Review
Biochemistry & Molecular Biology
Sandrine Laurance, Mickael Marin, Yves Colin
Summary: Central retinal vein occlusion (CRVO) is a common retinal disorder leading to blindness, but the primary cause and treatment remain unidentified. This review aims to provide an overview of CRVO pathophysiology, specifically focusing on the role of red blood cells (RBCs). The review explores the functions of RBCs beyond oxygen transport and their potential involvement in CRVO occurrence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Pasquale Loiudice, Giuseppe Covello, Michele Figus, Chiara Posarelli, Maria Sole Sartini, Giamberto Casini
Summary: This study aimed to evaluate the choroidal vascularity change in eyes with central and branch retinal vein occlusion (RVO). By analyzing the records of 47 patients, it was found that RVO eyes had higher choroidal vascularity index, total choroidal area, and luminal area compared to unaffected eyes. The changes varied according to the type of macular edema.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Karen M. Wai, Austen Knapp, Cassie A. Ludwig, Euna Koo, Ravi Parikh, Ehsan Rahimy, Prithvi Mruthyunjaya
Summary: This study compared the rates of stroke, myocardial infarction (MI), and death in patients with retinal artery occlusions (RAOs) and a control cohort. The results showed that patients with RAO had a higher risk of stroke, MI, and death in both short-term and long-term intervals. The findings suggest the need for multidisciplinary evaluation and long-term follow-up in patients post-RAO.
JAMA OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Joanna Roskal-Walek, Pawel Walek, Michal Biskup, Dominik Odrobina, Jerzy Mackiewicz, Stanislaw Gluszek, Beata Wozakowska-Kaplon
Summary: The study found that patients with central retinal artery occlusion (CRAO) and branch retinal artery occlusion (BRAO) have similar prognosis in terms of ischemic stroke, myocardial infarction, and all-cause mortality. The frequency of ischemic strokes occurring before and after RAO is similar, while myocardial infarctions are significantly more common before an episode of RAO.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Joanna Roskal-Walek, Pawel Walek, Michal Biskup, Jacek Sidlo, Elzbieta Ciesla, Dominik Odrobina, Jerzy Mackiewicz, Beata Wozakowska-Kaplon
Summary: The aim of this study was to evaluate the incidence of ischemic stroke, myocardial infarction, and all-cause mortality in patients with retinal artery occlusion (RAO). The study found that patients with RAO had a higher risk of all-cause mortality compared to those without RAO. Additionally, patients with RAO who were younger than 75 years were significantly more likely to experience ischemic stroke, death, or the composite endpoint after an occlusion event, as compared with individuals without RAO.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Jiwon Baek, Hae-Young Lopilly Park, Seong Ah Kim, Kyung Euy Hong, Soo Ji Jeon, Da Young Shin, Younhea Jung, Chan Kee Park
Summary: By using OCT-A, the study investigated parapapillary choroidal microvasculature dropout (MvD) in BRVO and OAG patients. It was found that the frequency of MvD was higher in OAG patients. The effect of MvD on VF change differed between BRVO and OAG, suggesting potential differences in underlying pathogenesis.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Medicine, General & Internal
Indre Matuleviciute, Agne Sidaraite, Vacis Tatarunas, Audrone Veikutiene, Olivija Dobiliene, Dalia Zaliuniene
Summary: This study used optical coherence tomography and optical coherence tomography angiography to investigate the relationship between retinal and choroidal microvascular changes and coronary heart disease. The results showed that a decrease in retinal and choroidal thickness as well as decreased vascular density may predict coronary artery disease. This study suggests that OCT and OCTA could be a significant, safe, and noninvasive tool for the prediction of coronary artery disease.
Article
Ophthalmology
Lulu Chen, Mingzhen Yuan, Lu Sun, Youxin Chen
Summary: The study found that patients with SRD had thicker choroid before treatment, and SRD may contribute to better anatomical recovery in RVO patients after receiving a single anti-VEGF treatment.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Daniel Duck-Jin Hwang, Kyung-Eun Lee, Yuwon Kim, Myoung-Suk Kim, Tyler Hyungtaek Rim, Mina Kim, Hasung Kim, Dae-Sung Kyoung, Ji In Park
Summary: This study examined whether comorbidities in patients with retinal artery occlusion (RAO) differ by subtype and whether mortality is higher. The results showed that the incidence rate of noncentral RAO was higher than that of central RAO, while the standardized mortality ratio (SMR) was higher for central RAO than noncentral RAO.
Article
Medicine, General & Internal
Marlena Schnieder, Charlotte V. Fischer-Wedi, Sebastian Bemme, Mai-Linh Kortleben, Nicolas Feltgen, Jan Liman
Summary: Central retinal artery occlusion (CRAO) results in sudden vision loss, with retrobulbar spot sign and prominent middle limiting membrane (p-MLM) sign being key indicators. The presence of p-MLM sign in SD-OCT is associated with better vision outcomes, while the retrobulbar spot sign may indicate a higher risk of secondary retinal ischemia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Dong-Wan Kang, Keun-Hwa Jung, Wookjin Yang, Hyeong Min Kim, Youngjoon Kim, Matthew Chung, Jiyeon Ha, Monique Therese Punsalan, Eung-Joon Lee, Han-Yeong Jeong, Jeong-Min Kim, Sang-Bae Ko, Seung-Hoon Lee
Summary: This study investigated the impact of embolic sources on outcomes in central retinal artery occlusion (CRAO) patients, finding that patients with embolic sources were more likely to experience visual improvement.
Article
Optics
Van Phuc Nguyen, Tianye Zhu, Jessica Henry, Wei Zhang, Xueding Wang, Yannis M. Paulus
Summary: This study presents a non-invasive, label-free in vivo imaging of retinal and choroidal vascular occlusion using a multimodal imaging system, including photoacoustic microscopy (PAM) and optical coherence tomography (OCT). The occlusions were clearly identified using spectroscopic PAM imaging, and this advanced imaging system shows promise for imaging retinal ischemia.
Article
Clinical Neurology
Brian Mac Grory, Sean R. Landman, Paul D. Ziegler, Chantal J. Boisvert, Shane P. Flood, Christoph Stretz, Tracy E. Madsen, Michael E. Reznik, Shawna Cutting, Elizabeth E. Moore, Hunter Hewitt, James B. Closser, Jose Torres, Patrick J. Lavin, Karen L. Furie, Ying Xian, Wayne Feng, Valerie Biousse, Matthew Schrag, Shadi Yaghi
Summary: The study found that the cumulative incidence of new atrial fibrillation (AF) after central retinal artery occlusion (CRAO) was approximately 49.6% at 2 years. Patients with CRAO had a higher risk of developing AF compared to controls and a similar risk to patients with stroke. CRAO was also associated with an increased incidence of new stroke.
Article
Ophthalmology
Nanna Vestergaard, Christian Torp-Pedersen, Henrik Vorum, Kristian Aasbjerg
Summary: This study evaluated the risk of stroke, MI, and death in patients with retinal artery occlusion (RAO) and the impact of various antithrombotic treatments for secondary prevention. Patients with RAO had increased risks for all three outcomes, which persisted for more than 1 year. There was no protective effect of antithrombotic treatments within the first year after RAO.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Ophthalmology
Wei Fan, Yanming Huang, Yuancheng Zhao, Rongdi Yuan
Summary: Multiple factors can lead to the absence of cherry-red spots in CRAO. OCT is the most effective imaging method for the early diagnosis of CRAO without cherry-red spots, showing increased hyperreflectivity of the inner retina.