Nonsense‐mediated mRNA decay: The challenge of telling right from wrong in a complex transcriptome

System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection

(2019) Manuel Garcia-Moreno et al.   MOLECULAR CELL

New insights into the interplay between the translation machinery and nonsense-mediated mRNA decay factors

(2018) Etienne Raimondeau et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner

(2018) Manjeera Gowravaram et al.   NUCLEIC ACIDS RESEARCH

Dissecting the functions of SMG5, SMG7, and PNRC2 in nonsense-mediated mRNA decay of human cells

(2018) Pamela Nicholson et al.   RNA

HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition

(2018) Francesca Fiorini et al.   Nature Communications

Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1

(2018) Isabel Aznarez et al.   Cell Reports

The evolution of posttranscriptional regulation

(2018) Bernhard Schaefke et al.   Wiley Interdisciplinary Reviews-RNA

ICE1 promotes the link between splicing and nonsense-mediated mRNA decay

(2018) Thomas D Baird et al.   eLife

UPF1-like helicase grip on nucleic acids dictates processivity

(2018) Joanne Kanaan et al.   Nature Communications

Nonsense‐mediated mRNA decay involves two distinct Upf1‐bound complexes

(2018) Marine Dehecq et al.   EMBO JOURNAL

hnRNP L‐dependent protection of normal mRNAs from NMD subverts quality control in B cell lymphoma

(2018) Aparna Kishor et al.   EMBO JOURNAL

Nonsense-mediated RNA decay in the brain: emerging modulator of neural development and disease

(2018) Samie R. Jaffrey et al.   NATURE REVIEWS NEUROSCIENCE

Interplay between coronavirus, a cytoplasmic RNA virus, and nonsense-mediated mRNA decay pathway

(2018) Masami Wada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein

(2018) Krystal A. Fontaine et al.   mBio

The Exon Junction Complex Undergoes a Compositional Switch that Alters mRNP Structure and Nonsense-Mediated mRNA Decay Activity

(2018) Justin W. Mabin et al.   Cell Reports

RNA virus evasion of nonsense-mediated decay

(2018) Jared P. May et al.   PLoS Pathogens

Directed hydroxyl radical probing reveals Upf1 binding to the 80S ribosomal E site rRNA at the L1 stalk

(2017) Anthony P Schuller et al.   NUCLEIC ACIDS RESEARCH

A system for coordinated analysis of translational readthrough and nonsense-mediated mRNA decay

(2017) Stacey L. Baker et al.   PLoS One

Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates

(2017) Franziska Ottens et al.   RNA

High-resolution profiling of NMD targets in yeast reveals translational fidelity as a basis for substrate selection

(2017) Alper Celik et al.   RNA

Conservation of Nonsense-Mediated mRNA Decay Complex Components Throughout Eukaryotic Evolution

(2017) Barry Causier et al.   Scientific Reports

Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer

(2016) Xiaomin Zhong et al.   MOLECULAR AND CELLULAR BIOLOGY

Resources for the Comprehensive Discovery of Functional RNA Elements

(2016) Balaji Sundararaman et al.   MOLECULAR CELL

Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex

(2016) Andrés López-Perrote et al.   NUCLEIC ACIDS RESEARCH

Evolution and Biological Roles of Alternative 3′UTRs

(2016) Christine Mayr   TRENDS IN CELL BIOLOGY

Structural basis of suppression of host translation termination by Moloney Murine Leukemia Virus

(2016) Xuhua Tang et al.   Nature Communications

Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences

(2016) Volker Boehm et al.   Nature Communications

Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay

(2016) Sébastien Durand et al.   Nature Communications

ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons

(2016) Lucas D. Serdar et al.   Nature Communications

Exon Junction Complexes Show a Distributional Bias toward Alternatively Spliced mRNAs and against mRNAs Coding for Ribosomal Proteins

(2016) Christian Hauer et al.   Cell Reports

Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability

(2016) Jonathan O Nelson et al.   eLife

Single molecule analysis reveals reversible and irreversible steps during spliceosome activation

(2016) Aaron A Hoskins et al.   eLife

The Arabidopsis NMD Factor UPF3 Is Feedback-Regulated at Multiple Levels and Plays a Role in Plant Response to Salt Stress

(2016) Karina Vexler et al.   Frontiers in Plant Science

The Clothes Make the mRNA: Past and Present Trends in mRNP Fashion

(2015) Guramrit Singh et al.   Annual Review of Biochemistry

Nonsense-mediated RNA decay - a switch and dial for regulating gene expression

(2015) Jenna E. Smith et al.   BIOESSAYS

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

(2015) Takashi Mino et al.   CELL

The unfolded protein response is shaped by the NMD pathway

(2015) R. Karam et al.   EMBO REPORTS

MicroRNA-181c targets Bcl-2 and regulates mitochondrial morphology in myocardial cells

(2015) Hongjiang Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Signature of the Five-Stranded vRRM Fold Defined by Functional, Structural and Computational Analysis of the hnRNP L Protein

(2015) Markus Blatter et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of Splicing Factors by Alternative Splicing and NMD Is Conserved between Kingdoms Yet Evolutionarily Flexible

(2015) Liana F. Lareau et al.   MOLECULAR BIOLOGY AND EVOLUTION

Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity

(2015) Suzanne R. Lee et al.   MOLECULAR CELL

The exon junction complex as a node of post-transcriptional networks

(2015) Hervé Le Hir et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The feedback control of UPF3 is crucial for RNA surveillance in plants

(2015) Evgeniya Degtiar et al.   NUCLEIC ACIDS RESEARCH

Control of mRNA decapping by positive and negative regulatory elements in the Dcp2 C-terminal domain

(2015) Feng He et al.   RNA

Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities

(2015) Francesca Fiorini et al.   Nature Communications

Emerging functions of alternative splicing coupled with nonsense-mediated decay

(2014) Fursham M. Hamid et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Host Nonsense-Mediated mRNA Decay Pathway Restricts Mammalian RNA Virus Replication

(2014) Giuseppe Balistreri et al.   Cell Host & Microbe

A post-translational regulatory switch on UPF1 controls targeted mRNA degradation

(2014) Tatsuaki Kurosaki et al.   GENES & DEVELOPMENT

Downregulation of miR-23a and miR-27a following Experimental Traumatic Brain Injury Induces Neuronal Cell Death through Activation of Proapoptotic Bcl-2 Proteins

(2014) B. Sabirzhanov et al.   JOURNAL OF NEUROSCIENCE

Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway

(2014) Ashton Trey Belew et al.   NATURE

A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD

(2014) Pamela Nicholson et al.   NUCLEIC ACIDS RESEARCH

Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6

(2014) Sutapa Chakrabarti et al.   NUCLEIC ACIDS RESEARCH

Interaction between the poly(A)-binding protein Pab1 and the eukaryotic release factor eRF3 regulates translation termination but not mRNA decay inSaccharomyces cerevisiae

(2014) Sylvain Roque et al.   RNA

MicroRNA-181 functions as a tumor suppressor in non-small cell lung cancer (NSCLC) by targeting Bcl-2

(2014) Ping Huang et al.   TUMOR BIOLOGY

3′ UTR Length and Messenger Ribonucleoprotein Composition Determine Endocleavage Efficiencies at Termination Codons

(2014) Volker Boehm et al.   Cell Reports

In Vivo Determination of Direct Targets of the Nonsense-Mediated Decay Pathway in Drosophila

(2014) Alex Chapin et al.   G3-Genes Genomes Genetics

Organizing Principles of Mammalian Nonsense-Mediated mRNA Decay

(2013) Maximilian Wei-Lin Popp et al.   Annual Review of Genetics

The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2

(2013) B. Loh et al.   GENES & DEVELOPMENT

Global analyses of UPF1 binding and function reveal expanded scope of nonsense-mediated mRNA decay

(2013) J. A. Hurt et al.   GENOME RESEARCH

Eukaryotic Release Factor 3 Is Required for Multiple Turnovers of Peptide Release Catalysis by Eukaryotic Release Factor 1

(2013) Daniel E. Eyler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB-mediated miR-30b regulation in cardiomyocytes cell death by targeting Bcl-2

(2013) Chuanyu Wei et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3′ UTRs

(2013) David Zünd et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rules that govern UPF1 binding to mRNA 3′ UTRs

(2013) Tatsuaki Kurosaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways

(2013) S. Metze et al.   RNA

Testing the faux-UTR model for NMD: Analysis of Upf1p and Pab1p competition for binding to eRF3/Sup35p

(2012) Stephanie Kervestin et al.   BIOCHIMIE

Introns in UTRs: Why we should stop ignoring them

(2012) Alicia A. Bicknell et al.   BIOESSAYS

Exome sequencing identifiesUPF3Bas the causative gene for a Chinese non-syndrome mental retardation pedigree

(2012) X Xu et al.   CLINICAL GENETICS

Broadening the phenotype associated with mutations in UPF3B: Two further cases with renal dysplasia and variable developmental delay

(2012) Sally Ann Lynch et al.   European Journal of Medical Genetics

The cryo-EM structure of the UPF–EJC complex shows UPF1 poised toward the RNA 3′ end

(2012) Roberto Melero et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of hundreds of novel UPF1 target transcripts by direct determination of whole transcriptome stability

(2012) Hidenori Tani et al.   RNA Biology

Pathology, pathogenesis and molecular genetics of follicular NHL

(2011) E. Leich et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

This message was inspected by Upf1: 3’UTR length sensing in mRNA quality control

(2011) J. Robert Hogg   CELL CYCLE

Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes

(2011) Vera P Pisareva et al.   EMBO JOURNAL

BCL2 mutations in diffuse large B-cell lymphoma

(2011) J M Schuetz et al.   LEUKEMIA

miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes

(2011) Yi-Bing Ouyang et al.   MITOCHONDRION

Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and Its Regulation by Upf2

(2011) Sutapa Chakrabarti et al.   MOLECULAR CELL

RNA Homeostasis Governed by Cell Type-Specific and Branched Feedback Loops Acting on NMD

(2011) Lulu Huang et al.   MOLECULAR CELL

Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish

(2011) Corina Anastasaki et al.   NUCLEIC ACIDS RESEARCH

Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations

(2011) I. Peixeiro et al.   NUCLEIC ACIDS RESEARCH

Interactions between Upf1 and the Decapping Factors Edc3 and Pat1 in Saccharomyces cerevisiae

(2011) Kylie D. Swisher et al.   PLoS One

Kinetic analysis reveals the ordered coupling of translation termination and ribosome recycling in yeast

(2011) C. J. Shoemaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A nonconservative amino acid change in the UPF3B gene in a patient with schizophrenia

(2011) Paulina Szyszka et al.   PSYCHIATRIC GENETICS

Autoregulation of the nonsense-mediated mRNA decay pathway in human cells

(2011) H. Yepiskoposyan et al.   RNA

Ordered and Dynamic Assembly of Single Spliceosomes

(2011) A. A. Hoskins et al.   SCIENCE

mRNP quality control goes regulatory

(2011) Oliver Mühlemann et al.   TRENDS IN GENETICS

The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia

(2010) Ulf Klein et al.   CANCER CELL

Upf1 ATPase-Dependent mRNP Disassembly Is Required for Completion of Nonsense- Mediated mRNA Decay

(2010) Tobias M. Franks et al.   CELL

Upf1 Senses 3′UTR Length to Potentiate mRNA Decay

(2010) J. Robert Hogg et al.   CELL

SF1 and SF2 helicases: family matters

(2010) Margaret E Fairman-Williams et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Nonsense-mediated mRNA decay maintains translational fidelity by limiting magnesium uptake

(2010) M. J. O. Johansson et al.   GENES & DEVELOPMENT

Nonsense-Mediated RNA Decay Regulation by Cellular Stress: Implications for Tumorigenesis

(2010) L. B. Gardner   MOLECULAR CANCER RESEARCH

UPF1 Association with the Cap-Binding Protein, CBP80, Promotes Nonsense-Mediated mRNA Decay at Two Distinct Steps

(2010) Jungwook Hwang et al.   MOLECULAR CELL

The Role of ABCE1 in Eukaryotic Posttermination Ribosomal Recycling

(2010) Andrey V. Pisarev et al.   MOLECULAR CELL

A novel frameshift mutation in UPF3B identified in brothers affected with childhood onset schizophrenia and autism spectrum disorders

(2010) A M Addington et al.   MOLECULAR PSYCHIATRY

Endogenous ribosomal frameshift signals operate as mRNA destabilizing elements through at least two molecular pathways in yeast

(2010) Ashton T. Belew et al.   NUCLEIC ACIDS RESEARCH

Large-Scale Evidence for Conservation of NMD Candidature Across Mammals

(2010) David A. de Lima Morais et al.   PLoS One

Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.

(2010) G. Buchwald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay

(2010) D. R. McIlwain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

hnRNP L binds to CA repeats in the 3′UTR of bcl-2 mRNA

(2009) Dong-Hyoung Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Disassembly of Exon Junction Complexes by PYM

(2009) Niels H. Gehring et al.   CELL

Execution of nonsense-mediated mRNA decay: what defines a substrate?

(2009) Indrani Rebbapragada et al.   CURRENT OPINION IN CELL BIOLOGY

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

(2009) Marcello Clerici et al.   EMBO JOURNAL

Inhibition of Nonsense-mediated mRNA Decay by the Natural Product Pateamine A through Eukaryotic Initiation Factor 4AIII

(2009) Yongjun Dang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonsense-Mediated mRNA Decay Effectors Are Essential for Zebrafish Embryonic Development and Survival

(2009) N. Wittkopp et al.   MOLECULAR AND CELLULAR BIOLOGY

Human Proline-Rich Nuclear Receptor Coregulatory Protein 2 Mediates an Interaction between mRNA Surveillance Machinery and Decapping Complex

(2009) Hana Cho et al.   MOLECULAR CELL

Mutations of the UPF3B gene, which encodes a protein widely expressed in neurons, are associated with nonspecific mental retardation with or without autism

(2009) F Laumonnier et al.   MOLECULAR PSYCHIATRY

The Hierarchy of Exon-Junction Complex Assembly by the Spliceosome Explains Key Features of Mammalian Nonsense-Mediated mRNA Decay

(2009) Niels H. Gehring et al.   PLOS BIOLOGY

Upf1 Phosphorylation Triggers Translational Repression during Nonsense-Mediated mRNA Decay

(2008) Olaf Isken et al.   CELL

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

(2008) Pavel V Ivanov et al.   EMBO JOURNAL

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

(2008) J. Weischenfeldt et al.   GENES & DEVELOPMENT

Hypoxic Inhibition of Nonsense-Mediated RNA Decay Regulates Gene Expression and the Integrated Stress Response

(2008) L. B. Gardner   MOLECULAR AND CELLULAR BIOLOGY

Nonsense-Mediated mRNA Decay in Yeast Does Not Require PAB1 or a Poly(A) Tail

(2008) Stacie Meaux et al.   MOLECULAR CELL

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

(2008) Andrea B Eberle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

(2008) E. Huntzinger et al.   RNA

Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense?

(2008) Nicholas J. McGlincy et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Competition between Stimulators and Antagonists of Upf Complex Recruitment Governs Human Nonsense-Mediated mRNA Decay

(2008) Guramrit Singh et al.   PLOS BIOLOGY

Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3′ Untranslated Region

(2008) Andrea B Eberle et al.   PLOS BIOLOGY