Generation of cattle knockout for galactose‐α1,3‐galactose and N‐glycolylneuraminic acid antigens

Reducing immunoreactivity of porcine bioprosthetic heart valves by genetically-deleting three major glycan antigens, GGTA1/β4GalNT2/CMAH

(2018) Runjie Zhang et al.   Acta Biomaterialia

Glycosphingolipids of porcine, bovine, and equine pericardia as potential immune targets in bioprosthetic heart valve grafts

(2018) Angela Barone et al.   XENOTRANSPLANTATION

Different approaches to heart valve decellularization: A comprehensive overview of the past 30 years

(2017) Filippo Naso et al.   XENOTRANSPLANTATION

Characterization of recombinant human lactoferrin N-glycans expressed in the milk of transgenic cows

(2017) Annabelle Le Parc et al.   PLoS One

Large-scale production of recombinant human lactoferrin from high-expression, marker-free transgenic cloned cows

(2017) Ming Wang et al.   Scientific Reports

Human risk of diseases associated with red meat intake: Analysis of current theories and proposed role for metabolic incorporation of a non-human sialic acid

(2016) Frederico Alisson-Silva et al.   MOLECULAR ASPECTS OF MEDICINE

Characterization of immunogenic Neu5Gc in bioprosthetic heart valves

(2016) Eliran Moshe Reuven et al.   XENOTRANSPLANTATION

The alpha-gal story: Lessons learned from connecting the dots

(2015) John W. Steinke et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rapid and highly efficient mammalian cell engineering via Cas9 protein transfection

(2015) Xiquan Liang et al.   JOURNAL OF BIOTECHNOLOGY

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

(2014) S. Kim et al.   GENOME RESEARCH

A red meat-derived glycan promotes inflammation and cancer progression

(2014) Annie N. Samraj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection

(2014) Ping Li et al.   XENOTRANSPLANTATION

Potential deleterious role of anti-Neu5Gc antibodies in xenotransplantation

(2014) Apolline Salama et al.   XENOTRANSPLANTATION

The combinational use of CRISPR/Cas9-based gene editing and targeted toxin technology enables efficient biallelic knockout of the α-1,3-galactosyltransferase gene in porcine embryonic fibroblasts

(2014) Masahiro Sato et al.   XENOTRANSPLANTATION

Long-Term IgG Response to Porcine Neu5Gc Antigens without Transmission of PERV in Burn Patients Treated with Porcine Skin Xenografts

(2013) L. Scobie et al.   JOURNAL OF IMMUNOLOGY

Physiological Level Production of Antigen-Specific Human Immunoglobulin in Cloned Transchromosomic Cattle

(2013) Akiko Sano et al.   PLoS One

Efficient nonmeiotic allele introgression in livestock using custom endonucleases

(2013) W. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

(2013) Andrew J. Lutz et al.   XENOTRANSPLANTATION

First quantification of alpha-Gal epitope in current glutaraldehyde-fixed heart valve bioprostheses

(2013) Filippo Naso et al.   XENOTRANSPLANTATION

Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation

(2012) Darius Ghaderi et al.   Biotechnology & Genetic Engineering Reviews

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

(2011) J. Hauschild et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune Response in Patients Receiving a Bioprosthetic Heart Valve: Lack of Response with Decellularized Valves

(2011) Oliver Bloch et al.   TISSUE ENGINEERING PART A

Cardiac xenotransplantation technology provides materials for improved bioprosthetic heart valves

(2010) Christopher G.A. McGregor et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Production of alpha 1,3-Galactosyltransferase gene-deficient pigs by somatic cell nuclear transfer: A novel selection method for gal alpha 1,3-Gal antigen-deficient cells

(2008) Tatsuya Fujimura et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT