Group II metabotropic glutamate receptor blockade promotes stress resilience in mice

Ventral CA3 Activation Mediates Prophylactic Ketamine Efficacy Against Stress-Induced Depressive-like Behavior

(2018) Alessia Mastrodonato et al.   BIOLOGICAL PSYCHIATRY

Convergent Mechanisms Underlying Rapid Antidepressant Action

(2018) Panos Zanos et al.   CNS DRUGS

Antidepressant potential of metabotropic glutamate receptor mGlu2 and mGlu3 negative allosteric modulators

(2018) Max E. Joffe et al.   NEUROPSYCHOPHARMACOLOGY

Comparative Effects of LY3020371, a Potent and Selective Metabotropic Glutamate (mGlu) 2/3 Receptor Antagonist, and Ketamine, a Noncompetitive N -Methyl-d-Aspartate Receptor Antagonist in Rodents: Evidence Supporting the Use of mGlu2/3 Antagonists, for the Treatment of Depression.

(2017) J.M. Witkin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Prophylactic Ketamine Attenuates Learned Fear

(2017) Josephine C McGowan et al.   NEUROPSYCHOPHARMACOLOGY

mGlu2/3 Receptor Antagonists as Novel Antidepressants

(2017) Shigeyuki Chaki   TRENDS IN PHARMACOLOGICAL SCIENCES

Ketamine as a Prophylactic Against Stress-Induced Depressive-like Behavior

(2016) Rebecca A. Brachman et al.   BIOLOGICAL PSYCHIATRY

Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine

(2016) Eric Wohleb et al.   Current Neuropharmacology

Previous Ketamine Produces an Enduring Blockade of Neurochemical and Behavioral Effects of Uncontrollable Stress

(2016) J. Amat et al.   JOURNAL OF NEUROSCIENCE

Learned helplessness at fifty: Insights from neuroscience.

(2016) Steven F. Maier et al.   PSYCHOLOGICAL REVIEW

Short-term environmental enrichment is sufficient to counter stress-induced anxiety and associated structural and molecular plasticity in basolateral amygdala

(2016) Archana Ashokan et al.   PSYCHONEUROENDOCRINOLOGY

Group II mGluRs modulate baseline and arthritis pain-related synaptic transmission in the rat medial prefrontal cortex

(2015) Takaki Kiritoshi et al.   NEUROPHARMACOLOGY

The Antidepressant Effects of an mGlu2/3 Receptor Antagonist and Ketamine Require AMPA Receptor Stimulation in the mPFC and Subsequent Activation of the 5-HT Neurons in the DRN

(2015) Kenichi Fukumoto et al.   NEUROPSYCHOPHARMACOLOGY

An excitatory synapse hypothesis of depression

(2015) Scott M. Thompson et al.   TRENDS IN NEUROSCIENCES

Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats

(2014) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

Mind the gap: glucocorticoids modulate hippocampal glutamate tone underlying individual differences in stress susceptibility

(2014) C Nasca et al.   MOLECULAR PSYCHIATRY

mGlu2/3 Agonist-Induced Hyperthermia: An In Vivo Assay for Detection of mGlu2/3 Receptor Antagonism and its Relation to Antidepressant-Like Efficacy in Mice

(2013) S.D. Gleason et al.   CNS & Neurological Disorders-Drug Targets

Chronic Stress Induces a Selective Decrease in AMPA Receptor-Mediated Synaptic Excitation at Hippocampal Temporoammonic-CA1 Synapses

(2013) A. J. Kallarackal et al.   JOURNAL OF NEUROSCIENCE

L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors

(2013) C. Nasca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of BDNF/TrkB signaling in antidepressant-like effects of a group II metabotropic glutamate receptor antagonist in animal models of depression

(2012) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice

(2012) Yukio Ago et al.   NEUROPHARMACOLOGY

CNS distribution of metabotropic glutamate 2 and 3 receptors: Transgenic mice and [3H]LY459477 autoradiography

(2012) Rebecca A. Wright et al.   NEUROPHARMACOLOGY

mTOR activation is required for the antidepressant effects of mGluR2/3 blockade

(2011) Jason M. Dwyer et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Characterization of an mGluR2/3 Negative Allosteric Modulator in Rodent Models of Depression

(2011) Brice Campo et al.   JOURNAL OF NEUROGENETICS

Environmental Enrichment Confers Stress Resiliency to Social Defeat through an Infralimbic Cortex-Dependent Neuroanatomical Pathway

(2011) M. L. Lehmann et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

A standardized protocol for repeated social defeat stress in mice

(2011) Sam A Golden et al.   Nature Protocols

Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists

(2011) Hiroyuki Koike et al.   NEUROPHARMACOLOGY

Rapid microelectrode measurements and the origin and regulation of extracellular glutamate in rat prefrontal cortex

(2010) Erin R. Hascup et al.   JOURNAL OF NEUROCHEMISTRY

On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039

(2010) Agnieszka Pałucha-Poniewiera et al.   PSYCHOPHARMACOLOGY

Prevalence and predictors of recurrence of major depressive disorder in the adult population

(2009) F. Hardeveld et al.   ACTA PSYCHIATRICA SCANDINAVICA

Behavioral control over shock blocks behavioral and neurochemical effects of later social defeat

(2009) J. Amat et al.   NEUROSCIENCE

Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression

(2008) Tibor Hajszan et al.   BIOLOGICAL PSYCHIATRY

Exercise, Learned Helplessness, and the Stress-Resistant Brain

(2008) Benjamin N. Greenwood et al.   NEUROMOLECULAR MEDICINE

Activation of the ventral medial prefrontal cortex during an uncontrollable stressor reproduces both the immediate and long-term protective effects of behavioral control

(2008) J. Amat et al.   NEUROSCIENCE