The mechanism(s) of action of antioxidants: From scavenging reactive oxygen/nitrogen species to redox signaling and the generation of bioactive secondary metabolites

Antioxidant-inspired drug discovery: antitumor metabolite is formed in situ from a hydroxycinnamic acid derivative upon free radical scavenging

(2019) Laura Fási et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biological and pharmacological effects of hexahydrocurcumin, a metabolite of curcumin

(2018) Yiyuan Huang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Metabolism and pharmacokinetics of resveratrol and pterostilbene

(2018) Pei Wang et al.   BIOFACTORS

The pharmacokinetics and tissue distribution of curcumin and its metabolites in mice

(2018) Junjun Wang et al.   BIOMEDICAL CHROMATOGRAPHY

Biomimetic Synthesis of Drug Metabolites in Batch and Continuous-Flow Reactors

(2018) Tamás Fődi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Polyphenols and Bioavailability: an update

(2018) Hui Teng et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

ROS and RNS signalling: adaptive redox switches through oxidative/nitrosative protein modifications

(2018) N. T. Moldogazieva et al.   FREE RADICAL RESEARCH

An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease

(2018) Anna E. Tschiffely et al.   HORMONES AND BEHAVIOR

Anti-inflammatory effects of luteolin: A review of in vitro, in vivo, and in silico studies

(2018) Nur Aziz et al.   JOURNAL OF ETHNOPHARMACOLOGY

HOCl and the control of oncogenesis

(2018) Georg Bauer   JOURNAL OF INORGANIC BIOCHEMISTRY

Flaxseed Bioactive Compounds and Colorectal Cancer Prevention

(2018) Jennifer A. A. DeLuca et al.   Current Oncology Reports

Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases

(2018) Nerino Allocati et al.   Oncogenesis

Fundamentals on the biochemistry of peroxynitrite and protein tyrosine nitration

(2018) Silvina Bartesaghi et al.   Redox Biology

Natural polyphenols as sirtuin 6 modulators

(2018) Minna Rahnasto-Rilla et al.   Scientific Reports

Luteolin as a potential preventive and therapeutic candidate for Alzheimer's disease

(2017) Youngjoo Kwon   EXPERIMENTAL GERONTOLOGY

Curcumin prevents reperfusion injury following ischemic stroke in rats via inhibition of NF-κB, ICAM-1, MMP-9 and caspase-3 expression

(2017) Wei Li et al.   Molecular Medicine Reports

Role of sulfotransferases in resveratrol metabolism in human adipocytes

(2017) Nele Gheldof et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Pharmacokinetics, tissue distribution and excretion of luteolin and its major metabolites in rats: Metabolites predominate in blood, tissues and are mainly excreted via bile

(2017) Changrui Deng et al.   Journal of Functional Foods

Enterolactone has stronger effects than enterodiol on ovarian cancer

(2017) Huidi Liu et al.   Journal of Ovarian Research

Resveratrol-Induced AMP-Activated Protein Kinase Activation Is Cell-Type Dependent: Lessons from Basic Research for Clinical Application

(2017) Fan Lan et al.   Nutrients

Biotransformation of food spice curcumin by gut bacterium Bacillus megaterium DCMB-002 and its pharmacological implications

(2017) Chun-Yan An et al.   Food & Nutrition Research

Anti-angiogenic effect of hexahydrocurcumin in rat corneal neovascularization

(2017) Chien-Neng Kuo et al.   INTERNATIONAL OPHTHALMOLOGY

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

(2017) Javier Egea et al.   Redox Biology

The Antitumor Effect of Singlet Oxygen

(2016) GEORG BAUER   ANTICANCER RESEARCH

Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E 2 production in LPS-induced murine and human macrophages cell lines

(2016) Mohd Fadhlizil Fasihi Mohd Aluwi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anti-cancer effects of vitamin C revisited

(2016) Jiska van der Reest et al.   CELL RESEARCH

Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects

(2016) Judy L. Bolton et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Superoxide Ion: Generation and Chemical Implications

(2016) Maan Hayyan et al.   CHEMICAL REVIEWS

Liquid phase oxidation chemistry in continuous-flow microreactors

(2016) Hannes P. L. Gemoets et al.   CHEMICAL SOCIETY REVIEWS

Interactions of gut microbiota with dietary polyphenols and consequences to human health

(2016) Francisco A. Tomás-Barberán et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Metabolic Disposition of Luteolin Is Mediated by the Interplay of UDP-Glucuronosyltransferases and Catechol- O -Methyltransferases in Rats

(2016) Liping Wang et al.   DRUG METABOLISM AND DISPOSITION

Curcumin and its promise as an anticancer drug: An analysis of its anticancer and antifungal effects in cancer and associated complications from invasive fungal infections

(2016) Jin Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A comparative evaluation of treatments with 17β-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease

(2016) Anna E. Tschiffely et al.   HORMONES AND BEHAVIOR

Metabolic Fate of Luteolin in Rats: Its Relationship to Anti-inflammatory Effect

(2016) Ayako Kure et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of Stable Degradation Products of Curcumin on Cancer Cell Proliferation and Inflammation

(2016) Katherine Z. Sanidad et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Influence of Intestinal Microbiota on the Catabolism of Flavonoids in Mice

(2016) Weiqun Lin et al.   JOURNAL OF FOOD SCIENCE

Porphyrins as Catalysts in Scalable Organic Reactions

(2016) Juan Barona-Castaño et al.   MOLECULES

Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity

(2016) Md Ashraful Alam et al.   Nutrition & Metabolism

The chemistry of gut microbial metabolism of polyphenols

(2016) Jan F. Stevens et al.   PHYTOCHEMISTRY REVIEWS

Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery

(2016) Istvan Merchenthaler et al.   Scientific Reports

How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies

(2016) Liang Shen et al.   Scientific Reports

A Bio-Inspired Total Synthesis of Tetrahydrofuran Lignans

(2015) Anna K. F. Albertson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electron Paramagnetic Resonance Study of the Free Radical Scavenging Capacity of Curcumin and Its Demethoxy and Hydrogenated Derivatives

(2015) Noppawan Phumala Morales et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease

(2015) K. G. Goozee et al.   BRITISH JOURNAL OF NUTRITION

Oxidative Transformation of Demethoxy- and Bisdemethoxycurcumin: Products, Mechanism of Formation, and Poisoning of Human Topoisomerase IIα

(2015) Odaine N. Gordon et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Bioactivation of luteolin by tyrosinase selectively inhibits glutathione S-transferase

(2015) Rajiv Balyan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

In vitro anticancer activity of methyl caffeate isolated from Solanum torvum Swartz. fruit

(2015) C. Balachandran et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Recent Applications for in Vitro Antioxidant Activity Assay

(2015) Andrei A. Bunaciu et al.   CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY

Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s)

(2015) Vânia Ortega Gutierres et al.   Evidence-based Complementary and Alternative Medicine

In vitro assessment of antioxidant activity of tyrosol, resveratrol and their acetylated derivatives

(2015) Ioanna C. Vlachogianni et al.   FOOD CHEMISTRY

Bioactivity of phenolic acids: Metabolites versus parent compounds: A review

(2015) Sandrina A. Heleno et al.   FOOD CHEMISTRY

Time-Dependent Metabolism of Luteolin by Human UDP-Glucuronosyltransferases and Its Intestinal First-Pass Glucuronidation in Mice

(2015) Lili Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Degradation of Curcumin: From Mechanism to Biological Implications

(2015) Claus Schneider et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Unraveling Curcumin Degradation

(2015) Odaine N. Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flavonoids activating adenosine monophosphate-activated protein kinase

(2015) Yeonjoong Yong et al.   Journal of the Korean Society for Applied Biological Chemistry

Potential protective properties of flax lignan secoisolariciresinol diglucoside

(2015) Muhammad Imran et al.   Nutrition Journal

Revisiting vitamin C and cancer

(2015) C. R. Reczek et al.   SCIENCE

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

(2015) J. Yun et al.   SCIENCE

The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

(2015) Laszlo Prokai et al.   Science Translational Medicine

Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance

(2015) Markus Morkel et al.   Oncotarget

Plant polyphenols as inhibitors of NF-κB induced cytokine production—a potential anti-inflammatory treatment for Alzheimer's disease?

(2015) Niloo Karunaweera et al.   Frontiers in Molecular Neuroscience

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Increasing the endogenous NO level causes catalase inactivation and reactivation of intercellular apoptosis signaling specifically in tumor cells

(2015) Georg Bauer   Redox Biology

A Biomimetic Catalytic Aerobic Functionalization of Phenols

(2014) Kenneth Virgel N. Esguerra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cytoprotective and regulatory functions of glutathione S-transferases in cancer cell proliferation and cell death

(2014) Simendra Singh   CANCER CHEMOTHERAPY AND PHARMACOLOGY

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Oilseeds ameliorate metabolic parameters in male mice, while contained lignans inhibit 3T3-L1 adipocyte differentiation in vitro

(2014) Giorgio Biasiotto et al.   EUROPEAN JOURNAL OF NUTRITION

Transition metal-promoted biomimetic steps in total syntheses

(2014) Xu-Wen Li et al.   NATURAL PRODUCT REPORTS

NF- B, an Active Player in Human Cancers

(2014) Y. Xia et al.   Cancer Immunology Research

The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer's disease

(2013) T. Jayasena et al.   AGEING RESEARCH REVIEWS

Remarkable Biomimetic Chemoselective Aerobic Oxidation of Flavano-Ellagitannins Found in Oak-Aged Wine

(2013) Emilie Petit et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Editorial (Hot Topic: Inhibition of PI3K/Akt/mTOR Signaling by Natural Products)

(2013) Shile Huang   Anti-Cancer Agents in Medicinal Chemistry

Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy

(2013) V. Nogueira et al.   CLINICAL CANCER RESEARCH

Antioxidant Properties of Hydroxycinnamic Acids: A Review of Structure- Activity Relationships

(2013) N. Razzaghi-Asl et al.   CURRENT MEDICINAL CHEMISTRY

Decomposition kinetics of peroxynitrite: influence of pH and buffer

(2013) Christian Molina et al.   DALTON TRANSACTIONS

Cytotoxicity of Coprinopsis atramentaria extract, organic acids and their synthesized methylated and glucuronate derivatives

(2013) Sandrina A. Heleno et al.   FOOD RESEARCH INTERNATIONAL

How do nutritional antioxidants really work: Nucleophilic tone and para-hormesis versus free radical scavenging in vivo

(2013) Henry J. Forman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence

(2013) Etsuo Niki   FREE RADICAL BIOLOGY AND MEDICINE

Regio- and Stereocontrolled Synthesis of Oligostilbenoids: Theoretical Highlights at the Supramolecular Level

(2013) Saraswati S. Velu et al.   JOURNAL OF NATURAL PRODUCTS

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

In vitro transformation of chlorogenic acid by human gut microbiota

(2013) Francisco Tomas-Barberan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Anti-estrogenic activity of a human resveratrol metabolite

(2013) R. Ruotolo et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Bioaccumulation of resveratrol metabolites in myocardial tissue is dose-time dependent and related to cardiac hemodynamics in diabetic rats

(2013) L. Bresciani et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Metabolism of secoisolariciresinol-diglycoside the dietary precursor to the intestinally derived lignan enterolactone in humans

(2013) Kenneth D. R. Setchell et al.   Food & Function

Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

(2012) Subash C. Gupta et al.   AAPS Journal

Oxidative Metabolites of Curcumin Poison Human Type II Topoisomerases

(2012) Adam C. Ketron et al.   BIOCHEMISTRY

Curcumin uptake and metabolism

(2012) Manfred Metzler et al.   BIOFACTORS

Antioxidant Therapy: Current Status and Future Prospects

(2012) O. Firuzi et al.   CURRENT MEDICINAL CHEMISTRY

Plant and mammalian lignans: A review of source, intake, metabolism, intestinal bacteria and health

(2012) J.M. Landete   FOOD RESEARCH INTERNATIONAL

Curcumin Bioavailability from Enriched Bread: The Effect of Microencapsulated Ingredients

(2012) Paola Vitaglione et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Absorption, Disposition, Metabolism, and Excretion of [3-14C]Caffeic Acid in Rats

(2012) Maizatul H. Omar et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antioxidant Activity of trans-Resveratrol toward Hydroxyl and Hydroperoxyl Radicals: A Quantum Chemical and Computational Kinetics Study

(2012) Cristina Iuga et al.   JOURNAL OF ORGANIC CHEMISTRY

Antioxidant and Antimicrobial Activities of Cinnamic Acid Derivatives

(2012) M. Sova   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Microbial metabolism. Part 14. Isolation and bioactivity evaluation of microbial metabolites of resveratrol

(2012) Wimal Herath et al.   NATURAL PRODUCT RESEARCH

Vanillin and ferulic acid: not the major degradation products of curcumin

(2012) Odaine N. Gordon et al.   TRENDS IN MOLECULAR MEDICINE

The pharmacology of curcumin: is it the degradation products?

(2012) Liang Shen et al.   TRENDS IN MOLECULAR MEDICINE

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Biological evaluation of phenolic constituents from the trunk of Berberis koreana

(2011) Ki Hyun Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure and Function of the Oxidation Products of Polyphenols and Identification of Potent Lipoxygenase Inhibitors from Fe-Catalyzed Oxidation of Resveratrol

(2011) Yoshimi Shingai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Ferulic acid promotes endothelial cells proliferation through up-regulating cyclin D1 and VEGF

(2011) Jun Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Chemistry and biology of reactive oxygen species in signaling or stress responses

(2011) Bryan C Dickinson et al.   Nature Chemical Biology

Hydrogen peroxide: a Jekyll and Hyde signalling molecule

(2011) D R Gough et al.   Cell Death & Disease

Regulation of SIRT1 in cellular functions: Role of polyphenols

(2010) Sangwoon Chung et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite

(2010) Joseph H. Holthoff et al.   BIOCHEMICAL PHARMACOLOGY

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Flaxseed Lignans: Source, Biosynthesis, Metabolism, Antioxidant Activity, Bio-Active Components, and Health Benefits

(2010) Alhassane Touré et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Antioxidation reaction mechanism studies of phenolic lignans, identification of antioxidation products of secoisolariciresinol from lipid oxidation

(2010) Toshiya Masuda et al.   FOOD CHEMISTRY

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Autoxidative and Cyclooxygenase-2 Catalyzed Transformation of the Dietary Chemopreventive Agent Curcumin

(2010) Markus Griesser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Synthesis and Biological Evaluation of Sulfate-Conjugated Resveratrol Metabolites

(2010) Juma Hoshino et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metabolic fate of polyphenols in the human superorganism

(2010) J. van Duynhoven et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Potential Influence of Plant Polyphenols on the Aging Process

(2010) E. Paul Cherniack   FORSCHENDE KOMPLEMENTARMEDIZIN

Insights into the inhibition of xanthine oxidase by curcumin

(2009) Liang Shen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Health effects with consumption of the flax lignan secoisolariciresinol diglucoside

(2009) Jennifer L. Adolphe et al.   BRITISH JOURNAL OF NUTRITION

Contribution of Degradation Products to the Anticancer Activity of Curcumin

(2009) L. Shen et al.   CLINICAL CANCER RESEARCH

Could Antitumor Activity of Curcumin in Patients Be due to Its Metabolites? A Response

(2009) N. Dhillon et al.   CLINICAL CANCER RESEARCH

Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems

(2009) Jian-Ming Lü et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibition Studies of Bovine Xanthine Oxidase by Luteolin, Silibinin, Quercetin, and Curcumin

(2009) James M. Pauff et al.   JOURNAL OF NATURAL PRODUCTS

In vitro and in vivo conjugation of dietary hydroxycinnamic acids by UDP-glucuronosyltransferases and sulfotransferases in humans

(2009) Chi Chun Wong et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Chemical Constituents from Clematis delavayi var. spinescens

(2009) Yang Li et al.   MOLECULES

Pharmacokinetics of Curcumin Conjugate Metabolites in Healthy Human Subjects

(2008) S. K. Vareed et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Vitamin C Antagonizes the Cytotoxic Effects of Antineoplastic Drugs

(2008) M. L. Heaney et al.   CANCER RESEARCH

Antioxidant and radical scavenging properties of curcumin

(2008) Tuba Ak et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

(2008) N. Dhillon et al.   CLINICAL CANCER RESEARCH

In VitroMethods of Assay of Antioxidants: An Overview

(2008) Sudhakar Singh et al.   FOOD REVIEWS INTERNATIONAL

Stacking interaction study oftrans-resveratrol (trans-3,5,4′-trihydroxystilbene) in solution by Nuclear Magnetic Resonance and Fourier Transform Infrared Spectroscopy

(2008) Claudia Bonechi et al.   MAGNETIC RESONANCE IN CHEMISTRY

Biologically inspired oxidation catalysis

(2008) Lawrence Que et al.   NATURE