Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity
出版年份 2019 全文链接
标题
Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity
作者
关键词
-
出版物
eLife
Volume 8, Issue -, Pages -
出版商
eLife Sciences Publications, Ltd
发表日期
2019-05-14
DOI
10.7554/elife.44146
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Intracellular cargo transport by single-headed kinesin motors
- (2019) Kristin I. Schimert et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Motor Reattachment Kinetics Play a Dominant Role in Multimotor-Driven Cargo Transport
- (2018) Qingzhou Feng et al. BIOPHYSICAL JOURNAL
- Processive Kinesin-14 HSET Exhibits Directional Flexibility Depending on Motor Traffic
- (2018) Dana N. Reinemann et al. CURRENT BIOLOGY
- Structural Delineation of the Neck Linker of Kinesin-3 for Processive Movement
- (2018) Jinqi Ren et al. JOURNAL OF MOLECULAR BIOLOGY
- A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function
- (2018) Joseph M. Muretta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Kinesin motility driven by subdomain dynamics
- (2017) Wonmuk Hwang et al. eLife
- The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry
- (2017) Joseph Atherton et al. eLife
- Structural basis of cooperativity in kinesin revealed by 3D reconstruction of a two-head-bound state on microtubules
- (2017) Daifei Liu et al. eLife
- Direct observation of intermediate states during the stepping motion of kinesin-1
- (2016) Hiroshi Isojima et al. Nature Chemical Biology
- Engineered kinesin motor proteins amenable to small-molecule inhibition
- (2016) Martin F. Engelke et al. Nature Communications
- The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5
- (2015) Joseph M. Muretta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Kinesin’s Front Head Is Gated by the Backward Orientation of Its Neck Linker
- (2015) Merve Yusra Dogan et al. Cell Reports
- Examining kinesin processivity within a general gating framework
- (2015) Johan OL Andreasson et al. eLife
- Transport by Populations of Fast and Slow Kinesins Uncovers Novel Family-Dependent Motor Characteristics Important for In Vivo Function
- (2014) Göker Arpağ et al. BIOPHYSICAL JOURNAL
- Integrating protein structural dynamics and evolutionary analysis with Bio3D
- (2014) Lars Skjærven et al. BMC BIOINFORMATICS
- Mechanical Role of Actin Dynamics in the Rheology of the Golgi Complex and in Golgi-Associated Trafficking Events
- (2014) David Guet et al. CURRENT BIOLOGY
- A method for multiprotein assembly in cells reveals independent action of kinesins in complex
- (2014) Stephen R. Norris et al. JOURNAL OF CELL BIOLOGY
- KIF14 Binds Tightly to Microtubules and Adopts a Rigor-Like Conformation
- (2014) Kritica Arora et al. JOURNAL OF MOLECULAR BIOLOGY
- The family-specific K-loop influences the microtubule on-rate but not the superprocessivity of kinesin-3 motors
- (2014) Virupakshi Soppina et al. MOLECULAR BIOLOGY OF THE CELL
- γ-Tubulin controls neuronal microtubule polarity independently of Golgi outposts
- (2014) Michelle M. Nguyen et al. MOLECULAR BIOLOGY OF THE CELL
- Motor coupling through lipid membranes enhances transport velocities for ensembles of myosin Va
- (2014) S. R. Nelson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dimerization of mammalian kinesin-3 motors results in superprocessive motion
- (2014) V. Soppina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Delineating cooperative responses of processive motors in living cells
- (2014) A. K. Efremov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The structure of apo-kinesin bound to tubulin links the nucleotide cycle to movement
- (2014) Luyan Cao et al. Nature Communications
- High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation
- (2014) Zhiguo Shang et al. eLife
- Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
- (2014) Joseph Atherton et al. eLife
- Kinesin-8 Is a Low-Force Motor Protein with a Weakly Bound Slip State
- (2013) Anita Jannasch et al. BIOPHYSICAL JOURNAL
- Modular Aspects of Kinesin Force Generation Machinery
- (2013) William R. Hesse et al. BIOPHYSICAL JOURNAL
- Structure of a kinesin–tubulin complex and implications for kinesin motility
- (2013) Benoît Gigant et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Recycling of Kinesin-1 Motors by Diffusion after Transport
- (2013) T. Lynne Blasius et al. PLoS One
- Mapping the Structural and Dynamical Features of Kinesin Motor Domains
- (2013) Guido Scarabelli et al. PLoS Computational Biology
- Kif18A Uses a Microtubule Binding Site in the Tail for Plus-End Localization and Spindle Length Regulation
- (2011) Lesley N. Weaver et al. CURRENT BIOLOGY
- A universal pathway for kinesin stepping
- (2011) Bason E Clancy et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Interhead tension determines processivity across diverse N-terminal kinesins
- (2011) S. Shastry et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Probing Intracellular Motor Protein Activity Using an Inducible Cargo Trafficking Assay
- (2010) Lukas C. Kapitein et al. BIOPHYSICAL JOURNAL
- Motor Proteins: Kinesin Drives with an Underhead Cam
- (2010) Matthew J. Lang et al. CURRENT BIOLOGY
- Neck Linker Length Determines the Degree of Processivity in Kinesin-1 and Kinesin-2 Motors
- (2010) Shankar Shastry et al. CURRENT BIOLOGY
- Kinesin-73 Is a Processive Motor That Localizes to Rab5-containing Organelles
- (2010) Thomas M. Huckaba et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An atomic-level mechanism for activation of the kinesin molecular motors
- (2010) C. V. Sindelar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanism of membrane nanotube formation by molecular motors
- (2009) Cécile Leduc et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Insights into the Mechanical Properties of the Kinesin Neck Linker Domain from Sequence Analysis and Molecular Dynamics Simulations
- (2009) Venkatesh Hariharan et al. Cellular and Molecular Bioengineering
- The Processivity of Kinesin-2 Motors Suggests Diminished Front-Head Gating
- (2009) Gayatri Muthukrishnan et al. CURRENT BIOLOGY
- ATP Hydrolysis in Eg5 Kinesin Involves a Catalytic Two-water Mechanism
- (2009) Courtney L. Parke et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Traffic control: regulation of kinesin motors
- (2009) Kristen J. Verhey et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Kinesin superfamily motor proteins and intracellular transport
- (2009) Nobutaka Hirokawa et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Molecular motors and the Golgi complex: Staying put and moving through
- (2009) Kim Brownhill et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Intramolecular Strain Coordinates Kinesin Stepping Behavior along Microtubules
- (2008) Ahmet Yildiz et al. CELL
- Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin
- (2008) Ryo Nitta et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Kinesin's cover-neck bundle folds forward to generate force
- (2008) A. S. Khalil et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Very fast prediction and rationalization of pKa values for protein-ligand complexes
- (2008) Delphine C. Bas et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Force Generation in Kinesin Hinges on Cover-Neck Bundle Formation
- (2008) Wonmuk Hwang et al. STRUCTURE
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