miR-122 and Ago interactions with the HCV genome alter the structure of the viral 5′ terminus

miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5′ end from the cellular pyrophosphatases, DOM3Z and DUSP11

(2018) Yalena Amador-Cañizares et al.   NUCLEIC ACIDS RESEARCH

OUP accepted manuscript

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microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site

(2018) Philipp Schult et al.   Nature Communications

RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus

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Cooperative enhancement of translation by two adjacent microRNA-122/Argonaute 2 complexes binding to the 5′ untranslated region of hepatitis C virus RNA

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Multivalent Recruitment of Human Argonaute by GW182

(2017) Elad Elkayam et al.   MOLECULAR CELL

A non-canonical site reveals the cooperative mechanisms of microRNA-mediated silencing

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Transcriptome-wide interrogation of RNA secondary structure in living cells with icSHAPE

(2016) Ryan A Flynn et al.   Nature Protocols

Hepatitis C Virus RNA Functionally Sequesters miR-122

(2015) Joseph M. Luna et al.   CELL

miR-122 Stimulates Hepatitis C Virus RNA Synthesis by Altering the Balance of Viral RNAs Engaged in Replication versus Translation

(2015) Takahiro Masaki et al.   Cell Host & Microbe

Molecular architecture of the ribosome-bound Hepatitis C Virus internal ribosomal entry site RNA

(2015) H. Yamamoto et al.   EMBO JOURNAL

Regulation of Hepatitis C Virus Genome Replication by Xrn1 and MicroRNA-122 Binding to Individual Sites in the 5′ Untranslated Region

(2015) Patricia A. Thibault et al.   JOURNAL OF VIROLOGY

Conserved RNA secondary structures and long-range interactions in hepatitis C viruses

(2015) Markus Fricke et al.   RNA

cis-Acting RNA elements in the hepatitis C virus RNA genome

(2015) Selena M. Sagan et al.   VIRUS RESEARCH

Cryo-EM structure of Hepatitis C virus IRES bound to the human ribosome at 3.9-Å resolution

(2015) Nick Quade et al.   Nature Communications

Comparative Clinical Effectiveness and Value of Novel Interferon-Free Combination Therapy for Hepatitis C Genotype 1

(2015) Jeffrey A. Tice et al.   JAMA Internal Medicine

Viral Determinants of miR-122-Independent Hepatitis C Virus Replication

(2015) Sharon E. Hopcraft et al.   mSphere

HuR and Ago2 Bind the Internal Ribosome Entry Site of Enterovirus 71 and Promote Virus Translation and Replication

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In VitroAntiviral Activity and Preclinical and Clinical Resistance Profile of Miravirsen, a Novel Anti-Hepatitis C Virus Therapeutic Targeting the Human Factor miR-122

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Global distribution and prevalence of hepatitis C virus genotypes

(2014) Jane P. Messina et al.   HEPATOLOGY

Structural basis for microRNA targeting

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Hepatitis C virus and human miR-122: insights from the bench to the clinic

(2014) Joyce A Wilson et al.   Current Opinion in Virology

Understanding the potential of hepatitis C virus internal ribosome entry site domains to modulate translation initiation via their structure and function

(2014) Anas Khawaja et al.   Wiley Interdisciplinary Reviews-RNA

Hepatitis C Virus Translation Inhibitors Targeting the Internal Ribosomal Entry Site

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A Mammalian Pre-mRNA 5′ End Capping Quality Control Mechanism and an Unexpected Link of Capping to Pre-mRNA Processing

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(2013) Behzad Hajarizadeh et al.   Nature Reviews Gastroenterology & Hepatology

Treatment of HCV Infection by Targeting MicroRNA

(2013) Harry L.A. Janssen et al.   NEW ENGLAND JOURNAL OF MEDICINE

The P body protein LSm1 contributes to stimulation of hepatitis C virus translation, but not replication, by microRNA-122

(2013) A. P. E. Roberts et al.   NUCLEIC ACIDS RESEARCH

Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure

(2013) Stefanie A. Mortimer et al.   NUCLEIC ACIDS RESEARCH

microRNA-122 Dependent Binding of Ago2 Protein to Hepatitis C Virus RNA Is Associated with Enhanced RNA Stability and Translation Stimulation

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The Making of a Slicer: Activation of Human Argonaute-1

(2013) Christopher R. Faehnle et al.   Cell Reports

RNA SHAPE analysis in living cells

(2012) Robert C Spitale et al.   Nature Chemical Biology

A twist in the tail: SHAPE mapping of long-range interactions and structural rearrangements of RNA elements involved in HCV replication

(2012) Andrew Tuplin et al.   NUCLEIC ACIDS RESEARCH

Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex

(2012) T. Shimakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication

(2012) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

QuShape: Rapid, accurate, and best-practices quantification of nucleic acid probing information, resolved by capillary electrophoresis

(2012) F. Karabiber et al.   RNA

The Crystal Structure of Human Argonaute2

(2012) N. T. Schirle et al.   SCIENCE

Requirements for human Dicer and TRBP in microRNA-122 regulation of HCV translation and RNA abundance

(2012) Chao Zhang et al.   VIROLOGY

Modulation of hepatitis C virus RNA abundance and virus release by dispersion of processing bodies and enrichment of stress granules

(2012) Cara T. Pager et al.   VIROLOGY

Structural Map of a MicroRNA-122:Hepatitis C Virus Complex

(2011) P. S. Pang et al.   JOURNAL OF VIROLOGY

miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components

(2011) Ashley P. E. Roberts et al.   NUCLEIC ACIDS RESEARCH

Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex

(2011) E. S. Machlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HCV IRES domain IIb affects the configuration of coding RNA in the 40S subunit's decoding groove

(2011) M. E. Filbin et al.   RNA

Dual regulation of hepatitis C viral RNA by cellular RNAi requires partitioning of Ago2 to lipid droplets and P-bodies

(2011) S. Y. Berezhna et al.   RNA

Crystal Structure of the HCV IRES Central Domain Reveals Strategy for Start-Codon Positioning

(2011) Katherine E. Berry et al.   STRUCTURE

Non-genotype-specific role of the hepatitis C virus 5′ untranslated region in virus production and in inhibition by interferon

(2011) Yi-Ping Li et al.   VIROLOGY

RNAstructure: software for RNA secondary structure prediction and analysis

(2010) Jessica S Reuter et al.   BMC BIOINFORMATICS

Human Ago2 Is Required for Efficient MicroRNA 122 Regulation of Hepatitis C Virus RNA Accumulation and Translation

(2010) J. A. Wilson et al.   JOURNAL OF VIROLOGY

SHAPE-directed RNA secondary structure prediction

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VARNA: Interactive drawing and editing of the RNA secondary structure

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Role of RNA Structures in Genome Terminal Sequences of the Hepatitis C Virus for Replication and Assembly

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Regulation of hepatitis C virus by microRNA-122: Figure 1

(2008) Catherine L. Jopling   BIOCHEMICAL SOCIETY TRANSACTIONS

Position-Dependent Function for a Tandem MicroRNA miR-122-Binding Site Located in the Hepatitis C Virus RNA Genome

(2008) Catherine L. Jopling et al.   Cell Host & Microbe

microRNA-122 stimulates translation of hepatitis C virus RNA

(2008) Jura Inga Henke et al.   EMBO JOURNAL

The MC-Fold and MC-Sym pipeline infers RNA structure from sequence data

(2008) Marc Parisien et al.   NATURE

Semiautomated and rapid quantification of nucleic acid footprinting and structure mapping experiments

(2008) Alain Laederach et al.   Nature Protocols

Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus

(2008) R. S. Russell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Throughput SHAPE Analysis Reveals Structures in HIV-1 Genomic RNA Strongly Conserved across Distinct Biological States

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