Direct role for the Drosophila GIGYF protein in 4EHP-mediated mRNA repression

4EHP-independent repression of endogenous mRNAs by the RNA-binding protein GIGYF2

(2018) Cinthia C Amaya Ramirez et al.   NUCLEIC ACIDS RESEARCH

Translational control of ERK signaling through miRNA/4EHP-directed silencing

(2018) Seyed Mehdi Jafarnejad et al.   eLife

Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells

(2018) Jacob W Freimer et al.   eLife

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression

(2017) Daniel Peter et al.   GENES & DEVELOPMENT

Cap-binding protein 4EHP effects translation silencing by microRNAs

(2017) Clément Chapat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Split-BioID a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes

(2017) Isabel Myriam Schopp et al.   Nature Communications

Post-transcriptional gene silencing activity of human GIGYF2

(2016) Marie-Hélène Kryszke et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The DEAD-Box Protein Dhh1p Couples mRNA Decay and Translation by Monitoring Codon Optimality

(2016) Aditya Radhakrishnan et al.   CELL

Drosophila 4EHP is essential for the larval–pupal transition and required in the prothoracic gland for ecdysone biosynthesis

(2016) Luca Valzania et al.   DEVELOPMENTAL BIOLOGY

miRISC and the CCR4–NOT complex silence mRNA targets independently of 43S ribosomal scanning

(2016) Duygu Kuzuoğlu‐Öztürk et al.   EMBO JOURNAL

The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation

(2016) Stefan Grüner et al.   MOLECULAR CELL

Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements

(2016) Rui Fu et al.   RNA

DrosophilaGyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis

(2015) Myungjin Kim et al.   Autophagy

Tristetraprolin Recruits Eukaryotic Initiation Factor 4E2 To Repress Translation of AU-Rich Element-Containing mRNAs

(2015) Xianzun Tao et al.   MOLECULAR AND CELLULAR BIOLOGY

P-body assembly requires DDX6 repression complexes rather than decay or Ataxin2/2L complexes

(2015) Jessica Ayache et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular Architecture of 4E-BP Translational Inhibitors Bound to eIF4E

(2015) Daniel Peter et al.   MOLECULAR CELL

Structure of a Human 4E-T/DDX6/CNOT1 Complex Reveals the Different Interplay of DDX6-Binding Proteins with the CCR4-NOT Complex

(2015) Sevim Ozgur et al.   Cell Reports

A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing

(2014) Ying Chen et al.   MOLECULAR CELL

Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression

(2014) Hansruedi Mathys et al.   MOLECULAR CELL

The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1

(2014) Chung-Te Chang et al.   NUCLEIC ACIDS RESEARCH

Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1

(2014) Christopher Rouya et al.   RNA

4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation

(2014) Cátia Igreja et al.   Nature Communications

DDX6 and its orthologs as modulators of cellular and viral RNA expression

(2014) Dirk H. Ostareck et al.   Wiley Interdisciplinary Reviews-RNA

GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation

(2013) Latifa Zekri et al.   EMBO JOURNAL

The role of disordered protein regions in the assembly of decapping complexes and RNP granules

(2013) S. Jonas et al.   GENES & DEVELOPMENT

Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing

(2013) A. Kamenska et al.   NUCLEIC ACIDS RESEARCH

Investigating the Consequences of eIF4E2 (4EHP) Interaction with 4E-Transporter on Its Cellular Distribution in HeLa Cells

(2013) Dorota Kubacka et al.   PLoS One

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

(2012) M. Morita et al.   MOLECULAR AND CELLULAR BIOLOGY

Principles of Translational Control: An Overview

(2012) J. W. B. Hershey et al.   Cold Spring Harbor Perspectives in Biology

An integrative approach to ortholog prediction for disease-focused and other functional studies

(2011) Yanhui Hu et al.   BMC BIOINFORMATICS

CUP promotes deadenylation and inhibits decapping of mRNA targets

(2011) C. Igreja et al.   GENES & DEVELOPMENT

Deciphering correct strategies for multiprotein complex assembly by co-expression: Application to complexes as large as the histone octamer

(2011) Marie-Laure Diebold et al.   JOURNAL OF STRUCTURAL BIOLOGY

Pat1 proteins: a life in translation, translation repression and mRNA decay

(2010) Aline Marnef et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The C-terminal α–α superhelix of Pat is required for mRNA decapping in metazoa

(2010) Joerg E Braun et al.   EMBO JOURNAL

Proteomic and functional analysis of the mitotic Drosophila centrosome

(2010) Hannah Müller et al.   EMBO JOURNAL

HPat provides a link between deadenylation and decapping in metazoa

(2010) Gabrielle Haas et al.   JOURNAL OF CELL BIOLOGY

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Conserved β-Hairpin Recognition by the GYF Domains of Smy2 and GIGYF2 in mRNA Surveillance and Vesicular Transport Complexes

(2010) Miriam-Rose Ash et al.   STRUCTURE

GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling

(2009) B. Giovannone et al.   HUMAN MOLECULAR GENETICS

Cytoplasmic Prep1 Interacts with 4EHP Inhibiting Hoxb4 Translation

(2009) J. Carlos Villaescusa et al.   PLoS One

Similar Modes of Interaction Enable Trailer Hitch and EDC3 To Associate with DCP1 and Me31B in Distinct Protein Complexes

(2008) F. Tritschler et al.   MOLECULAR AND CELLULAR BIOLOGY

The Control of mRNA Decapping and P-Body Formation

(2008) Tobias M. Franks et al.   MOLECULAR CELL