Toxoplasma gondii Modulates the Host Cell Responses: An Overview of Apoptosis Pathways

The Toxoplasma gondii ME-49 strain upregulates levels of A20 that inhibit NF-κB activation and promotes apoptosis in human leukaemia T-cell lines

(2018) Qian Chen et al.   Parasites & Vectors

Encephalitis is mediated by ROP18 ofToxoplasma gondii, a severe pathogen in AIDS patients

(2018) Ran An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxoplasma Chinese 1 Strain of WH3Δrop16I/III/gra15II Genetic Background Contributes to Abnormal Pregnant Outcomes in Murine Model

(2018) Cong Wang et al.   Frontiers in Immunology

IL-12 and IL-23 Production in Toxoplasma gondii- or LPS Treated Jurkat T Cells via PI3K and MAPK Signaling Pathways

(2017) Hassan Ahmed Hassan Ahmed Ismail et al.   KOREAN JOURNAL OF PARASITOLOGY

Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist

(2017) Erika Pellegrini et al.   STRUCTURE

NADPH oxidase 4 is required for the generation of macrophage migration inhibitory factor and host defense against Toxoplasma gondii infection

(2017) Ji Hye Kim et al.   Scientific Reports

Transcriptional profile of SH-SY5Y human neuroblastoma cells transfected by Toxoplasma rhoptry protein 16

(2016) Weiwei Fan et al.   Molecular Medicine Reports

Nitric oxide production increases during Toxoplasma gondii encephalitis in mice

(2015) Gungor Cagdas Dincel et al.   EXPERIMENTAL PARASITOLOGY

Toxoplasma gondii GRA7-Induced TRAF6 Activation Contributes to Host Protective Immunity

(2015) Chul-Su Yang et al.   INFECTION AND IMMUNITY

The IL-12 Response of Primary Human Dendritic Cells and Monocytes toToxoplasma gondiiIs Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion

(2015) Kevin W. Tosh et al.   JOURNAL OF IMMUNOLOGY

Increased expressions of ADAMTS-13 and apoptosis contribute to neuropathology duringToxoplasma gondiiencephalitis in mice

(2015) Gungor Cagdas Dincel et al.   NEUROPATHOLOGY

Deletion of mitogen-activated protein kinase 1 inhibits development and growth of Toxoplasma gondii

(2015) Lili Cao et al.   PARASITOLOGY RESEARCH

Intracellular Networks of the PI3K/AKT and MAPK Pathways for Regulating Toxoplasma gondii-Induced IL-23 and IL-12 Production in Human THP-1 Cells

(2015) Juan-Hua Quan et al.   PLoS One

Intravacuolar Membranes Regulate CD8 T Cell Recognition of Membrane-Bound Toxoplasma gondii Protective Antigen

(2015) Jodie Lopez et al.   Cell Reports

Toxoplasma gondii inhibits apoptosis via a novel STAT3-miR-17–92-Bim pathway in macrophages

(2014) Yihong Cai et al.   CELLULAR SIGNALLING

Infection by Toxoplasma gondii Specifically Induces Host c-Myc and the Genes This Pivotal Transcription Factor Regulates

(2014) Magdalena Franco et al.   EUKARYOTIC CELL

Toxoplasma gondiiVirulence Factor ROP18 Inhibits the Host NF-κB Pathway by Promoting p65 Degradation

(2014) Jian Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxoplasma gondii induce apoptosis of neural stem cells via endoplasmic reticulum stress pathway

(2014) TENG WANG et al.   PARASITOLOGY

Host Cell Subversion by Toxoplasma GRA16, an Exported Dense Granule Protein that Targets the Host Cell Nucleus and Alters Gene Expression

(2013) Alexandre Bougdour et al.   Cell Host & Microbe

Involvement of PI 3 kinase/Akt-dependent Bad phosphorylation in Toxoplasma gondii-mediated inhibition of host cell apoptosis

(2013) Juan-Hua Quan et al.   EXPERIMENTAL PARASITOLOGY

Toxoplasma gondii invasion and replication within neonate mouse astrocytes and changes in apoptosis related molecules

(2013) Carla O. Contreras-Ochoa et al.   EXPERIMENTAL PARASITOLOGY

TgMAPK1 is a Toxoplasma gondii MAP kinase that hijacks host MKK3 signals to regulate virulence and interferon-γ-mediated nitric oxide production

(2013) Michael J. Brumlik et al.   EXPERIMENTAL PARASITOLOGY

Toxoplasma gondii Rhoptry 16 Kinase Promotes Host Resistance to Oral Infection and Intestinal Inflammation Only in the Context of the Dense Granule Protein GRA15

(2013) Kirk D. C. Jensen et al.   INFECTION AND IMMUNITY

The RASSF6 Tumor Suppressor Protein Regulates Apoptosis and the Cell Cycle via MDM2 Protein and p53 Protein

(2013) Hiroaki Iwasa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AToxoplasmadense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

(2013) Laurence Braun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential apoptosis in BeWo cells after infection with highly (RH) or moderately (ME49) virulent strains of Toxoplasma gondii is related to the cytokine profile secreted, the death receptor Fas expression and phosphorylated ERK1/2 expression

(2013) M.B. Angeloni et al.   PLACENTA

Toxoplasma gondii Proliferation Require Down-Regulation of Host Nox4 Expression via Activation of PI3 Kinase/Akt Signaling Pathway

(2013) Wei Zhou et al.   PLoS One

c-IAP1 and c-IAP2 Redundancy Differs between T and B Cells

(2013) Maria Letizia Giardino Torchia et al.   PLoS One

Evidence for Finely-Regulated Asynchronous Growth of Toxoplasma gondii Cysts Based on Data-Driven Model Selection

(2013) Adam M. Sullivan et al.   PLoS Computational Biology

Neuronal gp130 Expression Is Crucial to Prevent Neuronal Loss, Hyperinflammation, and Lethal Course of Murine Toxoplasma Encephalitis

(2012) Ulrike Händel et al.   AMERICAN JOURNAL OF PATHOLOGY

Analysis of Protein Palmitoylation Reveals a Pervasive Role in Plasmodium Development and Pathogenesis

(2012) Matthew L. Jones et al.   Cell Host & Microbe

Toxoplasma gondii: Effects of exogenous nitric oxide on egress of tachyzoites from infected macrophages

(2012) Yong-sheng Ji et al.   EXPERIMENTAL PARASITOLOGY

NK Cell-Derived Interferon-γ Orchestrates Cellular Dynamics and the Differentiation of Monocytes into Dendritic Cells at the Site of Infection

(2012) Romina S. Goldszmid et al.   IMMUNITY

Reactive Oxygen Species-Triggered Trophoblast Apoptosis Is Initiated by Endoplasmic Reticulum Stress via Activation of Caspase-12, CHOP, and the JNK Pathway in Toxoplasma gondii Infection in Mice

(2012) Xiucai Xu et al.   INFECTION AND IMMUNITY

Modulation of innate immunity by Toxoplasma gondii virulence effectors

(2012) Christopher A. Hunter et al.   NATURE REVIEWS MICROBIOLOGY

The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii

(2011) Jonathan C Howard et al.   CURRENT OPINION IN MICROBIOLOGY

Invasion and intracellular survival by protozoan parasites

(2011) L. David Sibley   IMMUNOLOGICAL REVIEWS

Toxoplasma gondii Induces B7-2 Expression through Activation of JNK Signal Transduction

(2011) Pedro Morgado et al.   INFECTION AND IMMUNITY

Toxoplasma gondii inhibits granzyme B-mediated apoptosis by the inhibition of granzyme B function in host cells

(2011) Tatsuya Yamada et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Strain-specific activation of the NF-κB pathway by GRA15, a novelToxoplasma gondiidense granule protein

(2011) Emily E. Rosowski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toxoplasma gondii Rhoptry Kinase ROP16 Activates STAT3 and STAT6 Resulting in Cytokine Inhibition and Arginase-1-Dependent Growth Control

(2011) Barbara A. Butcher et al.   PLoS Pathogens

ToxoplasmaRhoptry Protein 16 (ROP16) Subverts Host Function by Direct Tyrosine Phosphorylation of STAT6

(2010) Yi-Ching Ong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxoplasma gondii infection inhibits the mitochondrial apoptosis through induction of Bcl-2 and HSP70

(2010) Il-Young Hwang et al.   PARASITOLOGY RESEARCH

Externally Triggered Egress Is the Major Fate of Toxoplasma gondii during Acute Infection

(2009) T. Tomita et al.   JOURNAL OF IMMUNOLOGY

STAT6 activation by Toxoplasma gondii infection induces the expression of Th2 C-C chemokine ligands and B clade serine protease inhibitors in macrophage

(2009) Hye-Jin Ahn et al.   PARASITOLOGY RESEARCH

GAP45 Phosphorylation Controls Assembly of theToxoplasmaMyosin XIV Complex

(2008) Stacey D. Gilk et al.   EUKARYOTIC CELL

The complexity of signaling in host–pathogen interactions revealed by the Toxoplasma gondii-dependent modulation of JNK phosphorylation

(2008) John C. Carmen et al.   EXPERIMENTAL CELL RESEARCH

The Gamma Interferon (IFN- )-Inducible GTP-Binding Protein IGTP Is Necessary for Toxoplasma Vacuolar Disruption and Induces Parasite Egression in IFN- -Stimulated Astrocytes

(2008) T. Melzer et al.   INFECTION AND IMMUNITY

Transient inhibition of poly(ADP-ribose) polymerase expression and activity by Toxoplasma gondii is dispensable for parasite-mediated blockade of host cell apoptosis and intracellular parasite replication

(2008) Andrea Gais et al.   MICROBES AND INFECTION

Apicomplexa in Mammalian Cells: Trafficking to the Parasitophorous Vacuole

(2008) Marie-France Cesbron-Delauw et al.   TRAFFIC