New viruses for cancer therapy: meeting clinical needs

Development of measles virus-based shielded oncolytic vectors: suitability of other paramyxovirus glycoproteins

(2013) A W Hudacek et al.   CANCER GENE THERAPY

Specific Elimination of CD133+ Tumor Cells with Targeted Oncolytic Measles Virus

(2013) P. Bach et al.   CANCER RESEARCH

Genome-Wide Epigenetic Regulation of miRNAs in Cancer

(2013) C. Baer et al.   CANCER RESEARCH

PEGylation of Vesicular Stomatitis Virus Extends Virus Persistence in Blood Circulation of Passively Immunized Mice

(2013) M. Z. Tesfay et al.   JOURNAL OF VIROLOGY

DARPin-targeting of Measles Virus: Unique Bispecificity, Effective Oncolysis, and Enhanced Safety

(2013) Katrin Friedrich et al.   MOLECULAR THERAPY

Measles Virus Entry Through the Signaling Lymphocyte Activation Molecule Governs Efficacy of Mantle Cell Lymphoma Radiovirotherapy

(2013) Tanner S Miest et al.   MOLECULAR THERAPY

Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer

(2013) Jeong Heo et al.   NATURE MEDICINE

MicroRNA-Mediated Suppression of Oncolytic Adenovirus Replication in Human Liver

(2013) Erkko Ylösmäki et al.   PLoS One

Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters

(2013) B. Dreier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo antitumor activity of intratumoral fludarabine phosphate in refractory tumors expressing E. coli purine nucleoside phosphorylase

(2012) Eric J. Sorscher et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Peptide targeting of adenoviral vectors to augment tumor gene transfer

(2012) E N Ballard et al.   CANCER GENE THERAPY

HER3 targeting of adenovirus by fiber modification increases infection of breast cancer cells in vitro, but not following intratumoral injection in mice

(2012) S H MacLeod et al.   CANCER GENE THERAPY

Transcriptional and epigenetic regulation of human microRNAs

(2012) Zifeng Wang et al.   CANCER LETTERS

Molecular Pathways: Rodent Parvoviruses--Mechanisms of Oncolysis and Prospects for Clinical Cancer Treatment

(2012) J. P. F. Nuesch et al.   CLINICAL CANCER RESEARCH

Enzymes To Die For: Exploiting Nucleotide Metabolizing Enzymes for Cancer Gene Therapy

(2012) Andressa Ardiani et al.   CURRENT GENE THERAPY

The Sodium Iodide Symporter (NIS) as an Imaging Reporter for Gene, Viral, and Cell-based Therapies

(2012) Alan R. Penheiter et al.   CURRENT GENE THERAPY

Oncolytic Viruses for Induction of Anti-Tumor Immunity

(2012) Alex W. Tong et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Targeted and Armed Oncolytic Poxviruses for Cancer: the Lead Example of JX-594

(2012) Caroline J. Breitbach et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Radiovirotherapy: Principles and Prospects in Oncology

(2012) Y. Touchefeu et al.   CURRENT PHARMACEUTICAL DESIGN

Using clinically approved cyclophosphamide regimens to control the humoral immune response to oncolytic viruses

(2012) K-W Peng et al.   GENE THERAPY

Combined Fiber Modifications Both to Target αvβ6 and Detarget the Coxsackievirus–Adenovirus Receptor Improve Virus Toxicity Profiles In Vivo but Fail to Improve Antitumoral Efficacy Relative to Adenovirus Serotype 5

(2012) Lynda Coughlan et al.   HUMAN GENE THERAPY

A First in Human Phase 1 Study of CG0070, a GM-CSF Expressing Oncolytic Adenovirus, for the Treatment of Nonmuscle Invasive Bladder Cancer

(2012) James M. Burke et al.   JOURNAL OF UROLOGY

MicroRNA Regulation of Oncolytic Adenovirus 6 for Selective Treatment of Castration-Resistant Prostate Cancer

(2012) Z. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Thymidine Kinase Suicide Gene-mediated Ganciclovir Ablation of Autologous Gene-modified Rhesus Hematopoiesis

(2012) Cecilia N Barese et al.   MOLECULAR THERAPY

Design and Selection of Toca 511 for Clinical Use: Modified Retroviral Replicating Vector With Improved Stability and Gene Expression

(2012) Omar D Perez et al.   MOLECULAR THERAPY

Effective Treatment of an Orthotopic Xenograft Model of Human Glioblastoma Using an EGFR-retargeted Oncolytic Herpes Simplex Virus

(2012) Hiroaki Uchida et al.   MOLECULAR THERAPY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Oncolytic virotherapy

(2012) Stephen J Russell et al.   NATURE BIOTECHNOLOGY

The sodium iodide symporter (NIS): Regulation and approaches to targeting for cancer therapeutics

(2012) Takahiko Kogai et al.   PHARMACOLOGY & THERAPEUTICS

Virus chimeras for gene therapy, vaccination, and oncolysis: adenoviruses and beyond

(2012) Johanna K. Kaufmann et al.   TRENDS IN MOLECULAR MEDICINE

Positron Emission Tomography Reporter Genes and Reporter Probes: Gene and Cell Therapy Applications

(2012) Shahriar S. Yaghoubi et al.   Theranostics

Viral and cellular contributions to herpes simplex virus entry into the cell

(2012) Gabriella Campadelli-Fiume et al.   Current Opinion in Virology

Evolution of oncolytic adenovirus for cancer treatment

(2011) Joung-Woo Choi et al.   ADVANCED DRUG DELIVERY REVIEWS

Active targeting and safety profile of PEG-modified adenovirus conjugated with herceptin

(2011) Pyung-Hwan Kim et al.   BIOMATERIALS

Bioreducible polymer-conjugated oncolytic adenovirus for hepatoma-specific therapy via systemic administration

(2011) Pyung-Hwan Kim et al.   BIOMATERIALS

Clinical development directions in oncolytic viral therapy

(2011) R M Eager et al.   CANCER GENE THERAPY

Oncolytic Herpes simplex virus expressing yeast cytosine deaminase: relationship between viral replication, transgene expression, prodrug bioactivation

(2011) S Yamada et al.   CANCER GENE THERAPY

Enhancing VSV oncolytic activity with an improved cytosine deaminase suicide gene strategy

(2011) S Leveille et al.   CANCER GENE THERAPY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Enhanced Safety Profiles of the Telomerase-Specific Replication-Competent Adenovirus by Incorporation of Normal Cell-Specific microRNA-Targeted Sequences

(2011) K. Sugio et al.   CLINICAL CANCER RESEARCH

Phase I Clinical Study of Seneca Valley Virus (SVV-001),a Replication-Competent Picornavirus, in Advanced Solid Tumors with Neuroendocrine Features

(2011) C. M. Rudin et al.   CLINICAL CANCER RESEARCH

Advances and Future Challenges in Adenoviral Vector Pharmacology and Targeting

(2011) Reeti Khare et al.   CURRENT GENE THERAPY

DARPins and other repeat protein scaffolds: advances in engineering and applications

(2011) Ykelien L Boersma et al.   CURRENT OPINION IN BIOTECHNOLOGY

A Transductionally Retargeted Adenoviral Vector for Virotherapy of Her2/neu-Expressing Prostate Cancer

(2011) M.K. Magnusson et al.   HUMAN GENE THERAPY

Multimodality molecular imaging of disease progression in living subjects

(2011) Pritha Ray   JOURNAL OF BIOSCIENCES

Adenovirus Serotype 5-Specific Neutralizing Antibodies Target Multiple Hexon Hypervariable Regions

(2011) R. R. Bradley et al.   JOURNAL OF VIROLOGY

Envelope-chimeric Entry-targeted Measles Virus Escapes Neutralization and Achieves Oncolysis

(2011) Tanner S Miest et al.   MOLECULAR THERAPY

MicroRNA-sensitive Oncolytic Measles Viruses for Cancer-specific Vector Tropism

(2011) Mathias F Leber et al.   MOLECULAR THERAPY

MicroRNA Regulation of Glycoprotein B5R in Oncolytic Vaccinia Virus Reduces Viral Pathogenicity Without Impairing Its Antitumor Efficacy

(2011) Mina Hikichi et al.   MOLECULAR THERAPY

A Mechanistic Proof-of-concept Clinical Trial With JX-594, a Targeted Multi-mechanistic Oncolytic Poxvirus, in Patients With Metastatic Melanoma

(2011) Tae-Ho Hwang et al.   MOLECULAR THERAPY

Construction of an Oncolytic Herpes Simplex Virus That Precisely Targets Hepatocellular Carcinoma Cells

(2011) Xinping Fu et al.   MOLECULAR THERAPY

Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans

(2011) Caroline J. Breitbach et al.   NATURE

Fusing structure and function: a structural view of the herpesvirus entry machinery

(2011) Sarah A. Connolly et al.   NATURE REVIEWS MICROBIOLOGY

Use of MicroRNA Let-7 to Control the Replication Specificity of Oncolytic Adenovirus in Hepatocellular Carcinoma Cells

(2011) Huajun Jin et al.   PLoS One

Imaging Devices for Use in Small Animals

(2011) Wade Koba et al.   SEMINARS IN NUCLEAR MEDICINE

Targeted entry of enveloped viruses: measles and herpes simplex virus I

(2011) Chanakha K Navaratnarajah et al.   Current Opinion in Virology

Tumor Cell Marker PVRL4 (Nectin 4) Is an Epithelial Cell Receptor for Measles Virus

(2011) Ryan S. Noyce et al.   PLoS Pathogens

Nectin 4 Overexpression in Ovarian Cancer Tissues and Serum

(2010) Melissa S. DeRycke et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Targeting HSV-1 virions for specific binding to epidermal growth factor receptor-vIII-bearing tumor cells

(2010) P Grandi et al.   CANCER GENE THERAPY

Oncolytic measles viruses encoding interferon β and the thyroidal sodium iodide symporter gene for mesothelioma virotherapy

(2010) H Li et al.   CANCER GENE THERAPY

Phase I Trial of Intraperitoneal Administration of an Oncolytic Measles Virus Strain Engineered to Express Carcinoembryonic Antigen for Recurrent Ovarian Cancer

(2010) E. Galanis et al.   CANCER RESEARCH

Targeted Chemotherapy for Head and Neck Cancer with a Chimeric Oncolytic Adenovirus Coding for Bifunctional Suicide Protein FCU1

(2010) J. D. Dias et al.   CLINICAL CANCER RESEARCH

Oncolytic (replication-competent) adenoviruses as anticancer agents

(2010) Karoly Toth et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Mantle cell lymphoma salvage regimen: synergy between a reprogrammed oncolytic virus and two chemotherapeutics

(2010) G Ungerechts et al.   GENE THERAPY

Molecular engineering and validation of an oncolytic herpes simplex virus type 1 transcriptionally targeted to midkine-positive tumors

(2010) Arturo R. Maldonado et al.   JOURNAL OF GENE MEDICINE

Novel tumour-specific promoters for transcriptional targeting of hepatocellular carcinoma by herpes simplex virus vectors

(2010) Pelagia Foka et al.   JOURNAL OF GENE MEDICINE

Retargeting of Adenovirus Vectors through Genetic Fusion of a Single-Chain or Single-Domain Antibody to Capsid Protein IX

(2010) K. L. Poulin et al.   JOURNAL OF VIROLOGY

Measles Virus Selectively Blind to Signaling Lymphocytic Activation Molecule (SLAM; CD150) Is Attenuated and Induces Strong Adaptive Immune Responses in Rhesus Monkeys

(2010) V. H. J. Leonard et al.   JOURNAL OF VIROLOGY

Transcriptional and Translational Dual-regulated Oncolytic Herpes Simplex Virus Type 1 for Targeting Prostate Tumors

(2010) Cleo YF Lee et al.   MOLECULAR THERAPY

Tropism-Modification Strategies for Targeted Gene Delivery Using Adenoviral Vectors

(2010) Lynda Coughlan et al.   Viruses-Basel

Targeting cancer by transcriptional control in cancer gene therapy and viral oncolysis

(2009) Dominik E. Dorer et al.   ADVANCED DRUG DELIVERY REVIEWS

HPMA copolymers for masking and retargeting of therapeutic viruses☆

(2009) Kerry D. Fisher et al.   ADVANCED DRUG DELIVERY REVIEWS

Local and Distant Immunity Induced by Intralesional Vaccination with an Oncolytic Herpes Virus Encoding GM-CSF in Patients with Stage IIIc and IV Melanoma

(2009) Howard L. Kaufman et al.   ANNALS OF SURGICAL ONCOLOGY

Visualization of gene expression in the live subject using the Na/I symporter as a reporter gene: applications in biotherapy

(2009) Patrick Baril et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fiber-chimeric adenoviruses expressing fibers from serotype 16 and 50 improve gene transfer to human pancreatic adenocarcinoma

(2009) K F D Kuhlmann et al.   CANCER GENE THERAPY

Identification of Nectin-4 Oncoprotein as a Diagnostic and Therapeutic Target for Lung Cancer

(2009) A. Takano et al.   CANCER RESEARCH

Expression of IFN-  Enhances Both Efficacy and Safety of Oncolytic Vesicular Stomatitis Virus for Therapy of Mesothelioma

(2009) C. L. Willmon et al.   CANCER RESEARCH

MicroRNA Regulation of Oncolytic Herpes Simplex Virus-1 for Selective Killing of Prostate Cancer Cells

(2009) C. Y. F. Lee et al.   CLINICAL CANCER RESEARCH

Engineering oncolytic viruses to exploit tumor specific defects in innate immune signaling pathways

(2009) Shruthi Naik et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Chemical Modification with High Molecular Weight Polyethylene Glycol Reduces Transduction of Hepatocytes and Increases Efficacy of Intravenously Delivered Oncolytic Adenovirus

(2009) Konstantin Doronin et al.   HUMAN GENE THERAPY

Safety Studies on Intrahepatic or Intratumoral Injection of Oncolytic Vesicular Stomatitis Virus Expressing Interferon-β in Rodents and Nonhuman Primates

(2009) Nathan Jenks et al.   HUMAN GENE THERAPY

Phase II Clinical Trial of a Granulocyte-Macrophage Colony-Stimulating Factor–Encoding, Second-Generation Oncolytic Herpesvirus in Patients With Unresectable Metastatic Melanoma

(2009) Neil N. Senzer et al.   JOURNAL OF CLINICAL ONCOLOGY

Attenuation of Vesicular Stomatitis Virus Encephalitis through MicroRNA Targeting

(2009) E. J. Kelly et al.   JOURNAL OF VIROLOGY

Inhibition of human tumor growth in mice by an oncolytic herpes simplex virus designed to target solely HER-2-positive cells

(2009) L. Menotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of Tissue-Specific MicroRNA to Control Pathology of Wild-Type Adenovirus without Attenuation of Its Ability to Kill Cancer Cells

(2009) Ryan Cawood et al.   PLoS Pathogens

A Phase I Study of Intravenous Oncolytic Reovirus Type 3 Dearing in Patients with Advanced Cancer

(2008) L. Vidal et al.   CLINICAL CANCER RESEARCH

Changing the adenovirus fiber for retaining gene delivery efficacy in the presence of neutralizing antibodies

(2008) M Särkioja et al.   GENE THERAPY

Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus

(2008) J Foloppe et al.   GENE THERAPY

Generation of a Conditionally Replicating Adenovirus Based on Targeted Destruction of E1A mRNA by a Cell Type-Specific MicroRNA

(2008) E. Ylosmaki et al.   JOURNAL OF VIROLOGY

Construction of a Fully Retargeted Herpes Simplex Virus 1 Recombinant Capable of Entering Cells Solely via Human Epidermal Growth Factor Receptor 2

(2008) L. Menotti et al.   JOURNAL OF VIROLOGY

Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial

(2008) Byeong-Ho Park et al.   LANCET ONCOLOGY

A Phase I Trial of Intratumoral Administration of Reovirus in Patients With Histologically Confirmed Recurrent Malignant Gliomas

(2008) Peter Forsyth et al.   MOLECULAR THERAPY

Engineering microRNA responsiveness to decrease virus pathogenicity

(2008) Elizabeth J Kelly et al.   NATURE MEDICINE

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS

Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded

(2008) Roberto Cattaneo et al.   NATURE REVIEWS MICROBIOLOGY

Modification of Adenovirus Gene Transfer Vectors With Synthetic Polymers: A Scientific Review and Technical Guide

(2007) Florian Kreppel et al.   MOLECULAR THERAPY