Review
Nutrition & Dietetics
Jiaxin Long, Jinlong Wang, Yang Li, Shuai Chen
Summary: This review provides a systematic overview of the link between gut microbiota and associated metabolites to the pathogenesis of ischemic stroke (IS), highlighting the potential implications of gut microbiota-dependent intervention in the treatment of IS.
FRONTIERS IN NUTRITION
(2022)
Review
Immunology
Jinchen Wang, Hongfei Zhang, Jianying He, Xiaoxing Xiong
Summary: This review summarizes the studies on the gut microbiota and its relationship with various neurological diseases, focusing on ischemic stroke. The review provides novel ideas for the prevention and treatment of ischemic stroke by exploring the physiological function of the gut microbiota and gut microbiota disorders related to the central nervous system.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Porntipha Vitheejongjaroen, Anongnard Kasorn, Narathip Puttarat, Fabien Loison, Malai Taweechotipatr
Summary: The results of this study suggest that B. animalis MSMC83 has a beneficial role in alleviating oxidative stress in rats by increasing the expression of antioxidant enzymes and reducing pro-inflammatory cytokines. It also restores microbiota diversity after D-galactose injection.
Article
Cardiac & Cardiovascular Systems
Yan Xu, Xiaobo Qu, Jia Zhou, Guangfu Lv, Dong Han, Jinlong Liu, Yuexin Liu, Ying Chen, Peng Qu, Xiaowei Huang
Summary: The study demonstrates that PAP-3.2KD can improve ADR-induced cardiac pathological changes in animal models, including myocardial fibrosis and heart tissue scores, by affecting the protein levels of Bcl-2, Bax, and caspase-3 to protect myocardial tissue.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Microbiology
Meiqi Zhao, Jiajia Ma, Huiru Liu, Ying Luo, Huiting Deng, Dandan Wang, Fengmei Wang, Peng Zhang
Summary: The gut microbiota plays a crucial role in the development of sepsis, with different enterotypes leading to varying levels of systemic inflammation. The amoxicillin-associated enterotype is characterized by an abundance of opportunistic pathogens, resulting in the most severe inflammation and liver injury in septic mice. These findings highlight the importance of modulating the gut microbiota to prevent or reduce the serious consequences of sepsis, particularly in gut-derived sepsis.
Review
Pharmacology & Pharmacy
Suxin Yuan, Zhengyao Cai, Xingzhao Luan, Haibo Wang, Yi Zhong, Li Deng, Jian Feng
Summary: The pathogenesis of diabetic cardiomyopathy is complex, involving oxidative stress, inflammation, insulin resistance, apoptosis, and autophagy. Some studies suggest that gut microbiota and its metabolites can influence the development of diabetic cardiomyopathy by regulating these mechanisms.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Shenhai Gong, Yinglin Feng, Yunong Zeng, Huanrui Zhang, Meiping Pan, Fangjie He, Rong Wu, Jingrui Chen, Jiuling Lu, Siyou Zhang, Songhua Yuan, Xia Chen
Summary: The study revealed that cisplatin treatment disrupted gut microbiota in mice, and gut microbiota depletion by antibiotics protected against hepatotoxicity. Antibiotic treatment reduced inflammation and oxidative stress levels in the liver. Fecal microbiota transplantation also confirmed the role of microbiota in individual susceptibility to cisplatin-induced hepatotoxicity.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Emma K. A. Schmidt, Pamela J. F. Raposo, Abel Torres-Espin, Keith K. Fenrich, Karim Fouad
Summary: The synthetic tetracycline derivative minocycline has been shown to have anti-inflammatory and neuroprotective properties, with potential therapeutic effects on central nervous system diseases and injuries. This study demonstrated that minocycline can improve gut dysbiosis and immune responses following spinal cord injury, which in turn may reduce anxiety-like behavior. However, while minocycline attenuated microglial activation, it did not impact lesion size or promote motor recovery.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Nutrition & Dietetics
Jumana Abuqwider, Angela Di Porzio, Valentina Barrella, Cristina Gatto, Giuseppina Sequino, Francesca De Filippis, Raffaella Crescenzo, Maria Stefania Spagnuolo, Luisa Cigliano, Gianluigi Mauriello, Susanna Iossa, Arianna Mazzoli
Summary: This study found that microencapsulation can effectively preserve the effectiveness of probiotics in the gastrointestinal tract and protect them from the negative effects of a Western diet. It has significant implications for improving gut function.
FRONTIERS IN NUTRITION
(2023)
Review
Food Science & Technology
Min Wu, Qingying Luo, Rongxuan Nie, Xingpan Yang, Zizhong Tang, Hong Chen
Summary: Polyphenols, as natural compounds derived from plants, have attracted increasing scientific interest for their potential anti-aging benefits in modulating oxidative damage, inflammation, autophagy, and gut microbiota. Research on novel polyphenol-based strategies and clinical trials are encouraged for the development of holistic anti-aging therapy.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Li-Bin Wang, Ling-Ling Xu, Li-Jian Chen, Kai-Kai Zhang, Qin-Yao Zhang, Yu-Kui Chen, Jia-Hao Li, Jia-Li Liu, Qi Wang, Xiao-Li Xie
Summary: METH abuse leads to intestinal toxicity and alters the gut microbiota. This study found that METH treatment weakened the intestinal barrier, increased LPS levels, and induced inflammation. Furthermore, METH treatment reduced probiotic diversity and increased pathogenic gut microbiota. Activation of the TLR4 pathway confirmed the presence of intestinal inflammation. Pretreatment with antibiotics or Tlr4 silencing alleviated METH-induced dysbiosis, LPS over-production, inflammation, and barrier disruption.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Jian Shen, Shuting Wang, Yong Huang, Zhengjie Wu, Shengyi Han, He Xia, Hui Chen, Lanjuan Li
Summary: The study found that Lactobacillus reuteri can improve gut microbiota composition and modulate immune response, showing therapeutic effects in acute lung injury (ALI) models. L. reuteri effectively attenuated lung tissue injury, reduced inflammation and infiltration, improved intestinal barrier function, and remodeled disordered gut microbiota.
Review
Gastroenterology & Hepatology
Tushar K. Das, Bhanu P. Ganesh
Summary: The microbiota-gut-brain axis is a crucial pathway that contributes to the pathogenesis of Alzheimer's disease (AD) by altering gut microbiota and increasing oxidative stress and inflammation. The relationship between specific bacteria and brain dysfunction in AD pathology is not fully understood. This review explores the connections between oxidative stress, inflammation, and gut dysbiosis in AD and suggests potential preventative and therapeutic strategies.
Article
Biochemistry & Molecular Biology
Yanping Wu, Baikui Wang, Li Tang, Yuanhao Zhou, Qi Wang, Li Gong, Jiajia Ni, Weifen Li
Summary: The study revealed that the probiotic Bacillus SC06 alleviates oxidative stress-induced liver injuries by optimizing the composition, metabolic pathways, and pathogenic replication and secretion of gut microbiota. This suggests a promising strategy for preventing liver diseases through targeting gut microbiota.
Article
Biochemistry & Molecular Biology
Hugo C. Barreto, Beatriz Abreu, Isabel Gordo
Summary: Iron availability is tightly regulated in the mammalian gut, and the adaptive allele of the iron regulation gene iscR undergoes fluctuating selection influenced by antibiotics, microbiota, and the immune system. Host immune protein Lipocalin-2 plays a major role in shaping the selection on iscR.
Article
Food Science & Technology
Lingyan Ma, Aqian Zheng, Liyang Ni, Lianxin Wu, Luting Hu, Yufeng Zhao, Zhengwei Fu, Yinhua Ni
Summary: The longevity-promoting probiotic strain LKM512 shows potential in improving hepatic lipid accumulation, reducing inflammation, and enhancing insulin sensitivity in high-fat diet-induced obese mice. It also has an impact on the composition and function of gut microbiota in these mice.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Engineering, Environmental
Xiaoxian Xie, Jiafeng Zhou, Luting Hu, Ruonan Shu, Mengya Zhang, Lei Sun, Fengchun Wu, Zhengwei Fu, Zezhi Li
Summary: This study investigated the toxicological effects of Hexafluoropropylene oxide trimer acid (HFPO-TA) on mitochondrial function and biogenesis. Results showed that exposure to HFPO-TA induced adverse physiological changes in mice and was associated with disrupted mitochondrial energy metabolism.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Reproductive Biology
Qihao Xu, Lingyu Hu, Wenyu Miao, Zhengwei Fu, Yuanxiang Jin
Summary: This study found that the environmental pollutant 3-MC has the potential to disrupt the endocrine system and spermatogenesis in mice. Female exposure to 3-MC can lead to decreased testosterone levels and disrupted testicular morphology in male offspring. However, the adverse effects on the offspring may be mitigated as they grow to adulthood.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Oncology
Mingcang Chen, Chunyu Wu, Zhengwei Fu, Sheng Liu
Summary: Bone-related events caused by breast cancer bone metastasis significantly impact patients' survival and quality of life. ICAM1, highly expressed in TNBC, correlates with prognosis in TNBC patients. ICAM1 interacts with integrins to activate signaling pathways, enhancing cell invasiveness, providing a rationale for ICAM1-targeted therapy.
Article
Endocrinology & Metabolism
Yinhua Ni, Fen Zhuge, Liyang Ni, Naoto Nagata, Tatsuya Yamashita, Naofumi Mukaida, Shuichi Kaneko, Tsuguhito Ota, Mayumi Nagashimada
Summary: This study investigates the roles of CX3CL1/CX3CR1 in macrophage migration and polarization in the livers of NASH mice. It is found that CX3CL1 and CX3CR1 expression is upregulated in NASH mice livers, and CX3CR1 is predominantly expressed by F4/80+ macrophages. CX3CR1 deficiency leads to increased inflammatory monocyte/macrophage infiltration and a shift towards M1 dominant macrophages, exacerbating NASH progression. Deletion of CCL2 in CX3CR1-deficient mice alleviates NASH progression by reducing macrophage infiltration and inducing a shift towards M2 dominant macrophages.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Food Science & Technology
Yinhua Ni, Kexin Zhou, Liqian Zhang, Sujie Nan, Zhengwei Fu
Summary: Hydrolyzed chicken meat extract (HCE) and its bioactive components (BC) can enhance phagocytic activity and attenuate oxidative stress in cells. They also affect macrophage activation through the modulation of specific pathways. Therefore, HCE and BC may serve as potential immunoregulatory agents.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Nutrition & Dietetics
Yinhua Ni, Aqian Zheng, Yating Hu, Nianke Rong, Qianpeng Zhang, Wenmin Long, Song Yang, Sujie Nan, Liqian Zhang, Kexin Zhou, Tianxing Wu, Zhengwei Fu
Summary: Dietary intervention with a low glycemic index and full nutritional support, such as the novel compound dietary fiber and high-grade protein diet (CFP), can effectively improve glycemic control, insulin resistance, and diabetes-related metabolic syndromes. CFP treatment enhances gut barrier function and alters gut microbiota composition and function, leading to a wider range of protection against diabetes compared to liraglutide.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Yinhua Ni, Liujie Zheng, Sujie Nan, Lehui Ke, Zhengwei Fu, Juan Jin
Summary: The role of gut-kidney crosstalk in the progression of diabetic nephropathy is of increasing concern. Renal dysfunction increases circulating uremic toxins and affects the gut microbiota, while intestinal dysbiosis destroys the epithelial barrier, leading to increased exposure to endotoxins, and exacerbating kidney damage through systemic inflammation. Dietary interventions and novel diabetic agents targeting the gut microbiota may be potential therapies for diabetic nephropathy.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Environmental Sciences
Luting Hu, Lei Sun, Jiafeng Zhou, Fengchun Wu, Zhengwei Fu, Xiaoxian Xie
Summary: HFPO-TA exposure results in imbalances and alterations in gut microbiota, as well as changes in metabolic pathways.
Article
Biochemistry & Molecular Biology
Chunlei Yang, Xiangfei Deng, Linjun Wu, Tianrui Jiang, Zhengwei Fu, Jinjun Li
Summary: This study investigated the efficacy of Morus root bark extract Morusin on ruminal epithelial cells (RECs) against pathogenic stimulus. The results showed that Morusin did not affect cell viability and exerted anti-inflammatory effects in a concentration-dependent manner. Transcriptome analysis revealed the regulation of cell signaling by Morusin, demonstrating its protective role in inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Juan Jin, Longqiang Wang, Yongjun Liu, Wenfang He, Danna Zheng, Yinhua Ni, Qiang He
Summary: Diabetic nephropathy (DN) is the leading cause of chronic kidney disease and end-stage renal failure. This study aimed to investigate the immune-driven pathogenesis of DN using mass cytometry. Results revealed substantial immune system alterations in the early onset of DN, including a significant decline in B cells and a marked increase in monocytes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biology
Yinhua Ni, Sujie Nan, Liujie Zheng, Liqian Zhang, Yufeng Zhao, Zhengwei Fu
Summary: The time-dependent effect of REV-ERBa agonist SR9009 on diet-induced nonalcoholic steatohepatitis (NASH) and microbiota was investigated in this study. Pharmacological activation of REV-ERBa alleviated hepatic steatosis, insulin resistance, liver inflammation, and fibrosis in NASH mice, accompanied by improved gut barrier function and altered microbial composition and function. The timing of SR9009 administration also affected the composition of the microbiota, with greater effects on beneficial bacteria enrichment and harmful bacteria reduction when administered at Zeitgeber time 0 (ZT0). These findings highlight the potential role of microbiota in the chronopharmacology of NASH and the possibility of discovering new therapeutic strategies.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Yinhua Ni, Yi Zhang, Liujie Zheng, Nianke Rong, Yuru Yang, Ping Gong, Yi Yang, Xuerong Siwu, Chenyang Zhang, Linxi Zhu, Zhengwei Fu
Summary: The effects of probiotic strains BL986 and LC122 on intestinal barrier function and gut microbiota in IBD zebrafish were investigated. The results showed that both probiotics improved intestinal mucosal barrier function and altered the composition and function of the microbiota in different IBD models. The impact of probiotics on IBD was influenced by the subtypes of IBD and the age of the zebrafish.
Article
Agriculture, Dairy & Animal Science
Chunlei Yang, Xiangfei Deng, Peter Lund, Haixia Liu, Xingwang Ding, Zhengwei Fu, Naifeng Zhang, Jinjun Li, Lifeng Dong
Summary: Developing alternatives to antibiotics for prevention of gastrointestinal dysbiosis in early-weaning farmed animals is urgently needed. This study explored the potential effects of trans-10, cis-12 conjugated linoleic acid (CLA) on maintaining ruminal homeostasis of young ruminants during the weaning transition period. Results showed that CLA supplementation enhanced the ruminal microbiota-driven transcriptional regulation and alleviated early-weaning stress in young ruminants.
