Enteroviral proteases: structure, host interactions and pathogenicity

Coxsackievirus counters the host innate immune response by blocking type III interferon expression

(2016) Katharina Lind et al.   JOURNAL OF GENERAL VIROLOGY

Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68

(2015) Liang Sun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Enterovirus D68

(2015) Feras Khan   EMERGENCY MEDICINE CLINICS OF NORTH AMERICA

Selective Removal of FG Repeat Domains from the Nuclear Pore Complex by Enterovirus 2Apro

(2015) Nogi Park et al.   JOURNAL OF VIROLOGY

Heterogeneous Nuclear Ribonucleoprotein M Facilitates Enterovirus Infection

(2015) Julienne M. Jagdeo et al.   JOURNAL OF VIROLOGY

Global quantitative proteomic analysis of human glioma cells profiled host protein expression in response to enterovirus type 71 infection

(2015) Lei-Ke Zhang et al.   PROTEOMICS

Analysis of EV71 infection progression using triple-SILAC-based proteomics approach

(2015) Hao-Yu Li et al.   PROTEOMICS

Severe dystrophic cardiomyopathy caused by the enteroviral protease 2A–mediated C-terminal dystrophin cleavage fragment

(2015) Matthew S. Barnabei et al.   Science Translational Medicine

Replication and Inhibitors of Enteroviruses and Parechoviruses

(2015) Lonneke Linden et al.   Viruses-Basel

The Enterovirus Protease Inhibitor Rupintrivir Exerts Cross-Genotypic Anti-Norovirus Activity and Clears Cells from the Norovirus Replicon

(2014) J. Rocha-Pereira et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Type III interferons are expressed by Coxsackievirus-infected human primary hepatocytes and regulate hepatocyte permissiveness to infection

(2014) K. Lind et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Acute flaccid paralysis following enterovirus D68 associated pneumonia, France, 2014

(2014) M Lang et al.   Eurosurveillance

Intricacies of cardiac damage in coxsackievirus B3 infection: Implications for therapy

(2014) Chandirasegaran Massilamany et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Enterovirus 2Apro Targets MDA5 and MAVS in Infected Cells

(2014) Q. Feng et al.   JOURNAL OF VIROLOGY

Coxsackievirus B Exits the Host Cell in Shed Microvesicles Displaying Autophagosomal Markers

(2014) Scott M. Robinson et al.   PLoS Pathogens

Rupintrivir is a promising candidate for treating severe cases of enterovirus-71 infection: Evaluation of antiviral efficacy in a murine infection model

(2013) Xiaonan Zhang et al.   ANTIVIRAL RESEARCH

Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2013)

(2013) M. J. Adams et al.   ARCHIVES OF VIROLOGY

Coxsackievirus B transmission and possible new roles for extracellular vesicles: Figure 1

(2013) Jameel M. Inal et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus

(2013) Sivakoteswara Rao Mandadapu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transcriptional networks regulating the costamere, sarcomere, and other cytoskeletal structures in striated muscle

(2013) Nelsa L. Estrella et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human Rhinoviruses

(2013) Samantha E. Jacobs et al.   CLINICAL MICROBIOLOGY REVIEWS

Enteroviral pathogenesis of type 1 diabetes

(2013) Didier Hober et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Inhibition of Coxsackievirus-associated dystrophin cleavage prevents cardiomyopathy

(2013) Byung-Kwan Lim et al.   JOURNAL OF CLINICAL INVESTIGATION

Crystal Structure of 2A Proteinase from Hand, Foot and Mouth Disease Virus

(2013) Zhixia Mu et al.   JOURNAL OF MOLECULAR BIOLOGY

3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses

(2013) J. Tan et al.   JOURNAL OF VIROLOGY

Induction of an Antiviral State and Attenuated Coxsackievirus Replication in Type III Interferon-Treated Primary Human Pancreatic Islets

(2013) K. Lind et al.   JOURNAL OF VIROLOGY

Conformational Plasticity of the 2A Proteinase from Enterovirus 71

(2013) Q. Cai et al.   JOURNAL OF VIROLOGY

Epidemiology of Enterovirus 71 Infections in Taiwan

(2013) Min-Yuan Chia et al.   Pediatrics and Neonatology

Rhinovirus 3C Protease Facilitates Specific Nucleoporin Cleavage and Mislocalisation of Nuclear Proteins in Infected Host Cells

(2013) Erin J. Walker et al.   PLoS One

Picornavirus uncoating intermediate captured in atomic detail

(2013) Jingshan Ren et al.   Nature Communications

Enterovirus 71 Protease 2Apro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses

(2013) Bei Wang et al.   PLoS Pathogens

An open conformation determined by a structural switch for 2A protease from coxsackievirus A16

(2013) Yao Sun et al.   Protein & Cell

Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery

(2012) R. Ramajayam et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Picornavirus and enterovirus diversity with associated human diseases

(2012) Caroline Tapparel et al.   INFECTION GENETICS AND EVOLUTION

Cleavage of Interferon Regulatory Factor 7 by Enterovirus 71 3C Suppresses Cellular Responses

(2012) Xiaobo Lei et al.   JOURNAL OF VIROLOGY

Viral Proteinase Requirements for the Nucleocytoplasmic Relocalization of Cellular Splicing Factor SRp20 during Picornavirus Infections

(2012) K. D. Fitzgerald et al.   JOURNAL OF VIROLOGY

Enterovirus 71 Disrupts Interferon Signaling by Reducing the Level of Interferon Receptor 1

(2012) J. Lu et al.   JOURNAL OF VIROLOGY

Crystal Structure of Human Enterovirus 71

(2012) P. Plevka et al.   SCIENCE

Combating enterovirus replication: State-of-the-art on antiviral research

(2011) Hendrik Jan Thibaut et al.   BIOCHEMICAL PHARMACOLOGY

Cleavage of serum response factor mediated by enteroviral protease 2A contributes to impaired cardiac function

(2011) Jerry Wong et al.   CELL RESEARCH

Immunology in the clinic review series; focus on type 1 diabetes and viruses: the innate immune response to enteroviruses and its possible role in regulating type 1 diabetes

(2011) K. Lind et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93

(2011) L. Costenaro et al.   JOURNAL OF VIROLOGY

Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues

(2011) J. Wang et al.   JOURNAL OF VIROLOGY

neXtProt: a knowledge platform for human proteins

(2011) L. Lane et al.   NUCLEIC ACIDS RESEARCH

The Coxsackievirus B 3Cpro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling

(2011) Amitava Mukherjee et al.   PLoS Pathogens

Poliovirus 2Apro induces the nucleic translocation of poliovirus 3CD and 3C' proteins

(2010) W. Tian et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Specific Cleavage of the Nuclear Pore Complex Protein Nup62 by a Viral Protease

(2010) Nogi Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The 3C Protein of Enterovirus 71 Inhibits Retinoid Acid-Inducible Gene I-Mediated Interferon Regulatory Factor 3 Activation and Type I Interferon Responses

(2010) X. Lei et al.   JOURNAL OF VIROLOGY

Internalization of Coxsackievirus A9 Is Mediated by  2-Microglobulin, Dynamin, and Arf6 but Not by Caveolin-1 or Clathrin

(2010) O. Heikkila et al.   JOURNAL OF VIROLOGY

Protein degradation systems in viral myocarditis leading to dilated cardiomyopathy

(2009) H. Luo et al.   CARDIOVASCULAR RESEARCH

RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage

(2009) A. Castello et al.   JOURNAL OF CELL SCIENCE

Rhinovirus 3C Protease Can Localize in the Nucleus and Alter Active and Passive Nucleocytoplasmic Transport

(2009) R. Ghildyal et al.   JOURNAL OF VIROLOGY

Scavenger receptor B2 is a cellular receptor for enterovirus 71

(2009) Seiya Yamayoshi et al.   NATURE MEDICINE

RIG-I is cleaved during picornavirus infection

(2009) Paola M. Barral et al.   VIROLOGY

Enterovirus 71 3C Protease Cleaves a Novel Target CstF-64 and Inhibits Cellular Polyadenylation

(2009) Kuo-Feng Weng et al.   PLoS Pathogens

Selective inhibitors of picornavirus replication

(2008) Armando M. De Palma et al.   MEDICINAL RESEARCH REVIEWS

5′ terminal deletions in the genome of a coxsackievirus B2 strain occurred naturally in human heart

(2008) Nora M. Chapman et al.   VIROLOGY