2-Deoxyglucose and Beta-Hydroxybutyrate: Metabolic Agents for Seizure Control

Cerebral Metabolic Changes During Sleep

(2018) Nadia Nielsen Aalling et al.   Current Neurology and Neuroscience Reports

Opposing effects of 2-deoxy-d-glucose on interictal- and ictal-like activity when K+ currents and GABAA receptors are blocked in rat hippocampus in vitro

(2018) Steen Nedergaard et al.   JOURNAL OF NEUROPHYSIOLOGY

Do ketone bodies mediate the anti-seizure effects of the ketogenic diet?

(2018) Timothy A. Simeone et al.   NEUROPHARMACOLOGY

Cerebrovascular heterogeneity and neuronal excitability

(2018) Laura Librizzi et al.   NEUROSCIENCE LETTERS

The Glycolytic Metabolite, Fructose-1,6-bisphosphate, Blocks Epileptiform Bursts by Attenuating Voltage-Activated Calcium Currents in Hippocampal Slices

(2018) Li-Rong Shao et al.   Frontiers in Cellular Neuroscience

Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII)

(2017) Meir Bialer et al.   EPILEPSIA

Epilepsy and astrocyte energy metabolism

(2017) Detlev Boison et al.   GLIA

Hungry Neurons: Metabolic Insights on Seizure Dynamics

(2017) Paolo Bazzigaluppi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glycolytic inhibition by 2-deoxy-d-glucose abolishes both neuronal and network bursts in an in vitro seizure model

(2017) Li-Rong Shao et al.   JOURNAL OF NEUROPHYSIOLOGY

Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte-neuron lactate shuttle in brain

(2017) Gerald A. Dienel   JOURNAL OF NEUROSCIENCE RESEARCH

Chronic inhibition of brain glycolysis initiates epileptogenesis

(2017) Evgeniya Samokhina et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Disrupting glucose-6-phosphate isomerase fully suppresses the “Warburg effect” and activates OXPHOS with minimal impact on tumor growth except in hypoxia

(2017) Monique Cunha de Padua et al.   Oncotarget

Non-ketogenic combination of nutritional strategies provides robust protection against seizures

(2017) Glenn Dallérac et al.   Scientific Reports

A randomized controlled trial of the ketogenic diet in refractory childhood epilepsy

(2016) D. A. J. E. Lambrechts et al.   ACTA NEUROLOGICA SCANDINAVICA

2-Deoxy-d-glucose enhances tonic inhibition through the neurosteroid-mediated activation of extrasynaptic GABAAreceptors

(2016) Nicola Forte et al.   EPILEPSIA

Mitochondrial Permeability Transition: New Findings and Persisting Uncertainties

(2016) Valentina Izzo et al.   TRENDS IN CELL BIOLOGY

Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet

(2016) Michael A. Rogawski et al.   Cold Spring Harbor Perspectives in Medicine

Metabolic Therapy for Temporal Lobe Epilepsy in a Dish: Investigating Mechanisms of Ketogenic Diet using Electrophysiological Recordings in Hippocampal Slices

(2016) Masahito Jr. Kawamura et al.   Frontiers in Molecular Neuroscience

Ketone bodies mediate antiseizure effects through mitochondrial permeability transition

(2015) Do Young Kim et al.   ANNALS OF NEUROLOGY

Seizure control by decanoic acid through direct AMPA receptor inhibition

(2015) Pishan Chang et al.   BRAIN

β-Hydroxybutyrate attenuates NMDA-induced spasms in rats with evidence of neuronal stabilization on MR spectroscopy

(2015) Mi-Sun Yum et al.   EPILEPSY RESEARCH

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Potent anti-seizure effects of D-leucine

(2015) Adam L. Hartman et al.   NEUROBIOLOGY OF DISEASE

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

(2015) Pierre J. Magistretti et al.   NEURON

Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices

(2015) Paula Valente-Silva et al.   NMR IN BIOMEDICINE

Targeting LDH enzymes with a stiripentol analog to treat epilepsy

(2015) N. Sada et al.   SCIENCE

Neuroprotective effects of dietary restriction: Evidence and mechanisms

(2015) Giovambattista Pani   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Immunity and Inflammation in Epilepsy

(2015) Annamaria Vezzani et al.   Cold Spring Harbor Perspectives in Medicine

2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy

(2014) Dongsheng Zhang et al.   CANCER LETTERS

Rationale for using intermittent calorie restriction as a dietary treatment for drug resistant epilepsy

(2014) Alan W.C. Yuen et al.   EPILEPSY & BEHAVIOR

Ketogenic diets, mitochondria, and neurological diseases

(2014) Lindsey B. Gano et al.   JOURNAL OF LIPID RESEARCH

Decreased carbon shunting from glucose toward oxidative metabolism in diet-induced ketotic rat brain

(2014) Yifan Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Epilepsy, energy deficiency and new therapeutic approaches including diet

(2014) Christopher A. Reid et al.   PHARMACOLOGY & THERAPEUTICS

The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages

(2014) Mahbubur Rahman et al.   Nature Communications

Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats

(2013) Dominic P. D'Agostino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The Antiepileptic Effect of the Glycolytic Inhibitor 2-Deoxy-d-Glucose is Mediated by Upregulation of KATP Channel Subunits Kir6.1 and Kir6.2

(2013) Heng Yang et al.   NEUROCHEMICAL RESEARCH

Sugar for the brain: the role of glucose in physiological and pathological brain function

(2013) Philipp Mergenthaler et al.   TRENDS IN NEUROSCIENCES

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

The ketogenic diet: metabolic influences on brain excitability and epilepsy

(2012) Andrew Lutas et al.   TRENDS IN NEUROSCIENCES

A validated bioanalytical HPLC method for pharmacokinetic evaluation of 2-deoxyglucose in human plasma

(2011) Murugesan K. Gounder et al.   BIOMEDICAL CHROMATOGRAPHY

Neuron-restrictive silencer factor is not required for the antiepileptic effect of the ketogenic diet

(2011) Xiao-Ling Hu et al.   EPILEPSIA

Antiepileptic effects of endogenous beta-hydroxybutyrate in suckling infant rats

(2011) Marat Minlebaev et al.   EPILEPSY RESEARCH

The ketogenic diet: What has science taught us?

(2011) Jong M. Rho et al.   EPILEPSY RESEARCH

Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models

(2011) J.-H. Cheong et al.   MOLECULAR CANCER THERAPEUTICS

β-Hydroxybutyrate is the preferred substrate for GABA and glutamate synthesis while glucose is indispensable during depolarization in cultured GABAergic neurons

(2011) Trine M. Lund et al.   NEUROCHEMISTRY INTERNATIONAL

2-Deoxy-D-Glucose Treatment Induces Ketogenesis, Sustains Mitochondrial Function, and Reduces Pathology in Female Mouse Model of Alzheimer's Disease

(2011) Jia Yao et al.   PLoS One

Anticonvulsant and proconvulsant actions of 2-deoxy-d-glucose

(2010) Maciej Gasior et al.   EPILEPSIA

Efficacy of ketogenic diet in severe refractory status epilepticus initiating fever induced refractory epileptic encephalopathy in school age children (FIRES)

(2010) Rima Nabbout et al.   EPILEPSIA

Glycolytic inhibition as a strategy for developing calorie restriction mimetics

(2010) Donald K. Ingram et al.   EXPERIMENTAL GERONTOLOGY

Ketones prevent synaptic dysfunction induced by mitochondrial respiratory complex inhibitors

(2010) Do Young Kim et al.   JOURNAL OF NEUROCHEMISTRY

Metabolic Autocrine Regulation of Neurons Involves Cooperation among Pannexin Hemichannels, Adenosine Receptors, and KATP Channels

(2010) M. Kawamura et al.   JOURNAL OF NEUROSCIENCE

Metabolic Control of Vesicular Glutamate Transport and Release

(2010) Narinobu Juge et al.   NEURON

Biochemical, Molecular and Epigenetic Mechanisms of Valproic Acid Neuroprotection

(2010) Barbara Monti et al.   Current Molecular Pharmacology

Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models

(2009) Carl E. Stafstrom et al.   ANNALS OF NEUROLOGY

Epilepsy, Regulation of Brain Energy Metabolism and Neurotransmission

(2009) Jean-Francois Cloix et al.   CURRENT MEDICINAL CHEMISTRY

Availability of neurotransmitter glutamate is diminished when β-hydroxybutyrate replaces glucose in cultured neurons

(2009) Trine M Lund et al.   JOURNAL OF NEUROCHEMISTRY

Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial

(2009) Samuel T Henderson et al.   Nutrition & Metabolism

Blood beta-hydroxybutyrate correlates better with seizure reduction due to ketogenic diet than do ketones in the urine

(2009) Renske van Delft et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

The ketogenic diet in a pill: Is this possible?

(2008) Jong M. Rho et al.   EPILEPSIA

Efficacy of the ketogenic diet in the 6-Hz seizure test

(2008) Adam L. Hartman et al.   EPILEPSIA

A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy

(2008) Elizabeth G. Neal et al.   EPILEPSIA

Oxidative impairment of hippocampal long-term potentiation involves activation of protein phosphatase 2A and is prevented by ketone bodies

(2008) Marwan Maalouf et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial

(2008) Elizabeth G Neal et al.   LANCET NEUROLOGY

2-Deoxy-d-glucose protects neural progenitor cells against oxidative stress through the activation of AMP-activated protein kinase

(2008) Mikyung Park et al.   NEUROSCIENCE LETTERS