The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence

Connexin–purinergic signaling in enteric glia mediates the prolonged effect of morphine on constipation

(2017) Sukhada Bhave et al.   FASEB JOURNAL

Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

(2017) Gregory Corder et al.   NATURE MEDICINE

Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents

(2017) Nicole E Burma et al.   NATURE MEDICINE

Chronic opioid use is associated with altered gut microbiota and predicts readmissions in patients with cirrhosis

(2016) C. Acharya et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication

(2016) Esther E. Fröhlich et al.   BRAIN BEHAVIOR AND IMMUNITY

Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring

(2016) Shelly A. Buffington et al.   CELL

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Safety concerns with long-term opioid use

(2016) Michael Harned et al.   Expert Opinion On Drug Safety

Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

(2016) P Zheng et al.   MOLECULAR PSYCHIATRY

Opioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation

(2016) S Banerjee et al.   Mucosal Immunology

Inflammation Effects on Motivation and Motor Activity: Role of Dopamine

(2016) Jennifer C Felger et al.   NEUROPSYCHOPHARMACOLOGY

Allostatic Mechanisms of Opioid Tolerance Beyond Desensitization and Downregulation

(2016) Catherine M. Cahill et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Modulatory Effects of Gut Microbiota on the Central Nervous System: How Gut Could Play a Role in Neuropsychiatric Health and Diseases

(2016) Shadi S Yarandi et al.   Journal of Neurogastroenterology and Motility

Alterations of the Host Microbiome Affect Behavioral Responses to Cocaine

(2016) Drew D. Kiraly et al.   Scientific Reports

Gut/brain axis and the microbiota

(2015) Emeran A. Mayer et al.   JOURNAL OF CLINICAL INVESTIGATION

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine

(2015) Anna M W Taylor et al.   NEUROPSYCHOPHARMACOLOGY

Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis

(2013) Francesco Ferrini et al.   NATURE NEUROSCIENCE

Suppression of Hypothalamic–Pituitary–Adrenal Axis by Acute Heroin Challenge in Rats During Acute and Chronic Withdrawal from Chronic Heroin Administration

(2013) Yan Zhou et al.   NEUROCHEMICAL RESEARCH

Morphine Induces Bacterial Translocation in Mice by Compromising Intestinal Barrier Function in a TLR-Dependent Manner

(2013) Jingjing Meng et al.   PLoS One

Quantitating the subtleties of microglial morphology with fractal analysis

(2013) Audrey Karperien et al.   Frontiers in Cellular Neuroscience

Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement

(2012) M. R. Hutchinson et al.   JOURNAL OF NEUROSCIENCE

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice

(2011) Premysl Bercik et al.   GASTROENTEROLOGY

Depletion of Murine Intestinal Microbiota: Effects on Gut Mucosa and Epithelial Gene Expression

(2011) Dag Henrik Reikvam et al.   PLoS One

Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions

(2010) Ross J. Tynan et al.   BRAIN BEHAVIOR AND IMMUNITY

Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample

(2010) J. G. Caporaso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

(2009) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Principles and clinical implications of the brain–gut–enteric microbiota axis

(2009) Sang H. Rhee et al.   Nature Reviews Gastroenterology & Hepatology

Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast)

(2008) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: Possible anatomical substrates for viscerosensory modulation of exploratory behavior

(2007) Lisa E. Goehler et al.   BRAIN BEHAVIOR AND IMMUNITY