Article
Multidisciplinary Sciences
Qi Ma, Li Wang, Xiang-Xin Liu, Zhi-Guo An, Xiao Luo, Li-Li Zhang, Ping Yan, Lu Jin, Ren Cai, Qi-Zhong Yi
Summary: This study suggests that GLP-1 shows potential in treating patients with comorbid MDD and DM by reducing cell apoptosis and necrocytosis and promoting neuroprotection.
Article
Agriculture, Dairy & Animal Science
Mostafa Helal, Mahmoud A. Ali, Amira H. Nadrin, Yomna I. Awad, Nada K. Younis, Basant M. Alasyed, Mohnad Jamal, Dima H. Eid, Hagar A. Soliman, Sara A. Eissa, Mohamed Ragab
Summary: This study explored the effects of three gene single nucleotide polymorphisms on the growth traits of rabbits. The results indicated that the IRS-1 gene had a significant impact on post-weaning body weight and weight gains. Breed-specific effects were suggested for the PPAR-gamma and LEP genes.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Food Science & Technology
Yun Huang, Tongxi Zhou, Yirui Zhang, Huiqi Huang, Yuanren Ma, Chaoqun Wu, Qiang Wang, Qinxiong Lin, Xinzhou Yang, Kejian Pang
Summary: The flavonoid-rich extract from Wisteria sinensis (WS-FRE) showed significant anti-diabetic effects in diabetic mice by promoting glucose uptake, improving insulin sensitivity and ameliorating glucose metabolism through mechanisms involving GLUT4, IRS-1 serine phosphorylation, PI3K phosphorylation, and Akt phosphorylation.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Psychiatry
Jiali Chen, Guangying Li, Pingping Qin, Jiaojiao Chen, Na Ye, John L. Waddington, Xuechu Zhen
Summary: SOMCL-668 shows promising therapeutic effects on PCP-induced behaviors in mice, improving hyperactivity, PPI disruption, social deficits, and cognitive impairment. These effects are mediated through the sigma-1 receptor, suggesting a novel approach for the treatment of psychotic illness.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Behavioral Sciences
Candan Saglam, Inci Turan, Hale Sayan Ozacmak
Summary: This study evaluated the effect of liraglutide on emotional behaviors in OVX rats and found that liraglutide reduced behavioral despair and anxiety levels, while maintaining BDNF and Nrf2 levels and decreasing oxidative stress and lipocalin 2 levels in the hippocampus.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Cong Duc Nguyen, Jaehee Yoo, Sun-Young Hwang, Sung-Young Cho, Myeonghun Kim, Hyemin Jang, Kyoung Ok No, Jeong Cheol Shin, Jae-Hong Kim, Gihyun Lee
Summary: Honeybee venom has antioxidant and neuroprotective effects, alleviating neural oxidative stress caused by amyloid-beta and enhancing cognitive ability and neural cell genesis. Therefore, honeybee venom is of significant importance in the treatment of neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Roberto Castiglione, Adele Vivacqua, Marta Santoro, Daniela De Rose, Giuseppina Peluso, Salvatore Panza, Saveria Aquila, Rosario D'Agata
Summary: Recent evidence suggests that the male gonad is a potential target of glucagon-like peptide-1 (GLP-1). This study investigated the effects of GLP-1 on sperm function and the molecular mechanisms involved. Incubation of semen samples with a GLP-1 mimetic analog prevented a decline in sperm motility and attenuated the negative effects of tumor necrosis factor (TNF-a) on sperm parameters. GLP-1 also reduced levels of negative kinases in sperm, suggesting a potential role in sperm physiopathology.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Neurosciences
Clara Rossetti, Antoine Cherix, Laetitia F. Guiraud, Jean-Rene Cardinaux
Summary: This article focuses on the critical role of CRTC1 in the neurobiology of depression and comorbid obesity, and discusses its involvement in neuronal plasticity and energy balance regulation.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Elena M. Kondaurova, Alexandra V. Plyusnina, Tatiana V. Ilchibaeva, Dmitry V. Eremin, Alexander Ya. Rodnyy, Yulia D. Grygoreva, Vladimir S. Naumenko
Summary: This study investigated the effects of knocking down the transcription factor Cc2d1a/Freud-1 in the hippocampus of mice, revealing its role in antidepressant effects, spatial memory impairment, regulation of the brain 5-HT system, and modulation of BDNF expression. The data indicate that Cc2d1a/Freud-1 is involved in the pathogenesis of depressive disorders through interactions with the 5-HT1A receptor, CREB, and BDNF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
Badrah S. Alghamdi, Fahad S. Alshehri
Summary: The study revealed the potential of melatonin in modulating morphine addiction by affecting gene expression levels such as GLT-1, BDNF, NF-kappa B, and CREB.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Eun-Joo Shin, Sung Hoon Lee, Naveen Sharma, Bao Trong Nguyen, Yoon Hee Chung, Sang Won Kang, Seung-Yeol Nah, Yu Jeung Lee, Toshitaka Nabeshima, Ji Hoon Jeong, Hyoung-Chun Kim
Summary: The study demonstrated that the GPx-1 gene protects against A beta (1-42)-induced memory impairments by activating the M1 mAChR-dependent CREB/BDNF signaling pathway.
FREE RADICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Radwa H. Lutfy, Amina E. Essawy, Haitham S. Mohammed, Marwa M. Shakweer, Sherine Abdel Salam
Summary: The prevalence of sleep deprivation is becoming increasingly common, especially among the elderly. This study investigated the effects of near infrared (NIR) light laser on cognitive impairment induced by sleep deprivation in young and old rats. The results showed that NIR photobiomodulation (PBM) attenuated cognitive deterioration in young rats but not in old rats. However, both young and old rats exhibited decreased anxiety-like behavior in response to PBM. Additionally, NIR had positive effects on neuronal survival and differentiation in old rats by regulating certain factors.
NEUROCHEMICAL RESEARCH
(2023)
Article
Behavioral Sciences
Meltem Donmez Kutlu, Seda Kose, Kubra Akillioglu
Summary: This study investigated the effects of GLP-1 agonist Liraglutide on CREB, BDNF, Trk-B expression and emotional/cognitive behaviors in an experimental schizophrenia-like behavior model induced by MK-801. The results showed that Liraglutide had positive effects on spatial learning and memory activity and improved the expression of BDNF/Trk-B and p-CREB/CREB in the hippocampus and PFC. However, Liraglutide did not reverse the negative effects of MK-801 on cognitive behavior.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Nazia Siddiqui, Javed Ali, Suhel Parvez, Saima Zameer, Abul Kalam Najmi, Mohd Akhtar
Summary: The study demonstrates the significant effect of Linagliptin in reversing motor and cognitive impairments, as well as modulating biochemical parameters in the hippocampus. Linagliptin dose-dependently increased GLP-1 levels, reduced Aβ (1-42) deposition, and improved neurobehavioral performance in the AD rat model.
Article
Neurosciences
Cinthia Coria-Lucero, Carina Ledezma, Andrea Castro, Silvia Delgado, Ana Cecilia Anzulovich, Lorena Navigatore-Fonzo
Summary: Alzheimer's disease is characterized by neuron loss in the elderly and is thought to be related to the accumulation of Aβ peptide in the brain. This study found that injecting Aβ aggregates into the rat temporal cortex affects the 24-hour rhythms of multiple factors, potentially by influencing clock factors as well as ApoE rhythms.
BRAIN RESEARCH BULLETIN
(2021)
Review
Clinical Neurology
Firas H. Bazzari, Dalaal M. Abdallah, Hanan S. El-Abhar
CURRENT ALZHEIMER RESEARCH
(2019)
Review
Neurosciences
Amjad H. Bazzari, Firas H. Bazzari
Summary: This article summarizes the maladaptation in sensory neural plasticity of nociceptive pathways and its association with chronic pain. The research evaluates the mechanisms and efficacy of non-pharmacological pain treatment modalities, including neurostimulation, virtual reality, cognitive therapy, and rehabilitation.
EGYPTIAN JOURNAL OF NEUROLOGY PSYCHIATRY AND NEUROSURGERY
(2022)
Review
Biochemistry & Molecular Biology
Amjad H. Bazzari, Firas H. Bazzari
Summary: Brain-derived neurotrophic factor (BDNF) is an important factor in the adult brain, playing essential roles in neuronal development, maintenance, transmission, and plasticity. Reduced BDNF levels are associated with various neuropsychiatric disorders, making it a potential biomarker. Restoring or augmenting BDNF transmission has shown promising therapeutic effects in animal models of neurological and psychiatric diseases, although the underlying mechanisms vary. This review summarizes the neurophysiology of BDNF and classifies the molecular mechanisms underlying its therapeutic potentials, including neuroprotection, synaptic maintenance, immunomodulation, plasticity facilitation, and preservation of cellular viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Firas H. Bazzari, Amjad H. Bazzari
Summary: This paper provides a comprehensive review of all BACE1 inhibitors that have reached clinical trials, and discusses the challenges and different perspectives on whether BACE1 inhibitors should be reconsidered or revitalized in the future.
Review
Pharmacology & Pharmacy
F. H. Bazzari, A. H. Bazzari
SA PHARMACEUTICAL JOURNAL
(2019)