptosis contributes to cell loss and tissue damage in neurological, cardiovascular, renal, hepatic, infectious, neoplastic, and inflammatory conditions.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Biochemistry & Molecular Biology
Francesco Di Virgilio, Valentina Vultaggio-Poma, Simonetta Falzoni, Anna Lisa Giuliani
Summary: The discovery of the P2X7 receptor in immune cells raised hopes for the development of anti-inflammatory drugs, but initial clinical trials were disappointing, reducing industry interest in P2X7-targeted therapies. However, recent findings have revitalized the use of P2X7 in diagnostic medicine, with new radioligands proving reliable for neuroinflammation diagnosis and P2X7 measurement in blood suggesting its potential as an inflammation marker. This review provides an overview of these novel developments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Sofia Ciliento, Veronica Venturelli, Natale Schettini, Riccardo Bertola, Carlo Garaffoni, Giovanni Lanza, Roberta Gafa, Alessandro Borghi, Monica Corazza, Alen Zabotti, Sonia Missiroli, Caterina Boncompagni, Simone Patergnani, Mariasole Perrone, Carlotta Giorgi, Paolo Pinton, Marcello Govoni, Carlo Alberto Scire, Alessandra Bortoluzzi, Ettore Silvagni
Summary: The aim of this systematic literature review was to investigate the effects of b/tsDMARDs on the synovial membrane of PsA patients and identify biomarkers of response to therapy. A meta-analysis of 22 studies showed a significant reduction in CD3+ lymphocytes and CD68+ macrophages in synovial biopsies from patients treated with bDMARDs for 4-12 weeks. Reduction in CD3+ was correlated with clinical response. The most consistent finding in the literature was the reduction in CD3+/CD68+ sublining cells during the first 3 months of treatment with TNF inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Valentina Vultaggio-Poma, Leticia Scussel Bergamin, Simonetta Falzoni, Mario Tarantini, Anna Lisa Giuliani, Dorianna Sandona, Patrizia Polverino De Laureto, Francesco Di Virgilio
Summary: ATP is released as a messenger in various physiological conditions and is present in small amounts in healthy tissues and blood. Fetal bovine sera commonly used in cell culture systems contain ATP in a range of 300-1300 pmol/L. This ATP is associated with albumin and microparticle/microvesicle fraction, and its presence affects in vitro cell responses. These findings highlight the varying levels of extracellular ATP and purinergic stimulation experienced by cells growing in serum-supplemented media.
PURINERGIC SIGNALLING
(2023)
Editorial Material
Pharmacology & Pharmacy
Anna Lisa Giuliani, Alessandra Bortoluzzi, Francesca Oliviero
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Valentina Vultaggio-Poma, Juana Maria Sanz, Andrea Amico, Alessandra Violi, Sara Ghisellini, Stefano Pizzicotti, Angelina Passaro, Alberto Papi, Marco Libanore, Francesco Di Virgilio, Anna Lisa Giuliani
Summary: This study found that the levels of sP2X7R in the blood of patients with COVID-19 were increased and correlated with adverse clinical outcomes. sP2X7R may be a useful marker of disease progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Giorgio Galoppini, Antonio Marangoni, Francesca Cirilli, Francesca Ruffilli, Carlo Garaffoni, Marcello Govoni, Carlo Alberto Scire, Ettore Silvagni, Alessandra Bortoluzzi
Summary: Systemic lupus erythematosus (SLE) requires a multidisciplinary (MD) approach for optimal patient care. This systematic literature review aimed to evaluate the data and outcomes of the MD approach in managing SLE patients. The review found a lack of data supporting the MD strategy, with most available evidence focused on SLE during pregnancy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Letizia Penolazzi, Maria Pina Notarangelo, Elisabetta Lambertini, Valentina Vultaggio-Poma, Mario Tarantini, Francesco Di Virgilio, Roberta Piva
Summary: The main objective of this study was to determine the presence of the P2X7 receptor in human skeletal system cells. P2X7 receptor was found to be localized not only in the plasma membrane and cytoplasm, but also in the nucleus and mitochondria of osteoblasts, chondrocytes, and intervertebral disc cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Microbiology
Carla Enrica Gallenga, Martina Maritati, Marco Mura, Francesco Di Virgilio, Pio Conti, Carlo Contini
Summary: Follicular conjunctivitis has become a relevant symptom of SARS-CoV-2. The conjunctiva reacts to viral antigens, forming B cell follicles with T cells and NK cells on its surface. The NLRP3 inflammasome releases pro-inflammatory factors, leading to congestion and inflammation in follicular conjunctivitis, even in asymptomatic patients.
Review
Rheumatology
C. Garaffoni, A. Adinolfi, A. Bortoluzzi, G. Filippou, A. Giollo, G. Sakellariou, S. Sirotti, N. Ughi, C. A. Scire, E. Silvagni
Summary: New evidence has emerged in the treatment of rheumatoid arthritis, with updated guidelines emphasizing the importance of global patient care and shifting the role of older drugs. The safety of Janus kinase inhibitors and the efficacy of vaccinations in the RA population have been investigated. Machine learning and biomarkers development show promise in the area of precision/personalized medicine.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Rheumatology
M. Lorenzin, N. Ughi, A. Ariani, B. Raffeiner, F. Ceccarelli, R. Lucchetti, A. Bortoluzzi, M. A. Cimmino, A. Di Matteo, P. Frallonardo, A. Hoxha, A. Ortolan, M. Favero, S. Parisi, F. Furini, A. Zanetti, G. Carrara, C. A. Scire, A. Doria, R. Ramonda
Summary: The study assessed the performance of ACR/EULAR gout classification criteria in an Italian cohort, finding that it performed well in patients with acute arthritis but showed differences in early-stage disease.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)