A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD

Revealing transient structures of nucleosomes as DNA unwinds

(2014) Yujie Chen et al.   NUCLEIC ACIDS RESEARCH

The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2

(2013) B. Loh et al.   GENES & DEVELOPMENT

Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay

(2013) Akio Yamashita   GENES TO CELLS

Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1

(2013) Clarivel Lasalde et al.   NUCLEIC ACIDS RESEARCH

Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways

(2013) S. Metze et al.   RNA

The Cellular EJC Interactome Reveals Higher-Order mRNP Structure and an EJC-SR Protein Nexus

(2012) Guramrit Singh et al.   CELL

Long-Range Interactions in Nonsense-Mediated mRNA Decay Are Mediated by Intrinsically Disordered Protein Regions

(2012) Lajos Kalmar et al.   JOURNAL OF MOLECULAR BIOLOGY

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

(2012) Susanne A.I. Seidel et al.   METHODS

CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex

(2012) Jérôme Saulière et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains

(2012) Francesca Fiorini et al.   NUCLEIC ACIDS RESEARCH

SMG5–PNRC2 is functionally dominant compared with SMG5–SMG7 in mammalian nonsense-mediated mRNA decay

(2012) Hana Cho et al.   NUCLEIC ACIDS RESEARCH

Molecular Interaction Studies Using Microscale Thermophoresis

(2011) Moran Jerabek-Willemsen et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8

(2011) E. Arias-Palomo et al.   GENES & DEVELOPMENT

Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and Its Regulation by Upf2

(2011) Sutapa Chakrabarti et al.   MOLECULAR CELL

Thermophoretic melting curves quantify the conformation and stability of RNA and DNA

(2011) C. J. Wienken et al.   NUCLEIC ACIDS RESEARCH

N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD

(2011) Yukiko Okada-Katsuhata et al.   NUCLEIC ACIDS RESEARCH

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Autoregulation of the nonsense-mediated mRNA decay pathway in human cells

(2011) H. Yepiskoposyan et al.   RNA

Mechanisms of endonuclease-mediated mRNA decay

(2011) Daniel R. Schoenberg   Wiley Interdisciplinary Reviews-RNA

Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases

(2011) Kim M. Keeling et al.   Wiley Interdisciplinary Reviews-RNA

Cutting the nonsense: the degradation of PTC-containing mRNAs

(2010) Pamela Nicholson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

(2010) I. Kashima et al.   GENES & DEVELOPMENT

Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex

(2010) Israel S. Fernández et al.   NUCLEIC ACIDS RESEARCH

AAA+ Proteins RUVBL1 and RUVBL2 Coordinate PIKK Activity and Function in Nonsense-Mediated mRNA Decay

(2010) N. Izumi et al.   Science Signaling

The telomeric transcriptome and SMG proteins at the crossroads

(2009) R. Chawla et al.   CYTOGENETIC AND GENOME RESEARCH

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

(2009) Marcello Clerici et al.   EMBO JOURNAL

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

(2009) A. Yamashita et al.   GENES & DEVELOPMENT

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

(2008) Pavel V Ivanov et al.   EMBO JOURNAL

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

(2008) Andrea B Eberle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay

(2008) A. L. Silva et al.   RNA

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

(2008) E. Huntzinger et al.   RNA

A Competition between Stimulators and Antagonists of Upf Complex Recruitment Governs Human Nonsense-Mediated mRNA Decay

(2008) Guramrit Singh et al.   PLOS BIOLOGY

Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3′ Untranslated Region

(2008) Andrea B Eberle et al.   PLOS BIOLOGY