A potential role for the gut microbiome in substance use disorders

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

(2018) Morgane Sonia Thion et al.   CELL

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis

(2018) M Anthony Sofia et al.   INFLAMMATORY BOWEL DISEASES

Epigenetic regulation of brain region-specific microglia clearance activity

(2018) Pinar Ayata et al.   NATURE NEUROSCIENCE

The gut–liver axis and the intersection with the microbiome

(2018) Anupriya Tripathi et al.   Nature Reviews Gastroenterology & Hepatology

Gut microbiota varies by opioid use, circulating leptin and oxytocin in African American men with diabetes and high burden of chronic disease

(2018) Elena Barengolts et al.   PLoS One

Prescription opioids are associated with higher mortality in patients diagnosed with sepsis: A retrospective cohort study using electronic health records

(2018) Rui Zhang et al.   PLoS One

Alcohol, microbiome, and their effect on psychiatric disorders

(2018) Thomas Hillemacher et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Gut microbiota modulates alcohol withdrawal-induced anxiety in mice

(2018) Hui-wen Xiao et al.   TOXICOLOGY LETTERS

Liver–Microbiome Axis in Health and Disease

(2018) Timon E. Adolph et al.   TRENDS IN IMMUNOLOGY

Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine

(2018) Erin S. Calipari et al.   Nature Communications

Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model

(2018) Fuyuan Wang et al.   Scientific Reports

Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

(2018) Smitha Krishnan et al.   Cell Reports

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

(2018) Jing Gao et al.   Frontiers in Cellular and Infection Microbiology

The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis

(2018) Bruno Bonaz et al.   Frontiers in Neuroscience

Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders

(2018) Sigrid Breit et al.   Frontiers in Psychiatry

A Neural Circuit for Gut-Induced Reward

(2018) Wenfei Han et al.   CELL

Neuroimmune mechanisms of psychostimulant and opioid use disorders

(2018) Rebecca S. Hofford et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Morphine Potentiates Dysbiotic Microbial and Metabolic Shifts in Acute SIV Infection

(2018) Gregory M. Sindberg et al.   Journal of Neuroimmune Pharmacology

Gut microbiome correlates with altered striatal dopamine receptor expression in a model of compulsive alcohol seeking

(2018) Kshitij S. Jadhav et al.   NEUROPHARMACOLOGY

The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence

(2018) Kevin Lee et al.   NEUROPSYCHOPHARMACOLOGY

Alterations in the Gut Microbiota of Rats Chronically Exposed to Volatilized Cocaine and Its Active Adulterants Caffeine and Phenacetin

(2018) Cecilia Scorza et al.   NEUROTOXICITY RESEARCH

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

Bile diversion, a bariatric surgery, and bile acid signaling reduce central cocaine reward

(2018) India A. Reddy et al.   PLOS BIOLOGY

Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens

(2018) Zhendong Li et al.   Frontiers in Cellular and Infection Microbiology

Gut Microbiota and Relevant Metabolites Analysis in Alcohol Dependent Mice

(2018) Guanhao Wang et al.   Frontiers in Microbiology

Chronic alcohol exposure induced gut microbiota dysbiosis and its correlations with neuropsychic behaviors and brain BDNF/Gabra1 changes in mice

(2018) Zheng Xu et al.   BIOFACTORS

Ghrelin receptor deletion reduces binge-like alcohol drinking in rats

(2018) Lia J. Zallar et al.   JOURNAL OF NEUROENDOCRINOLOGY

Pharmacotherapy of alcoholism – an update on approved and off-label medications

(2017) Michael Soyka et al.   EXPERT OPINION ON PHARMACOTHERAPY

Microbiota-Gut-Brain Axis: Modulator of Host Metabolism and Appetite

(2017) Marcel van de Wouw et al.   JOURNAL OF NUTRITION

Influence of diet on the gut microbiome and implications for human health

(2017) Rasnik K. Singh et al.   Journal of Translational Medicine

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

(2017) Hao Wu et al.   NATURE MEDICINE

Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia

(2017) Lindsay M. De Biase et al.   NEURON

A role for the peripheral immune system in the development of alcohol use disorders?

(2017) Philippe de Timary et al.   NEUROPHARMACOLOGY

Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats

(2017) Michael J Lacagnina et al.   NEUROPSYCHOPHARMACOLOGY

Chronic ethanol intake induces partial microglial activation that is not reversed by long-term ethanol withdrawal in the rat hippocampal formation

(2017) Catarina Cruz et al.   NEUROTOXICOLOGY

Peripheral levels of BDNF and opiate-use disorder: literature review and update

(2017) Raul Felipe Palma-Álvarez et al.   REVIEWS IN THE NEUROSCIENCES

Gut microbiome and liver disease

(2017) Naga S. Betrapally et al.   Translational Research

Feeding the microbiota-gut-brain axis: diet, microbiome, and neuropsychiatry

(2017) Kiran V. Sandhu et al.   Translational Research

Effect of different treatments and alcohol addiction on gut microbiota in minimal hepatic encephalopathy patients

(2017) Zan Zuo et al.   Experimental and Therapeutic Medicine

Alcohol-associated intestinal dysbiosis impairs pulmonary host defense against Klebsiella pneumoniae

(2017) Derrick R. Samuelson et al.   PLoS Pathogens

Gut Microbiota Analysis in Rats with Methamphetamine-Induced Conditioned Place Preference

(2017) Tingting Ning et al.   Frontiers in Microbiology

Modified Mediterranean Diet for Enrichment of Short Chain Fatty Acids: Potential Adjunctive Therapeutic to Target Immune and Metabolic Dysfunction in Schizophrenia?

(2017) Jamie Joseph et al.   Frontiers in Neuroscience

Plasma Brain-Derived Neurotrophic Factor Levels in Newborn Infants with Neonatal Abstinence Syndrome

(2017) Lochan Subedi et al.   Frontiers in Pediatrics

Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial

(2017) R.F. Slykerman et al.   EBioMedicine

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Chronic opioid use is associated with altered gut microbiota and predicts readmissions in patients with cirrhosis

(2016) C. Acharya et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

A Critical Role of Brain-Derived Neurotrophic Factor in Alcohol Consumption

(2016) Subhash C. Pandey   BIOLOGICAL PSYCHIATRY

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

(2016) Melanie Schirmer et al.   CELL

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Relationship Between Microbiota of the Colonic Mucosa vs Feces and Symptoms, Colonic Transit, and Methane Production in Female Patients With Chronic Constipation

(2016) Gopanandan Parthasarathy et al.   GASTROENTEROLOGY

Metabolites: messengers between the microbiota and the immune system

(2016) Maayan Levy et al.   GENES & DEVELOPMENT

Current Understanding of Dysbiosis in Disease in Human and Animal Models

(2016) Arianna K. DeGruttola et al.   INFLAMMATORY BOWEL DISEASES

Targeted Epigenetic Remodeling of the Cdk5 Gene in Nucleus Accumbens Regulates Cocaine- and Stress-Evoked Behavior

(2016) E. A. Heller et al.   JOURNAL OF NEUROSCIENCE

Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents

(2016) R. Adron Harris et al.   JOURNAL OF NEUROSCIENCE

Targeting the ecology within: The role of the gut–brain axis and human microbiota in drug addiction

(2016) Patrick D. Skosnik et al.   MEDICAL HYPOTHESES

Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition

(2016) M-L Wong et al.   MOLECULAR PSYCHIATRY

Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

(2016) P Zheng et al.   MOLECULAR PSYCHIATRY

Opioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation

(2016) S Banerjee et al.   Mucosal Immunology

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization

(2016) Gil M. Lewitus et al.   NEURON

Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress

(2016) Jing Sun et al.   NEUROSCIENCE LETTERS

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

(2016) Alexandra Zhernakova et al.   SCIENCE

Gut Homeostasis, Microbial Dysbiosis, and Opioids

(2016) Fuyuan Wang et al.   TOXICOLOGIC PATHOLOGY

Psychobiotics and the Manipulation of Bacteria–Gut–Brain Signals

(2016) Amar Sarkar et al.   TRENDS IN NEUROSCIENCES

Fermented milk containing Lactobacillus casei strain Shirota prevents the onset of physical symptoms in medical students under academic examination stress

(2016) A. Kato-Kataoka et al.   Beneficial Microbes

Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior

(2016) Mar Gacias et al.   eLife

Regulation of prefrontal cortex myelination by the microbiota

(2016) A E Hoban et al.   Translational Psychiatry

Bloom and bust: intestinal microbiota dynamics in response to hospital exposures and Clostridium difficile colonization or infection

(2016) Caroline Vincent et al.   Microbiome

Alterations of the Host Microbiome Affect Behavioral Responses to Cocaine

(2016) Drew D. Kiraly et al.   Scientific Reports

Multiple faces of BDNF in cocaine addiction

(2015) Xuan Li et al.   BEHAVIOURAL BRAIN RESEARCH

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

(2015) S.M. O’Mahony et al.   BEHAVIOURAL BRAIN RESEARCH

A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood

(2015) Laura Steenbergen et al.   BRAIN BEHAVIOR AND IMMUNITY

Brain-derived neurotrophic factor and addiction: Pathological versus therapeutic effects on drug seeking

(2015) Jacqueline M. Barker et al.   BRAIN RESEARCH

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

(2015) Christopher S. Reigstad et al.   FASEB JOURNAL

DAT isn’t all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling

(2015) A L Northcutt et al.   MOLECULAR PSYCHIATRY

Neutrophil ageing is regulated by the microbiome

(2015) Dachuan Zhang et al.   NATURE

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Molecular mechanisms of synaptic remodeling in alcoholism

(2015) Evan J. Kyzar et al.   NEUROSCIENCE LETTERS

Fate, activity, and impact of ingested bacteria within the human gut microbiota

(2015) Muriel Derrien et al.   TRENDS IN MICROBIOLOGY

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

(2015) John R. Kelly et al.   Frontiers in Cellular Neuroscience

Microglia Function in Central Nervous System Development and Plasticity

(2015) Dorothy P. Schafer et al.   Cold Spring Harbor Perspectives in Biology

Opioid Exacerbation of Gram-positive sepsis, induced by Gut Microbial Modulation, is Rescued by IL-17A Neutralization

(2015) Jingjing Meng et al.   Scientific Reports

Disruption of gut homeostasis by opioids accelerates HIV disease progression

(2015) Jingjing Meng et al.   Frontiers in Microbiology

Associations of Cocaine Use and HIV Infection With the Intestinal Microbiota, Microbial Translocation, and Inflammation

(2015) Gretchen E Volpe et al.   Journal of Studies on Alcohol and Drugs

Role of Inflammatory Pathways, Blood Mononuclear Cells, and Gut-Derived Bacterial Products in Alcohol Dependence

(2014) Sophie Leclercq et al.   BIOLOGICAL PSYCHIATRY

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

The global epidemiology and burden of psychostimulant dependence: Findings from the Global Burden of Disease Study 2010

(2014) Louisa Degenhardt et al.   DRUG AND ALCOHOL DEPENDENCE

Emerging drugs for the treatment of cocaine use disorder: a review of neurobiological targets and pharmacotherapy

(2014) Daryl Shorter et al.   EXPERT OPINION ON EMERGING DRUGS

The Intestinal Metabolome: An Intersection Between Microbiota and Host

(2014) Luke K. Ursell et al.   GASTROENTEROLOGY

Interactions Between the Intestinal Microbiome and Liver Diseases

(2014) Bernd Schnabl et al.   GASTROENTEROLOGY

Epigenetic Signaling in Psychiatric Disorders

(2014) Catherine J. Peña et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural changes in the gut microbiome of constipated patients

(2014) Lixin Zhu et al.   PHYSIOLOGICAL GENOMICS

Acute Binge Drinking Increases Serum Endotoxin and Bacterial DNA Levels in Healthy Individuals

(2014) Shashi Bala et al.   PLoS One

Use of gnotobiotic mice to identify and characterize key microbes responsible for the development of the intestinal immune system

(2014) Yoshinori UMESAKI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity

(2014) Sophie Leclercq et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relating the metatranscriptome and metagenome of the human gut

(2014) E. A. Franzosa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis

(2014) A. Mortha et al.   SCIENCE

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system

(2013) Dorothy P. Schafer et al.   CURRENT OPINION IN NEUROBIOLOGY

Microbial genes, brain & behaviour - epigenetic regulation of the gut-brain axis

(2013) R. M. Stilling et al.   GENES BRAIN AND BEHAVIOR

Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation

(2013) Pamela J Kennedy et al.   NATURE NEUROSCIENCE

Human intestinal microbiota composition is associated with local and systemic inflammation in obesity

(2013) Froukje J. Verdam et al.   Obesity

Metagenomic Analyses of Alcohol Induced Pathogenic Alterations in the Intestinal Microbiome and the Effect of Lactobacillus rhamnosus GG Treatment

(2013) Lara Bull-Otterson et al.   PLoS One

Morphine Induces Bacterial Translocation in Mice by Compromising Intestinal Barrier Function in a TLR-Dependent Manner

(2013) Jingjing Meng et al.   PLoS One

Microglia: Scapegoat, Saboteur, or Something Else?

(2013) A. Aguzzi et al.   SCIENCE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

The Long-Term Stability of the Human Gut Microbiota

(2013) J. J. Faith et al.   SCIENCE

Colonic microbiome is altered in alcoholism

(2012) Ece A. Mutlu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects

(2012) Sophie Leclercq et al.   BRAIN BEHAVIOR AND IMMUNITY

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Christopher J L Murray et al.   LANCET

Kynurenines in the CNS: recent advances and new questions

(2012) László Vécsei et al.   NATURE REVIEWS DRUG DISCOVERY

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Gut microbiota and gastrointestinal health: current concepts and future directions

(2012) Q. Aziz et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The Role of Histone Acetylation in Cocaine-Induced Neural Plasticity and Behavior

(2012) George A Rogge et al.   NEUROPSYCHOPHARMACOLOGY

Morphine Decreases Enteric Neuron Excitability via Inhibition of Sodium Channels

(2012) Tricia H. Smith et al.   PLoS One

Pseudomonas aeruginosa Virulence Expression Is Directly Activated by Morphine and Is Capable of Causing Lethal Gut-Derived Sepsis in Mice During Chronic Morphine Administration

(2011) Trissa Babrowski et al.   ANNALS OF SURGERY

Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice

(2011) Y.A. Blednov et al.   BRAIN BEHAVIOR AND IMMUNITY

The Inhibition of Histone Deacetylases Reduces the Reinstatement of Cocaine-Seeking Behavior in Rats

(2011) Pascal Romieu et al.   Current Neuropharmacology

Cytokine Signaling Modulates Blood-Brain Barrier Function

(2011) Weihong Pan et al.   CURRENT PHARMACEUTICAL DESIGN

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice

(2011) Premysl Bercik et al.   GASTROENTEROLOGY

Serum Analysis of Tryptophan Catabolism Pathway: Correlation With Crohnʼs Disease Activity

(2011) Nitin K. Gupta et al.   INFLAMMATORY BOWEL DISEASES

Morphine, but Not Trauma, Sensitizes to Systemic Acinetobacter baumannii Infection

(2011) Jessica M. Breslow et al.   Journal of Neuroimmune Pharmacology

The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication

(2011) P. Bercik et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of psychotropic-like properties of a probiotic formulation ( Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects

(2010) Michaël Messaoudi et al.   BRITISH JOURNAL OF NUTRITION

Enteric dysbiosis associated with a mouse model of alcoholic liver disease

(2010) Arthur W. Yan et al.   HEPATOLOGY

Creating and characterizing communities of human gut microbes in gnotobiotic mice

(2010) Jeremiah J Faith et al.   ISME Journal

Endogenous Morphine Levels Are Increased in Sepsis: A Partial Implication of Neutrophils

(2010) Elise Glattard et al.   PLoS One

Intestinal Dysbiosis: A Possible Mechanism of Alcohol-Induced Endotoxemia and Alcoholic Steatohepatitis in Rats

(2009) Ece Mutlu et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Gut chemosensing: Interactions between gut endocrine cells and visceral afferents

(2009) Helen E. Raybould   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Modulation of Chromatin Modification Facilitates Extinction of Cocaine-Induced Conditioned Place Preference

(2009) Melissa Malvaez et al.   BIOLOGICAL PSYCHIATRY

Bile Acids and Metabolic Regulation: Mechanisms and clinical responses to bile acid sequestration

(2009) B. Staels et al.   DIABETES CARE

Endotoxemia and gut barrier dysfunction in alcoholic liver disease

(2009) Radhakrishna Rao   HEPATOLOGY

Principles and clinical implications of the brain–gut–enteric microbiota axis

(2009) Sang H. Rhee et al.   Nature Reviews Gastroenterology & Hepatology

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

(2009) P. J. Turnbaugh et al.   Science Translational Medicine

Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study

(2008) Irina A. Kirpich et al.   ALCOHOL

Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats

(2008) Ali Keshavarzian et al.   JOURNAL OF HEPATOLOGY

Histone Deacetylase Inhibitors Decrease Cocaine But Not Sucrose Self-Administration in Rats

(2008) P. Romieu et al.   JOURNAL OF NEUROSCIENCE

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

(2008) Michael Maes et al.   METABOLIC BRAIN DISEASE