Wnt and BMP signals control intestinal adenoma cell fates

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

(2011) Jan Paul Medema et al.   NATURE

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

Colon Cancer Stem Cells: Promise of Targeted Therapy

(2010) Matilde Todaro et al.   GASTROENTEROLOGY

Bone Morphogenetic Protein 4 Induces Differentiation of Colorectal Cancer Stem Cells and Increases Their Response to Chemotherapy in Mice

(2010) Ylenia Lombardo et al.   GASTROENTEROLOGY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

An inducible RNA interference system for the functional dissection of mouse embryogenesis

(2010) Joana A. Vidigal et al.   NUCLEIC ACIDS RESEARCH

Newly characterised ex vivo colospheres as a three-dimensional colon cancer cell model of tumour aggressiveness

(2009) L-B Weiswald et al.   BRITISH JOURNAL OF CANCER

Prominin-1/CD133 Marks Stem Cells and Early Progenitors in Mouse Small Intestine

(2009) Hugo J. Snippert et al.   GASTROENTEROLOGY

OLFM4 Is a Robust Marker for Stem Cells in Human Intestine and Marks a Subset of Colorectal Cancer Cells

(2009) Laurens G. van der Flier et al.   GASTROENTEROLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

(2009) Akifumi Ootani et al.   NATURE MEDICINE

Cancer stem cells: mirage or reality?

(2009) Piyush B Gupta et al.   NATURE MEDICINE

CD44 is of Functional Importance for Colorectal Cancer Stem Cells

(2008) L. Du et al.   CLINICAL CANCER RESEARCH

Characterization of a subpopulation of colon cancer cells with stem cell-like properties

(2008) Peter Chu et al.   INTERNATIONAL JOURNAL OF CANCER

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity

(2008) L. Vermeulen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer

(2007) Liudmila L. Kodach et al.   CANCER