Unmasking cellular response of a bloom-forming alga to viral infection by resolving expression profiles at a single-cell level

Single-cell transcriptional dynamics of flavivirus infection

(2018) Fabio Zanini et al.   eLife

Extreme heterogeneity of influenza virus infection in single cells

(2018) Alistair B Russell et al.   eLife

Tissue dual RNA-seq allows fast discovery of infection-specific functions and riboregulators shaping host–pathogen transcriptomes

(2017) Aaron M. Nuss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell Virology: On-Chip Investigation of Viral Infection Dynamics

(2017) Feng Guo et al.   Cell Reports

Morphological switch to a resistant subpopulation in response to viral infection in the bloom-forming coccolithophore Emiliania huxleyi

(2017) Miguel José Frada et al.   PLoS Pathogens

Resolving host–pathogen interactions by dual RNA-seq

(2017) Alexander J. Westermann et al.   PLoS Pathogens

Communication via extracellular vesicles enhances viral infection of a cosmopolitan alga

(2017) Daniella Schatz et al.   Nature Microbiology

Tunable Single-Cell Extraction for Molecular Analyses

(2016) Orane Guillaume-Gentil et al.   CELL

Root Regeneration Triggers an Embryo-like Sequence Guided by Hormonal Interactions

(2016) Idan Efroni et al.   CELL

Modulation of host ROS metabolism is essential for viral infection of a bloom-forming coccolithophore in the ocean

(2016) Uri Sheyn et al.   ISME Journal

Viral infection of the marine alga Emiliania huxleyi triggers lipidome remodeling and induces the production of highly saturated triacylglycerol

(2016) Sergey Malitsky et al.   NEW PHYTOLOGIST

Viral serine palmitoyltransferase induces metabolic switch in sphingolipid biosynthesis and is required for infection of a marine alga

(2016) Carmit Ziv et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virocell Metabolism: Metabolic Innovations During Host–Virus Interactions in the Ocean

(2016) Shilo Rosenwasser et al.   TRENDS IN MICROBIOLOGY

A Viral Immunity Chromosome in the Marine Picoeukaryote, Ostreococcus tauri

(2016) Sheree Yau et al.   PLoS Pathogens

Gene Expression Correlates with the Number of Herpes Viral Genomes Initiating Infection in Single Cells

(2016) Efrat M. Cohen et al.   PLoS Pathogens

Single-cell RNA-seq ties macrophage polarization to growth rate of intracellular Salmonella

(2016) Antoine-Emmanuel Saliba et al.   Nature Microbiology

Phenotypic heterogeneity driven by nutrient limitation promotes growth in fluctuating environments

(2016) Frank Schreiber et al.   Nature Microbiology

Characterization of the Small RNA Transcriptome of the Marine Coccolithophorid, Emiliania huxleyi

(2016) Xiaoyu Zhang et al.   PLoS One

Organic and Inorganic Nitrogen Impact Chlorella variabilis Productivity and Host Quality for Viral Production and Cell Lysis

(2015) Yu-Shen Cheng et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses

(2015) Roi Avraham et al.   CELL

A multitrophic model to quantify the effects of marine viruses on microbial food webs and ecosystem processes

(2015) Joshua S Weitz et al.   ISME Journal

Phenotypic diversity of diploid and haploid Emiliania huxleyi cells and of cells in different growth phases revealed by comparative metabolomics

(2015) Michaela A. Mausz et al.   JOURNAL OF PLANT PHYSIOLOGY

Single-cell messenger RNA sequencing reveals rare intestinal cell types

(2015) Dominic Grün et al.   NATURE

A functional perspective on phenotypic heterogeneity in microorganisms

(2015) Martin Ackermann   NATURE REVIEWS MICROBIOLOGY

Identification of the algal dimethyl sulfide-releasing enzyme: A missing link in the marine sulfur cycle

(2015) U. Alcolombri et al.   SCIENCE

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Single-cell analysis shows that paracrine signaling by first responder cells shapes the interferon-β response to viral infection

(2015) Sonali Patil et al.   Science Signaling

Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infection

(2015) Frank S. Heldt et al.   Nature Communications

Single-cell analysis shows that paracrine signaling by first responder cells shapes the interferon-β response to viral infection

(2015) Sonali Patil et al.   Science Signaling

Elevated CO2and Phosphate Limitation Favor Micromonas pusilla through Stimulated Growth and Reduced Viral Impact

(2014) Douwe S. Maat et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Improving transcriptome construction in non-model organisms: integrating manual and automated gene definition in Emiliania huxleyi

(2014) Ester Feldmesser et al.   BMC GENOMICS

Decoupling Physical from Biological Processes to Assess the Impact of Viruses on a Mesoscale Algal Bloom

(2014) Yoav Lehahn et al.   CURRENT BIOLOGY

Dual analysis of host and pathogen transcriptomes in ostreid herpesvirus 1-positiveCrassostrea gigas

(2014) U. Rosani et al.   ENVIRONMENTAL MICROBIOLOGY

Single-cell RNA-seq reveals dynamic paracrine control of cellular variation

(2014) Alex K. Shalek et al.   NATURE

Hijacking of an autophagy-like process is critical for the life cycle of a DNA virus infecting oceanic algal blooms

(2014) Daniella Schatz et al.   NEW PHYTOLOGIST

Rewiring Host Lipid Metabolism by Large Viruses Determines the Fate of Emiliania huxleyi, a Bloom-Forming Alga in the Ocean

(2014) S. Rosenwasser et al.   PLANT CELL

Single-Cell Genomics Reveals Hundreds of Coexisting Subpopulations in Wild Prochlorococcus

(2014) N. Kashtan et al.   SCIENCE

Comparative metagenomic analyses reveal viral-induced shifts of host metabolism towards nucleotide biosynthesis

(2014) Hagay Enav et al.   Microbiome

“Megavirales”, a proposed new order for eukaryotic nucleocytoplasmic large DNA viruses

(2013) Philippe Colson et al.   ARCHIVES OF VIROLOGY

Phage infection of an environmentally relevant marine bacterium alters host metabolism and lysate composition

(2013) Nana Yaw D Ankrah et al.   ISME Journal

Pan genome of the phytoplankton Emiliania underpins its global distribution

(2013) Betsy A. Read et al.   NATURE

Quantitative assessment of single-cell RNA-sequencing methods

(2013) Angela R Wu et al.   NATURE METHODS

Metabolic reprogramming by viruses in the sunlit and dark ocean

(2013) Bonnie L Hurwitz et al.   GENOME BIOLOGY

Data exploration, quality control and testing in single-cell qPCR-based gene expression experiments

(2012) Andrew McDavid et al.   BIOINFORMATICS

Dual RNA-seq of pathogen and host

(2012) Alexander J. Westermann et al.   NATURE REVIEWS MICROBIOLOGY

Host-virus dynamics and subcellular controls of cell fate in a natural coccolithophore population

(2012) A. Vardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CEL-Seq: Single-Cell RNA-Seq by Multiplexed Linear Amplification

(2012) Tamar Hashimshony et al.   Cell Reports

A chemical arms race at sea mediates algal host–virus interactions

(2011) Kay D Bidle et al.   CURRENT OPINION IN MICROBIOLOGY

Phage auxiliary metabolic genes and the redirection of cyanobacterial host carbon metabolism

(2011) L. R. Thompson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell Genomics Reveals Organismal Interactions in Uncultivated Marine Protists

(2011) H. S. Yoon et al.   SCIENCE

A unicellular algal virus, Emiliania huxleyi virus 86, exploits an animal-like infection strategy

(2009) L. C. M. Mackinder et al.   JOURNAL OF GENERAL VIROLOGY

Population context determines cell-to-cell variability in endocytosis and virus infection

(2009) Berend Snijder et al.   NATURE

mRNA-Seq whole-transcriptome analysis of a single cell

(2009) Fuchou Tang et al.   NATURE METHODS

Viral Glycosphingolipids Induce Lytic Infection and Cell Death in Marine Phytoplankton

(2009) A. Vardi et al.   SCIENCE

The "Cheshire Cat" escape strategy of the coccolithophore Emiliania huxleyi in response to viral infection

(2008) M. Frada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phytoplankton Calcification in a High-CO2 World

(2008) M. D. Iglesias-Rodriguez et al.   SCIENCE