Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians

A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases

(2017) Jian Zhao et al.   NATURE GENETICS

Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants

(2017) Jason H. Karnes et al.   Science Translational Medicine

Transancestral mapping and genetic load in systemic lupus erythematosus

(2017) Carl D. Langefeld et al.   Nature Communications

Negatively-charged amino acids at the peptide-binding pocket of HLA-DPB1 alleles are associated with susceptibility to anti-topoisomerase I-positive systemic sclerosis

(2016) Jeong Seok Lee et al.   HUMAN IMMUNOLOGY

Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease

(2016) Fusheng Zhou et al.   NATURE GENETICS

Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture

(2015) Philip E. Stuart et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The amino acid variation within the binding pocket 7 and 9 of HLA-DRB1 molecules are associated with primary Sjögren's syndrome

(2015) Renliang Huang et al.   JOURNAL OF AUTOIMMUNITY

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

(2015) Philippe Goyette et al.   NATURE GENETICS

Construction of a population-specific HLA imputation reference panel and its application to Graves' disease risk in Japanese

(2015) Yukinori Okada et al.   NATURE GENETICS

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

(2015) James Bentham et al.   NATURE GENETICS

Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

(2015) Javier Gutierrez-Achury et al.   NATURE GENETICS

The first step of peptide selection in antigen presentation by MHC class I molecules

(2015) Malgorzata A. Garstka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new statistical approach to combining p-values using gamma distribution and its application to genome-wide association study

(2015) Zhongxue Chen et al.   BMC BIOINFORMATICS

Fine Mapping Seronegative and Seropositive Rheumatoid Arthritis to Shared and Distinct HLA Alleles by Adjusting for the Effects of Heterogeneity

(2014) Buhm Han et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Fine Mapping Major Histocompatibility Complex Associations in Psoriasis and Its Clinical Subtypes

(2014) Yukinori Okada et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations

(2014) Yukinori Okada et al.   HUMAN MOLECULAR GENETICS

Construction and Application of a Korean Reference Panel for Imputing Classical Alleles and Amino Acids of Human Leukocyte Antigen Genes

(2014) Kwangwoo Kim et al.   PLoS One

Origins of specificity and affinity in antibody–protein interactions

(2014) Hung-Pin Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HLA-DRβ1 amino acid positions 11–13–26 explain the majority of SLE–MHC associations

(2014) Kwangwoo Kim et al.   Nature Communications

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Transcriptome and genome sequencing uncovers functional variation in humans

(2013) Tuuli Lappalainen et al.   NATURE

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

(2013) Christopher J Lessard et al.   NATURE GENETICS

Association of Increased Frequencies of HLA-DPB1*05∶01 with the Presence of Anti-Ro/SS-A and Anti-La/SS-B Antibodies in Japanese Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients

(2013) Hiroshi Furukawa et al.   PLoS One

Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens

(2013) Xiaoming Jia et al.   PLoS One

Properties of MHC Class I Presented Peptides That Enhance Immunogenicity

(2013) Jorg J. A. Calis et al.   PLoS Computational Biology

Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects

(2013) Nikolaos A. Patsopoulos et al.   PLoS Genetics

Unraveling Multiple MHC Gene Associations with Systemic Lupus Erythematosus: Model Choice Indicates a Role for HLA Alleles and Non-HLA Genes in Europeans

(2012) David L. Morris et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians

(2012) Wanling Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A combined DPA1∼DPB1 amino acid epitope is the primary unit of selection on the HLA-DP heterodimer

(2012) Jill A. Hollenbach et al.   IMMUNOGENETICS

The genetic contribution of HLA-DRB5*01:01 to systemic lupus erythematosus in Thailand

(2012) W. Louthrenoo et al.   International Journal of Immunogenetics

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

(2012) Soumya Raychaudhuri et al.   NATURE GENETICS

Antigenicity and Epitope Specificity of ZnT8 Autoantibodies in Type 1 Diabetes

(2012) H. Skärstrand et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese

(2012) Yukinori Okada et al.   PLoS Genetics

Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases

(2011) Hon-Cheong So et al.   GENETIC EPIDEMIOLOGY

Genome-wide association study identifies susceptibility loci for IgA nephropathy

(2011) Ali G Gharavi et al.   NATURE GENETICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

HLA genotyping in the international Type 1 Diabetes Genetics Consortium

(2010) Josyf C Mychaleckyj et al.   Clinical Trials

HLA DPA1, DPB1 Alleles and Haplotypes Contribute to the Risk Associated With Type 1 Diabetes

(2010) Michael D. Varney et al.   DIABETES

Novel sequence feature variant type analysis of the HLA genetic association in systemic sclerosis

(2009) David R. Karp et al.   HUMAN MOLECULAR GENETICS

Choosing an optimal method to combineP-values

(2009) Sungho Won et al.   STATISTICS IN MEDICINE

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice

(2008) F. Menconi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA