MLN4924 Exerts a Neuroprotective Effect against Oxidative Stress via Sirt1 in Spinal Cord Ischemia-Reperfusion Injury

Sirt1-hypoxia-inducible factor-1α interaction is a key mediator of tubulointerstitial damage in the aged kidney

(2019) Dong Ryeol Ryu et al.   AGING CELL

TRAF6 neddylation drives inflammatory arthritis by increasing NF-κB activation

(2019) Kewei Liu et al.   LABORATORY INVESTIGATION

Celastrol protects from cholestatic liver injury though modulation of SIRT1-FXR signaling

(2019) Qi Zhao et al.   MOLECULAR & CELLULAR PROTEOMICS

Berberine protects renal tubular cells against hypoxia/reoxygenation injury via the Sirt1/p53 pathway

(2018) Yuanbang Lin et al.   Journal of Natural Medicines

Protective effect of nicotinamide adenine dinucleotide (NAD+) against spinal cord ischemia–reperfusion injury via reducing oxidative stress-induced neuronal apoptosis

(2017) Lei Xie et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury

(2017) Kojiro Nakamura et al.   JOURNAL OF HEPATOLOGY

Hydrogen Sulfide Inhibits Autophagic Neuronal Cell Death by Reducing Oxidative Stress in Spinal Cord Ischemia Reperfusion Injury

(2017) Lei Xie et al.   Oxidative Medicine and Cellular Longevity

Nicotinamide Adenine Dinucleotide Protects against Spinal Cord Ischemia Reperfusion Injury-Induced Apoptosis by Blocking Autophagy

(2017) Lei Xie et al.   Oxidative Medicine and Cellular Longevity

Hydrogen sulfide protects against TNF-α induced neuronal cell apoptosis through miR-485-5p/TRADD signaling

(2016) Zhiqiang Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PI3K/SGK1/GSK3β signaling pathway is involved in inhibition of autophagy in neonatal rat cardiomyocytes exposed to hypoxia/reoxygenation by hydrogen sulfide

(2016) Huan Jiang et al.   EXPERIMENTAL CELL RESEARCH

N-acetylcysteine reduces the renal oxidative stress and apoptosis induced by hemorrhagic shock

(2016) Miriam Aparecida Moreira et al.   JOURNAL OF SURGICAL RESEARCH

Role of autophagy in the bimodal stage after spinal cord ischemia reperfusion injury in rats

(2016) Bo Fang et al.   NEUROSCIENCE

The MLN4924 inhibitor exerts a neuroprotective effect against oxidative stress injury via Nrf2 protein accumulation

(2016) Ana Cristina Andérica-Romero et al.   Redox Biology

Synaptic structure and function are altered by the neddylation inhibitor MLN4924

(2015) Samantha L. Scudder et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

High-dose ascorbic acid administration improves functional recovery in rats with spinal cord contusion injury

(2014) M Yan et al.   SPINAL CORD

Link Between Oxidative Stress and Acute Brain Ischemia

(2013) Djordje Radak et al.   ANGIOLOGY

Neddylation pathway regulates the proliferation and survival of macrophages

(2013) Lihui Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of Neddylation Represses Lipopolysaccharide-induced Proinflammatory Cytokine Production in Macrophage Cells

(2012) Fang-Mei Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The effects of splenectomy on lipid peroxidation and neuronal loss in experimental spinal cord ischemia/reperfusion injury

(2012) Caglar Temiz et al.   Turkish Neurosurgery

Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis

(2012) Y Zhao et al.   Cell Death & Disease

Sirtuin 1 in lipid metabolism and obesity

(2011) Thaddeus T. Schug et al.   ANNALS OF MEDICINE

Exogenous Hydrogen Sulfide Protects Against Traumatic Hemorrhagic Shock Via Attenuation of Oxidative Stress

(2011) Wei Chai et al.   JOURNAL OF SURGICAL RESEARCH

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF- B-dependent lymphoma

(2010) M. A. Milhollen et al.   BLOOD

Silent Information Regulator 1 Protects the Heart From Ischemia/Reperfusion

(2010) Chiao-Po Hsu et al.   CIRCULATION

Sirt1 activation protects the mouse renal medulla from oxidative injury

(2010) Wenjuan He et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE