Article
Medicine, Research & Experimental
Poliana C. Marinello, Paola S. Cella, Mayra T. J. Testa, Phillipe B. Guirro, Walison Augusto da Silva Brito, Camila S. Padilha, Alessandra L. Cecchini, Robin P. da Silva, Jose Alberto R. Duarte, Rafael Deminice
Summary: This study investigated the effects of creatine supplementation on the pathogenesis of non-alcoholic fatty liver disease and alcoholic liver disease. The results showed that creatine supplementation prevented high-fat diet-induced non-alcoholic fatty liver disease but exacerbated ethanol-induced alcoholic liver disease. The exacerbating effects may be related to oxidative stress and inflammation-mediated upregulation of ethanol metabolism.
Review
Biochemistry & Molecular Biology
Yoon Mee Yang, Ye Eun Cho, Seonghwan Hwang
Summary: Alcoholic liver disease (ALD), caused by excessive alcohol consumption, results in liver damage. Studies have shown that there is a relationship between hepatic oxidative stress and inflammatory responses, which may be useful for developing therapeutic approaches for ALD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jingxuan Zhou, Nanhai Zhang, Adil Aldhahrani, Mohamed Mohamed Soliman, Liebing Zhang, Feng Zhou
Summary: Puerarin improves high-fat and high-fructose diet-induced nonalcoholic fatty liver disease (NAFLD) by modulating liver lipid accumulation, liver function, oxidative stress, and inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Margalida Monserrat-Mesquida, Magdalena Quetglas-Llabres, Cristina Bouzas, Sofia Montemayor, Catalina M. Mascaro, Miguel Casares, Isabel Llompart, Lucia Ugarriza, J. Alfredo Martinez, Josep A. Tur, Antoni Sureda
Summary: A greater adherence to the Mediterranean diet is associated with greater improvements in intrahepatic fat content, cardiorespiratory fitness, and oxidative stress and inflammatory status in non-alcoholic fatty liver disease patients after a 6-month nutritional intervention based on the Mediterranean diet.
Article
Pharmacology & Pharmacy
Yongyao Gao, Xiaomeng Jiang, Daigang Yang, Wentong Guo, Dandan Wang, Ke Gong, Ying Peng, Hong Jiang, Cunyuan Shi, Yajun Duan, Yuanli Chen, Jihong Han, Xiaoxiao Yang
Summary: This study investigates the protective effects of roxadustat in alcoholic liver disease (ALD). The results show that roxadustat can reduce liver lipid accumulation, inflammation, and oxidative stress in ALD through the regulation of HIF-1α. These findings suggest that roxadustat may be a potential drug for the treatment of ALD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Bangyan Li, Qianqian Mao, Dandan Zhou, Min Luo, Renyou Gan, Hangyu Li, Siyu Huang, Adila Saimaiti, Ao Shang, Huabin Li
Summary: Oolong tea and dark tea can prevent AFLD induced by chronic alcohol exposure by modulating gut microbiota.
Article
Biochemistry & Molecular Biology
Bartosz Fotschki, Katarzyna Ognik, Joanna Fotschki, Dorota Napiorkowska, Ewelina Cholewinska, Magdalena Krauze, Jerzy Juskiewicz
Summary: The study investigated the effects of chromium supplementation and switching dietary habits on lipid metabolism, inflammation, and oxidative stress in Wistar rats. The combination of chromium nanoparticles and dietary changes showed the strongest reduction in fat content and cholesterol in the liver. This combination also had favorable antioxidative effects. Supplementation with chromium nanoparticles alone also improved lipid metabolism and oxidative stress, although to a lesser extent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Shihang Tang, Zhiyin Huang, Jingsun Jiang, Jinhang Gao, Chong Zhao, Yang Tai, Xiao Ma, Linhao Zhang, Yanting Ye, Can Gan, Wei Su, Xintong Jia, Rui Liu, Hao Wu, Chengwei Tang
Summary: Splenomegaly contributes to the development of liver cirrhosis by enhancing oxidative stress in the liver, while Celecoxib effectively alleviates liver cirrhosis by reducing inflammatory cytokines and immune cells derived from the spleen and suppressing oxidative stress.
Article
Pharmacology & Pharmacy
Yunjia Li, Menghan Yang, Haiyan Lin, Weixin Yan, Guanghui Deng, Haixin Ye, Hao Shi, Chaofeng Wu, Guoliang Ma, Shu Xu, Qinxiang Tan, Zhuowei Gao, Lei Gao
Summary: Limonin has a protective effect on NAFLD by reducing lipid droplet accumulation, regulating lipogenic transcription factors, suppressing inflammation and oxidative stress, and reversing unfavorable changes through activating the NRF2/HO-1 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Fikret Altindag, Seda Bogoksayan, Sinan Bayram
Summary: This study evaluated the protective effects of eumelanin on diethylnitrosamine-induced liver injury. The results showed that eumelanin treatment reduced histopathological changes, inflammation, and necrotic cells in the liver. Eumelanin also decreased cell apoptosis and the expression of inflammatory mediators.
Article
Oncology
Deniz Kuscuoglu, Lisa Bewersdorf, Kathrin Wenzel, Annika Gross, Gokce Kobazi Ensari, Yizhao Luo, Konrad Kilic, Kanishka Hittatiya, Nicole Golob-Schwarzl, Rudolf E. Leube, Christian Preisinger, Jacob George, Mayada Metwally, Mohammed Eslam, Pietro Lampertico, Salvatore Petta, Alessandra Mangia, Thomas Berg, Andre Boonstra, Willem P. Brouwer, Maria Lorena Abate, Alessandro Loglio, Angela Sutton, Pierre Nahon, Benedikt Schaefer, Heinz Zoller, Elmar Aigner, Christian Trautwein, Johannes Haybaeck, Pavel Strnad
Summary: The simultaneous presence of two prevalent proteotoxic stresses promotes liver injury development via protein retention and activation of the p62-Nrf2 axis. Specifically, HBs-PiZ mice showed retention of AAT/HBs, leading to accumulation of p62 and perilipin-2, resulting in activation of the p62-Nrf2 axis and generation of reactive oxygen species.
JOURNAL OF PATHOLOGY
(2021)
Article
Medicine, Research & Experimental
Bianca Sulzbacher da Silva, Angelica Macedo Borges Paulino, Maiara Taffarel, Ian Gabriel Borba, Luciana Ortega Telles, Victor Vitorino Lima, Danilo Henrique Aguiar, Marcos Correa Dias, Andre Ferreira Nascimento, Valeria Dornelles Gindri Sinhorin, Renata de Azevedo Melo Luvizotto, Gisele Facholi Bomfim
Summary: The study showed that a high sucrose diet in animals with thioacetamide-induced cirrhosis can reduce liver fibrosis and inflammatory infiltration, improve malnutrition, and alleviate oxidative stress.
Article
Biochemistry & Molecular Biology
Susara Madduma Hewage, Suvira Prashar, O. Karmin, Yaw L. Siow
Summary: Lingonberry supplementation can protect against high-fat diet-induced liver injury by alleviating hepatic lipid accumulation, oxidative stress, and inflammatory response.
Article
Biochemistry & Molecular Biology
Mara Caputo, Yeshwant Kurhe, Sima Kumari, Emmelie Cansby, Manoj Amrutkar, Eli Scandalis, Sheri L. Booten, Marcus Stahlman, Jan Boren, Hanns-Ulrich Marschall, Mariam Aghajan, Margit Mahlapuu
Summary: This study identifies MST3 as a critical regulator of ectopic fat accumulation in human hepatocytes and shows that targeting MST3 signaling with ASOs can effectively mitigate NAFLD progression in obese mice. MST3 ASOs suppress lipogenic gene expression, reduce lipotoxicity-mediated oxidative and endoplasmic reticulum stress, and correlate with NAFLD severity in human liver biopsies. These findings suggest that MST3 inhibitors may offer a new strategy for treating NAFLD patients.
Review
Biochemistry & Molecular Biology
Pablo Muriel, Pedro Lopez-Sanchez, Erika Ramos-Tovar
Summary: Chronic diseases, particularly metabolic syndrome and non-alcoholic fatty liver disease (NAFLD), are major health challenges globally, with fructose overconsumption playing a significant role in their development. Fructose-induced inflammation, fibrosis, and oncogenic signaling pathways contribute to the progression of NAFLD, leading to serious liver complications such as NASH and ultimately liver cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Jasmina Brboric, Aleksandra Klisic, Jelena Kotur-Stevuljevic, Giovanna Delogu, Darinka Gjorgieva Ackova, Kristina Kostic, Maria Antonietta Dettori, Davide Fabbri, Paola Carta, Luciano Saso
Summary: The aim of this study was to identify representatives of natural and natural-like phenol monomers and their C2-symmetric dimers with the strongest antioxidant activity and the lowest prooxidant activity. The results showed that dehydrozingerone derivatives (compounds 6 and 12) exhibited the highest antioxidant activity and could be potential precursors for the synthesis of novel polyphenolic molecules with therapeutic applications.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Aleksandra Vukasinovic, Barbara Ostanek, Aleksandra Klisic, Srdjan Kafedzic, Marija Zdravkovic, Ivan Ilic, Miron Sopic, Sasa Hinic, Milica Stefanovic, Lidija Memon, Branka Gakovic, Natasa Bogavac-Stanojevic, Vesna Spasojevic-Kalimanovska, Janja Marc, Aleksandar N. Neskovic, Jelena Kotur-Stevuljevic
Summary: There is an association between leukocyte telomere length, telomerase activity, coronary artery disease (CAD) and oxidative stress. Telomerase activity and telomere length are higher in thromboaspirates compared to peripheral blood leukocytes, and they have diagnostic ability to differentiate patients with ST-segment elevation myocardial infarction (STEMI) from healthy individuals.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Klisic, Irena Radoman Vujacic, Jelena Kostadinovic, Ana Ninic
Summary: This study examined the relationship between metabolic and renal biomarkers and vitamin D in postmenopausal women. The results showed that the joint involvement of renal function biomarkers and metabolic syndrome-related features can differentiate postmenopausal women with lower vitamin D levels.
JOURNAL OF MEDICAL BIOCHEMISTRY
(2023)
Article
Ophthalmology
Roberta Verta, Gabriele Saccu, Adele Tanzi, Cristina Grange, Lola Buono, Sharmila Fagoonee, Maria Chiara Deregibus, Giovanni Camussi, Simona Scalabrin, Raffaele Nuzzi, Benedetta Bussolati
Summary: This study characterized the extracellular vesicles (EVs) in human aqueous humor and found that they have a mean size of approximately 100 nm, express specific markers, and promote corneal cell proliferation and repair.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Medicine, Research & Experimental
Aleksandra Klisic, Jelena Kotur-Stevuljevic, Ana Ninic
Summary: This study examined the relationship between serum endocan level and UKPDS risk engine score in type 2 diabetes patients. The results showed that endocan is an independent predictor for moderate and high estimated risks of cardiovascular disease in these patients.
METABOLIC SYNDROME AND RELATED DISORDERS
(2023)
Article
Nutrition & Dietetics
Marialaura Scarcella, Emidio Scarpellini, Sara Piergallini, Emanuele Rinninella, Karen Routhiaux, Carlo Rasetti, Ludovico Abenavoli, Edoardo De Robertis, Pietro Manzi, Rita Commissari, Riccardo Monti, Michela Zanetti
Summary: In this study, we found that immune-nutrition (IN) can prevent malnutrition and decrease inflammatory markers in overweight patients with COVID-19 during the fourth wave of the pandemic in 2021.
Article
Pediatrics
Ljiljana Bjelakovic, Lazar Stosic, Aleksandra Klisic, Marko Jovic, Sanja Stankovic, Aleksandra Stankovic, Sasa Pantelic, Danijela Zivkovic, Vladimir Vukovic, Bojko Bjelakovic
Summary: This study investigated the awareness and knowledge of familial hypercholesterolemia (FH) among pediatricians in Serbia. The results showed that although most pediatricians had knowledge about the genetic inheritance and long-term health risks of FH, there was a substantial lack of practical clinical knowledge, and a low awareness of international guidelines for FH drug treatment.
FRONTIERS IN PEDIATRICS
(2023)
Review
Medicine, General & Internal
Ludovico Abenavoli, Michele Montori, Gianluca Svegliati Baroni, Maria Eva Argenziano, Francesca Giorgi, Giuseppe Guido Maria Scarlata, Francesca Ponziani, Emidio Scarpellini
Summary: Hepatocellular carcinoma (HCC) is the leading cause of liver cancer worldwide, and the use of immune checkpoint inhibitors (ICIs) has shown promise in treating advanced HCC. However, a significant proportion of patients with HCC do not respond to immunotherapy.
MEDICINA-LITHUANIA
(2023)
Article
Gastroenterology & Hepatology
Tomislav Preveden, Benjamin Veres, Maja Ruzic, Maria Pete, Sanja Bogic, Nadica Kovacevic, Anna C. Procopio, Sharmila Fagoonee, Francesco Luzza, Ludovico Abenavoli
Summary: This study aimed to evaluate the accuracy of the non-invasive surrogate scores HSI and TyG index in detecting liver steatosis in patients with chronic hepatitis C. The results showed that both scores have good performance in detecting liver steatosis and could be valuable assets in assessing liver steatosis outside of liver biopsy.
MINERVA GASTROENTEROLOGY
(2023)
Review
Medicine, General & Internal
Stefan Lucian Popa, Abdulrahman Ismaiel, Ludovico Abenavoli, Alexandru Marius Padureanu, Miruna Oana Dita, Roxana Bolchis, Mihai Alexandru Munteanu, Vlad Dumitru Brata, Cristina Pop, Andrei Bosneag, Dinu Iuliu Dumitrascu, Maria Barsan, Liliana David
Summary: This systematic review provides a comprehensive analysis of the performance of AI systems in diagnosing liver fibrosis. The findings suggest that AI-assisted non-invasive techniques can perform as accurately as human experts in detecting and staging liver fibrosis. However, further clinical trials are needed to confirm these results before implementing them into clinical practice.
MEDICINA-LITHUANIA
(2023)
Review
Biochemistry & Molecular Biology
Michele Montori, Gialuca Svegliati Baroni, Pierangelo Santori, Catia Di Giampaolo, Francesca Ponziani, Ludovico Abenavoli, Emidio Scarpellini
Summary: COVID-19 pandemic waves have led to pulmonary and gastrointestinal symptoms, including acute liver damage. Acute liver damage is common in COVID-19 patients and is generally self-limiting. However, patients with pre-existing chronic liver disease, such as metabolic-associated fatty liver disease (MAFLD), have a less favorable prognosis. Early recognition, monitoring, and treatment of liver damage are crucial. Recognition of acute hepatic decompensation due to the virus and/or drugs used for COVID-19 treatment is essential in the ongoing pandemic.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Medicine, General & Internal
Ludovico Abenavoli, Giuseppe Guido Maria Scarlata, Emidio Scarpellini, Luigi Boccuto, Rocco Spagnuolo, Bruno Tilocca, Paola Roncada, Francesco Luzza
Summary: Metabolic-dysfunction-associated fatty liver disease (MAFLD) is a newly named condition that links non-alcoholic fatty liver disease (NAFLD) with metabolic dysfunction. Its diagnosis is still debated and is generally associated with steatosis and at least one pathological condition among overweight/obesity, type 2 diabetes mellitus, and metabolic dysregulation. The pathogenesis of MAFLD involves changes in the gut microbiota, which has also been investigated in other diseases such as obesity, type 2 diabetes mellitus, and NAFLD. However, only a few studies have specifically correlated gut dysbiosis with MAFLD.
MEDICINA-LITHUANIA
(2023)
Review
Medicine, Research & Experimental
Matteo Vitali, Stefano Marasco, Tatsiana Romenskaya, Angela Elia, Yaroslava Longhitano, Christian Zanza, Ludovico Abenavoli, Emidio Scarpellini, Alessandro Bertuccio, Andrea Barbanera
Summary: Traumatic brain injury is a severe pathology with significant social and economic concerns. Decompressive craniectomy is a life-saving surgical option for treating elevated intracranial hypertension. This narrative review summarizes the literature and discusses key issues related to indication, timing, surgical procedure, outcome, and complications in adult patients undergoing decompressive craniectomy for severe traumatic brain injury.
Article
Medicine, General & Internal
Ludovico Abenavoli, Rocco Spagnuolo, Giuseppe Guido Maria Scarlata, Emidio Scarpellini, Luigi Boccuto, Francesco Luzza
Summary: This study investigated the prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with inflammatory bowel disease (IBD) using ultrasound examination. The results showed that the prevalence of NAFLD in IBD patients was 23%, with higher values of age, body mass index, waist circumference, disease duration, and age at onset observed in NAFLD patients. Additionally, NAFLD patients also exhibited a higher percentage of hypertension and metabolic comorbidities.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Mirjana Bakic, Aleksandra Klisic, Vesna Karanikolic
Summary: The study revealed higher levels of NLR and IL-22 in patients with atopic dermatitis (AD) over the age of 50, and a higher inflammatory state in both psoriasis (PsO) and AD patients with comorbidities as reflected by certain platelet indexes.
MEDICINA-LITHUANIA
(2023)