Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis

Hypoxia-inducible factor-1 (HIF-1) activation in myeloid cells accelerates DSS-induced colitis progression in mice

(2018) Young-Eun Kim et al.   Disease Models & Mechanisms

Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids

(2017) Pamela Riemer et al.   JOURNAL OF CELL BIOLOGY

Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis

(2017) Veronika Bäcker et al.   PLoS One

Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis

(2017) Derrick D Eichele et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

(2016) Philippe Gascard et al.   GENES & DEVELOPMENT

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

The ever-expanding role of HIF in tumour and stromal biology

(2016) Edward L. LaGory et al.   NATURE CELL BIOLOGY

Targeting hypoxia-mediated mucin 2 production as a therapeutic strategy for mucinous tumors

(2016) Ashok K. Dilly et al.   Translational Research

Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis

(2015) Rafael Kramann et al.   Cell Stem Cell

HIF1α deficiency reduces inflammation in a mouse model of proximal colon cancer

(2015) Dessislava N. Mladenova et al.   Disease Models & Mechanisms

Cyclic adenosine monophosphate-responsive element modulator alpha overexpression impairs function of hepatic myeloid-derived suppressor cells and aggravates immune-mediated hepatitis in mice

(2015) Linda Hammerich et al.   HEPATOLOGY

Classification and biology of tumour associated stromal cells

(2015) Lizzia Raffaghello et al.   IMMUNOLOGY LETTERS

Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitis

(2015) K Flück et al.   Mucosal Immunology

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

(2015) Alexandre Calon et al.   NATURE GENETICS

Stromal contribution to the colorectal cancer transcriptome

(2015) Claudio Isella et al.   NATURE GENETICS

Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis

(2015) Jing Xue et al.   Nature Communications

Activation of HIF-1α does not increase intestinal tumorigenesis

(2014) Xiang Xue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Inhibition of hypoxia-inducible factors limits tumor progression in a mouse model of colorectal cancer

(2014) Jessica E.S. Shay et al.   CARCINOGENESIS

In situ proliferation contributes to accumulation of tumor-associated macrophages in spontaneous mammary tumors

(2014) Piotr Tymoszuk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnt high Metastatic Colon Cancer Cells

(2014) Simone Ragusa et al.   Cell Reports

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Hypoxia-Induced Secretion of TGF-β1 in Mesenchymal Stem Cell Promotes Breast Cancer Cell Progression

(2013) Shun-Pei Hung et al.   CELL TRANSPLANTATION

Endothelial PAS Domain Protein 1 Activates the Inflammatory Response in the Intestinal Epithelium to Promote Colitis in Mice

(2013) Xiang Xue et al.   GASTROENTEROLOGY

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Tumor fibroblast–derived epiregulin promotes growth of colitis-associated neoplasms through ERK

(2013) Clemens Neufert et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Tumor-associated macrophages: functional diversity, clinical significance, and open questions

(2013) Subhra K. Biswas et al.   Seminars in Immunopathology

Molecularly targeted cancer therapy: some lessons from the past decade

(2013) Min Huang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Loss of Fibroblast HIF-1  Accelerates Tumorigenesis

(2012) J.-w. Kim et al.   CANCER RESEARCH

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

(2012) J. B. Mitchem et al.   CANCER RESEARCH

Interleukin-6 - A Key Regulator of Colorectal Cancer Development

(2012) Maximilian J. Waldner et al.   International Journal of Biological Sciences

Wnt and BMP signals control intestinal adenoma cell fates

(2012) Alexandra L. Farrall et al.   INTERNATIONAL JOURNAL OF CANCER

Enhanced production of early lineages of monocytic and granulocytic cells in mice with colitis

(2012) M. D. Trottier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Role of mast cells in colorectal cancer development, the jury is still out

(2010) J. Heijmans et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Macrophage Expression of Hypoxia-Inducible Factor-1  Suppresses T-Cell Function and Promotes Tumor Progression

(2010) A. L. Doedens et al.   CANCER RESEARCH

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

Improved serum-free culture conditions for spleen-derived murine fibrocytes

(2010) Jeffrey R. Crawford et al.   JOURNAL OF IMMUNOLOGICAL METHODS

O2 regulates stem cells through Wnt/β-catenin signalling

(2010) Jolly Mazumdar et al.   NATURE CELL BIOLOGY

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

Hypoxia enhances MUC1 expression in a lung adenocarcinoma cell line

(2009) Yuji Mikami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF–Dependent Inflammatory Signaling Cascade

(2008) Yatrik M. Shah et al.   GASTROENTEROLOGY

HIF-1α and HIF-2α have divergent roles in colon cancer

(2008) Takaaki Imamura et al.   INTERNATIONAL JOURNAL OF CANCER

Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis

(2008) Christian Stockmann et al.   NATURE

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

(2007) Eoin P. Cummins et al.   GASTROENTEROLOGY

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

(2007) Andreas Robinson et al.   GASTROENTEROLOGY