Nanoparticle exposure driven circulating bioactive peptidome causes systemic inflammation and vascular dysfunction

N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration

(2018) Chia-yi Chen et al.   MATRIX BIOLOGY

Neutrophil-Mediated Proteolysis of Thrombospondin-1 Promotes Platelet Adhesion and String Formation

(2018) Katharina Seif et al.   THROMBOSIS AND HAEMOSTASIS

Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge

(2017) Vicki Stone et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Cigarette smoke extract induced exosome release is mediated by depletion of exofacial thiols and can be inhibited by thiol-antioxidants

(2017) Birke J. Benedikter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Modeling vascular inflammation and atherogenicity after inhalation of ambient levels of ozone: exploratory lessons from transcriptomics

(2017) Andrea Tham et al.   INHALATION TOXICOLOGY

Thrombospondin-1 mediates multi-walled carbon nanotube induced impairment of arteriolar dilation

(2017) W. Kyle Mandler et al.   Nanotoxicology

Serum-borne bioactivity caused by pulmonary multiwalled carbon nanotubes induces neuroinflammation via blood–brain barrier impairment

(2017) Mario J. Aragon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum from obstructive sleep apnea patients induces inflammatory responses in coronary artery endothelial cells

(2016) Katherine E. Zychowski et al.   ATHEROSCLEROSIS

Beyond PM2.5: The role of ultrafine particles on adverse health effects of air pollution

(2016) Rui Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Recent advances of liquid chromatography–(tandem) mass spectrometry in clinical and forensic toxicology — An update

(2016) Daniela Remane et al.   CLINICAL BIOCHEMISTRY

Label-free quantification in ion mobility–enhanced data-independent acquisition proteomics

(2016) Ute Distler et al.   Nature Protocols

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Surface area-dependence of gas-particle interactions influences pulmonary and neuroinflammatory outcomes

(2016) Christina R. Tyler et al.   Particle and Fibre Toxicology

MMP-9-Dependent Serum-Borne Bioactivity Caused by Multiwalled Carbon Nanotube Exposure Induces Vascular Dysfunction via the CD36 Scavenger Receptor

(2016) Mario Aragon et al.   TOXICOLOGICAL SCIENCES

Twenty years of theMEROPSdatabase of proteolytic enzymes, their substrates and inhibitors

(2015) Neil D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1

(2015) Tina El Rayes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Matricryptins and matrikines: biologically active fragments of the extracellular matrix

(2014) Sylvie Ricard-Blum et al.   EXPERIMENTAL DERMATOLOGY

Molecular Basis of Antiangiogenic Thrombospondin-1 Type 1 Repeat Domain Interactions With CD36

(2013) Philip A. Klenotic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Post-Acute Brain Injury Urinary Signature: A New Resource for Molecular Diagnostics

(2013) Andrew K. Ottens et al.   JOURNAL OF NEUROTRAUMA

A Proteomics Search Algorithm Specifically Designed for High-Resolution Tandem Mass Spectra

(2013) Craig D. Wenger et al.   JOURNAL OF PROTEOME RESEARCH

Six-month follow-up study of health markers of nanomaterials among workers handling engineered nanomaterials

(2013) Hui-Yi Liao et al.   Nanotoxicology

Carbon nanotube dosimetry: from workplace exposure assessment to inhalation toxicology

(2013) Aaron Erdely et al.   Particle and Fibre Toxicology

Extrapulmonary transport of MWCNT following inhalation exposure

(2013) Robert R Mercer et al.   Particle and Fibre Toxicology

Extracellular vesicles in physiological and pathological conditions

(2012) Yuana Yuana et al.   BLOOD REVIEWS

False discovery rates in spectral identification

(2012) Kyowon Jeong et al.   BMC BIOINFORMATICS

High-capacity peptide-centric platform to decode the proteomic response to brain injury

(2012) Diego F. Cortes et al.   ELECTROPHORESIS

Impairment of Coronary Arteriolar Endothelium-Dependent Dilation after Multi-Walled Carbon Nanotube Inhalation: A Time-Course Study

(2012) Phoebe Stapleton et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tissue factor–bearing exosome secretion from human mechanically stimulated bronchial epithelial cells in vitro and in vivo

(2012) Jin-Ah Park et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The outdoor air pollution and brain health workshop

(2012) Michelle L. Block et al.   NEUROTOXICOLOGY

PROSPER: An Integrated Feature-Based Tool for Predicting Protease Substrate Cleavage Sites

(2012) Jiangning Song et al.   PLoS One

Identification of Systemic Markers from A Pulmonary Carbon Nanotube Exposure

(2011) Aaron Erdely et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Nanoparticle inhalation alters systemic arteriolar vasoreactivity through sympathetic and cyclooxygenase-mediated pathways

(2011) Travis L. Knuckles et al.   Nanotoxicology

SignalP 4.0: discriminating signal peptides from transmembrane regions

(2011) Thomas Nordahl Petersen et al.   NATURE METHODS

mMass3: A Cross-Platform Software Environment for Precise Analysis of Mass Spectrometric Data

(2010) Martin Strohalm et al.   ANALYTICAL CHEMISTRY

Particulate Matter Air Pollution and Cardiovascular Disease

(2010) Robert D. Brook et al.   CIRCULATION

Cardiopulmonary response to inhalation of biogenic secondary organic aerosol

(2010) Jacob D. McDonald et al.   INHALATION TOXICOLOGY

Platelet adhesion and fibrinogen deposition in murine microvessels upon inhalation of nanosized carbon particles

(2010) A. KHANDOGA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Multiplex N-terminome Analysis of MMP-2 and MMP-9 Substrate Degradomes by iTRAQ-TAILS Quantitative Proteomics

(2010) Anna Prudova et al.   MOLECULAR & CELLULAR PROTEOMICS

Multi-walled carbon nanotubes (Baytubes®): Approach for derivation of occupational exposure limit

(2010) Jürgen Pauluhn   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Translocation and extra pulmonary toxicities of multi wall carbon nanotubes in rats

(2010) A. Rama Narsimha Reddy et al.   TOXICOLOGY MECHANISMS AND METHODS

Vehicular Emissions Induce Vascular MMP-9 Expression and Activity Associated With Endothelin-1–Mediated Pathways

(2009) Amie K. Lund et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endosomal Leakage and Nuclear Translocation of Multiwalled Carbon Nanotubes: Developing a Model for Cell Uptake

(2009) Qingxin Mu et al.   NANO LETTERS

Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice

(2009) L. A. Mitchell et al.   Nature Nanotechnology

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

(2009) J. Chen et al.   NUCLEIC ACIDS RESEARCH

Proteomics and the lung: Analysis of bronchoalveolar lavage fluid

(2009) Praveen Govender et al.   Proteomics Clinical Applications

Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes

(2009) Dale W. Porter et al.   TOXICOLOGY

Potential in vitro effects of carbon nanotubes on human aortic endothelial cells

(2009) Valerie G. Walker et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The interaction of Thrombospondins with extracellular matrix proteins

(2009) Kemin Tan et al.   Journal of Cell Communication and Signaling

MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer

(2008) Douglas D. Taylor et al.   GYNECOLOGIC ONCOLOGY

Pharmacoproteomics of a Metalloproteinase Hydroxamate Inhibitor in Breast Cancer Cells: Dynamics of Membrane Type 1 Matrix Metalloproteinase-Mediated Membrane Protein Shedding

(2008) G. S. Butler et al.   MOLECULAR AND CELLULAR BIOLOGY

Cross-Talk between Lung and Systemic Circulation during Carbon Nanotube Respiratory Exposure. Potential Biomarkers

(2008) Aaron Erdely et al.   NANO LETTERS

Exposure to ultrafine carbon particles at levels below detectable pulmonary inflammation affects cardiovascular performance in spontaneously hypertensive rats

(2008) Swapna Upadhyay et al.   Particle and Fibre Toxicology