Article
Rheumatology
Siddharth Jain, Varun Dhir, Amita Aggarwal, Ranjan Gupta, Bidyalaxmi Leishangthem, Shankar Naidu, Aastha Khullar, Supriya Maurya, Veena Dhawan, Shefali Khanna Sharma, Aman Sharma, Sanjay Jain
Summary: This study compared the efficacy and safety of different dose escalation strategies of oral MTX in RA patients over a period of 16-24 weeks. The results showed that a faster escalation strategy was not more effective than the usual strategy, but was associated with higher gastrointestinal adverse events in the initial phase.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, General & Internal
Athimalaipet Ramanan, Pierre Quartier, Nami Okamoto, Ivan Foeldvari, Alberto Spindler, Sarka Fingerhutova, Jordi Anton, Zhongkai Wang, Gabriella Meszaros, Joana Araujo, Ran Liao, Stuart Keller
Summary: Baricitinib demonstrated good efficacy and acceptable safety in the treatment of polyarticular juvenile idiopathic arthritis, extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, and juvenile psoriatic arthritis.
Article
Rheumatology
Koray Tascilar, Melanie Hagen, Arnd Kleyer, David Simon, Michaela Reiser, Axel J. Hueber, Bernhard Manger, Matthias Englbrecht, Stephanie Finzel, Hans-Peter Tony, Florian Schuch, Stefan Kleinert, Joerg Wendler, Monika Ronneberger, Camille P. Figueiredo, Jayme F. Cobra, Martin Feuchtenberger, Martin Fleck, Karin Manger, Wolfgang Ochs, Matthias Schmitt-Haendle, Hanns-Martin Lorenz, Hubert Nuesslein, Rieke Alten, Klaus Kruger, Joerg Henes, Georg Schett, Juergen Rech
Summary: The study investigated tapering and withdrawal of DMARDs in patients with rheumatoid arthritis in sustained remission, and found reducing antirheumatic drugs in stable remission is feasible, with maintenance of remission occurring in about half of the patients. Close monitoring is required for patients who tapered or stopped antirheumatic drugs to prevent relapse.
LANCET RHEUMATOLOGY
(2021)
Article
Rheumatology
Pascal Richette, Augustin Latourte, Jeremie Sellam, Daniel Wendling, Muriel Piperno, Philippe Goupille, Yves-Marie Pers, Florent Eymard, Sebastien Ottaviani, Paul Ornetti, Rene-Marc Flipo, Bruno Fautrel, Olivier Peyr, Jean Pierre Bertola, Eric Vicaut, Xavier Chevalier
Summary: The study found that tocilizumab was not more effective than placebo in relieving pain in patients with hand osteoarthritis. Apart from the primary endpoint, there were no significant differences in secondary outcomes between the tocilizumab group and the placebo group.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Carlo Scognamiglio Renner Araujo, Ana Cristina Medeiros-Ribeiro, Carla G. S. Saad, Karina Rossi Bonfiglioli, Diogo Souza Domiciano, Andrea Yukie Shimabuco, Matheus Santos Rodrigues Silva, Emily Figueiredo Neves Yuki, Sandra Gofinet Pasoto, Tatiana Pedrosa, Leonard de Vinci Kanda Kupa, Gioanna Zou, Rosa M. R. Pereira, Clovis Artur Silva, Nadia Emi Aikawa, Eloisa Bonfa
Summary: This study evaluated the effect of discontinuing methotrexate (MTX) for 2 weeks after each dose of the Sinovac-CoronaVac vaccine on immunogenicity and safety in patients with rheumatoid arthritis (RA). The results showed that the group that discontinued MTX had a higher rate of seroconversion and higher antibody titers compared to the group that continued MTX. However, there was an increased risk of flare after the second MTX withdrawal.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Maarten Boers, Linda Hartman, Daniela Opris-Belinski, Reinhard Bos, Marc R. Kok, Jose A. P. Da Silva, Eduard N. Griep, Ruth Klaasen, Cornelia F. Allaart, Paul Baudoin, Hennie G. Raterman, Zoltan Szekanecz, Frank Buttgereit, Pavol Masaryk, L. Thomas Klausch, Sabrina Paolino, Annemarie M. Schilder, Willem F. Lems, Maurizio Cutolo
Summary: This study compared the effects and side effects of low-dose prednisolone and placebo treatment in elderly patients with active rheumatoid arthritis. The results showed that low-dose prednisolone can reduce disease activity and joint damage, but the side effects also increased by 24%.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Roy Fleischmann, Alan Friedman, Edit Drescher, Atul Singhal, Gregorio Cortes-Maisonet, Thao Doan, Wenjing Lu, Zailong Wang, Ahmed Nader, William Housley, Stanley Cohen, Peter C. Taylor, Ricardo Blanco
Summary: This study aimed to evaluate the efficacy and safety of ABBV-599 in the treatment of active rheumatoid arthritis. The results showed that the JAK inhibitor upadacitinib, used in combination with ABBV-599, had a significant impact on improving disease activity, while the BTK inhibitor elsubrutinib had no discernible effect. The combination therapy of the two drugs demonstrated good safety.
LANCET RHEUMATOLOGY
(2022)
Article
Rheumatology
Vibeke Strand, Philip J. Mease, Ervant J. Maksabedian Hernandez, Bradley S. Stolshek, Lyrica X. H. Liu, David H. Collier, Gregory Kricorian, Joseph F. Merola
Summary: In patients with Psoriatic Arthritis (PsA), those receiving etanercept monotherapy or MTX+ etanercept combination therapy showed greater improvements in several patient-reported outcomes (PROs) compared to those receiving MTX monotherapy. PROs should be considered in treatment discussions between patients and clinicians to determine the most beneficial treatment options for PsA patients.
Article
Rheumatology
Kim Papp, Richard B. Warren, Lawrence Green, Kristian Reich, Richard G. Langley, Carle Paul, Akihiko Asahina, Lynne Johnson, Vipin Arora, Olawale Osuntokun, Mark Lebwohl
Summary: In this phase 3 trial, mirikizumab showed superiority over placebo and secukinumab in treating moderate-to-severe plaque psoriasis. The safety profile of mirikizumab was consistent with other IL-23 inhibitors. However, the study sponsor has decided not to pursue licensing of mirikizumab in this patient population.
LANCET RHEUMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Omar Al Tabaa, Adrien Etcheto, Sophie Dumas, Frederic Batteux, Claire Goulvestre, Anna Molto, Corinne Miceli-Richard, Maxime Dougados
Summary: This study aimed to describe the switch from iETN to bETN, evaluate factors associated with the switch, and assess the efficacy of the switch. Findings suggest that physician age and position may influence the likelihood of patients switching to bETN. After 6 months of follow-up, the bETN retention rate was 83%.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Qiong Fu, Ping Feng, Ling-Yun Sun, Xiao-Xia Zuo, Dong-Bao Zhao, Dong-Yi He, Hua-Xiang Wu, Wei Zhang, Wei Zhang, Fang Du, Chun-De Bao
Summary: The study showed that the combination of Tc-99-MDP with MTX inhibited structural damage and improved disease activity in RA patients, without increasing the rate of adverse events. Additional clinical studies of Tc-99-MDP therapy in patients with RA are warranted.
CHINESE MEDICAL JOURNAL
(2021)
Article
Immunology
Mahmoud S. Abdallah, Sumaiah J. Alarfaj, Dalia S. Saif, Mostafa E. El-Naggar, Mohamed A. Elsokary, Hozaifa K. Elsawah, Shimaa Abdelsattar Zaki, Engy A. Wahsh, Hend E. Abo Mansour, Esraa M. Mosalam
Summary: Metformin (MET) can enhance the anti-rheumatic effect of MTX through its anti-inflammatory actions, making it a beneficial adjunctive treatment in patients with rheumatoid arthritis (RA).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Rheumatology
Andreas Kerschbaumer, Zaida Iasha Rivai, Josef S. Smolen, Daniel Aletaha
Summary: This study analyzed the response differences in patients with rheumatoid arthritis receiving placebo treatment, comparing those who continued background therapy with methotrexate (MTX) and those without any disease modifying antirheumatic drugs (DMARDs). The results showed that placebo responses were higher in patients who continued MTX background therapy, suggesting a more consequent intake of background therapy during the trial period.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Medicine, General & Internal
Nicolino Ruperto, Hermine Brunner, Olga Synoverska, Tracy Ting, Carlos Abud Mendoza, Alberto Spindler, Yulia Vyzhga, Katherine Marzan, Lyudmila Grebenkina, Irit Tirosh, Lisa Imundo, Rita Jerath, Daniel J. Kingsbury, Betul Sozeri, Sheetal S. Vora, Sampath Prahalad, Elena Zholobova, Yonatan Butbul Aviel, Vyacheslav Chasnyk, Melissa Lerman, Kabita Nanda, Heinrike Schmeling, Heather Tory, Yosef Uziel, Diego O. Viola, Holly B. Posner, Keith S. Kanik, Ann Wouters, Cheng Chang, Richard Zhang, Irina Lazariciu, Ming-Ann Hsu, Ricardo M. Suehiro, Alberto Martini, Daniel J. Lovell
Summary: The trial showed that tofacitinib is an effective treatment for patients with polyarticular course JIA. New oral therapies are particularly relevant for children and adolescents, who might prefer to avoid injections.
Article
Gastroenterology & Hepatology
Stephen Hanauer, Bernd Liedert, Sigrid Balser, Ekkehard Brockstedt, Viktoria Moschetti, Stefan Schreiber
Summary: The biosimilar BI 695501 showed similar efficacy and safety to adalimumab reference product in patients with Crohn's disease. Patients who switched from adalimumab reference product to BI 695501 maintained treatment benefits. These results further support the approval of BI 695501 as an alternative treatment for Crohn's disease patients.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Rheumatology
Sang-Cheol Bae, Soo-Kyung Cho, Soyoung Won, Hye-Soon Lee, Sang-Heon Lee, Young Mo Kang, Sang-Hoon Lee, Yeon-Ah Lee, Jung-Yoon Choe, Won-Tae Chung, Chang-Hee Suh, Seung-Cheol Shim, Jisoo Lee, Bo Young Yoon, Dong-Wook Kim, Shin-Seok Lee, Wan-Hee Yoo, Jin-Seok Kim, Young-Ok Jung, Seong-Su Nah, Choong-Ki Lee, Gwan-Gyu Song, Sung Jae Choi, Chung-Il Joung, Hyein Koh, Young-Joo Kim
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2018)
Article
Rheumatology
In Seol Yoo, Sun Young Lee, Chan Keol Park, Jeong Chan Lee, Young Kim, Su Jin Yoo, Seung Cheol Shim, Yoon Seok Choi, Young Lee, Seong Wook Kang
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2018)
Article
Medicine, General & Internal
Sang-Cheol Bae, Young Ho Lee
POSTGRADUATE MEDICAL JOURNAL
(2018)
Article
Rheumatology
S. -C. Bae, Y. H. Lee
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2018)
Article
Rheumatology
Y. H. Lee, S. -C. Bae
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2018)
Article
Rheumatology
S. -C. Bae, Y. H. Lee
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2018)
Article
Rheumatology
Megan R. W. Barber, John G. Hanly, Li Su, Murray B. Urowitz, Yvan St Pierre, Juanita Romero-Diaz, Caroline Gordon, Sang-Cheol Bae, Sasha Bernatsky, Daniel J. Wallace, David A. Isenberg, Anisur Rahman, Ellen M. Ginzler, Michelle Petri, Ian N. Bruce, Paul R. Fortin, Dafna D. Gladman, Jorge Sanchez-Guerrero, Rosalind Ramsey-Goldman, Munther A. Khamashta, Cynthia Aranow, Meggan Mackay, Graciela S. Alarcon, Susan Manzi, Ola Nived, Andreas Jonsen, Asad A. Zoma, Ronald F. van Vollenhoven, Manuel Ramos-Casals, Guillermo Ruiz-Irastorza, S. Sam Lim, Kenneth C. Kalunian, Murat Inanc, Diane L. Kamen, Christine A. Peschken, Soren Jacobsen, Anca Askanase, Chris Theriault, Vernon Farewell, Ann E. Clarke
ARTHRITIS CARE & RESEARCH
(2018)
Article
Medicine, General & Internal
Soo-Kyoung Cho, Dam Kim, Soyoung Won, Jiyoung Lee, Chan-Bum Choi, Jung-Yoon Choe, Seung-Jae Hong, Jae-Bum Jun, Tae-Hwan Kim, Eunmi Koh, Hye-Soon Lee, Jisoo Lee, Dae-Hyun Yoo, Bo Young Yoon, Sang-Cheol Bae, Yoon-Kyoung Sung
KOREAN JOURNAL OF INTERNAL MEDICINE
(2019)
Article
Rheumatology
Young Kim, Kyu Sang Song, Eun Hee Sohn, Seong Wook Kang, In Seol Yoo, Seung-Cheol Shim, Su-Jin Yoo, Jinhyun Kim
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2019)
Article
Rheumatology
Desiree van der Heijde, Vibeke Strand, Yoshiya Tanaka, Edward Keystone, Joel Kremer, Cristiano A. F. Zerbini, Mario H. Cardiel, Stanley Cohen, Peter Nash, Yeong-Wook Song, Dana Tegzova, David Gruben, Gene Wallenstein, Carol A. Connell, Roy Fleischmann, Stephen Hall, David Nicholls, Maureen Rischmueller, Milton F. Baker, Louis Bessette, Alfred A. Cividino, Boulos Haraoui, Henry Niall Jones, Edward Keystone, Majed Khraishi, J. Thorne, Charles Allen Birbara, Herbert Stuart Block Baraf, Joan Marie Bathon, Alan Lawrence Brodsky, John Joseph Cush, Ara Hagop Dikranian, Erdal Diri, Paul Andrew Dura, Kristine Marie Lohr, Roy Fleischmann, Robert Michael Griffin, Dale George Halter, Jody Kay Hargrove, David William Bouda, Suresh Kumar Reddy Pasya, Geneva Louise Hill, Raymond Edward Jackson, Shelly Pearl Kafka, Jeffrey Louis Kaine, Paul L. Katzenstein, Kevin James Kempf, Karen Sue Kolba, Joel Kremer, Selden Longley, Steven D. Mathews, Ami Charise Milton, Richard James Misischia, Haydon Anthony Moorman, Larry Wayne Moreland, Mark William Niemer, William Rodney Palmer, Michael Eugene Sayers, Patrick Thomas Schuette, Talha Shamim, William Julius Shergy, David Hilton Sikes, Joel Charles Silverfield, Chokkalingam Siva, James D. Taborn, Bridget Tyrell Walsh, Alvin Francis Wells, Sanford Mayer Wolfe, Prabha Adhikari, Kouichi Amano, Sang-Cheol Bae, Srikantiah Chandrashekara, Arvind K. Chopra, Ping-Ning Hsu, Mitsuhiro Iwahashi, Jugal Kishore Kadel, Yojiro Kawabe, Eun-Mi Koh, Joung-liang Lan, Soo-Kon Lee, Hsiao-Yi Lin, Lieh-bang Liou, Ming-Fei Liu, Kiyoshi Migita, Toshiaki Miyamoto, Nobuyuki Miyasaka, Shunsuke Mori, Yasuhiko Munakata, Shuji Ohta, Won Park, Sung-Hwan Park, Uppuluri Ramakrishna Rao, Seung Cheol Shim, Vineeta Shobha, Yeong-Wook Song, Yoshinari Takasaki, Tsutomu Takeuchi, Yoshiya Tanaka, Shigeto Tohma, Wen-Chan Tsai, Yukitaka Ueki, Sarath Chandra Mouli Veeravalli, Shrikant Wagh, Hisashi Yamanaka, Bin Yoo, Anastas Batalov, Daniela Bichoversuska, Zdenek Dvorak, Ivan Goranov, Halyna M. Hrytsenko, Jana Kopackova, Zdenka Mosterova, Boycho Oparanov, Andriy Petrov, Ines Pokrzywnicka-Gajek, Vladyslav V. Povoroznyuk, Jan Rosa, Zofia Ruzga, Loukas Settas, Mykola A. Stanislavchuk, Dana Tegzova, Vira Iosypivna Tseluyko, Petr Vitek, Cristiano A. F. Zerbini, Joao Carlos Tavares Brenol, Mario H. Cardiel, William Jose Otero Escalante, Maria Concepcion Maldonado--Lopez, Juan Jose Jaller Raad, Javier Dario Marquez Hernandez, Edwin Antonio Jauregui, Mauro W. Keiserman, Ana Claudia Cauceglia Melazzi, Virginia Pascual-Ramos, Luciana Teixeira Pinto, Sebastiao C. Radominski, Antonio Carlos Ximenes, Sol Villegas de Morales
ARTHRITIS & RHEUMATOLOGY
(2019)
Article
Oncology
Chang-Hee Suh, Dae Hyun Yoo, Alfredo Berrocal Kasay, Elia Chalouhi El-Khouri, Francisco Fidenci Cons Molina, Pavel Shesternya, Pedro Miranda, Francisco G. Medina-Rodriguez, Piotr Wiland, Slawomir Jeka, Jose Chavez-Corrales, Thomas Linde, Pawel Hrycaj, Mauricio Abello-Banfi, Ihor Hospodarskyy, Janusz Jaworski, Mariusz Piotrowski, Marek Brzosko, Marek Krogulec, Sergii Shevchuk, Armando Calvo, Daina Andersone, Won Park, Seung Cheol Shim, Sang Joon Lee, Sung Young Lee
Article
Genetics & Heredity
Julio E. Molineros, Loren L. Looger, Kwangwoo Kim, Yukinori Okada, Chikashi Terao, Celi Sun, Xu-jie Zhou, Prithvi Raj, Yuta Kochi, Akari Suzuki, Shuji Akizuki, Shuichiro Nakabo, So-Young Bang, Hye-Soon Lee, Young Mo Kang, Chang-Hee Suh, Won Tae Chung, Yong-Beom Park, Jung-Yoon Choe, Seung-Cheol Shim, Shin-Seok Lee, Xiaoxia Zuo, Kazuhiko Yamamoto, Quan-Zhen Li, Nan Shen, Lauren L. Porter, John B. Harley, Kek Heng Chua, Hong Zhang, Edward K. Wakeland, Betty P. Tsao, Sang-Cheol Bae, Swapan K. Nath
Article
Rheumatology
Xianyong Yin, Kwangwoo Kim, Hiroyuki Suetsugu, So-Young Bang, Leilei Wen, Masaru Koido, Eunji Ha, Lu Liu, Yuma Sakamoto, Sungsin Jo, Rui-Xue Leng, Nao Otomo, Viktoryia Laurynenka, Young-Chang Kwon, Yujun Sheng, Nobuhiko Sugano, Mi Yeong Hwang, Weiran Li, Masaya Mukai, Kyungheon Yoon, Minglong Cai, Kazuyoshi Ishigaki, Won Tae Chung, He Huang, Daisuke Takahashi, Shin-Seok Lee, Mengwei Wang, Kohei Karino, Seung-Cheol Shim, Xiaodong Zheng, Tomoya Miyamura, Young Mo Kang, Dongqing Ye, Junichi Nakamura, Chang-Hee Suh, Yuanjia Tang, Goro Motomura, Yong-Beom Park, Huihua Ding, Takeshi Kuroda, Jung-Yoon Choe, Chengxu Li, Hiroaki Niiro, Youngho Park, Changbing Shen, Takeshi Miyamoto, Ga-Young Ahn, Wenmin Fei, Tsutomu Takeuchi, Jung-Min Shin, Keke Li, Yasushi Kawaguchi, Yeon-Kyung Lee, Yongfei Wang, Koichi Amano, Dae Jin Park, Wanling Yang, Yoshifumi Tada, Ken Yamaji, Masato Shimizu, Takashi Atsumi, Akari Suzuki, Takayuki Sumida, Yukinori Okada, Koichi Matsuda, Keitaro Matsuo, Yuta Kochi, Leah C. Kottyan, Matthew T. Weirauch, Sreeja Parameswaran, Shruti Eswar, Hanan Salim, Xiaoting Chen, Kazuhiko Yamamoto, John B. Harley, Koichiro Ohmura, Tae-Hwan Kim, Sen Yang, Takuaki Yamamoto, Bong-Jo Kim, Nan Shen, Shiro Ikegawa, Hye-Soon Lee, Xuejun Zhang, Chikashi Terao, Yong Cui, Sang-Cheol Bae
Summary: This study conducted the largest genome-wide meta-analysis for SLE in East Asian populations, identifying 46 novel loci and prioritizing putative causal variants using Bayesian statistical approach. The findings highlight the power of large-scale genetic discovery in shedding light on the genetic and biological understandings of SLE.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Health Care Sciences & Services
Jeong Seok Lee, Harris Ahmad, Seung-Cheol Shim, Sang-Cheol Bae, Yeong Wook Song, Eun Young Lee
PATIENT-PATIENT CENTERED OUTCOMES RESEARCH
(2019)
Article
Medicine, General & Internal
Jason Jungsik Song, Yeong Wook Song, Sang Cheol Bae, Hoon-Suk Cha, Jung-Yoon Choe, Sung Jae Choi, Hyun Ah Kim, Jinseok Kim, Sung-Soo Kim, Choong-Ki Lee, Jisoo Lee, Sang-Heon Lee, Shin-Seok Lee, Soo-Kon Lee, Sung Won Lee, Sung-Hwan Park, Won Park, Seung Cheol Shim, Chang-Hee Suh, Bin Yoo, Dae-Hyun Yoo, Wan-Hee Yoo
JOURNAL OF KOREAN MEDICAL SCIENCE
(2018)