Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival

Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth

(2017) Chiara Di Malta et al.   SCIENCE

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

(2017) Brian M. Castellano et al.   SCIENCE

Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C. elegans

(2017) Eva Bang Harvald et al.   Cell Systems

Brain Disorders Due to Lysosomal Dysfunction

(2016) Alessandro Fraldi et al.   Annual Review of Neuroscience

Autophagy-mediated longevity is modulated by lipoprotein biogenesis

(2015) Nicole E. Seah et al.   Autophagy

Unsaturated fatty acids induce non-canonical autophagy

(2015) M. Niso-Santano et al.   EMBO JOURNAL

The Ubiquitination of RagA GTPase by RNF152 Negatively Regulates mTORC1 Activation

(2015) Lu Deng et al.   MOLECULAR CELL

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans

(2015) A. Folick et al.   SCIENCE

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

TMC-1 attenuates C. elegans development and sexual behaviour in a chemically defined food environment

(2015) Liusuo Zhang et al.   Nature Communications

Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis

(2014) José A. Martina et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Innate Host Defense Requires TFEB-Mediated Transcription of Cytoprotective and Antimicrobial Genes

(2014) Orane Visvikis et al.   IMMUNITY

Sphingolipid lysosomal storage disorders

(2014) Frances M. Platt   NATURE

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

(2014) J. A. Martina et al.   Science Signaling

Lysosome: regulator of lipid degradation pathways

(2014) Carmine Settembre et al.   TRENDS IN CELL BIOLOGY

 -6 Polyunsaturated fatty acids extend life span through the activation of autophagy

(2013) E. J. O'Rourke et al.   GENES & DEVELOPMENT

To Grow or Not to Grow: Nutritional Control of Development During Caenorhabditis elegans L1 Arrest

(2013) L. R. Baugh   GENETICS

Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes

(2013) Jose A. Martina et al.   JOURNAL OF CELL BIOLOGY

The microRNA miR-235 couples blast-cell quiescence to the nutritional state

(2013) Hidefumi Kasuga et al.   NATURE

MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability

(2013) Eyleen J. O’Rourke et al.   NATURE CELL BIOLOGY

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

Density dependence in Caenorhabditis larval starvation

(2013) Alexander B. Artyukhin et al.   Scientific Reports

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia/Reperfusion Injury

(2012) Xiucui Ma et al.   CIRCULATION

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Lysosomal storage disorders: The cellular impact of lysosomal dysfunction

(2012) Frances M. Platt et al.   JOURNAL OF CELL BIOLOGY

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

(2012) Alejo Efeyan et al.   NATURE

Caenorhabditis elegans Battling Starvation Stress: Low Levels of Ethanol Prolong Lifespan in L1 Larvae

(2012) Paola V. Castro et al.   PLoS One

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Clarifying lysosomal storage diseases

(2011) Mark L. Schultz et al.   TRENDS IN NEUROSCIENCES

Vacuolar (H+)-ATPases in Caenorhabditis elegans: What can we learn about giant H+ pumps from tiny worms?

(2010) Sun-Kyung Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Polyunsaturated fatty acids are involved in regulatory mechanism of fatty acid homeostasis via daf-2/insulin signaling in Caenorhabditis elegans

(2010) Makoto Horikawa et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A Multiparameter Network Reveals Extensive Divergence between C. elegans bHLH Transcription Factors

(2009) Christian A. Grove et al.   CELL

Metabolic Adaptations to Interrupted Glycosaminoglycan Recycling

(2009) Josh C. Woloszynek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents

(2009) Todd E. Haim et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hepatocyte Nuclear Factor 4  Coordinates a Transcription Factor Network Regulating Hepatic Fatty Acid Metabolism

(2009) C. P. Martinez-Jimenez et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of an Endogenous Ligand Bound to a Native Orphan Nuclear Receptor

(2009) Xiaohui Yuan et al.   PLoS One

RNA Pol II Accumulates at Promoters of Growth Genes During Developmental Arrest

(2009) L. Ryan Baugh et al.   SCIENCE

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Fat synthesis and adiposity regulation in Caenorhabditis elegans

(2009) Jennifer L. Watts   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Caenorhabditis elegans HNF4α Homolog, NHR-31, Mediates Excretory Tube Growth and Function through Coordinate Regulation of the Vacuolar ATPase

(2009) Annett Hahn-Windgassen et al.   PLoS Genetics

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics