Coxsackievirus B3 Responds to Polyamine Depletion via Enhancement of 2A and 3C Protease Activity

The 3C protease of enterovirus A71 counteracts the activity of host zinc-finger antiviral protein (ZAP)

(2018) Li Xie et al.   JOURNAL OF GENERAL VIROLOGY

Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer

(2018) Eugene W. Gerner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Difluoromethylornithine in cancer: new advances

(2017) George A Alexiou et al.   Future Oncology

Chikungunya Virus Overcomes Polyamine Depletion by Mutation of nsP1 and the Opal Stop Codon To Confer Enhanced Replication and Fitness

(2017) Bryan C. Mounce et al.   JOURNAL OF VIROLOGY

Polyamines and Their Role in Virus Infection

(2017) Bryan C. Mounce et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Cleavage of osmosensitive transcriptional factor NFAT5 by Coxsackieviral protease 2A promotes viral replication

(2017) Ye Qiu et al.   PLoS Pathogens

Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses

(2016) Bryan C. Mounce et al.   Cell Host & Microbe

2,3,4-Trihydroxybenzyl-hydrazide analogues as novel potent coxsackievirus B3 3C protease inhibitors

(2016) Bo-Kyoung Kim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploring the thermal stability and activity of α-chymotrypsin in the presence of spermine

(2016) Sadegh Farhadian et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses

(2016) Bryan C. Mounce et al.   JOURNAL OF VIROLOGY

Enteroviral proteases: structure, host interactions and pathogenicity

(2016) Olli H. Laitinen et al.   REVIEWS IN MEDICAL VIROLOGY

Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes

(2015) P J Hanson et al.   CELL DEATH AND DIFFERENTIATION

Benserazide, the first allosteric inhibitor of Coxsackievirus B3 3C protease

(2015) Bo-Kyoung Kim et al.   FEBS LETTERS

Soluble Coxsackievirus B3 3C Protease Inhibitor Prevents Cardiomyopathy in an Experimental Chronic Myocarditis Murine Model

(2015) Byung-Kwan Lim et al.   VIRUS RESEARCH

Enterovirus 2Apro Targets MDA5 and MAVS in Infected Cells

(2014) Q. Feng et al.   JOURNAL OF VIROLOGY

Protease 2A induces stress granule formation during coxsackievirus B3 and enterovirus 71 infections

(2014) Shuo Wu et al.   Virology Journal

A 3Cpro-dependent bioluminescence imaging assay for in vivo evaluation of anti-enterovirus 71 agents

(2013) Zhiwei Guo et al.   ANTIVIRAL RESEARCH

Conformational Plasticity of the 2A Proteinase from Enterovirus 71

(2013) Q. Cai et al.   JOURNAL OF VIROLOGY

Assessing Activity and Inhibition of Middle East Respiratory Syndrome Coronavirus Papain-Like and 3C-Like Proteases Using Luciferase-Based Biosensors

(2013) A. Kilianski et al.   JOURNAL OF VIROLOGY

Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells

(2013) S. Mandal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Bioluminescence imaging of Hepatitis C virus NS3/4A serine protease activity in cells and living animals

(2010) Licui Wang et al.   ANTIVIRAL RESEARCH

Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds

(2009) Cheng-Chung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effect of Difluoromethylornithine on Decreasing Prostate Size and Polyamines in Men: Results of a Year-Long Phase IIb Randomized Placebo-Controlled Chemoprevention Trial

(2008) A. R. Simoneau et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION