A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues, and the Intermediate Role of Signaling Pathways

Sonic Hedgehog Is a Remotely Produced Cue that Controls Axon Guidance Trans-axonally at a Midline Choice Point

(2018) Jimmy Peng et al.   NEURON

Highly conserved molecular pathways, including Wnt signaling, promote functional recovery from spinal cord injury in lampreys

(2018) Paige E. Herman et al.   Scientific Reports

The NCLX-type Na+/Ca2+Exchanger NCX-9 Is Required for Patterning of Neural Circuits inCaenorhabditis elegans

(2017) Vishal Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sonic Hedgehog Guides Axons via Zipcode Binding Protein 1-Mediated Local Translation

(2017) Léa Lepelletier et al.   JOURNAL OF NEUROSCIENCE

Actin-based growth cone motility and guidance

(2017) Omotola F. Omotade et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Floor-plate-derived netrin-1 is dispensable for commissural axon guidance

(2017) Chloé Dominici et al.   NATURE

Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord

(2017) Supraja G. Varadarajan et al.   NEURON

The Wound Microenvironment Reprograms Schwann Cells to Invasive Mesenchymal-like Cells to Drive Peripheral Nerve Regeneration

(2017) Melanie P. Clements et al.   NEURON

Wnt signaling promotes axonal regeneration following optic nerve injury in the mouse

(2017) Amit K. Patel et al.   NEUROSCIENCE

Sema-1a Reverse Signaling Promotes Midline Crossing in Response to Secreted Semaphorins

(2017) Melissa Hernandez-Fleming et al.   Cell Reports

Sonic Hedgehog switches on Wnt/planar cell polarity signaling in commissural axon growth cones by reducing levels of Shisa2

(2017) Keisuke Onishi et al.   eLife

Brorin is required for neurogenesis, gliogenesis, and commissural axon guidance in the zebrafish forebrain

(2017) Ayumi Miyake et al.   PLoS One

Using NGF heparin-poloxamer thermosensitive hydrogels to enhance the nerve regeneration for spinal cord injury

(2016) Ying-Zheng Zhao et al.   Acta Biomaterialia

The multicellular complexity of peripheral nerve regeneration

(2016) Anne-Laure Cattin et al.   CURRENT OPINION IN NEUROBIOLOGY

Cytoskeletal social networking in the growth cone: How +TIPs mediate microtubule-actin cross-linking to drive axon outgrowth and guidance

(2016) Garrett M. Cammarata et al.   Cytoskeleton

Syk kinases are required for spinal commissural axon repulsion at the midline via the ephrin/Eph pathway

(2016) Nelly Noraz et al.   DEVELOPMENT

Exosomes mediate cell contact–independent ephrin-Eph signaling during axon guidance

(2016) Jingyi Gong et al.   JOURNAL OF CELL BIOLOGY

The Adhesion Molecule-Characteristic HNK-1 Carbohydrate Contributes to Functional Recovery After Spinal Cord Injury in Adult Zebrafish

(2016) Liping Ma et al.   MOLECULAR NEUROBIOLOGY

Expression changes of nerve cell adhesion molecules L1 and semaphorin 3A after peripheral nerve injury

(2016) Yan-pei Gong et al.   Neural Regeneration Research

BDNF promotes the axonal regrowth after sciatic nerve crush through intrinsic neuronal capability upregulation and distal portion protection

(2016) Jinyu Zheng et al.   NEUROSCIENCE LETTERS

Co-immobilization of semaphorin3A and nerve growth factor to guide and pattern axons

(2015) Aleesha M. McCormick et al.   Acta Biomaterialia

Netrin-1 induces the migration of Schwann cells via p38 MAPK and PI3K-Akt signaling pathway mediated by the UNC5B receptor

(2015) Jianwei Lv et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional evaluation of peripheral nerve regeneration and target reinnervation in animal models: a critical overview

(2015) Xavier Navarro   EUROPEAN JOURNAL OF NEUROSCIENCE

Conditional genetic deletion of PTEN after a spinal cord injury enhances regenerative growth of CST axons and motor function recovery in mice

(2015) Camelia A. Danilov et al.   EXPERIMENTAL NEUROLOGY

Experimental and computational models of neurite extension at a choice point in response to controlled diffusive gradients

(2015) G C Catig et al.   Journal of Neural Engineering

Pten Deletion Promotes Regrowth of Corticospinal Tract Axons 1 Year after Spinal Cord Injury

(2015) K. Du et al.   JOURNAL OF NEUROSCIENCE

Activation of the Wnt/β-catenin signaling cascade after traumatic nerve injury

(2015) S. Kurimoto et al.   NEUROSCIENCE

Finely Tuned Temporal and Spatial Delivery of GDNF Promotes Enhanced Nerve Regeneration in a Long Nerve Defect Model

(2015) Laura M. Marquardt et al.   TISSUE ENGINEERING PART A

Cofilin 1 activation prevents the defects in axon elongation and guidance induced by extracellular alpha-synuclein

(2015) Sharada Tilve et al.   Scientific Reports

Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse

(2015) Soraia Barão et al.   Cell Reports

Complete Loss of Netrin-1 Results in Embryonic Lethality and Severe Axon Guidance Defects without Increased Neural Cell Death

(2015) Jenea M. Bin et al.   Cell Reports

Glypican Is a Modulator of Netrin-Mediated Axon Guidance

(2015) Cassandra R. Blanchette et al.   PLOS BIOLOGY

Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons

(2015) Sebastian Poliak et al.   eLife

EphA4 Receptor Shedding Regulates Spinal Motor Axon Guidance

(2014) Graziana Gatto et al.   CURRENT BIOLOGY

Semaphorin 6B acts as a receptor in post-crossing commissural axon guidance

(2014) I. Andermatt et al.   DEVELOPMENT

The Ephrin receptor EphA4 restricts axonal sprouting and enhances branching in the injured mouse optic nerve

(2014) Sandrine Joly et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Abrogation of  -Catenin Signaling in Oligodendrocyte Precursor Cells Reduces Glial Scarring and Promotes Axon Regeneration after CNS Injury

(2014) J. P. Rodriguez et al.   JOURNAL OF NEUROSCIENCE

The Role of Arp2/3 in Growth Cone Actin Dynamics and Guidance Is Substrate Dependent

(2014) J. E. San Miguel-Ruiz et al.   JOURNAL OF NEUROSCIENCE

Robo3.1A suppresses Slit-mediated repulsion by triggering degradation of Robo2

(2014) Lingyong Li et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Nerve growth factor improves functional recovery by inhibiting endoplasmic reticulum stress-induced neuronal apoptosis in rats with spinal cord injury

(2014) Hongyu Zhang et al.   Journal of Translational Medicine

CRMP1 Interacted with Spy1 During the Collapse of Growth Cones Induced by Sema3A and Acted on Regeneration After Sciatic Nerve Crush

(2014) Li Yao et al.   MOLECULAR NEUROBIOLOGY

PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments

(2014) Céline Delloye-Bourgeois et al.   NATURE NEUROSCIENCE

Pioneer midbrain longitudinal axons navigate using a balance of Netrin attraction and Slit repulsion

(2014) Minkyung Kim et al.   Neural Development

Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury

(2014) Luigi Aloe et al.   Neural Regeneration Research

Signaling Switch of the Axon Guidance Receptor Robo3 during Vertebrate Evolution

(2014) Pavol Zelina et al.   NEURON

Local delivery of controlled released nerve growth factor promotes sciatic nerve regeneration after crush injury

(2014) Hailong Yu et al.   NEUROSCIENCE LETTERS

Extracellular Matrix Regulates UNC-6 (Netrin) Axon Guidance by Controlling the Direction of Intracellular UNC-40 (DCC) Outgrowth Activity

(2014) Yong Yang et al.   PLoS One

Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism

(2014) K. Xu et al.   SCIENCE

Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections

(2014) K.-Y. Wu et al.   Science Signaling

The collagen scaffold with collagen binding BDNF enhances functional recovery by facilitating peripheral nerve infiltrating and ingrowth in canine complete spinal cord transection

(2014) S Han et al.   SPINAL CORD

ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS

(2014) J C Koch et al.   Cell Death & Disease

Microtubule dynamics in axon guidance

(2014) Guofa Liu et al.   Neuroscience Bulletin

Axon growth inhibition by RhoA/ROCK in the central nervous system

(2014) Yuki Fujita et al.   Frontiers in Neuroscience

Wnt5a evokes cortical axon outgrowth and repulsive guidance by tau mediated reorganization of dynamic microtubules

(2013) Li Li et al.   Developmental Neurobiology

Neurotrophic factor NT-3 displays a non-canonical cell guidance signaling function for cephalic neural crest cells

(2013) Juan P. Zanin et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Differential Role of PTEN Phosphatase in Chemotactic Growth Cone Guidance

(2013) Steven J. Henle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PAK-PIX interactions regulate adhesion dynamics and membrane protrusion to control neurite outgrowth

(2013) M. Santiago-Medina et al.   JOURNAL OF CELL SCIENCE

Direct binding of TUBB3 with DCC couples netrin-1 signaling to intracellular microtubule dynamics in axon outgrowth and guidance

(2013) C. Qu et al.   JOURNAL OF CELL SCIENCE

Collaborative and Specialized Functions of Robo1 and Robo2 in Spinal Commissural Axon Guidance

(2013) A. Jaworski et al.   JOURNAL OF NEUROSCIENCE

PTEN Inhibition to Facilitate Intrinsic Regenerative Outgrowth of Adult Peripheral Axons

(2013) K. J. Christie et al.   JOURNAL OF NEUROSCIENCE

Shh/Boc Signaling Is Required for Sustained Generation of Ipsilateral Projecting Ganglion Cells in the Mouse Retina

(2013) L. Sanchez-Arrones et al.   JOURNAL OF NEUROSCIENCE

Antagonistic Functions of Dishevelleds Regulate Frizzled3 Endocytosis via Filopodia Tips in Wnt-Mediated Growth Cone Guidance

(2013) K. Onishi et al.   JOURNAL OF NEUROSCIENCE

Misdirection and guidance of regenerating axons after experimental nerve injury and repair

(2013) Godard C. W. de Ruiter et al.   JOURNAL OF NEUROSURGERY

Sonic Hedgehog Regulates Its Own Receptor on Postcrossing Commissural Axons in a Glypican1-Dependent Manner

(2013) Nicole H. Wilson et al.   NEURON

Misguidance and modulation of axonal regeneration by Stat3 and Rho/ROCK signaling in the transparent optic nerve

(2013) V Pernet et al.   Cell Death & Disease

PI3K–GSK3 signalling regulates mammalian axon regeneration by inducing the expression of Smad1

(2013) Saijilafu et al.   Nature Communications

Blocking Apoptotic Signaling Rescues Axon Guidance in Netrin Mutants

(2013) Gunnar Newquist et al.   Cell Reports

Long-Term Viral Brain-Derived Neurotrophic Factor Delivery Promotes Spasticity in Rats with a Cervical Spinal Cord Hemisection

(2013) Karim Fouad et al.   Frontiers in Neurology

Electro-acupuncture on functional peripheral nerve regeneration in mice: a behavioural study

(2012) Ngoc Son Hoang et al.   BMC Complementary and Alternative Medicine

Ret Is a Multifunctional Coreceptor that Integrates Diffusible- and Contact-Axon Guidance Signals

(2012) Dario Bonanomi et al.   CELL

β-Site Amyloid Precursor Protein (APP)-cleaving Enzyme 1 (BACE1)-deficient Mice Exhibit a Close Homolog of L1 (CHL1) Loss-of-function Phenotype Involving Axon Guidance Defects

(2012) Brian Hitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Jun N-terminal Kinase 1 (JNK1) Is Required for Coordination of Netrin Signaling in Axon Guidance

(2012) Chao Qu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Focal adhesion kinase modulates Cdc42 activity downstream of positive and negative axon guidance cues

(2012) Jonathan P. Myers et al.   JOURNAL OF CELL SCIENCE

Role of EphA/ephrin-A signaling in the development of topographic maps in mouse corticothalamic projections

(2012) Masaaki Torii et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Genetic Evidence for a Contribution of EphA:EphrinA Reverse Signaling to Motor Axon Guidance

(2012) I. Dudanova et al.   JOURNAL OF NEUROSCIENCE

Netrin/DCC Signaling Guides Olfactory Sensory Axons to Their Correct Location in the Olfactory Bulb

(2012) V. Lakhina et al.   JOURNAL OF NEUROSCIENCE

EphB2 receptor forward signaling controls cortical growth cone collapse via Nck and Pak

(2012) Nishi Srivastava et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The Control of Semaphorin-1a-Mediated Reverse Signaling by Opposing Pebble and RhoGAPp190 Functions in Drosophila

(2012) Sangyun Jeong et al.   NEURON

gdnf Activates Midline Repulsion by Semaphorin3B via NCAM during Commissural Axon Guidance

(2012) Camille Charoy et al.   NEURON

UNC-6/netrin and its receptors UNC-5 and UNC-40/DCC modulate growth cone protrusion in vivo in C. elegans

(2011) A. D. Norris et al.   DEVELOPMENT

Robo1 and Robo2 have distinct roles in pioneer longitudinal axon guidance

(2011) Minkyung Kim et al.   DEVELOPMENTAL BIOLOGY

Asymmetric PI(3,4,5)P3 and Akt Signaling Mediates Chemotaxis of Axonal Growth Cones

(2011) S. J. Henle et al.   JOURNAL OF NEUROSCIENCE

Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons

(2011) P. Parikh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EphB Signaling Directs Peripheral Nerve Regeneration through Sox2-Dependent Schwann Cell Sorting

(2010) Simona Parrinello et al.   CELL

The Tripartite Motif Protein MADD-2 Functions with the Receptor UNC-40 (DCC) in Netrin-Mediated Axon Attraction and Branching

(2010) Joe C. Hao et al.   DEVELOPMENTAL CELL

Activation of ADF/cofilin mediates attractive growth cone turning toward nerve growth factor and netrin-1

(2010) Bonnie M. Marsick et al.   Developmental Neurobiology

Brain-derived neurotrophic factor and the development of structural neuronal connectivity

(2010) Susana Cohen-Cory et al.   Developmental Neurobiology

Wnt/calcium signaling mediates axon growth and guidance in the developing corpus callosum

(2010) B. Ian Hutchins et al.   Developmental Neurobiology

Segregation of Ipsilateral Retinal Ganglion Cell Axons at the Optic Chiasm Requires the Shh Receptor Boc

(2010) P. J. Fabre et al.   JOURNAL OF NEUROSCIENCE

Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II

(2010) Hyota Takamatsu et al.   NATURE IMMUNOLOGY

Tsc2-Rheb signaling regulates EphA-mediated axon guidance

(2010) Duyu Nie et al.   NATURE NEUROSCIENCE

Olfactory sensory axon growth and branching is influenced by sonic hedgehog

(2009) Qizhi Gong et al.   DEVELOPMENTAL DYNAMICS

Electro-acupuncture promotes differentiation of mesenchymal stem cells, regeneration of nerve fibers and partial functional recovery after spinal cord injury

(2009) Qing Yan et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism

(2009) J. O. Bush et al.   GENES & DEVELOPMENT

BDNF-Hypersecreting Human Mesenchymal Stem Cells Promote Functional Recovery, Axonal Sprouting, and Protection of Corticospinal Neurons after Spinal Cord Injury

(2009) M. Sasaki et al.   JOURNAL OF NEUROSCIENCE

Axotomy-Induced Smad1 Activation Promotes Axonal Growth in Adult Sensory Neurons

(2009) H. Zou et al.   JOURNAL OF NEUROSCIENCE

Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury

(2009) Laura Taylor Alto et al.   NATURE NEUROSCIENCE

The trip of the tip: understanding the growth cone machinery

(2009) Laura Anne Lowery et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sonic Hedgehog Guides Axons through a Noncanonical, Src-Family-Kinase-Dependent Signaling Pathway

(2009) Patricia T. Yam et al.   NEURON

Wnt Signals Organize Synaptic Prepattern and Axon Guidance through the Zebrafish unplugged/MuSK Receptor

(2009) Lili Jing et al.   NEURON

DSCAM functions as a netrin receptor in commissural axon pathfinding

(2009) Guofa Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Bayesian model predicts the response of axons to molecular gradients

(2009) D. Mortimer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DSCAM Is a Netrin Receptor that Collaborates with DCC in Mediating Turning Responses to Netrin-1

(2008) Alice Ly et al.   CELL

BMP type I receptor complexes have distinct activities mediating cell fate and axon guidance decisions

(2008) K. Yamauchi et al.   DEVELOPMENT

Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells

(2008) Q. Schwarz et al.   DEVELOPMENT

Misdirection of regenerating motor axons after nerve injury and repair in the rat sciatic nerve model

(2008) Godard C.W. de Ruiter et al.   EXPERIMENTAL NEUROLOGY

BMP inhibition enhances axonal growth and functional recovery after spinal cord injury

(2008) Iichiro Matsuura et al.   JOURNAL OF NEUROCHEMISTRY

Trio Mediates Netrin-1-Induced Rac1 Activation in Axon Outgrowth and Guidance

(2008) A. Briancon-Marjollet et al.   MOLECULAR AND CELLULAR BIOLOGY

p75NTR Mediates Ephrin-A Reverse Signaling Required for Axon Repulsion and Mapping

(2008) Yoo-Shick Lim et al.   NEURON

Regulation of Actin Assembly Associated With Protrusion and Adhesion in Cell Migration

(2008) Christophe Le Clainche et al.   PHYSIOLOGICAL REVIEWS

CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure

(2007) Michael T. Fitch et al.   EXPERIMENTAL NEUROLOGY