Journal
NEUROSCIENCE LETTERS
Volume 566, Issue -, Pages 177-181Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2014.02.065
Keywords
Nerve growth factor (NGF); Microsphere; Controlled released; Nerve crush injury; Peripheral nerve
Categories
Funding
- Science and Key Technology Research and Development Program of Liaoning Province [2011225041, 20112225019]
- Twelfth Five-Year Plan Scientific Research Funds Project of Chinese PLA [CWS11J209]
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Controlled released nerve growth factor (NGF)-microspheres are able to enhance peripheral nerve regeneration across short nerve gaps. However, such beneficial effect has never been investigated in crush injury model in vivo. The present study was designed to investigate such a possibility. The rats subjected to sciatic nerve crush injury were intraperitoneally administrated daily for 4 weeks with NGF or normal saline or locally injected controlled released NGF-microspheres only once. Sham operation group without injury was defined as normal group. Nerve regeneration was investigated by morphometric analysis. The recovery of nerve function was estimated by electrophysiological analysis, behavioral tests and morphometric observation of the denervated muscles. The results showed that both NGF and NGF-microspheres improved nerve regeneration and recovery of nerve function. In addition, NGF-microspheres achieved better results than NGF group. These findings show that this controlled released NGF-microspheres could enhance the beneficial effect of NGF on nerve regeneration and recovery of motor and sensory function after sciatic nerve crush injury in rats, indicating that the NGF-microspheres have the potential to be a neuroprotective agent for nerve crush injury repair applications. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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