LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer’s Disease

The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM

(2018) Steffen E. Storck et al.   BRAIN BEHAVIOR AND IMMUNITY

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

(2018) Qingyi Ma et al.   Molecular Neurodegeneration

Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies

(2017) Mitsuru Shinohara et al.   JOURNAL OF LIPID RESEARCH

Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition

(2017) Chia-Chen Liu et al.   JOURNAL OF NEUROSCIENCE

Functional Roles of the Interaction of APP and Lipoprotein Receptors

(2017) Theresa Pohlkamp et al.   Frontiers in Molecular Neuroscience

Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration

(2016) Verena K. Rabiej et al.   EXPERIMENTAL CELL RESEARCH

Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier

(2015) Steffen E. Storck et al.   JOURNAL OF CLINICAL INVESTIGATION

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

The amyloid precursor protein: A biochemical enigma in brain development, function and disease

(2013) Natalia N. Nalivaeva et al.   FEBS LETTERS

Neuronal Clearance of Amyloid-  by Endocytic Receptor LRP1

(2013) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype

(2013) Wladislaw Maier et al.   Molecular Neurodegeneration

Cellular Prion Protein Participates in Amyloid-β Transcytosis across the Blood—Brain Barrier

(2012) Thorsten Pflanzner et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid- 

(2012) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Impaired LDL Receptor-Related Protein 1 Translocation Correlates with Improved Dyslipidemia and Atherosclerosis in apoE-Deficient Mice

(2012) Philip L.S.M. Gordts et al.   PLoS One

Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

(2010) Bart De Strooper et al.   Annual Review of Cell and Developmental Biology

Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing

(2010) Oh Yeun Kwon et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrier

(2010) Thorsten Pflanzner et al.   NEUROBIOLOGY OF AGING

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Inactivation of the LRP1 Intracellular NPxYxxL Motif in LDLR-Deficient Mice Enhances Postprandial Dyslipidemia and Atherosclerosis

(2009) Philip L.S.M. Gordts et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis

(2009) Sara M. Reekmans et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

α-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation

(2009) Sebastian Jäger et al.   JOURNAL OF NEUROCHEMISTRY

The Functional Role of the Second NPXY Motif of the LRP1 β-Chain in Tissue-type Plasminogen Activator-mediated Activation ofN-Methyl-D-aspartate Receptors

(2008) Anne M. Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS