Mechanisms of Human Innate Immune Evasion by Toxoplasma gondii

Toxoplasma gondii infection induces the formation of host’s nuclear granules containing poly(A)-binding proteins

(2018) Karlee Fischer et al.   CANADIAN JOURNAL OF MICROBIOLOGY

miR-20a inhibition using locked nucleic acid (LNA) technology and its effects on apoptosis of human macrophages infected by Toxoplasma gondii RH strain

(2018) Fatemeh Rezaei et al.   MICROBIAL PATHOGENESIS

Evasion of Human Neutrophil-Mediated Host Defense during Toxoplasma gondii Infection

(2018) Tatiane S. Lima et al.   mBio

NADPH Oxidase and Guanylate Binding Protein 5 Restrict Survival of Avirulent Type III Strains of Toxoplasma gondii in Naive Macrophages

(2018) Sumit K. Matta et al.   mBio

Characterization of a Toxoplasma effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammation

(2018) Huan He et al.   eLife

NLRP3 and Potassium Efflux Drive Rapid IL-1β Release from Primary Human Monocytes duringToxoplasma gondiiInfection

(2017) Lanny Gov et al.   JOURNAL OF IMMUNOLOGY

Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression

(2016) Philipp Olias et al.   Cell Host & Microbe

Human GBP1 does not localize to pathogen vacuoles but restrictsToxoplasma gondii

(2016) Ashleigh C. Johnston et al.   CELLULAR MICROBIOLOGY

Toxoplasma gondiiTgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses

(2016) Gabrielle Gay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells

(2016) Barbara Clough et al.   PLoS Pathogens

Poly(A)-binding proteins and mRNA localization: who rules the roost?

(2015) N. K. Gray et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The IL-12 Response of Primary Human Dendritic Cells and Monocytes toToxoplasma gondiiIs Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion

(2015) Kevin W. Tosh et al.   JOURNAL OF IMMUNOLOGY

Toxoplasma gondiidissemination: a parasite's journey through the infected host

(2015) K. S. Harker et al.   PARASITE IMMUNOLOGY

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells

(2015) Elizabeth M. Selleck et al.   mBio

Toxoplasma gondii inhibits apoptosis via a novel STAT3-miR-17–92-Bim pathway in macrophages

(2014) Yihong Cai et al.   CELLULAR SIGNALLING

In Vitro Infection of Human Nervous Cells by Two Strains of Toxoplasma gondii: A Kinetic Analysis of Immune Mediators and Parasite Multiplication

(2014) Nour Mammari et al.   PLoS One

Host Cell Subversion by Toxoplasma GRA16, an Exported Dense Granule Protein that Targets the Host Cell Nucleus and Alters Gene Expression

(2013) Alexandre Bougdour et al.   Cell Host & Microbe

Toxoplasma gondii Inhibits Gamma Interferon (IFN-γ)- and IFN-β-Induced Host Cell STAT1 Transcriptional Activity by Increasing the Association of STAT1 with DNA

(2013) Emily E. Rosowski et al.   INFECTION AND IMMUNITY

Toxoplasma gondii Proliferation Require Down-Regulation of Host Nox4 Expression via Activation of PI3 Kinase/Akt Signaling Pathway

(2013) Wei Zhou et al.   PLoS One

Human Innate Immunity to Toxoplasma gondii Is Mediated by Host Caspase-1 and ASC and Parasite GRA15

(2013) L. Gov et al.   mBio

Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondii

(2013) Elizabeth M. Selleck et al.   PLoS Pathogens

A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii

(2012) Masahiro Yamamoto et al.   IMMUNITY

Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma gondii

(2012) A. Alicia Koblansky et al.   IMMUNITY

Toxoplasma gondii Clonal Strains All Inhibit STAT1 Transcriptional Activity but Polymorphic Effectors Differentially Modulate IFNγ Induced Gene Expression and STAT1 Phosphorylation

(2012) Emily E. Rosowski et al.   PLoS One

Murine Guanylate Binding Protein 2 (mGBP2) controls Toxoplasma gondii replication

(2012) D. Degrandi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCF/LEFs and Wnt Signaling in the Nucleus

(2012) K. M. Cadigan et al.   Cold Spring Harbor Perspectives in Biology

Toxoplasma gondii inhibits granzyme B-mediated apoptosis by the inhibition of granzyme B function in host cells

(2011) Tatsuya Yamada et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Strain-specific activation of the NF-κB pathway by GRA15, a novelToxoplasma gondiidense granule protein

(2011) Emily E. Rosowski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential Effects of Three CanonicalToxoplasmaStrains on Gene Expression in Human Neuroepithelial Cells

(2010) Jianchun Xiao et al.   INFECTION AND IMMUNITY

Toxoplasma gondiiActivates Hypoxia-inducible Factor (HIF) by Stabilizing the HIF-1α Subunit via Type I Activin-like Receptor Kinase Receptor Signaling

(2010) Mandi Wiley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ToxoplasmaRhoptry Protein 16 (ROP16) Subverts Host Function by Direct Tyrosine Phosphorylation of STAT6

(2010) Yi-Ching Ong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxoplasma gondii infection inhibits the mitochondrial apoptosis through induction of Bcl-2 and HSP70

(2010) Il-Young Hwang et al.   PARASITOLOGY RESEARCH

A New Model for the Transition of APAF-1 from Inactive Monomer to Caspase-activating Apoptosome

(2009) Thomas F. Reubold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxoplasma gondii infection confers resistance against BimS-induced apoptosis by preventing the activation and mitochondrial targeting of pro-apoptotic Bax

(2009) D. Hippe et al.   JOURNAL OF CELL SCIENCE

A single polymorphic amino acid onToxoplasma gondiikinase ROP16 determines the direct and strain-specific activation of Stat3

(2009) Masahiro Yamamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Disruption of the Toxoplasma gondii Parasitophorous Vacuole by IFNγ-Inducible Immunity-Related GTPases (IRG Proteins) Triggers Necrotic Cell Death

(2009) Yang O. Zhao et al.   PLoS Pathogens

Toxoplasma gondii exploits UHRF1 and induces host cell cycle arrest at G2 to enable its proliferation

(2008) Julie Brunet et al.   CELLULAR MICROBIOLOGY

Infection with Toxoplasma gondii results in dysregulation of the host cell cycle

(2008) Robert E. Molestina et al.   CELLULAR MICROBIOLOGY

Fas/CD95-Mediated Apoptosis of Type II Cells Is Blocked by Toxoplasma gondii Primarily via Interference with the Mitochondrial Amplification Loop

(2008) D. Hippe et al.   INFECTION AND IMMUNITY

Recruitment of Stat1 to chromatin is required for interferon-induced serine phosphorylation of Stat1 transactivation domain

(2008) Iwona Sadzak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA